Guesthouse vacation rentals in Mississippi River

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mississippi River guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Siloam Springs
4.95 out of 5 average rating, 154 reviews

Little House on Broadway

JulieRating, 5 stars1 week ago
Excellent! Was glad to find this place for a last minute trip.
Top guest favorite
Guesthouse in Bartlesville
4.92 out of 5 average rating, 191 reviews

Cabin in the Woods, 10 minutes to Bartlesville

JonnieRating, 5 stars2 months ago
Wow! Blown away by Don and Sharon’s hospitality! I was very hesitant on getting an Airbnb bc I’ve never gotten one by myself before so I asked a lot of questions haha. Sharon put me at ease and answered all of my questions. Their cabin is very very COZY! A PERFECT GETAWAY for those in need of solitude! Birds are always chirping, and when the flowers on the residence are in bloom, it’s very captivating. Whenever I needed help with something , they were very quick to respond. I highly recommend this wonderful place! Make sure to ask Mr. Don about how God changed his life! It’s a beautiful story!
Top guest favorite
Guesthouse in Stockton
4.98 out of 5 average rating, 363 reviews

Highview Country Escape - Cozy Cabin with a view

RafalRating, 5 stars1 month ago
We had a fantastic stay at this beautiful property nestled on a hill in the middle of nature. The location is peaceful and scenic—perfect for a relaxing getaway. Our dogs absolutely loved the wide open space to run and explore, which made the trip even more special. One of the highlights was the lovely pond on the property, full of fish and a great spot to sit by and enjoy the surroundings. Highly recommend this place for nature lovers and pet owners alike!
Top guest favorite
Guesthouse in Roach
4.95 out of 5 average rating, 326 reviews

Quiet Cottage

JacobRating, 5 starstoday
Clark was an amazing host with a beautiful piece of land. Very nice host with great recommendations and very accommodating to our needs. Set us up perfect for the weekend with a private space and got fires started for us both nights which really helped make our weekend special thank you so much! Highly recommend!
Guest favorite
Guesthouse in Nevada
4.88 out of 5 average rating, 219 reviews

FarmPond Inn

TeriRating, 5 stars1 week ago
Evie’s place was nice for a weekend away. Beautiful green surroundings. Nice deck to view from and even had outdoor music on Friday. I would recommend Evie’s place!
Guest favorite
Guesthouse in Cape Girardeau
4.93 out of 5 average rating, 516 reviews

Downtown Guesthouse- Romantic Getaway

HannahRating, 5 stars1 month ago
Thank you! Loves the space.
Top guest favorite
Guesthouse in Laurel
4.98 out of 5 average rating, 894 reviews

Mallorie's Cottage! Rated Top 1% in the World!

CliffordRating, 5 stars3 days ago
We celebrated our 52nd anniversary and could not have chosen a better place. The cottage was everything we could have hoped for! Beautiful, spotless, quiet, warm and welcoming! The cottage is stocked with anything you can possibly think of. She left no stones unturned! Mallorie is the perfect host! She and Jim both are very friendly and we were honored to have met them. Laurel is a beautiful town and just seeing the homes that were renovated by the Home Town show was so much fun. We highly recommend staying at Mallorie's cottage! You will not be disappointed!
Top guest favorite
Guesthouse in Mount Horeb
4.96 out of 5 average rating, 606 reviews

Cool, Scenic Country Art Studio

GraceRating, 5 stars1 week ago
Nina is such a wonderful host! She let us use her kitchen to make dinner and everything was so organized and clean. Everything she described about her place is completely accurate, it is so beautiful and private. I had a great time walking around the property with my boyfriend and the kitties who roamed around outside kept us great company. Nina is so sweet and inviting, her style and vibrancy is pleasant, I would definitely come back!

Guest house rentals with a patio

Top guest favorite
Guesthouse in Owasso
4.97 out of 5 average rating, 152 reviews

The Apartment Away

GingerRating, 5 stars1 month ago
This was our first time to stay with Ashley it it won't be our last. We have to travel to Tulsa 6-8 times a year and Owasso is the perfect place between our Grand kids in Claremore and our business in Tulsa.
Top guest favorite
Guesthouse in St. Louis
4.99 out of 5 average rating, 143 reviews

The PS Carriage House: Spa Tub + Walk Everywhere!

AnnaRating, 5 stars1 week ago
I would definitely stay here again! It was very clean and in a safer neighborhood than most in St. Louis. Katie and Tyler were extremely friendly and helpful. It’s a beautiful guest home and worth the price! I felt safe staying here and it was quiet and peaceful-easy place to relax at. I will be recommending friends and family to stay here as well. Thanks again, Anna & Jordan.
Guest favorite
Guesthouse in Atlanta
4.93 out of 5 average rating, 102 reviews

The Farmhouse in the Woods

AbelardoRating, 5 starstoday
We had a great stay at the farmhouse. The place was amazing. The area was peaceful and quiet. The host was very responsive and welcoming. We would definitely stay again.
Top guest favorite
Guesthouse in Hot Springs
4.98 out of 5 average rating, 112 reviews

Clearcreek Farm Private Guest Cabin For Two

MattRating, 5 stars2 weeks ago
Can't say enough about how much we enjoyed our stay here. Peaceful, beautiful surroundings and a well-appointed, comfortable cabin for a quiet retreat. Tami was extremely responsive and helpful. Take advantage of a massage if you can! My wife enjoyed it, and added to the relaxing atmosphere. Sitting on the porch and watching the hummingbirds and deer was a added bonus for what is already an excellent rental just near enough to all there is to do in Hot Springs, but in the country enough to enjoy the peace and quiet.
Top guest favorite
Guesthouse in Joplin
4.99 out of 5 average rating, 151 reviews

