Guesthouse vacation rentals in Upstate South Carolina

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Upstate South Carolina guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Liberty
4.93 out of 5 average rating, 197 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

RittaRating, 5 stars1 month ago
Jen’s Hideaway is the perfect private spot to come back to after visiting Central and Clemson. It is extremely clean and well appointed. The bed is very comfortable. Jen is a friendly host. She even baked us delicious blueberry muffins.
Top guest favorite
Guesthouse in Greer
4.94 out of 5 average rating, 287 reviews

Executive Suite on a farm @GSP Airport

VexRating, 5 stars6 days ago
Exactly as described and shown. Peaceful, clean, huge TV with lots of streaming services, all furniture very comforable, beautiful interior. I can't say enough great things about this place. Joey himself was friendly and responsive. Any issue I had was taken care of rather quickly and he was friendly about it. We are already wanting to come back. This location is very ideal for anyone traveling to upstate SC. Thank you for offering your space, Joey. We felt at home.
Top guest favorite
Guesthouse in Swannanoa
4.98 out of 5 average rating, 657 reviews

Bramble Cottage: 10 min from Asheville & Blk Mtn

DeborahRating, 5 stars5 days ago
Jenny accepted by booking on VERY short notice, and at a busy time for her, and I really appreciated her graciousness for the spontaneous trip. Her home is completely lovely, and it feels serene despite the store across the street; I think her lovely trees and flowers help with that a lot. I heard street noise briefly, but that ended early, and it was a very quiet night, with a wonderful bed. And the porch! Oh, my. It's on the back of the house and feels like it's miles from city busyness. Yet, the things we planned to do in Asheville were only 15-20 minutes away. And the muffins are DELICIOUS. Jenny responded quickly to both my request to book and to other comments from me. Her home is spotless and welcoming, filled with lovely treasures and good books. I hope to return soon!
Guest favorite
Guesthouse in Rutherfordton
4.96 out of 5 average rating, 242 reviews

Tryon Foothills Getaway - NC wineries! - TIEC

DeniseRating, 5 stars2 months ago
We truly enjoyed our stay at Evelyn’s place we live in West Texas now I’m from Rutherford County I grew up there and forgot just how beautiful it is there. Was close to the equestrian center and wineries. The place was very clean cute little getaway! Would definitely stay there again!
Top guest favorite
Guesthouse in Donalds
4.99 out of 5 average rating, 379 reviews

Home on the farm

TimothyRating, 5 starstoday
Ruth and Bob were the best hosts ever!! We were greeted in the driveway, shown around the property, made to feel like we were right at home and part of the family. Good deal on a gorgeous piece of property that they are willing to share.
Top guest favorite
Guesthouse in Tryon
4.98 out of 5 average rating, 111 reviews

Historic Jockey Cottage, TIEC 20 mins, Tryon 5

CourtenayRating, 5 stars1 month ago
I’m selfishly not wanting to write this great review because I will be sad if the place is booked when I go back to Tryon! The place was perfect for my pup and I while showing at TIEC. The hosts are lovely, and the place stocked with a coffee bar and water, and the community itself is beautiful. Quiet, peaceful, yet super convenient for restaurants and shopping. I will be back! Also, apologies. I stole your box of tissue under the bathroom sink because my allergies were killing me at the horse show: I meant to replace it with one I night but I forgot this morning. I apologize again and thank you!
Top guest favorite
Guesthouse in Avery Creek
4.99 out of 5 average rating, 319 reviews

Loft in the Countryside

Thomas MichaelRating, 5 stars2 weeks ago
Laura washed all the bedding to reduce the fragrance from the usual detergents she uses. It was a big help. Very comfortable mattress and spacious interior. Quiet. Beautiful landscape and pasture across the street. Great place to unwind!
Top guest favorite
Guesthouse in Swannanoa
4.98 out of 5 average rating, 359 reviews

Buckeye Studio-between Asheville and Black Mtn.

LoraRating, 5 stars1 month ago
If I could live here for the rest of my life, I would. Judy and Steve are wonderful hosts who happen to be living on a slice of perfection. The space is large, squeaky clean, quiet, and I hadn’t slept as well in years. Perfectly appointed. Parking is right outside in their large driveway with a dedicated spot. I chose to walk in the evenings and saw horses, sheep, goats, and a very friendly donkey next door. The best rental space I have ever stayed in which has been numerous. Thank you for sharing, Judy and Steve.

Guest house rentals with a patio

Top guest favorite
Guesthouse in Ashville
4.97 out of 5 average rating, 187 reviews

Firefly Cove Guesthouse

Megan And D.J.Rating, 5 stars2 weeks ago
Such a beautiful, peaceful gem of a stay. Erin and Rob (and their friends) are lovely—generous, kind, warm. And they’ve cultivated a true home away from home. Can’t recommend enough!
Top guest favorite
Guesthouse in Hendersonville
4.97 out of 5 average rating, 104 reviews

Modern Studio near downtown

TimRating, 5 stars1 week ago
Great place to stay, centrally located to get out and explore the area.
Guest favorite
Guesthouse in Candler
4.96 out of 5 average rating, 106 reviews

Yes please we need you! Spacious w/ amazing view!

