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Boutique hotel vacation rentals in Mississippi River

Find and book unique boutique hotel rentals on Airbnb

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Popular amenities for Mississippi River boutique hotel rentals

Family-friendly boutique hotels rentals

Hotel room in Pequot Lakes

4.94 out of 5 average rating, 16 reviews

Barn Lodge - The Oliver Acreage

Mar 23 – 30

G$238,250 GYD per night
Guest favorite

Boutique hotel in Bay Saint Louis

4.97 out of 5 average rating, 202 reviews

The Happy Place

Aug 13 – 20

G$21,433 GYD per night
Superhost

Hotel room in Hot Springs National Park

4.9 out of 5 average rating, 209 reviews

Room 10 · Holiday Road Room-Dame Fortune’s Cottage Court

Sep 6 – 13

G$28,653 GYD per night
Superhost

Hotel room in New Orleans

4.67 out of 5 average rating, 181 reviews

b 3rd/4th fl Studio

Jun 8 – 15

G$22,121 GYD per night
Guest favorite

Boutique hotel in New Orleans

4.97 out of 5 average rating, 37 reviews

A short walk to Frenchman St & the French Quarter!

Mar 18 – 25

G$35,535 GYD per night
Guest favorite

Hotel room in Abita Springs

5.0 out of 5 average rating, 54 reviews

Town View King Room

Jan 29 – Feb 5

G$37,579 GYD per night
Superhost

Hotel room in Hermann

4.94 out of 5 average rating, 36 reviews

Hermann Crown's New Pet Friendly Shepherd's Suite

Apr 28 – May 5

G$40,304 GYD per night
Superhost

Hotel room in Jonesboro

4.69 out of 5 average rating, 48 reviews

Downtown 1 BR Studio, Short walk to St. Bernards!

Jun 4 – 11

G$28,952 GYD per night

Boutique hotels rentals with a patio

Guest favorite

Hotel room in Hot Springs

5.0 out of 5 average rating, 7 reviews

Best Court No. 10 One King Bed, One Side Queen BR

Jul 29 – Aug 5

G$27,138 GYD per night
Guest favorite

Boutique hotel in Laurel

4.86 out of 5 average rating, 51 reviews

Hotel Pinehurst- Central Ave Suite 208

Jul 18 – 25

G$32,034 GYD per night
Guest favorite

Boutique hotel in Vivian

4.86 out of 5 average rating, 35 reviews

Historic Firehouse in charming small town America.

Apr 10 – 17

G$30,268 GYD per night
Superhost

Boutique hotel in Clayton

4.93 out of 5 average rating, 27 reviews

Cozy White Cottage Room #1 King Suite Clayton, OK

Oct 31 – Nov 7

G$25,147 GYD per night
Guest favorite

Boutique hotel in Versailles

4.96 out of 5 average rating, 25 reviews

Cozy hotel secluded in the woods 4 Full size beds

Jan 15 – 22

G$19,079 GYD per night
Superhost

Boutique hotel in Breaux Bridge

4.71 out of 5 average rating, 7 reviews

The Stork Room

Feb 9 – 16

G$28,619 GYD per night
Guest favorite

Boutique hotel in Hardy

5.0 out of 5 average rating, 20 reviews

Spring River Stonehouse Inn, Ben's Room

Dec 4 – 11

G$15,130 GYD per night
Superhost

Boutique hotel in Carthage

4.83 out of 5 average rating, 6 reviews

Room 7 (sleeps 2) at Chipley's Squareview Inn

Jan 28 – Feb 4

G$30,689 GYD per night

Destinations to explore