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Hotel vacation rentals in Mississippi River

Find and book unique hotel rentals on Airbnb

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Popular amenities for Mississippi River hotel rentals

Family-friendly hotel rentals

Guest favorite
The spacious sleeping area features a floating King bed with white bedding and decorative pillows. A contemporary light fixture hangs above. A seating area is visible in the background, along with a mini-kitchen. Natural light floods in from the sliding glass doors leading to the courtyard.
Hotel room in Fairhope
4.92 out of 5 average rating, 142 reviews

Cool, cozy, contemporary and romantic! Location!

LaurenRating, 5 stars1 month ago
Great, very new and well appointed. Nice access to the bay. Wonderful location. We will definitely be back.
Guest favorite
A bright bedroom is adorned with a light blue wall, creating a serene atmosphere. The spacious bed is covered with a decorative blanket, flanked by crisp white linens. A bedside table and a dresser provide practical storage, while a large window allows natural light to fill the room.
Hotel room in St. Louis
4.87 out of 5 average rating, 720 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

TannerRating, 5 stars3 weeks ago
Great stay, second time in this location, will be interested in coming back
Guest favorite
Aerial view captures the Great Lodge nestled alongside Little Hanging Horn Lake, surrounded by lush greenery. The calm water reflects the hues of sunset, while a wooden pier extends into the lake, offering a serene connection to nature.
Hotel room in Barnum
4.97 out of 5 average rating, 70 reviews

Hanging Horn Lakeside Resort #6 Woods View Room

BrianRating, 5 stars2 weeks ago
unfortunately we only spent one night at Hanging Horn. It was a beautiful setting and would have loved to spend more time exploring the area.
A round wooden dining table is surrounded by six matching chairs in a sunlit room. Large windows reveal a scenic view of the beach and gulf beyond, with natural light flooding the space. A ceiling fan provides a cooling breeze, enhancing comfort.
Hotel room in Grand Isle
4.9 out of 5 average rating, 30 reviews

Gulf Front Suite - 2 Bedrooms with Kitchen

EthanRating, 5 stars3 weeks ago
Place was in a great location with an awesome deck, check in was easy and host was very responsive. Great place to stay in Grand Isle.
Top guest favorite
The exterior of the Courtland Hotel showcases red brick architecture, featuring large windows with green trim. A sidewalk runs alongside, complemented by planters and benches, enhancing the inviting atmosphere of the surrounding downtown area.
Hotel room in Fort Scott
4.9 out of 5 average rating, 71 reviews

Charming Historic Hotel lodging

CharlesRating, 5 stars1 month ago
Had a great stay. Frank was very flexible with early check in….really appreciate that.
Superhost
A cozy room is furnished with a double bed dressed in a checkered blanket and accented by matching pillows. A wooden nightstand is positioned beside the bed, with a mirror and framed artwork displayed on the wall behind. Soft lighting enhances the space.
Hotel room in Windsor
4.72 out of 5 average rating, 32 reviews

Single Full XL Bed at Windsor Crossroads Motel

LynnRating, 5 stars8 months ago
This is our third time at Windsor Crossroads Motel. Just a short ride to both the Katy Trail and the Rock Island. Quaint 1950’s style motel, very clean and we really like the staff. Very friendly and helpful. The room is small but all we need is a place to shower and sleep between rides on the trail. Perfect spot!
Top guest favorite
A cozy seating area is shown, featuring a white couch adorned with pastel green and yellow cushions. Framed artwork is displayed on the wall above the couch, complementing the light yellow walls. Soft lighting is provided by a lamp on a nearby side table.
Hotel room in Bay St. Louis
4.97 out of 5 average rating, 232 reviews

The Happy Place

AlexanderRating, 5 stars3 days ago
We thoroughly enjoyed our weekend in Bay St. Louis and our stay at this lovely place. There is a magical quality to the property, with its lush garden complete with a goldfish pond and the cats and dogs. The place was comfortable (for two people) and the location is great. It's an easy walk to the heart of the town and the beach.
Guest favorite
A cozy bedroom features a spacious bed with white linens, complemented by artistic nautical decor. Two bedside lamps illuminate the room, while a decorative net with an anchor and fish adds a coastal theme to the vibrant turquoise wall.
Resort in Grafton
4.94 out of 5 average rating, 69 reviews

River View Guest House, The Fishing Hole

LeeAnneRating, 5 stars8 months ago
place was fresh and very clean. walkable distance to all the bars and nightlife. I loved that there was a menu to the restaurant next door it really wrapped the night up great.

