Boutique hotel vacation rentals in Mississippi River

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Mississippi River

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

A bright sunroom features large windows allowing natural light to fill the space, showcasing wooden flooring and a mix of vintage and modern decor. A wooden table is set with glassware, while a round bar stool and a globe add character to the room.

Hotel room in Spring

4.67 out of 5 average rating, 3 reviews

Stay in Old Town Spring B&B-walk to shops/dining

Chic + historic: luxe comfort near it all! Unwind in a beautifully designed suite featuring a regal Queen bed with adjustable head, plush linens, fluffy pillows, walk-in shower, and dedicated workspace. Enjoy a 43" TV, mini fridge, cozy robes, and access to elegant shared spaces. Just minutes from IAH Airport, perfect for a layover—and steps from shops, dining, and live music in Old Town Spring. Traveling with others? Book additional suites and enjoy old town charm at the Inn together in style!

Superhost

A spacious sleeping area features a large bed covered with a patterned navy duvet and multiple white pillows. A pair of nightstands with lamps is positioned next to the bed. Nearby, a cozy armchair sits beside a window dressed with sheer curtains, allowing natural light to enter.

Hotel room in Two Harbors

4.86 out of 5 average rating, 127 reviews

King #6 Vine & Branches Inn-Two Blocks from Beach

Vine & Branches is a chic relaxing getaway. Soak in views of Lake Superior, walk a few steps and enjoy some smoked fish & ice cream from Lou’s, or candy & gifts at Burlington Station! Want to spend time on the trails? Trailer parking and trail access right outside your door. Close to State Parks, restaurants, shops & other attractions. Suites feature a king or queen bed, AC, full bath, mini fridge, microwave, WiFi, Netflix & YouTubeTV on a 49” screen. Self-check in is a breeze with keypads.

Guest favorite

The Grand Manor features a three-story façade with classic architectural details, framed by tall palm trees. Illuminated paths lead to the entrance, creating an inviting atmosphere. A vibrant sunset sky adds color to the scene, highlighting the mansion's elegant charm.

Hotel room in Galveston

4.85 out of 5 average rating, 592 reviews

Grand Manor Luxury Suites- Vanilla Orchid Room

The elegant Grand Manor, built in 1905, a true southern tropical mansion. Luxurious amenities seamlessly blended with Victorian grace. Located in Galveston's East End Historic District & is considered one of the top architectural structures on the Island.Guest rooms are richly appointed, with king size beds. Private baths are Jacuzzi or claw-footed tubs. Best walking location B&B on Island . The beach,Funky bars & rooftop patios minutes away at WORLD FAMOUS STRAND . (2 other rooms available)

Superhost

An inviting hallway features a wooden wall with warm lighting from two wall sconces. A large, black door labeled '2' provides access to the elevator. Green foliage from a nearby plant adds a touch of nature to the space.

Hotel room in Springfield

4.88 out of 5 average rating, 33 reviews

Culture Boutique Hotel: Pokhara Suite

We're located on Historic C-Street, home to artisan shops, Askinosie, a farmer’s market, yoga studios, wedding venues + more. Downstairs from our hotel is our very own coffee shop! Our loft-like suites feature furniture made from reclaimed materials from our building, a converted mattress factory. Each suite is inspired by a city in Eurasia. The rooms boast high ceilings, a 39in tv, a refrigerator, microwave and a V60, Electric Kettle, + complimentary coffee from Eurasia Coffee & Tea.

Top guest favorite

A spacious studio-style suite features a king bed with white linens, accompanied by bedside lamps. A work desk and dining table for four are positioned across the room. A flat-screen television is mounted on the wall, with large windows allowing natural light inside.

Hotel room in Hot Springs

5 out of 5 average rating, 26 reviews

Historic Best Court 10, King and Queen Suite

Located near Downtown Hot Springs, this Mid-Century style space is retro chic! Built in 1933, this historic landmark was recently transformed into a hip and stylish destination. Our prime location is minutes away from the most popular attractions including the famous Bathhouse Row, North Woods Trail, Oaklawn Racing & Casino, Garvan Gardens, the Entertainment District and our Beautiful Lakes. Our friendly team is eager to help make your visit comfortable, memorable and special!

Guest favorite

The spacious sleeping area features a floating King bed with white bedding and decorative pillows. A contemporary light fixture hangs above. A seating area is visible in the background, along with a mini-kitchen. Natural light floods in from the sliding glass doors leading to the courtyard.

Hotel room in Fairhope

4.91 out of 5 average rating, 140 reviews

Cool, cozy, contemporary and romantic! Location!

