
Guesthouse vacation rentals in Upstate South Carolina
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Top-rated guesthouse rentals in Upstate South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Scenic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Historic 19th Century Cabin/Guest House
This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Nishleigh's Nook - West End Downtown Greenville
Welcome to your cozy retreat in the West End of Downtown Greenville! This newly constructed, detached garage studio near the up and coming West End Village, Unity Park, and downtown offers easy access to the city's best entertainment, boutique shops, and vibrant food scene. Enjoy a queen-sized memory foam bed, a fully equipped kitchen, and a dedicated dining area. High-speed Wi-Fi and a smart TV are included. Perfect for a peaceful escape with all the comforts you need for a memorable stay.

The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Windcrest Loft- charming retreat near the river.
Welcome to Windcrest Loft! If you’re looking for a homey place to stay while visiting the mountains, this is it! Kids and pets are welcome too. Centrally located, within minutes to shops and restaurants in Dillsboro and Sylva, 10 mins to WCU and 20 to Franklin, Bryson City & Waynesville. Convenient Tuckasegee river access across the street and close to many hiking spots! When not touring the area, relax outdoors and enjoy the antics of our resident goats, donkeys, geese and chickens.

Gorgeous Downtown Studio & Dog Friendly!
This has moved to 30 days+ starting Jan 2024! Message me if you're trying to book and your dates aren't showing available! This location is unmatched. Steps from Falls Park which includes one of the most majestic waterfalls, green space and Swamp Rabbit Trail for all your running/walking and biking needs. Directly across the street from the Greenville Drive baseball stadium. One block from all the finest restaurants, shopping and best attractions downtown offers.

The Lodge at Pythian Park
Situated in a 3+ acre gated compound surrounded on three sides by Fairforest Creek, our guest house feels like a mountain hideaway yet it's only a 3 minute drive to downtown Spartanburg. Enjoy the private patio overlooking the creek to relax or prepare a meal on the gas grill. Dogs are welcome, and we have 2 very social dogs that you will probably encounter during your stay. There's ample parking for vehicles and room to roam and enjoy the park-like setting.

Private Suite in Downtown Simpsonville
Cozy 1 bed/1 bath apartment in downtown Simpsonville. With this private single unit above a garage used for storage only, you do not share walls with anyone! You are within walking distance to restaurants & shopping! This private unit is a rare find for the price!! As you pull into your own parking space, you overlook a private yard. ***Please note there is a train near the home that runs once midday and once late at night.

Foothills Favorite
Custom designed 1 bedroom suite in the Lake Bowen/Landrum/Inman area. Comfortable yet sleek space tucked above a semi-detached garage; private entry & stairway to suite. Private deck overlooks green spaces, wooded area & Lake Bowen (best views late fall and winter). Enjoy mountain views at nearby Lake Bowen park, local wineries, and scenic highways. Minutes from Landrum & Tryon & Equestrian Center.

Shou-Sugi-Ban Retreat on the Saluda River
The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Sally's Cottage
Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Breathtaking Romantic Rustic Style Loft - Clemson
Rustic styled 800 sq/ft full apartment above our barn-garage that sleeps 4. This amazing space is roomy and has separate parking and private entrance. Equipped with full kitchen, laundry, private deck and fire pit. We have adequate parking and pull thru drive for guests with boats. Pets are not permitted as some of our guests have allergies.
Popular amenities for Upstate South Carolina guesthouse rentals
Family-friendly guest house rentals

The Nest; private tiny home @Reblooming Rose

Holly Hideaway! 10 Highway miles to Clemson U!

Bungalow on a 3 acre mini farm

Warrior Hall Cottage 1

Campus Cottage

Cozy Cottage - 5 miles from TIEC

Blessed Haven - king bed guest house

Charming Tiny House by the Biltmore Village
Guest house rentals with a patio

Cozy Rustic Lakefront Cabin

Modern Studio near downtown

Country-Clubhouse Tiny Home. Close to downtown!

The Nest, Charming Country Setting south of Athens

Fairy Forest Cabin with Hot Tub at Table Rock

Coltsfoot Cottage

Birch Cottage

Downtown guest house with private hot tub & deck
Guest house rentals with a washer and dryer

Upscale cottage in Downtown Fountain Inn

Art, Biking, Food, and Shopping in Watkinsville

MeadowHill Guesthouse - Mountain view-3 mi to town

The Guest House By The River

⭐️⭐️⭐️⭐️⭐️Casita Blanca 🚶🏽➡️Dining, BREWS,SHOPS📍DTWN📍LUX

Pisgah Hideaway Studio

Tryon Foothills Getaway - NC wineries! - TIEC

Private-Lake getaway-7 mile view from dock
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- Blue Ridge Parkway
- The North Carolina Arboretum
- Gorges State Park
- Table Rock State Park
- Chimney Rock State Park
- Ski Sapphire Valley
- Lake Lure Beach and Water Park
- Jump Off Rock
- Tryon International Equestrian Center
- Wade Hampton Golf Club
- Victoria Valley Vineyards
- Discovery Island
- Burntshirt Vineyards
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- City Scape Winery
- Saint Paul Mountain Vineyards
- Overmountain Vineyards
- Wellborn Winery
- Russian Chapel Hills Winery
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