House vacation rentals in Upstate South Carolina

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Top-rated house rentals in Upstate South Carolina

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Top guest favorite
A welcoming entryway features a brick patio surrounded by trees, providing a natural setting. Two chairs and a small table sit on one side, with a cozy seating area visible. The home showcases large windows that allow for ample natural light.
Home in Greenville
4.98 out of 5 average rating, 212 reviews

A Tranquil Place (near downtown Greenville)

A Tranquil Space is conveniently located close to Downtown Greenville. The large suite includes the bedroom, living area, kitchenette (fridge/freezer/convection oven), bathroom, and study/eating area. It is newly renovated area on the end of my home with a private entrance. The space is welcoming and inviting...a perfect space to get away from the hustle. Although minutes from Downtown, the suite feels like you're in the mountains with a private back yard and many trees. Enjoy your stay!

Superhost
A cozy living area features a leather couch adorned with pink cushions, positioned near a decorative glass coffee table. Sunlight filters through the windows, illuminating a flat-screen television above a white mantel. A small side table and a bookshelf add functional charm to the space.
Home in Greenville
4.81 out of 5 average rating, 177 reviews

Fenced in Yard, 2 Queen Beds, Downtown!

Hard to beat this amazing value! Nestled on a quiet street 5 minutes from downtown, this 2bed/1bath property is perfect for your visit to Greenville. Each bedroom has a queen bed and plenty of closet space with hangers. Out back, there's a spacious deck to relax on, and the property has a fenced in yard which would be ideal for your curious furry friend. This property is minutes from hospitals & interstate 85. Ideal for work travelers, or simply curious visitors. There's a driveway for parking.

Top guest favorite
A modern one-story ranch house is depicted in a tranquil setting, featuring a spacious driveway and manicured landscaping. Natural light illuminates the exterior, enhanced by a welcoming entryway with decorative planters and a covered porch, surrounded by lush greenery and large trees.
Home in Travelers Rest
5 out of 5 average rating, 148 reviews

Modern Wooded Retreat

Come enjoy this modern, 1.6 acre retreat! Relax with the whole family in a place you'll never want to leave. Located 5 min. to downtown TR and less than 20 min to downtown Greenville! Roast marshmallows by the firepit, play yard jenga, connect 4 and cornhole in the fully fenced, dog friendly back yard. Close to the swamp rabbit trail, and centrally located to lakes, hiking, fishing and exciting nightlife. Let us host you, while you explore everything Greenville and Travelers Rest have to offer.

Top guest favorite
An open-concept living area features a modern kitchen with stainless steel appliances and a spacious island, complemented by a dining table. A cozy living room is equipped with a soft sectional sofa facing a mounted television and warm electric fireplace. Natural light enhances the inviting atmosphere.
Home in Greenville
4.98 out of 5 average rating, 140 reviews

Greenville GEM Luxurious Retreat in Prime Location

Beautifully renovated 3 beds, 2 baths haven! This gem is a tranquil & stylish retreat, blending modern & cozy charm. Spacious bedrooms, each with plush bedding and storage. Two Bathrooms with soaking tub and a spacious walk-in shower. Cozy living room with a fireplace, TV, and comfy seating.  Fully equipped kitchen, Wi-Fi, Private deck and gazebo, fenced yard. Close to the city's best attractions, dining, and entertainment options. This is the perfect home base for your Greenville adventures.

Top guest favorite
The front of the house is showcased with a white exterior and a welcoming porch. Two rocking chairs are positioned on the porch, surrounded by planters displaying seasonal flowers. A well-maintained pathway leads to the entrance, framed by decorative brick steps and a railing.
Home in Greenville
4.97 out of 5 average rating, 249 reviews

Spectacular home 1 mile from Main St Greenville!

Enjoy your stay in this charming up to date house 1 mile from Main St Greenville! Take a walk through the Historic Pinckney district on your way to Greenville’s museums, restaurants, theaters, and stunning Reedy River Falls Park. Easy access to the Swamp Rabbit biking and walking trail, and just 4 blocks from the upcoming Unity Park. House is located on quiet residential street with private driveway. Relax on rocking chairs on front porch or around a portable fire pit in large backyard.

Top guest favorite
A charming cabin exterior is framed by trees, with a rustic wooden porch offering scenic views of the surrounding mountains. Warm light spills from windows, enhancing the evening ambiance. The cabin's unique architecture reflects a natural aesthetic, inviting guests to unwind in the serene environment.
Home in Lake Toxaway
4.99 out of 5 average rating, 355 reviews

Cabin I Private hiking trails | Hot Tub I Sauna

Welcome to your private mountain escape in Lake Toxaway, NC! This 1-bedroom, 2-bathroom cabin is a one-of-a-kind retreat, offering breathtaking sunset views, a peaceful wooded setting, and unique architectural details. Unwind in the hot tub under the stars, relax in the sauna, challenge your partner to air hockey, or cozy up by the fire pit—all while enjoying the beauty of nature. Plus, enjoy exclusive access to 3 miles of private hiking trails, perfect for exploring the great outdoors!

