
Guesthouse vacation rentals in Mississippi River
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Top-rated guesthouse rentals in Mississippi River
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

The Downtown Hermann Hen House Food/Bar/Music/Fun
Free Buffet Breakfast/Free Drink Tickets/Live Music Nightly through Oct./Personalized $20 Per Person Shuttle (Trolley is $30)1837 Bar/Restaurant. Put All Your Eggs in the Hen House’s Basket. Right by Restaurants/Shopping/Bars. 2 Bedrooms, 2 Private Bathrooms, & 2 Queen Pullout Sleepers in Living Room. Room for 8 Guests. Full Kitchen & Large Farm Table for Dining or Games with Your Friends. Property Managed by the Hermann Crown Suites next door. Call Hermann Crown to Reserve Spot on Shuttle Now.
4.94 out of 5 average rating, 145 reviews
Cozy Cottage on C
Welcome to our structural masonry guesthouse cottage in the heart of Downtown Bentonville. You'll feel like you're stepping back in time into a historic building made entirely out of brick, but our backyard cottage was completed in 2023 as a labor of love and hospitality. Enjoy direct access to Park Springs Park and trails at the end of the block, or a short walk/ride to the Downtown square. We live in the main house on the property, but designed the cottage to maximize guest privacy. Welcome!
4.98 out of 5 average rating, 390 reviews
The Loft - Mt. Views & Close River Access (0.7)
Created just for two, this cozy haven is the perfect base camp for your outdoor adventures. The Loft features gorgeous mountain views and quick access to the Buffalo River. This 352 square foot modern studio boasts an exceptional outdoor living space. Sit on the porch with your morning coffee before you head out for adventure and keep an eye out for the deer that feel right at home on our 40 acre property. PLEASE SEE the “Other details to note “ section regarding proximity to the main house.
4.99 out of 5 average rating, 162 reviews
Spacious Country Apartment with Modern Amenities
Welcome to Louisburg! Spacious, private entry, 1000 sq. ft. apartment above detached garage within minutes of wineries, antiques & Cider Mill. Set on 15 acres, and 2 miles down a gravel road, you are out of the city and seeing stars, with an amazing 2nd story view. Sleeps up to 6 with separate bedroom with queen bed and low ceiling (62” great for kids!) loft with 2 twins & a double. All wrapped in unique finishes including an amazing shower! Located only 45 minutes from downtown Kansas City!
4.96 out of 5 average rating, 164 reviews
Private Guest Lake House On 37 Acres In Country
Private guest lake house, located next to main house, on private lake in the country. 2 bedroom, 1 full bath, full kitchen, washer and dryer and large attached screen porch. Private 37 acres of woods and prairie. Fishing and walking trails. Great window views of lake, woods, prairies and river valley. Please note, this guest house is located 1 mile down a county maintained gravel road. 25 minutes from Galesburg, IL, 20 minutes from Monmouth, IL and 35 minutes from Macomb, IL.
4.99 out of 5 average rating, 267 reviews
Panther Creek Guesthouse
Small farmhouse, private fenced and gated yard, on a tiny farm on a gravel road. Host next door has dwarf goats, chickens, ducks, guineas (1 pair regularly visits/patrols the guesthouse yard), turkeys, a goose, and a couple of LGDs. Horses live across the road and around the curve and up the hill. Eggs and some other basic food items included! Less than 5 miles off Hwy 60 north of Fordland Café, Dollar General, gas in Fordland Springfield 24 Branson 55 7.5 miles from I-44 @ Northview
4.92 out of 5 average rating, 216 reviews
Turtle Cove- Hot tub, Kayaks, Fire Wood Included
Come and enjoy a peaceful getaway in our quiet cove on Table Rock Lake. Relax in our guest house with a private deck, hot tub, outdoor shower, fire pit and beach at your back door! Enjoy swimming or fishing in the cove, sunning on a paddle board or kayaking at sunset. Paddle boards and kayaks included! Welcome family time relaxing on the hammock listening to the water lapping, barbecuing on the deck or chilling by the fire pit (firewood included). Come rejuvenate in nature's beauty!!
4.97 out of 5 average rating, 303 reviews
tiny guest house pool 2 bed / Fire-pit
Relax and calm stylish cottage loft place,just a perfect get away , yoga , walk, hiking, enjoy the fire place or swimming pool/watching the birds, beautiful nature breath a flash air , new comfortable bed , recommend for 2 guests, but can sleep up to 5 , there is a king size , a queen size, and a rollaway bed consult with you host, close to shopping stores, gas station, hospitals,culinary institutions school, 25 minutes to Little Rock and hot springs ,not for parties or events
4.9 out of 5 average rating, 216 reviews
The Penthouse in DTR
Enjoy a stay at the only Luxury apartment rental conveniently located just two blocks from downtown Rogers. The Penthouse in Downtown Rogers is a modern and stylish apartment with all the amenities you need for a short stay or a long retreat: sumptious Sleep Number bed and bedding, gourmet kitchen and outdoor barbecue area, luxe shower and outdoor hot tub with an outdoor fire pit to boot. Just 3 blocks from the Railyard mountain bike park, a short trail to lake Atalanta park.
4.98 out of 5 average rating, 368 reviews
Tanyard Creek | Waterfall · Bike In/Out
Walk to the waterfall. Ride to the trails. Relax in the trees. Set directly above Tanyard Creek, this private guesthouse offers immediate access to scenic hiking paths and nearby MTB trails—making it the perfect basecamp for both riders and nature-focused stays. Designed for those who want to be outside during the day and fully recharge at night, the space is dialed for comfort with Tempur-Pedic beds and a specialty coffee setup to start your mornings right.
4.94 out of 5 average rating, 156 reviews
Just off the beaten path
Take it easy at this unique and tranquil getaway. 5 minutes from I-70. Enjoy nature in the woods in our cozy, quiet guesthouse. Close to the University of Missouri for events, medical and business travelers, as well as the Katy Trail for cyclists, wineries, and I-70 for the weary traveler needing a quiet rest and relax. Coffee/tea to wake up enjoying breathtaking views from your private deck.
4.98 out of 5 average rating, 394 reviews
Salt River Alpacas Guesthouse
Kick back and relax in this newly built guesthouse. Located on a peninsula on Mark Twain Lake, this guesthouse is surrounded by 130 acres of rolling pastures, plenty of woodlands, and the lake on three sides of the property. Whether you enjoy hiking, canoeing/kayaking, fishing, hunting, learning about our alpacas, or you just want a quiet place to relax, this property has it all!
4.99 out of 5 average rating, 224 reviewsPopular amenities for Mississippi River guesthouse rentals
Family-friendly guest house rentals

