Guesthouse vacation rentals in South Carolina

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for South Carolina guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Two classic cars are parked in front of a detached garage, showcasing a vintage white convertible and a sleek gray vehicle. The garage features two closed doors, framed by light green siding and surrounded by trees, adding to the serene environment.
Guesthouse in Summerville
4.88 out of 5 average rating, 804 reviews

New Loft in Historic Summerville

AngelinaRating, 5 stars3 days ago
Absolutely lovely. Cozy space, plenty of room for 2 people! Jacquelynn was great at responding and was very kind!
Top guest favorite
The exterior of the guest house displays a charming architectural style, featuring a gabled roof and large windows. Lush greenery surrounds the structure, with ferns and neatly trimmed hedges enhancing the outdoor space. A seating area is visible on the porch, inviting relaxation.
Guesthouse in Beaufort
4.98 out of 5 average rating, 418 reviews

The Wren Guest House

ChristianaRating, 5 stars3 days ago
This was a great Airbnb! Exactly as described. We ubered most places due to the weather so I’m not sure about walkability, but all Ubers to restaurants and shopping took under 10 minutes. Space was very clean and we had an extremely easy check in with clear instructions. Definitely recommend for a party of 2!
Top guest favorite
The exterior of a barn-style home is framed by vibrant pink azaleas and lush greenery. The building features a sloped roof with a red trim, white siding, and dark shutters. A covered porch area is visible, providing a shaded outdoor space.
Guesthouse in Greer
4.94 out of 5 average rating, 286 reviews

Executive Suite on a farm @GSP Airport

TiffanyRating, 5 stars4 days ago
This was by far our favorite!!! This home is absolutely lovely! Decorated so well, cozy and inviting and the bed very comfy! The grounds are gorgeous! Honestly I can’t say enough the only problem we had was not getting to spend enough time there to really enjoy it as we were there for work :( However would most definitely book again! Joey is a fabulous host and always so responsive! THANK YOU!!!
Guest favorite
A serene bedroom features a spacious bed with a white coverlet and decorative pillows. Natural light enters through a window, illuminating a bedside lamp and a small table. A dresser complements the decor, while artwork adds a touch of color to the muted green walls.
Guesthouse in North Charleston
4.93 out of 5 average rating, 403 reviews

Cozy Park Circle, Charleston Guest House

CatherineRating, 5 stars3 weeks ago
Our second stay here. The place had everything we needed. She lives next door and I can tell she is making thoughtful upgrades over time.
Top guest favorite
A well-maintained front yard features manicured grass, landscaped bushes, and trees providing shade. A parked vehicle is visible in the driveway, with the entrance of the home framed by greenery and a welcoming porch in the background.
Guesthouse in Columbia
5 out of 5 average rating, 431 reviews

Cozy studio apartment, convenient location

TamaraRating, 5 stars1 week ago
A wonderful place to stay. Sharon has everything decorated beautifully. All the amenities are so appreciated. We will definitely plan to stay here again our next time we visit the area. Thank you Sharon for everything.
Top guest favorite
A comfortable living area is presented with a mix of seating options, including a couch and two armchairs. Natural light enters through the windows, which are dressed in soft curtains. A coffee table sits in the center, complemented by tasteful decor on the walls.
Guesthouse in Donalds
4.99 out of 5 average rating, 377 reviews

Home on the farm

PeggysueRating, 5 stars2 weeks ago
This was our 3rd time there. It is the most relaxing place to stay. Ruth thinks of everything, you don’t want for anything. You will not find any better hosts than Ruth and Bob. We absolutely love our stays, have stayed in both the apartment and the cabin and we’ve been extremely happy in both. If we could live there we would! I highly recommend staying in either place. Ruth is the sweetest person you will ever meet and makes you feel like family.
Top guest favorite
A tranquil waterfront view features a dock extending into calm waters, framed by lush greenery and trees. A hammock can be seen suspended from the dock, inviting relaxation. The sunlight glistens on the water's surface, creating a serene atmosphere.
Guesthouse in Charleston
4.99 out of 5 average rating, 300 reviews

Spacious Daniel Island Apartment

AmandaRating, 5 stars1 week ago
We had an amazing stay. Everything was extremely clean, bed and living room furniture are so comfortable. David and Shirlie are super responsive, very clear with all communication and gave excellent restaurant recommendations. The nearby park and lake were a dream. We caught several fish and enjoyed the peaceful scenery on Daniel Island. Highly recommended 100/10!
Guest favorite
A spacious room is furnished with a large bed dressed in a colorful patchwork quilt. A small table sits next to the bed. The room features a television, window treatments allowing natural light, and a ceiling fan, enhancing comfort throughout.
Guesthouse in Charleston
4.92 out of 5 average rating, 375 reviews

Mother in Law in James Island Riverland Terrace

ChloeRating, 5 stars1 week ago
This was a very cute and quiet place. It is in the backyard of the host and the host were quiet. We felt very safe and it was nice parking in the driveway and not the road. The location is perfect. It is easy and quick to get to about anywhere you want to go. There is a very cute movie theater and pizza place down the road.

Guest house rentals with a patio

Guest favorite
An outdoor lounge area features a spacious sectional sofa in dark upholstery, surrounding a low wooden coffee table. Potted plants add greenery around the space. A shed with blue siding and double glass doors sits in the background, framed by tall trees and a wooden fence.
Guesthouse in Charleston
4.95 out of 5 average rating, 241 reviews

Quaint Cottage Studio in Ashley Forest (Avondale).

