Vacation home rentals in Mississippi River

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in Mississippi River

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1
Top guest favorite
A private pool is visible with a gently sloping lounge chair floating on the water's surface. Surrounding palm trees and natural stone formations create a serene ambiance under bright blue skies.
Vacation home in Montgomery
4.95 out of 5 average rating, 188 reviews

Prancing Horse Estates:10 acre resort w/pool, spa

Welcome to Prancing Horse Estates! This is a private gated 10 acre estate with private pool, spa and waterfall + 4 bedroom home. You’ll love it if you like upscale indoor style combined with beautiful outdoor space. 10 acres- 4 meadow and 6 densely wooded with 2 paths along the creek, with lovely poolside space with seating for 16+. Well stocked library, children’s room, indoor/outdoor games. Certified Wildlife Habitat® site with the National Wildlife Federation and Texas Conservation Alliance.

Top guest favorite
A seating area features brightly colored adirondack chairs in orange, yellow, and blue, arranged around a fire pit. The view overlooks the serene lake, with lush greenery lining the shore and a clear sky above.
Vacation home in Alexandria
4.99 out of 5 average rating, 127 reviews

Lake home with great views in Alexandria

Lake Henry is the hidden gem of Alexandria. This lower traffic lake is perfect for swimming or boating and it has some of the best Walleye fishing in the area. Located in the heart of Alexandria this house is minutes from everything while still having a country feel- you will not find more stunning views. The stylish interior has a fully equipped kitchen, washer/dryer, multiple TVs, and fast Wifi. The exterior has a beautiful 3-season porch and deck that faces the lake along with a fire pit.

Top guest favorite
The historic home features blue siding and a wide front porch adorned with festive garlands. Nestled among bare trees, the property showcases multi-story architecture, with a well-kept yard, providing a welcoming entrance. A gravel pathway leads toward the entrance of the home.
Vacation home in Carthage
4.94 out of 5 average rating, 140 reviews

Grandma Ruby's Vintage Victorian Downstairs Suite

This historic home built in 1884 has been completely renovated with loving care by a granddaughter with fond memories of magical times at her grandparents' unique home. With ten foot ceilings and beautiful craftsmanship, this spacious downstairs unit provides a master suite with a king sized bed and a big screen TV, a large kitchen, a queen bedroom, access to a large private back yard and plenty of parking. All conveniently located to town attractions and just 5 minutes from the interstate.

Top guest favorite
A spacious open-concept living area is shown, featuring a cozy seating arrangement with two sofas and a chair. A coffee table is centered on a decorative area rug. Natural light enters through windows, and the kitchen is visible in the background, showcasing a dining area.
Vacation home in Lebanon
4.92 out of 5 average rating, 105 reviews

Shouse 2 bed/2 bath near Bennett Spring Lebanon MO

Have fun with the whole family at this stylish shouse. Close to Bennett Spring State Park, this super modern shop house is perfect for family vacations & couples get aways. Out door fire-pit overlooks a field full of deer almost every evening. 2 bedrooms each have their own full baths. Common area has full kitchen & laundry room. Wi-fi & parking! Feel like you are in the country, yet close to town for any essentials! Super clean / modern. Close to Lake of the Ozarks, FT Leonard Wood & Rolla

Guest favorite
Adirondack chairs are arranged along the shoreline, facing a calm lake. A large tree provides shade, while vibrant green grass extends along the bank. A small dock is visible on the water, reflecting the surrounding trees under a clear blue sky.
Vacation home in Adams
4.9 out of 5 average rating, 155 reviews

Vacation on the Lake! 15 min from Downtown Dells!

Enjoy a vacation get away on the beautiful and peaceful Easton Lake in Adams, WI. Take out the stand-up paddle boards or kayaks on the lake which travels up Campbell Creek. Bring your poles and enjoy some fishing. Visit Fawn Creek Winery just a few minutes down the road. Just 15 minutes away from Wisconsin Dells, there are endless options for activities such as golf, shopping, escape rooms, water parks, the Ducks tour rides as well as a variety of restaurants and bars. Pet friendly with a fee.

Top guest favorite
The exterior of a two-level tiny duplex features a spacious deck with railings, supported by a wooden structure. Steps lead to a private entrance. Lush green grass and landscaped flower beds enhance the surroundings. A clear blue sky provides a bright backdrop.
Vacation home in Highlandville
4.99 out of 5 average rating, 145 reviews

Two Rivers Guest House (no cleaning fee)

Please read thoroughly: Bike to Two Rivers Mountain Bike Park for a morning ride or relax in a comfortable space after a late evening at Greenhouse Two Rivers. Our place is perfectly situated between the two! This newly constructed private retreat space is conveniently located between between Springfield and Branson. Enjoy relaxing on the spacious deck overlooking the woods, book a blacksmithing or enameling class with us, or use our place as a base while you explore Springfield or Branson.