Newly renovated with a fresh contemporary feel and large private courtyard with fire pit and spacious area to hang out. The South Point Suite is our most private and located in the newly renovated boutique hotel...Little Point Clear suites & space. Lovely for a couples getaway, honeymoon or business trip - Private deck entrance with fire pit and outdoor seating & onsite parking - Pet Friendly - Coffee bar, frig & microwave - Close to town & beaches

Guest favorite

A stylish bedroom features a green velvet bed and a matching sofa. A large floral artwork adorns one wall beside a bright window, while light fixtures hang from the ceiling, providing illumination. The space is complemented by a patterned area rug and a bedside table.

Hotel room in Galveston

4.93 out of 5 average rating, 107 reviews

RM 3 @theolanderhotelgalveston

First of its kind in the downtown historical area of Galveston. Walk 40 yards to the best restaurants and bars where the locals go. Memory foam mattress, luxurious linens, mini fridge, microwave, snacks and hottubs with the coolest outdoor area in town. Free off road designated parking. Enjoy the glamour of this stylish, upscale place one mile from the ocean. Private bedroom and bath with secure private entrance into the 10 room botique hotel.

Guest favorite

A historic guesthouse is showcased, featuring a neutral-colored façade with intricate architectural details. Pink shutters frame large windows, which are adorned with light curtains. A gentle slope of steps leads to the entrance, and a decorative wrought-iron railing enhances the front porch area.

Hotel room in New Orleans

4.85 out of 5 average rating, 144 reviews

Grand Suite in Historic Victorian Guest House

Stay in the center of the action in this one-of-a-kind place located in the Historic French Quarter. Enjoy easy access to popular shops and restaurants from this charming place nestled in the historic heart of the city and surrounded by three of New Orleans' most famous streets Bourbon St, Royal St, and Esplanade Ave! Want to book adjoining rooms? Book the Bunk Room or Mardi Gras room and let us know you're traveling together.

Guest favorite

The Richard I. Bong Veterans Historical Center is illuminated at night, showcasing its modern arching roof and large glass windows. The building features a combination of natural and artificial light, with signage clearly visible, creating an inviting space for visitors.

Hotel room in Superior

4.88 out of 5 average rating, 413 reviews

Superior Bay Boutique Motel Unit #5

Newly renovated boutique motel in an excellent location for exploring in the Twin Ports. Every room offers unique decor, detailed amenities and includes some of the basics for a short stay. The unit features a queen bed, a dining table and chairs, and some of the basics: Dishes, glasses, silverware, salad bowls, coffee maker, toaster, microwave, refrigerator/freezer.

Guest favorite

A shared balcony area is furnished with multiple wicker chairs and small tables. A large floral artwork adorns one wall, while potted greenery adds a touch of nature. The space features tiled flooring and string lights above, contributing to a relaxed setting.

Hotel room in Laurel

4.9 out of 5 average rating, 117 reviews

Hotel Pinehurst- Central Ave Suite 208

Enjoy easy access to popular shops and restaurants from this charming place . Downtown Laurel is such a beautiful city that's the epitome of southern hospitality. This property is not only classy, but each room tells a story and is named after iconic properties and places. Historic pictures are displayed throughout the property.

Guest favorite

A three-story boutique hotel with a distinct yellow exterior stands amidst lush green landscaping. The structure features multiple balconies with wooden railings and large windows. Palm trees and shrubs are situated in the foreground, reflecting the coastal ambiance of the Gulf of Mexico.

Hotel room in Gulfport

4.92 out of 5 average rating, 138 reviews

Melinda@ Almanett hotel & Bistro Aquarium & beach

Melinda is a guest room within The Almanett Hotel & Bistro (as seen on CNN 15 charming Southern Cities) a gorgeous boutique hotel overlooking sand beaches on the Gulf of Mexico. Melinda: Fling the doors open and sleep in this room as the cool gulf breezes flow over your private balcony....

Guest favorite

A cozy living space features four leather armchairs arranged around a rustic wooden coffee table on a soft area rug. Wood paneling and a staircase create a warm ambiance, while a stone fireplace serves as a focal point. Bookshelves line the walls, filled with various titles.

Hotel room in Duluth

4.89 out of 5 average rating, 27 reviews

Jay Cooke Suite Shared Patio & Sauna

The Jay Cooke Suite is the only room located on main level of the GG Barnum Mansion. The room features a king bed, creek view and direct access to the spacious three season patio. This property is intended for adult getaways, no persons under the age of 16 are permitted.