JocelynRating, 5 stars2 months ago
The view was amazing! Our favorite place was sitting by the fireplace. It looked just like the pictures. Quiet and peaceful. Nice touches with the decor. Anglea responded and answered questions quickly. It's approximately 15 - 20 minutes from Asheville. 10/10 would recommend.
Top guest favorite
Guesthouse in Bishop
4.99 out of 5 average rating, 141 reviews

The Nest, Charming Country Setting south of Athens

TylerRating, 5 stars1 week ago
Always a great place to stay! Donna is a great host and the space is so peaceful!
Top guest favorite
Guesthouse in Maggie Valley
4.99 out of 5 average rating, 356 reviews

Starswept Studio–Walk to Brewery, Near BRP & GSMNP

JoanRating, 5 stars2 weeks ago
Nancy’s place was beautiful and serene. Accommodations were comfortable and quaint, and worth the price. Nancy responds quickly to questions, and makes you feel right at home.
Guest favorite
Guesthouse in Travelers Rest
4.97 out of 5 average rating, 124 reviews

Modern guesthouse in downtown TR

RonRating, 5 stars3 weeks ago
Fun little space! Great kitchen for a tiny home if you like to cook. Only trouble coming with lots of food to prepare is there are so many restaurants, EXCELLENT restaurants, just a few blocks away. I strongly recommend "TOPSOIL"! I enjoyed my privacy and found it so easy to get on the road and go any direction.
Guest favorite
Guesthouse in Clyde
4.97 out of 5 average rating, 113 reviews

Super Cute Modern Guest Cottage

Deborah And MarkRating, 5 stars3 days ago
This was a lovely cottage, perfectly located near my church conference at Lake Junaluska. It was beautifully decorated and appointed! Very comfortable!
Guest favorite
Guesthouse in Watkinsville
4.98 out of 5 average rating, 165 reviews

Downtown guest house with private hot tub & deck

MelissaRating, 5 stars3 weeks ago
I’ve stayed in gobs of AirBnb rentals, but this cottage may be the cutest! The owner has created a perfect little space for a couples’ getaway - the decor is so tasteful, the bathroom is clean and modern, and the bed is very comfortable. We appreciated all the extras, as well; she provided a snack basket, coffee and a water filter. The hot tub was nice and private, and the location was great for walking around town. Our stay was perfect!

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in Arden, NC 28704, USA
4.93 out of 5 average rating, 401 reviews

Explore the Woods from a Quiet Apartment near Sierra Nevada

John & ShariRating, 5 stars1 month ago
Daniel's place was an oasis in middle of a busy area. The convince factor is excellent. Plenty of restaurants, close to airport & interstate, close to national forest and a Walmart nearby for any needs. Given that description, one would think this place is in busy suburbia....and it is, but you would never know it. Beautiful wooded and gated neighborhood with a pond, cute homes, safe and walkable. Really can't beat this location. Would not hesitate to book in future.
Guest favorite
Guesthouse in Greenville
4.98 out of 5 average rating, 104 reviews

The Spring Valley Retreat

CoraleeRating, 5 stars4 weeks ago
We had a lovely stay and was a great place to host our adult kids for family dinner and games. It was comfortable for our downtime. We would stay again when we visit. Peter, the cat, was a welcome visitor!
Guest favorite
Guesthouse in Hartwell
4.97 out of 5 average rating, 167 reviews

Guest House at Lake Hartwell

MatiasRating, 5 stars2 weeks ago
This place has it all! Great location on the lake with a perfect dock to hang out all day or watch the stars at night. I absolutely loved the layout of the house with the kitchen opening up into the living room so everyone could spend time together while cooking/cleaning. There is also a cute screened in sunroom looking over the backyard and lake. All the amenities you can think of were provided and the host was super prompt and helpful with all responses from before the stay until the end! Will definitely be returning, we had the best time!
Top guest favorite
Guesthouse in Watkinsville
4.98 out of 5 average rating, 399 reviews

Art, Biking, Food, and Shopping in Watkinsville

BrittanyRating, 5 stars2 weeks ago
My goodness is this place precious. From the permaculture garden, to the mighty fig trees, to the landscaping, to the gorgeous weathered board and batten studio and the adorable cottage/apartment house. We will book here every time my daughter attends soccer camp! They have created quite the oasis! We felt secluded but we were just a hop, skip and a jump to all the things. I also loved all the sculptures throughout the garden. Well done!
Top guest favorite
Guesthouse in Watkinsville
4.99 out of 5 average rating, 209 reviews

Gallery Carriage House DT Watkinsville w EV

BrianRating, 5 starstoday
Kathleen’s place is a favorite for my trips to Athens. The location is perfect, quiet and close to everything . Love the decor and the bed is comfy! Kathleen’s treats are a thoughtful touch! Highly recommend
Top guest favorite
Guesthouse in Mountain Rest
5 out of 5 average rating, 105 reviews

The Guest House By The River

ChristyRating, 5 stars1 month ago
Thank you so much Kay!! It was a beautiful place!! Enjoyed it so much!! The charcuterie board was amazing!! I look forward to staying there again!!
Top guest favorite
Guesthouse in Pendergrass
4.97 out of 5 average rating, 405 reviews

Peaceful Guesthouse on 15 Acres with Pool

CherylRating, 5 stars1 month ago
I have stayed at many Airbnb’s, but this might be my favorite. Not only was it so peaceful, roomy, and priced reasonably, but the salt water pool was the icing on the cake for this swimmer! And the hosts were so kind to help me in and out with my luggage and even sprayed my car off before I departed!
Top guest favorite
Guesthouse in Westminster
4.99 out of 5 average rating, 178 reviews

Lit'l Bit O' Heaven- Rocky Top Lodge

JimmyRating, 5 stars2 weeks ago
this lil cabin is amazing. kitchen well stocked, beautiful patio. even the fire pit was setup, ready to light it up. great breakfast selection. I highly recommend this cabin

Destinations to explore