House vacation rentals in Upstate South Carolina

Find and book unique houses on Airbnb

Top-rated house rentals in Upstate South Carolina

Guests agree: these houses are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Top guest favorite
A welcoming entryway features a brick patio surrounded by trees, providing a natural setting. Two chairs and a small table sit on one side, with a cozy seating area visible. The home showcases large windows that allow for ample natural light.
Home in Greenville
4.98 out of 5 average rating, 212 reviews

A Tranquil Place (near downtown Greenville)

A Tranquil Space is conveniently located close to Downtown Greenville. The large suite includes the bedroom, living area, kitchenette (fridge/freezer/convection oven), bathroom, and study/eating area. It is newly renovated area on the end of my home with a private entrance. The space is welcoming and inviting...a perfect space to get away from the hustle. Although minutes from Downtown, the suite feels like you're in the mountains with a private back yard and many trees. Enjoy your stay!

Top guest favorite
A modern one-story ranch house is depicted in a tranquil setting, featuring a spacious driveway and manicured landscaping. Natural light illuminates the exterior, enhanced by a welcoming entryway with decorative planters and a covered porch, surrounded by lush greenery and large trees.
Home in Travelers Rest
5 out of 5 average rating, 148 reviews

Modern Wooded Retreat

Come enjoy this modern, 1.6 acre retreat! Relax with the whole family in a place you'll never want to leave. Located 5 min. to downtown TR and less than 20 min to downtown Greenville! Roast marshmallows by the firepit, play yard jenga, connect 4 and cornhole in the fully fenced, dog friendly back yard. Close to the swamp rabbit trail, and centrally located to lakes, hiking, fishing and exciting nightlife. Let us host you, while you explore everything Greenville and Travelers Rest have to offer.

Top guest favorite
An open-concept living area features a modern kitchen with stainless steel appliances and a spacious island, complemented by a dining table. A cozy living room is equipped with a soft sectional sofa facing a mounted television and warm electric fireplace. Natural light enhances the inviting atmosphere.
Home in Greenville
4.98 out of 5 average rating, 140 reviews

Greenville GEM Luxurious Retreat in Prime Location

Beautifully renovated 3 beds, 2 baths haven! This gem is a tranquil & stylish retreat, blending modern & cozy charm. Spacious bedrooms, each with plush bedding and storage. Two Bathrooms with soaking tub and a spacious walk-in shower. Cozy living room with a fireplace, TV, and comfy seating.  Fully equipped kitchen, Wi-Fi, Private deck and gazebo, fenced yard. Close to the city's best attractions, dining, and entertainment options. This is the perfect home base for your Greenville adventures.

Top guest favorite
The front of the house is showcased with a white exterior and a welcoming porch. Two rocking chairs are positioned on the porch, surrounded by planters displaying seasonal flowers. A well-maintained pathway leads to the entrance, framed by decorative brick steps and a railing.
Home in Greenville
4.97 out of 5 average rating, 249 reviews

Spectacular home 1 mile from Main St Greenville!

Enjoy your stay in this charming up to date house 1 mile from Main St Greenville! Take a walk through the Historic Pinckney district on your way to Greenville’s museums, restaurants, theaters, and stunning Reedy River Falls Park. Easy access to the Swamp Rabbit biking and walking trail, and just 4 blocks from the upcoming Unity Park. House is located on quiet residential street with private driveway. Relax on rocking chairs on front porch or around a portable fire pit in large backyard.

Top guest favorite
A charming cabin exterior is framed by trees, with a rustic wooden porch offering scenic views of the surrounding mountains. Warm light spills from windows, enhancing the evening ambiance. The cabin's unique architecture reflects a natural aesthetic, inviting guests to unwind in the serene environment.
Home in Lake Toxaway
4.99 out of 5 average rating, 355 reviews

Cabin I Private hiking trails | Hot Tub I Sauna

Welcome to your private mountain escape in Lake Toxaway, NC! This 1-bedroom, 2-bathroom cabin is a one-of-a-kind retreat, offering breathtaking sunset views, a peaceful wooded setting, and unique architectural details. Unwind in the hot tub under the stars, relax in the sauna, challenge your partner to air hockey, or cozy up by the fire pit—all while enjoying the beauty of nature. Plus, enjoy exclusive access to 3 miles of private hiking trails, perfect for exploring the great outdoors!