Top guest favorite
A spacious living area is illuminated by natural light, featuring large windows with scenic mountain views. Soft, neutral-colored seating is arranged for comfort, including a cozy sectional sofa and armchairs. Decorative curtains frame the windows, enhancing the inviting atmosphere.
Home in Saluda
4.98 out of 5 average rating, 118 reviews

Orchard Hill Vintage Cottage

Come enjoy this magnificent view in Saluda! Relax in the swings or sit on the porch and enjoy the peacefulness. The fire pit under the stars is so Saludacrous! Our cozy cottage is just steps from Judds Peak and 2 miles from downtown, where there is always food and fun! The Gorge Zipline is located in our quaint little town and the Green River has hiking, tubing, kayaking, white water rafting, rock climbing! The towns of Hendersonville, Flat Rock and Asheville are just minutes away.

Guest favorite
A living area features large windows that allow ample natural light, complemented by soft white drapes. A comfortable sofa and two armchairs are arranged around a light area rug, with a small table nearby. A television is mounted above a modern fireplace.
Home in Greenville
4.9 out of 5 average rating, 143 reviews

Greenville Prime Location-Steps from Swamp Rabbit

You'll love the abundant natural light in this peaceful one bedroom retreat. We are located in the Pettigru Historic District and are just a 5 minute walk from Bon Secours Wellness Arena and a 15 minute walk to Main Street. This is an upstairs unit (1 of 3 total units located within the triplex) and has a private, exterior entrance. There's a kitchen with all the utensils, pots, bowls, plates, cups, etc. that you could need for your stay as well as a stocked Nespresso machine!

Guest favorite
A cozy living room features a warm leather chair and a round coffee table on a light rug. A spacious dining area, with a wooden table and stylish seating, is illuminated by natural light. Elegant wallpaper depicting trees adds a serene backdrop.
Home in Greenville
4.98 out of 5 average rating, 106 reviews

West Village Modern Sanctuary

Step outside your private abode and explore the Swamp Rabbit Trail, a scenic greenway perfect for biking, or a quick drive to downtown's main attractions. Immerse yourself in the artistic energy of the West End Village's galleries, or try delicious local restaurants, coffee shops, and bakeries. This charming retreat offers the perfect blend of comfort, convenience, and purposeful style, ideal for families, friends, or remote workers seeking an authentic Greenville experience.

Top guest favorite
A charming exterior view of the home features light beige siding and a welcoming blue front door. Windows with blinds allow natural light to brighten the interior. The manicured front yard includes low shrubs, and a concrete walkway leads to the entrance.
Home in Greenville
4.95 out of 5 average rating, 129 reviews

Greenville Modern Retreat - 8 minutes to Downtown

Decorated in a mid century modern theme, this home is perfect for couples and business travelers looking for a peaceful, modern aesthetic filled with natural light. This home is located in San Souci just 2.5 mi (8min drive) to downtown Greenville. It is also conveniently located 1/2 mi to the Swamp rabbit trail and the Swamp Rabbit Grocery. Please see “Where you’ll be” section for further description of location and the neighborhood. We're excited to have you join us!

Guest favorite
The treehouse structure features a distinctive A-frame design with large glass paneling allowing for abundant natural light. Surrounded by trees, an outdoor deck with seating complements the lush woodland setting. The rooftop deck above adds to the unique architectural appeal.
Home in Greenville
4.99 out of 5 average rating, 241 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Top guest favorite
A welcoming living area features a modern gas fireplace embedded in a stone wall, complemented by a large flat-screen TV above it. Comfortable seating includes a gray sofa and an accent chair, arranged around a glass coffee table on a plush area rug.
Home in Ashville
4.95 out of 5 average rating, 546 reviews

Villa Rose-On 2 Acres. FP, King Bed, 1mi Biltmore

Chic Modern, Luxurious, Cozy-styled & Large private KING Bed & Barn view one-bedroom in-law apt. (1,050 sqft) w/ Fireplace. On 2 Beautiful Acres under towering trees, while only being 3 min.(1 mi) to the Biltmore Estate. 5-min. (4 mi) to the Heart of Downtown Asheville, NC; Blue Ridge Parkway, & South Slope DT breweries, coffee houses, and restaurants. Romantic, Quiet, Retreat Cottage, Nestled in Nature. A unique gem, close to it all

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