French Woods Quarters
4.88 out of 5 average rating, 318 reviews
Serene setting w/ private Illinois River access
4.89 out of 5 average rating, 121 reviews
Cozy cabin on farm near Jerseyville and Grafton IL
4.96 out of 5 average rating, 200 reviews
Rustic tool shed stay unique tiny home experience
4.96 out of 5 average rating, 1089 reviews
Camp Wandawega: Lakeside 3 Bedroom Cabin
4.98 out of 5 average rating, 183 reviews
Bunkhouse on the Water
5.0 out of 5 average rating, 162 reviews
1 of a Kind Guesthouse on 4 Acres. Dogs allowed
5.0 out of 5 average rating, 259 reviews
Country Escape in beautiful Ozarks
5.0 out of 5 average rating, 127 reviewsGuest house rentals with a patio

Ouachita River Treehouse
4.98 out of 5 average rating, 175 reviews
Rustic digs on acreage Near Mt Hebron Park, Rogers
4.96 out of 5 average rating, 307 reviews
Women of the Woods • Where the Forest Finds You
5.0 out of 5 average rating, 120 reviews
Earthen Oasis - Nature Retreat Minutes to Downtown
4.93 out of 5 average rating, 141 reviews
Cozy cottage getaway in garden paradise
4.89 out of 5 average rating, 267 reviews
Adorable 1 bedroom guest house
4.95 out of 5 average rating, 214 reviews
The Rose Cottage w/ Gardens & easy access to Tulsa
4.96 out of 5 average rating, 105 reviews
Charming Hummingbird Cottage
4.96 out of 5 average rating, 113 reviewsGuest house rentals with a washer and dryer

Westwood cottage in garden setting
4.99 out of 5 average rating, 726 reviews
Lafon's Flippin Cottage
5.0 out of 5 average rating, 102 reviews
The Little Shop House
4.94 out of 5 average rating, 124 reviews
Little House on Broadway
4.96 out of 5 average rating, 250 reviews
Bright and Modern Private Guesthouse near Route 66
4.97 out of 5 average rating, 719 reviews
Harvest Hill Hideaway
4.97 out of 5 average rating, 343 reviews
Bayou Long Beard - Bayou view! We greet everyone!
5.0 out of 5 average rating, 353 reviews
Studio Guest House
4.99 out of 5 average rating, 275 reviewsDestinations to explore
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