Top guest favorite
A charming exterior view of the home features light beige siding and a welcoming blue front door. Windows with blinds allow natural light to brighten the interior. The manicured front yard includes low shrubs, and a concrete walkway leads to the entrance.
Home in Greenville
4.95 out of 5 average rating, 129 reviews

Greenville Modern Retreat - 8 minutes to Downtown

Decorated in a mid century modern theme, this home is perfect for couples and business travelers looking for a peaceful, modern aesthetic filled with natural light. This home is located in San Souci just 2.5 mi (8min drive) to downtown Greenville. It is also conveniently located 1/2 mi to the Swamp rabbit trail and the Swamp Rabbit Grocery. Please see “Where you’ll be” section for further description of location and the neighborhood. We're excited to have you join us!

Guest favorite
The treehouse structure features a distinctive A-frame design with large glass paneling allowing for abundant natural light. Surrounded by trees, an outdoor deck with seating complements the lush woodland setting. The rooftop deck above adds to the unique architectural appeal.
Home in Greenville
4.99 out of 5 average rating, 241 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Top guest favorite
A welcoming living area features a modern gas fireplace embedded in a stone wall, complemented by a large flat-screen TV above it. Comfortable seating includes a gray sofa and an accent chair, arranged around a glass coffee table on a plush area rug.
Home in Ashville
4.95 out of 5 average rating, 546 reviews

Villa Rose-On 2 Acres. FP, King Bed, 1mi Biltmore

Chic Modern, Luxurious, Cozy-styled & Large private KING Bed & Barn view one-bedroom in-law apt. (1,050 sqft) w/ Fireplace. On 2 Beautiful Acres under towering trees, while only being 3 min.(1 mi) to the Biltmore Estate. 5-min. (4 mi) to the Heart of Downtown Asheville, NC; Blue Ridge Parkway, & South Slope DT breweries, coffee houses, and restaurants. Romantic, Quiet, Retreat Cottage, Nestled in Nature. A unique gem, close to it all

Top guest favorite
A wooden deck is highlighted by a fire pit at its center, surrounded by comfortable seating. Warm lighting adorns the overhead beams, casting a gentle glow over the space. The tranquil lake is visible in the background, with trees framing the scene against a dusky sky.
Home in Anderson
4.97 out of 5 average rating, 141 reviews

Sunset Point-Best view on Broadway - HOT TUB!

This gorgeous property is situated on the picturesque Broadway Lake in Anderson, SC, offering 300 acres of pristine water ideal for pontoon rides, fishing, and making unforgettable memories. This tiered lot boasts an impressive 100 feet of water frontage and a private dock, complete with four kayaks (3 single and one tandem), two paddle boards, and various floats and water fun for guests to explore the lake at their leisure.

Top guest favorite
A bright living area showcases an inviting layout with two sets of double doors leading to a patio. A comfortable gray sofa is positioned near a wooden coffee table, complemented by a fireplace and a dining table set for six. Natural light enhances the overall space.
Home in Greenville
4.96 out of 5 average rating, 140 reviews

GVL Historic Luxury-Walk to Downtown/Swamp Rabbit

Welcome to Natural Light Delight, your bright and inviting stay in Greenville’s charming Pettigru Historic District. High ceilings and large windows fill the space with natural light, creating a calm, welcoming atmosphere. You’ll be in one of Greenville’s most walkable neighborhoods — just minutes walk from the Swamp Rabbit Trail, Downtown, and the city’s best restaurants, shops, and parks.

Top guest favorite
A charming red bungalow is seen from the front gate, surrounded by lush greenery and well-maintained landscaping. A stone pathway leads to the entrance, flanked by shrubs and trees, creating a welcoming atmosphere. The house features a cozy porch with steps leading to the front door.
Home in Brevard
5 out of 5 average rating, 339 reviews

Deluxe Downtown Bungalow, fenced yard!

A true Brevard downtown locals luxury experience. This beautiful home sits in the vibrant heart of the lumber yard arts district and sleeps seven-plus in two bedrooms. Enjoy two full luxury baths, a fully equipped gourmet kitchen, a large dining room, a cozy living room with a gas fireplace, a fenced-in yard for pets, and ample parking. It is a short walk or ride to EVERYTHING BREVARD!

Top guest favorite
A covered porch features wooden ceiling beams and a fan, providing a shaded area. Two adirondack chairs are positioned beside a small table, inviting relaxation. A welcoming front door is visible, with a doormat placed in front. The surrounding grass is neatly trimmed.
Home in Iva
5 out of 5 average rating, 122 reviews

Slate Roof Cottage~Farm Animals!

Take it easy at this unique and tranquil getaway in the country. Relax on the porch swing or take a walk and say hello to our farm animals. We are in the country and are certain that you will enjoy a peaceful visit. 10 miles to Historic Abbeville 5 miles to Erskine College 18 miles - Heyward Manor wedding venue 10 minutes to Diamond Hill Mine 30 minutes to Greenwood or Anderson

Popular amenities for Upstate South Carolina house rentals

Destinations to explore