Hotel rentals with a pool

Superhost
The exterior of The Westin Chicago Northwest is showcased against a clear blue sky. Colorful flowers line the foreground, leading to a serene pond with a fountain, while the hotel building stands prominently in the background.
Hotel room in Itasca
4.87 out of 5 average rating, 174 reviews

Guest room with 2 Double Beds + PET Friendly

JasonRating, 5 stars2 weeks ago
Beautiful property, great room, and AMAZING pool! Such a deal for the price and everything. Love it. Will come back for sure!
Guest favorite
A spacious room features a king bed with white bedding, a seating area with a gray sofa and a burgundy armchair. A dining table with black chairs is positioned near the kitchenette. Natural light flows in from a large window, and a flat-screen TV is mounted on the wall.
Hotel room in Branson
4.89 out of 5 average rating, 19 reviews

Indian Point Walk In Condo 123, FREE SDC shuttle

BrittanyRating, 5 stars3 weeks ago
Although I never had to contact her during our stay, she was good about having communication started before the day of our stay. Very polite in asking if we’d need a pack n play since she saw our “guests” would include infants. It was really nice being able to park right in front of the door to load everything inside with ease. I love how it had hardwood throughout instead of the typical carpeting like at a hotel. Very cozy kitchen that would have everything you’d need for a long stay.
Superhost
A well-appointed hotel room features a spacious bed with crisp linens and a light wood frame. A modern desk and chair are positioned next to a large window with sheer curtains, allowing natural light in. A flat-screen TV and minibar are present on a sleek media console.
Hotel room in Brookfield
4.72 out of 5 average rating, 184 reviews

Family Retreat | Museums . Free Shuttle

IndiaRating, 5 stars2 weeks ago
Very clean, and comfortable stay
Guest favorite
A spacious room features a large bed dressed in white linens, complemented by navy blue pillows. A modern chair and bedside tables with lamps enhance the decor. A flat-screen television is mounted on the wall, and natural light enters through the window adorned with light shades.
Hotel room in Rogers
5 out of 5 average rating, 18 reviews

Beaver Lake Boutique Motel - King Room

BryceRating, 5 stars1 week ago
Easy check in. Good communication. Clean room.
A light-filled studio is depicted, featuring a spacious kitchen with black and stainless steel appliances. A comfortable seating area is provided with a plush sofa and decorative rug. Large windows open to a balcony with outdoor furnishings and greenery visible.
Hotel room in New Orleans
5 out of 5 average rating, 11 reviews

Luxury Studio Apt w Balcony in Memoir Building

ChloeRating, 5 stars1 week ago
I truly enjoyed my stay. The room was beautiful and clean. The concierge was so kind and helpful. We spent an amazing Sunday afternoon at the beautiful pool. The stay itself was really amazing. The one thing that chapped me was I wasn’t made aware of a $42 fee I would have to pay to use the pool and have access to their social club. The Airbnb was already pretty pricey so having to pay a fee when i arrived and not being made aware of said fee was a little annoying. Also the parking situation was nice because it’s across the street so very convenient but again pricey adding another 50 dollars to our trip. Overall the stay was lovely i just wish there was a little more price transparency especially since i figured the Airbnb was priced at that point to reflect the amenities you would enjoy.
Superhost
An outdoor swimming pool is positioned within a fenced area, surrounded by various lounge chairs and tables. Colorful seating options are visible, along with several potted plants. Nearby, a vehicle is parked next to a dock, and water can be seen beyond the enclosure.
Resort in Rockaway Beach
4.82 out of 5 average rating, 55 reviews

Expedition Cabin - On the Lake Fishing Cabin

SeanRating, 5 stars3 weeks ago
Wonderful peaceful stay right on the lake! Exactly what we were looking for. We loved it and will be back!
Top guest favorite
Hotel room in Branson
4.98 out of 5 average rating, 53 reviews

Double Queen room in Branson

JenniferRating, 5 stars4 days ago
Nice location and very affordable. We had one small issue but it was resolved quickly and Michael was very responsive and gracious. It is very evident that Michael cares about his property and more importantly his guests’ experience.
Guest favorite
An outdoor courtyard features a brick patio surrounding a small pool. Comfortable seating is arranged around a table, with greenery and brick walls providing a secluded atmosphere. The space is complemented by sunny skies and a few scattered trees, enhancing the overall charm.
Hotel room in New Orleans
4.96 out of 5 average rating, 137 reviews

Grenoble House Courtyard Balcony Loft Suite

ToddRating, 5 stars2 weeks ago
We enjoyed our 5 nights at The Grenoble House! The place was great. The host was very responsive and accommodating. We are looking forward to coming back!

Hotel rentals with a patio

Guest favorite
The exterior of the Vivian Fire House is depicted, featuring a vintage red fire truck parked in front. The building is painted in a soft pink hue with the 'VIVIAN FIRE HOUSE' sign prominently displayed above. Surrounding elements include a well-kept lawn and ornamental details.
Hotel room in Vivian
4.88 out of 5 average rating, 43 reviews

Historic Firehouse in charming small town America.