Mike & Angie’s Private-Cozy furnished Guest House

RonRating, 5 stars1 week ago
Comfy cottage on beautiful grounds on a year-round creek just a little ways downstream from Grand Falls. Nearby is a lovely park with a disc golf course, which we walked to and enjoyed a firefly show at dusk! Angela is an attentive and generous host who makes extra effort to assure a comfortable and relaxing stay. This place is a gem, a little bit out of the way, but oh so worth it!
Top guest favorite
Guesthouse in Vicksburg
4.95 out of 5 average rating, 282 reviews

Lakeside Cottage with pool minutes from Vicksburg

LucyRating, 5 stars1 week ago
We highly recommend this beautiful cottage. The cottage is well stocked with everything we needed. The property is lovely and in a quiet neighborhood. The hosts are friendly and welcoming. If you’re in this area, don’t miss this cottage!
Top guest favorite
Guesthouse in Lovelady
5 out of 5 average rating, 121 reviews

Bunkhouse Getaway 1 room with private hot tub

SoraRating, 5 stars2 weeks ago
I absolutely loved my stay at this charming bunkhouse! From the moment I arrived, I felt right at home. The peaceful country setting was exactly what I needed to unwind. The hot tub was a dream, perfect for relaxing under the stars after a long day. I also really enjoyed the cozy fire pit, which made for such peaceful evenings. One of the sweetest surprises was the fresh treats left for guests. It was such a thoughtful touch that made the stay feel extra special. The host also provided excellent travel directions, which made getting there a breeze. Everything was clean, comfortable, and well thought-out. If you're looking for a quiet, cozy retreat with plenty of charm, this is the place. I’ll definitely be back.
Top guest favorite
Guesthouse in Bentonville
4.95 out of 5 average rating, 168 reviews

Adorable 1 bedroom guest house

MattieRating, 5 stars4 days ago
Cute airbnb in a nice neighborhood. We enjoyed our stay

Guest house rentals with a washer and dryer

Top guest favorite
Guesthouse in Monroe
5 out of 5 average rating, 270 reviews

Bayou Long Beard - Bayou view! We greet everyone!

KristieRating, 5 stars2 days ago
I can’t say enough about this home! From the moment we met Joy and walked inside, this place just felt like a second home. Not a single detail has been over looked. From comfort of the bed to cleanliness of the place. Right down to the peaceful views and deck to sit and relax on. Everything has been thought of. This home and the host are exactly what an Airbnb is supposed to be. If it’s available I’ll be booking here first before anywhere else. Go ahead and book this place you can’t go wrong.
Top guest favorite
Guesthouse in Hot Springs
4.99 out of 5 average rating, 141 reviews

Entire King Suite • Private Lake Balboa Guesthouse

GailRating, 5 stars2 weeks ago
Totally enjoyed the guest house. It was exactly as described. The lake is beautiful and the dock was a great place to sit and enjoy a cup of coffee. We did get to visit with Cynthia and she was charming. The snacks and coffee were welcomed extras. The only thing I can recommend is to bring your own pillow. I was fine with the pillows there but my husband thought they were too big. Thankfully we always carry his when we travel. Definitely would recommend this guest house.
Top guest favorite
Guesthouse in Webb City
4.97 out of 5 average rating, 572 reviews

Bright and Modern Private Guesthouse near Route 66

DonnaRating, 5 stars1 day ago
This was a great experience. Such a cute and homey place. Perfect! Would highly recommend. Great communication.
Top guest favorite
Guesthouse in Tulsa
4.97 out of 5 average rating, 107 reviews

The Curious Little Cottage

BrittanyRating, 5 stars1 week ago
This has to be the neatest space I’ve ever rented! The pictures don’t do it justice; it’s so much more fun and intriguing in person! There was such a cornucopia of interesting curiosities in every corner. The place was super clean, with every accommodation we could’ve hoped to have and more. The shower is also incredible, along with the unique bathroom sink! We were very comfortable and couldn’t have selected a more perfect place for a weekend getaway. It makes me only want to stay at themed Airbnbs going forward :)
Guest favorite
Guesthouse in Everton
4.97 out of 5 average rating, 132 reviews

Sumerset Cottage

CaitlynRating, 5 stars1 week ago
Susan’s cottage was perfect for us! The views were incredible and the cottage was absolutely gorgeous. She gave us great recommendations and was super responsive. Can’t wait to stay here again!
Guest favorite
Guesthouse in Owasso
4.88 out of 5 average rating, 263 reviews

French Woods Quarters

KathyRating, 5 stars1 month ago
Thank you so much Stacey and Shon. Your place is so lovely and comfortable. My granddaughter loved the pool and grounds. We enjoyed our meals on the porch everyday and having a Sprouts just down the road made it convenient for us to get grocery’s. We will definitely stay again when we come back to visit family in Claremore. Thanks again, Kathy, Nicole and Delilaah.
Top guest favorite
Guesthouse in Westwood
4.99 out of 5 average rating, 603 reviews

Westwood cottage in garden setting

MicheleRating, 5 stars2 days ago
In town with my daughter for a softball tournament. This was the cutest whimsical air b&b. The host provided clear instructions and the amenities were abundant. The air b&b was stocked above and beyond for anything you need Plus so many nice "extras" like snacks, drinks. Love the artsy style of the place. Very clean and just the perfect size for the two of us. Located in a safe, walkable neighborhood. Saw many people walking and friendly atmosphere. Will absolutely look to come back to stay at Georgia's place when we are in town again.
Top guest favorite
Guesthouse in Shawnee
5 out of 5 average rating, 228 reviews

1 of a Kind Guesthouse on 4 Acres. Dogs allowed

CarolynRating, 5 stars1 week ago
Loved our stay It was all great!

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