Family-friendly vacation rentals in Upstate South Carolina

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Upstate South Carolina

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

Apartment in Greenville

4.97 out of 5 average rating, 439 reviews

North Greenville Luxury Suite Furman U. / S.R.T.

Luxurious and modern one bedroom apartment next to Furman University and Paris Mountain, street access to Swamp Rabbit Trail. It’s a direct 15 minute drive to downtown Greenville, conveniently located to Routes 276 & 25, and easy to access all of the area attractions. Check the Pet Fee Rates in this Description Section! No cats! Please be respectful of the AirBNB rules for booking this Luxurious Apartment! Friendly reminder: “NO THIRD PARTY BOOKINGS “ Any violation will be reported to AirBNB!

Nov 3 – 10

G$22,490 GYD per night

Guest favorite

Guesthouse in Fountain Inn

4.92 out of 5 average rating, 264 reviews

Main Street Guest Cottage

The Main Street Cottage is close to downtown Fountain Inn, five excellent restaurants, the county library, Younts performance center, museum, Farmers Market, Swamp Rabbit Trail (hiking, cycling), and I-385 (Greenville in 20 min). You’ll love this separate apartment because of the location, the outdoors space and the small town ambiance. Very good for couples, business travelers, and families (with kids). We are within two blocks of downtown, but the apartment enjoys a quiet residential setting.

Jul 19 – 26

G$17,231 GYD per night

Superhost

Condo in Greenville

4.92 out of 5 average rating, 323 reviews

Heart of Downtown Greenville on Main St + Balcony

Very cozy condo with lots of natural light located in the heart of the city. You will find that having a car won’t be needed and everything is walkable. The condo does come with WiFi, a very comfortable Tempur-Pedic bed with a 55” 4K smart Tv in the bed room and living room. Like coffee? Well we have a keurig and as well located next door to Star-bucks. The condo is professionally cleaned after each guest. Paid Parking is $7 a day, Daily Rate (1st hr):FREE Daily Rate (2nd hr): $2.00 max is $7.

Jul 23 – 30

G$34,463 GYD per night

Guest favorite

Cabin in Franklin

4.95 out of 5 average rating, 244 reviews

Mountain Air Cabin

Adorable & freshly renovated cabin located in a private wooded community between Highlands and Franklin in the Nantahala National Forest. Our light & airy cabin is nestled on almost 4 acres of woodsy, mountainous terrain and is private and picturesque, yet still convenient to town. We love relaxing on the front porch, surrounded by nature and enjoying the sounds of the streams & views of the mountains. It is a peaceful cabin to relax & enjoy the cool breezes and scenery of the Smoky Mountains.

Apr 5 – 12

G$28,721 GYD per night

Guest favorite

Guesthouse in Greenville

4.92 out of 5 average rating, 582 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Feb 8 – 15

G$14,979 GYD per night

Guest favorite

Apartment in Greer

4.95 out of 5 average rating, 236 reviews

Clean, Cozy Studio Near Greer Hospital, GSP, & BMW

This cozy studio apartment is 3 mi. from GSP, 4 mi. from BMW, 2 mi. from downtown Greer, and a mile from the Greer Memorial Hospital. It's close to shopping & restaurants, yet has a country feel nurtured by fruit trees and a few chickens. WE HAVE PARKING SPACE FOR ONLY 1 REGULAR-SIZED VEHICLE. Please note: We do not allow smoking anywhere on our property. We don't want to breathe the smoke, nor do we want to endanger future guests who have allergies. We do not allow animals.

Jul 29 – Aug 5

G$15,837 GYD per night

Guest favorite

Guesthouse in Anderson

4.94 out of 5 average rating, 233 reviews

Be Our Guest

Relax & enjoy the peace & tranquility of the lake in our charming second-floor guesthouse! Convenient location for families, fishermen & Clemson fans. Two bedrooms, full kitchen, spacious single bath, high ceilings, ceiling fans, fireplace & open floor plan in private unit. Fire pit & ample off-street parking for multiple boats & trailers. Close to Anderson & Clemson, less than 1 mile to boat launch. SMOKING PERMITTED OUTDOORS, NO PETS. Please do not sleep on the sofa.

Sep 20 – 27

G$24,804 GYD per night

Guest favorite

Guest suite in Chapin

4.98 out of 5 average rating, 456 reviews

LAKE FRONT SWEET - Dog Friendly

In Chapin on beautiful Lake Murray near Dreher Island State Park. Enjoy the view from the patio, relax on our dock, or float in the lake! There's room for your boat and trailer. Lower level of the house is all yours- incl. bedrm, bathrm, living rm & patio. Kitchenette-No stove, but there's a small kitchen sink, gas grill, full size fridge, microwave, toaster, coffee maker & dishes. We provide linens, coffee, cream, sugar. Dog friendly -1 dog if you agree to our rules.

Mar 27 – Apr 3

G$25,862 GYD per night

Guest favorite

Cabin in Pickens

4.95 out of 5 average rating, 132 reviews

Peace-In-The-Forest Retreat

PEACE-IN-THE-FOREST RETREAT offers a reprieve by providing privacy & quiet in a beautiful, custom-built cabin, on 100 forested acres w/ miles of hiking trails. REGARDING COVID-19, we provide a healthy place to be, breathe & move & WE ARE GOING THE EXTRA MILE to ensure that all touchable surfaces in our cabin are sanitized. We are 20-40 minutes from 6 SC State Parks+Dupont Forest, State Heritage Preserves; Lakes Keowee, Jocassee & Hartwell; Foothills trail &more!

Jul 28 – Aug 4

G$18,121 GYD per night

Guest favorite

Guesthouse in Donalds

4.99 out of 5 average rating, 344 reviews

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

Dec 25 – Jan 1

G$27,934 GYD per night

Guest favorite

Guest suite in Hartwell

4.97 out of 5 average rating, 209 reviews

Relaxing retreat on Lake Hartwell.

NEW IN 2021: New carpet, paint and mattress! Our one bedroom "apartment" has everything you need for a relaxing getaway. Room for air mattresses too. There is swimming, fishing, kayaking, and just plain relaxing here. We are close to hiking and waterfalls. Approximately one hour from UGA or one hour from Clemson for a getaway football weekend. Come enjoy and bring your pets too—they are always welcome!

Jan 13 – 20

G$21,548 GYD per night

Guest favorite

Cabin in Easley

4.93 out of 5 average rating, 314 reviews

Relaxing Retreat Right on the Water

Long Term Rentals Available! Stunning views, quiet still waters, wildlife in its natural habitat. This & more is what you'll find at Lakepoint on the Saluda. Better yet, this property is located on the water & is just minutes from downtown Greenville, Furman, and Paris Mtn. Small dogs considered with a non-refundable deposit.

Oct 16 – 23

G$24,515 GYD per night