Top guest favorite
A serene landscape is captured at sunrise, featuring a lone tree silhouetted against a vibrant sky. Rolling hills stretch into the distance, bathed in warm morning light, while a frosted ground adds a touch of winter's chill.
Vacation home in Norwood
5 out of 5 average rating, 109 reviews

Janie Holler Hide-a-way

Come stay at the ranch! As we no longer need a farmhand, we are offering the cabin as a place to relax and enjoy the Ozarks at their finest! Come enjoy stunning views, sunrises and sunsets, fresh country air, starlit skies, and of course, cows. All from your porch. The house has been recently repainted, a soaking tub added, and the gas fireplace upgraded. The kitchen is fully furnished and a propane grill provided. Park your vehicle in the shop beside the house. Live the simple life!

Top guest favorite
A paddleboard floats on calm lake water with a scenic backdrop of trees and a sunset. A hand holds a cup of dark beverage beside the paddle. The vibrant blue surface of the paddleboard adds a pop of color to the tranquil setting.
Vacation home in Bella Vista
4.96 out of 5 average rating, 186 reviews

Getaway to the lake

This isn't just a house, this is an experience! Over 2000sqft dream house with lots of natural lighting. Lake without a steep descent or stairs. Fast Wi-Fi speeds, & tv's (no cable) throughout. All basic (soap, hair dryer) items supplied including a fully equipped kitchen. 6 queen beds, 1 twin bed, 1 sofa twin, & 1 full bed and full futon bed with 2.5 bathrooms (see access section.) Arcade games, in/outside games, a game table for cards/puzzle building, and a full-sized foosball game.

Top guest favorite
A spacious bed is centered against a light-colored wall, flanked by two bedside tables with matching lamps. A decorative metal art piece adds a rustic touch above the headboard, while the bedding features a soft, neutral-toned quilt.
Vacation home in Wilburton
4.98 out of 5 average rating, 127 reviews

Peaceful retreat @ Four Star Ranch

Bring the whole family to this great place with lots of room for fun. Enjoy the country setting with beautiful views in every direction. Close enough to town for easy access to restaurants, shopping and the College. Enjoy a free coffee at the Vintage Rose Boutique at 126 E Main Street, just mention you’re our guest! I Maximum number of guest is 8. We do not allow gatherings of any type. If you have any questions please contact us before your stay. Absolutely no pets allowed.

Top guest favorite
A spacious dining area features a large wooden table surrounded by black chairs. A living space is visible in the background with comfortable seating, large windows, and a sleek gas fireplace. Natural light fills the room, highlighting the open and airy layout.
Vacation home in Galena
4.97 out of 5 average rating, 155 reviews

Summer in Galena | Hot Tub, Fire Pit & Views

Welcome to Shenandoah Ridge—our thoughtfully designed 4-bedroom, 4.5-bath vacation rental tucked into the woods of The Galena Territory. Spacious, peaceful, and full of cozy touches to help you unwind. Whether you’re here for a family getaway, group trip, remote work retreat, or just time in nature, you’ll find everything you need to feel at home. Just 7 minutes to the Owners Club and 15 minutes to downtown Galena—close to the action, but still calm and quiet.

Superhost
A rustic cabin perched beside a serene pond reflects the warm glow of the setting sun. Surrounding trees provide a natural frame, enhancing the peaceful atmosphere of the heavily wooded area. The clear water mirrors the landscape, creating a tranquil retreat.
Vacation home in Mena
4.83 out of 5 average rating, 412 reviews

Heart Shaped Tub for Two at Raspberry Retreat

Get away to a romantic cabin hidden deep in the Oachita Mountains! The cabin is located within a few yards of the national forest boundary. Relax on the covered front porch and look at the stars on a clear night. Or, hear the rain on the roof while soaking in the heart shaped hot tub on a stormy night! Either way, you will find a peaceful stay here! From the town of Mena, AR it is about a 15 minute drive to the property.

Guest favorite
A charming red cottage is nestled among tall aspen trees. A winding stone pathway leads to the entrance, which features a wooden door and large window. Lush greenery surrounds the house, enhancing the tranquil forest setting.
Vacation home in Galena
4.94 out of 5 average rating, 138 reviews

Aspen House - A Secluded Getaway In Nature

Relax with your loved ones at the peaceful Aspen House. A Miner's Cottage nestled in a beautiful stand of aspen trees = a quiet retreat just for you! The property is surrounded by protected wooded green space with the Taylor Run trail adjacent on the northwest side. The Owners Club, pools & lake are accessible by hiking/ 5 minute drive. Enjoy bird watching, fishing, hiking and picnicking without driving anywhere!

Popular amenities for Mississippi River vacation home rentals

Destinations to explore