House vacation rentals in Upstate South Carolina

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Top-rated house rentals in Upstate South Carolina

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Iva

4.98 out of 5 average rating, 349 reviews

Country Cottage ~ Farm Animals!

Step away from your hustle as you enjoy this cozy, quiet setting in the country. We offer a small kitchen, microwave, toaster, a Keurig, refrigerator, and two-burner stove. You will find a comfy dining/sitting room area. Meander around outside, relax on the porch, or visit our farm animal pets. 20 minutes from Historic Abbeville. Greenwood or Anderson in 30 min. Greenville approx 1 hr. 5 miles from Erskine College 15 min to the famous Diamond Hill Mine! Heyward Manor wedding venue: 18 miles

Jun 21 – 28

G$17,919 GYD per night

Guest favorite

Home in Taylors

4.99 out of 5 average rating, 138 reviews

Vintage home near downtown Greenville.

Cozy home with vintage look. Be in downtown Greenville or Paris Mt. State Park in under ten minutes. Close to shopping and the state Farmer's Market is a mile away. Acre yard gives spacious feeling. A complimentary Power Point of South Carolina and local history, culture, events, and business is available to help introduce you to one of the country's best kept secrets. Cut flowers and help yourself to our organic garden for use during your stay (seasonally). Small RV parking but no hook ups.

Jan 21 – 28

G$20,709 GYD per night

Guest favorite

Home in Greenville

4.97 out of 5 average rating, 152 reviews

A Tranquil Place (near downtown Greenville)

A Tranquil Space is conveniently located close to Downtown Greenville. The large suite includes the bedroom, living area, kitchenette (fridge/freezer/convection oven), bathroom, and study/eating area. It is newly renovated area on the end of my home with a private entrance. The space is welcoming and inviting...a perfect space to get away from the hustle. Although minutes from Downtown, the suite feels like you're in the mountains with a private back yard and many trees. Enjoy your stay!

Sep 10 – 17

G$20,982 GYD per night

Guest favorite

Home in Iva

4.98 out of 5 average rating, 156 reviews

Moonshine Bay

Your home away from home on South Carolina’s hidden gem, Lake Secession. Private wooded drive opens up to phenomenal lake view with shallow water entrance. Great for water sports, swimming, fishing and relaxation. If swimming isn’t for you, many beautiful reasonably priced golf courses are near by. Only 10 miles from Anderson & 36 miles to Clemson Stadium. Pull your boat to the dock or just enjoy some of our non-motorized lake toys. You’ll love it so much you want to come back year after year!

Mar 10 – 17

G$33,813 GYD per night

Guest favorite

Home in Pendleton

4.89 out of 5 average rating, 128 reviews

Comfort & Convenience Close to Campus

The perfect blend of modern charm and full comfort & convenience just minutes from Clemson, The Pendleton Square and HWY access. You will be sure to have everything you need for your visit. Comfortably sized bedrooms with queen size beds. Spacious living area with cable TV & Netflix. Bright and open kitchen and dining fully equipped for all your cooking needs. Whether you're traveling alone for a little peace & quiet, with friends, or with family... we hope you enjoy your time here!

Aug 2 – 9

G$25,022 GYD per night

Guest favorite

Home in Lake Toxaway

4.99 out of 5 average rating, 259 reviews

Treehouse with a Hot Tub, Hiking Trails & View

Perfect Mountain getaway. A place to unplug, reconnect & recharge in our fully stocked little treehouse in the woods. Enjoy swinging on the porch while watching the sunset over the mountainous view or roast marshmallows at the outdoor fire pit. The home a uniquely crafted Cabin. Prive Hiking Trails on property, outdoor pizza oven, Hot tub under the stars, cold plunge & sauna. This little cabin has so much to offer 25 minutes to Cashiers 25 minutes to Brevard 1 hour from Asheville

Mar 9 – 16

G$41,512 GYD per night

Guest favorite

Home in Spartanburg

4.92 out of 5 average rating, 280 reviews

beautiful nature,3bedroom, 2 king and 2 queen beds

Our home is located in beautiful neighborhood. We love our view. House has 3 bedrooms ( two bedrooms have king beds and one bedroom has two queen beds), also have two futons in living room that can be used as full size beds. This home was remodeled by my husband and me and were constantly adding new ideas to it. however, we do not tolerate any kind of wild parties that include hard liquor or smoking. absolutely no smoking in the house the wood in house will peneteate the smell.

Nov 21 – 28

G$23,839 GYD per night

Guest favorite

Home in Easley

4.9 out of 5 average rating, 276 reviews

“Lake House Paradise” Waterfront Oasis

“Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views from your bed of the water. Your en suite Master Bathroom has a large luxury marble shower. You will spend many hours of relaxation and peace in the most desirable location in the southeast. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.

Oct 3 – 10

G$31,630 GYD per night

Guest favorite

Home in Greenville

4.99 out of 5 average rating, 129 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Jan 5 – 12

G$63,474 GYD per night

Guest favorite

Home in Anderson

4.99 out of 5 average rating, 178 reviews

Lake Escape

This is the perfect lake house for your next family vacation, Clemson football game, or just a long weekend at the lake! Enjoy full access to Lake Hartwell with a private dock and swimming area. The house is located just 20 minutes from both Clemson and Anderson and also just 5 minutes from Portman Marina. Kayaks do not come included with the house but can be rented if inquired about ahead of time. Come enjoy some nature, relaxation, and fun at the Lake Escape!

Feb 26 – Mar 5

G$27,537 GYD per night

Guest favorite

Home in Pickens

4.97 out of 5 average rating, 133 reviews

Our Slice of Heaven w/Views of Table Rock-Pickens

Our slice of heaven is located in the foothills of the Blue Ridge Mountains only 8 mins from Table Rock State Park. Our guest house is sitting on 55 wooded acres with our 4-acre pond and amazing awe-inspiring panoramic views of Pinnacle and Table Rock Mountain. Wrap yourself in the serenity of nature, with nothing more to wake you in the morning than the pleasant sounds of songbirds beckoning you to delight in the new day.

May 7 – 14

G$26,782 GYD per night

Guest favorite

Home in Abbeville

4.99 out of 5 average rating, 226 reviews

**Oak View**Peaceful**8 min to Erskine

If you are looking for a place to kick your shoes off and relax this is it! Whether its on the comfortable couches or on your own private deck watching the sunset and the cows grazing peacefully in the pasture. Everything has been updated from the new floors, paint, and new appliances and it's sparkling clean. the big bedroom has a king size bed and plenty of space to unpack and relax.

Mar 23 – 30

G$15,119 GYD per night