Guesthouse vacation rentals in Upstate South Carolina

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Top-rated guesthouse rentals in Upstate South Carolina

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Abbeville

4.97 out of 5 average rating, 286 reviews

Quiet, Peaceful Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Aug 3 – 10

G$13,669 GYD per night

Guest favorite

Guesthouse in Anderson

5.0 out of 5 average rating, 218 reviews

Game Day Cottage in the Woods

Great location just off of I-85 at Exit 14; less than 8 miles to Clemson University, 7 miles to Green Pond Landing, and 1000 feet to Eighteen Mile Creek Boat Landing. Our cottage is located behind our home with a beautiful wooded setting. You will find a tranquil and secluded space, yet be close enough to our areas best restaurants and entertainment. We are also close enough to the Blue Ridge Mountain for a nice day trip. Please note our rate is $240 per night during Clemson home games.

Aug 8 – 15

G$24,623 GYD per night

Guest favorite

Guesthouse in Fountain Inn

4.92 out of 5 average rating, 264 reviews

Main Street Guest Cottage

The Main Street Cottage is close to downtown Fountain Inn, five excellent restaurants, the county library, Younts performance center, museum, Farmers Market, Swamp Rabbit Trail (hiking, cycling), and I-385 (Greenville in 20 min). You’ll love this separate apartment because of the location, the outdoors space and the small town ambiance. Very good for couples, business travelers, and families (with kids). We are within two blocks of downtown, but the apartment enjoys a quiet residential setting.

Jul 19 – 26

G$17,218 GYD per night

Guest favorite

Guesthouse in Greer

4.96 out of 5 average rating, 260 reviews

CLEAN 1 BD Suite - 1.7 Miles From Downtown Greer

Welcome to our NEW modern detached guesthouse. It features a private entrance with plenty of parking. The kitchen is equipped with a refrigerator, oven, microwave, Beverage station, and Basic kitchen tools. The living room includes a couch that seats 3, a tv, and access to your own private outdoor area. The bedroom features a comfortable queen-size bed and TV. The bathroom has a huge walk-in tiled shower. We're Located 1.7 miles from downtown Greer, so there is always something to do nearby.

Jul 9 – 16

G$20,896 GYD per night

Guest favorite

Guesthouse in Greenville

4.92 out of 5 average rating, 582 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Feb 8 – 15

G$14,968 GYD per night

Guest favorite

Guesthouse in Sunset

4.92 out of 5 average rating, 344 reviews

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Dec 24 – 31

G$28,913 GYD per night

Guest favorite

Guesthouse in Lyman

4.99 out of 5 average rating, 123 reviews

Blue Heron Hideaway Lakeside Retreat

Welcome to this bright, lakefront space with views from every window. Enjoy kayaking, swimming, fishing, and evenings by the fire-pit. In winter, cozy up by the indoor fireplace and just relax. Take a drive into downtown Greenville, the gem of the upstate, where a walk through Falls Park and across the suspension bridge is a must! We are 15 minutes from GSP airport and BMW, in the foothills of the beautiful Blue Ridge mountains. You won’t be at a loss for things to do here in the upstate.

Jul 11 – 18

G$27,548 GYD per night

Guest favorite

Guesthouse in Greenwood

4.94 out of 5 average rating, 181 reviews

Private Lakefront Cabin on Lake Greenwood

Get ready to enjoy beautiful lake views from this home! Private lake house right on Lake Greenwood. This recently remodeled guest house has one bedroom with a queen bed, full bath, and a large main room with a huge sectional sofa. Strong WIFI. 50" tv: Roku/Netflix/Hulu equipped. Enjoy 128ft of lakeshore including a fire pit, concrete pier, pergola seating area, beach, swimming area in lake, and putting green. 2 Kayaks available, free to use. 20ft pontoon for rent based on availability.

Jun 23 – 28

G$35,746 GYD per night

Guest favorite

Guesthouse in Spartanburg

5.0 out of 5 average rating, 422 reviews

The Cottage in Spartanburg

This charming and private studio cottage is located in Spartanburg's downtown historic district Hampton Heights. Guests will find a comfortable foam mattress sofa bed (no bars or springs), full bathroom, closet, and complete kitchen amenities. Located less than a mile from the restaurants, bars, and shops of Downtown Spartanburg, and close to Converse College, VCOM, and Wofford College, this cozy studio cottage is the perfect place to rest your head after a busy day visiting the Upstate.

Jul 15 – 22

G$13,115 GYD per night

Guest favorite

Guesthouse in Greenville

4.99 out of 5 average rating, 358 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Apr 13 – 20

G$24,307 GYD per night

Guest favorite

Guesthouse in Toccoa

4.99 out of 5 average rating, 108 reviews

Cozy Rustic Lakefront Cabin

“on the edge” is a cozy, rustic, lakefront cabin with easy walk to a private dock on Lake Hartwell. Great for fishing and swimming. Public boat ramp 2 miles. Living/dining area, two bedrooms one with queen and twin other with twin and twin bunk. Relax on the large porch with swing and rocking chairs. Fire pit with wood. House includes TV, microwave, fridge, toaster and coffee maker. Perfect getaway but also near charming downtown Toccoa, Toccoa Falls, Currahee Mountain, hiking…..

Jul 12 – 19

G$27,084 GYD per night

Guest favorite

Guesthouse in Greenville

4.97 out of 5 average rating, 190 reviews

Greenville With A View!

ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Aug 23 – 30

G$28,723 GYD per night