MichaelRating, 5 stars1 month ago
This place was super cute, and you have a pizza and ice cream shop underneath you! What more could you ask for? Excellent overnight stay with Family Dollar across the street and Walmart a mile away.
Guest favorite
A queen bed is covered with a textured blue blanket, surrounded by light grey walls. A window is fitted with sheer and solid curtains, allowing natural light. A small desk and a chair are positioned nearby, complementing the room's simple decor.
Hotel room in Branson
4.95 out of 5 average rating, 22 reviews

Lake, Room 7 upper level

BrittinieRating, 5 stars1 month ago
My husband and I did a weekend getaway here and we picked the Landmark Inn due to its perfect location. It was only about a 3 minute walk to the Branson Landing and a 3 minute walk to Main Street. Once we were there we didn't have to drive anywhere until we checked out to go home. The room was just as described in the photos. It was very clean and modern. Dede was a perfect host down to letting us know the room would be ready early and checking in on us the next day making sure we didn't need anything. We will definitely be back and can't wait to bring the kids next time.
Guest favorite
A spacious king suite features a large bed with soft linens, complemented by a cozy armchair and a stylish lamp. A separate jacuzzi tub is situated nearby, and natural light flows in through the window, illuminating the light-colored decor and wood accents.
Hotel room in New Glarus
4.94 out of 5 average rating, 79 reviews

Chalet King Suite with Jacuzzi

JasonRating, 5 stars5 days ago
A great renovated place to stay at while in New Glarus. Picnic area and coffee shop on site. Self service check in and amenities. Host is thoughtful and responsive. Don’t let the motel exterior fool you.
Guest favorite
A living area is presented with a comfortable sofa and a blue accent chair. A coffee table sits in the center on a patterned rug. A television is mounted above a cabinet, while a ceiling fan provides ventilation. A coastal-themed artwork is displayed on the wall.
Hotel room in Disney
4.96 out of 5 average rating, 27 reviews

The Historic Dam Hotel - Sunrise Suite

ShannonRating, 5 stars1 month ago
Super cute place! The stairs up to the rooms could be better lit under the deck as it was pretty hard to see after dark, but other than that, everything was great!
Top guest favorite
A cozy sleeping area is illuminated by a bedside lamp, creating a comfortable setting. The bed is adorned with a colorful quilt featuring intricate patterns. Soft curtains frame the window, allowing natural light to brighten the room.
Hotel room in Mead
4.97 out of 5 average rating, 35 reviews

Reel ‘Em Inn 2: Cozy & Clean | Convenient location

EricaRating, 5 stars2 days ago
We absolutely loved our stay at this super cute, charming vintage motel! It was spotless, full of personality, and such a great value. The space was cozy and well cared for, with fun retro touches that made it feel special. What really stood out was the host’s kindness—she went above and beyond to make my daughter’s 12th birthday extra memorable. She surprised her with the sweetest little basket filled with candy, a cute cup, fun socks, and other birthday goodies. It was such a thoughtful and personal touch, and my daughter was over the moon! Highly recommend this place if you’re looking for something clean, unique, and hosted by someone who genuinely cares about your stay. We’ll definitely be back!
Guest favorite
A modern suite is equipped with a practical coffee station and a decorative mirror. Two green sofas are positioned next to a bedside table and lamp, providing a cozy lounging area. The spacious bed is visible in the background, contributing to a comfortable atmosphere.
Hotel room in Laurel
4.88 out of 5 average rating, 118 reviews

Hotel Pinehurst- Jean Theatre, Suite 103

MarthaRating, 5 stars2 weeks ago
This was a great place to stay right downtown and easy to walk to where we wanted to eat and shop. Everything was very clean and the bed was very comfortable. The instructions for entry were very clear and easy to understand and we had no complaints.
Superhost
A serene lakeside view captures a sunset reflecting on calm waters. Soft light filters through trees and shrubs, highlighting the natural landscape. The vibrant sky is filled with clouds, creating a peaceful ambiance in this private retreat setting.
Private room in Waterloo
4.8 out of 5 average rating, 15 reviews

Bedroom #1 - main lodge on serene 25 acres w/ lake

KirstonRating, 5 stars11 months ago
I absolutely loved this place! Me and my husband had the best time! We fought so many fish in their lake, cooked in their beautiful kitchen, walked some trails, and so much more. The pictures really don’t do this place justice. Everybody was super friendly as well. 10/10 recommend and I will definitely be back and telling some friends!!!
Top guest favorite
A serene bedroom is featured with a king size bed adorned with cozy bedding, flanked by bedside tables with lamps. Hanging lights provide a warm glow. A small seating area includes a table and chairs, and a macramé hanging chair is present in the corner.
Hotel room in Perryville
4.95 out of 5 average rating, 20 reviews

Historic Hotel & Day Spa

ChristaRating, 5 stars3 weeks ago
I loved the stay! Host was very responsive. The place so neat and clean. I would definitely stay again.

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