TachelleRating, 5 stars2 weeks ago
Great place for an individual or couple to use as homebase when visiting Charleston. Has just what you need for a weekend.
Top guest favorite
A tree house-like bungalow is set in a lush green landscape, featuring a cozy fire pit surrounded by four wooden chairs. The exterior showcases a combination of light-colored siding and warm wood accents, with a gently sloping roof and large windows that invite natural light.
Guesthouse in Campobello
4.97 out of 5 average rating, 121 reviews

Bungalow on a 3 acre mini farm

RoyRating, 5 stars3 days ago
Great place, really private and wonderful atmosphere. Went with my spouse and our two daughters and the loft sleeping arrangements worked amazing. We were worried at first since our youngest is 2 years old but there was an extremely Sturdy gate for the top of the stairs waiting for us which was a great touch, host even had some basic items in the fridge which was great and saved us some time in the morning. It is definitely private and away from the hussle and bustle which worked great for us. My daughters even got to chase lightning bugs which was a new experience for them (we live in an area where lightning bugs aren’t around)
Top guest favorite
The interior features a cozy living area with a dark gray sectional sofa, complemented by decorative pillows. A circular coffee table sits in front, holding a tray with books and a remote. The kitchen appears in the background, showcasing a modern design with white cabinetry.
Guesthouse in Inman
4.99 out of 5 average rating, 128 reviews

Foothills Favorite

KellyRating, 5 stars1 week ago
This is a great airbnb for exploring Landrum, the foothills, and surrounding areas. It's not far from the freeway, but feels like it is out in the country. Phyllis is very friendly and extremely helpful. She has extra touches such as some continental breakfast items, real cream for the coffee, etc. The airbnb is spotless. Lots of natural light, an amazing shower, and a very comfortable bed. Great stay!
Top guest favorite
A light-filled living area features a comfortable sectional sofa and a ceiling fan. Two windows provide natural light, while a TV is mounted on the wall. A decorative painting adds color above the sofa, and a woven area rug lies underfoot.
Guesthouse in Johns Island
4.96 out of 5 average rating, 127 reviews

Driftwood Cottage

LoghanRating, 5 stars4 days ago
Very clear and simple instructions, would stay here again!
Top guest favorite
A combined living and sleeping area features a gray couch with decorative pillows, a small coffee table, and a light-colored area rug. A twin bed with a white quilt and pillows is visible in the background, with large windows draped in yellow curtains allowing natural light to enter.
Guesthouse in Hilton Head Island
4.93 out of 5 average rating, 189 reviews

Alli B's Air B and B-Great Country access off 278

BrittanyRating, 5 stars1 week ago
Clean and exactly as described. Good communication responds quickly. Was able to have early check In.
Top guest favorite
A well-maintained outdoor pool is surrounded by a concrete patio, featuring a railing and steps for easy access. Lush greenery and landscaping provide a natural backdrop, with a shed visible in the distance. Outdoor seating is arranged nearby for relaxation.
Guesthouse in Greenville
4.97 out of 5 average rating, 135 reviews

Finished Room over Garage (FROG) on Reedy River

LanceRating, 5 stars2 weeks ago
Enjoyed, as always. Thanks Brett,
Top guest favorite
The studio apartment features a cozy sleeping area with a spacious bed framed by warm-colored bedding. A leather sofa and a blue accent chair are arranged in the living space, complemented by side tables and soft lighting creating a calm ambiance.
Guesthouse in Columbia
5 out of 5 average rating, 130 reviews

Restful Refuge

CarolynRating, 5 stars2 days ago
Thoroughly enjoyed this cozy Airbnb while on a business trip. Very clean and private. Very peaceful spot on the water. Loved the extra little items to make it feel like home such as the spices, all the dishes/ cook items you could need, chocolates by the pillow, water in the fridge, coffee and creamers. Truly appreciated how they go above and beyond for the guest. I would highly reccomend and will be back!
Guest favorite
A charming cottage is surrounded by tall trees, showcasing vibrant autumn foliage. Large glass doors provide plenty of natural light, while a small porch is visible to the side. Greenery and shrubs add to the serene outdoor setting.
Guesthouse in Johns Island
4.9 out of 5 average rating, 184 reviews

Cozy Cottage! 5 mins from Kiawah!

ReneeRating, 5 stars3 weeks ago
My husband and I thoroughly enjoyed our stay in Lucy’s super cute cottage. It was clean, well appointed, and with the perfect amount of space for a couple. Although we didn’t get a chance to try it out (a little too chilly), the outdoor bathtub was a charming feature, in addition to the other outdoor spaces available. We loved the close proximity to the beach and to downtown Charleston. We felt very comfortable and rested really well. We would absolutely come back to Lucy’s cottage, and I’m sure you will feel the same way!

Guest house rentals with a washer and dryer

Top guest favorite
A charming yellow studio is nestled among trees, accessible via stairs on the left. The home features several windows that brighten the exterior. A well-maintained garden with a manicured lawn surrounds the property, creating a welcoming first impression.
Guesthouse in Columbia
5 out of 5 average rating, 134 reviews

Amazing Studio Guesthouse in COLA suburb.

RachelRating, 5 stars2 weeks ago
It was a wonderful place to stay in. Exactly like the pictures. The bed was super comfortable. He made it super welcoming when we came in. Raul was extremely responsive and communicative. He provided clear instructions for checking in and out. Would definitely stay again.
Top guest favorite
The exterior of the garage apartment is presented with a light grey facade. A gabled roof enhances the structure's height. The garage door features three sections with paned windows at the top, while surrounding greenery and a simple front pathway contribute to a welcoming atmosphere.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 253 reviews

Cozy Apartment in Mount Pleasant

TaylorRating, 5 stars3 weeks ago
Dorothy's stay was perfect! It's such a cozy apartment and had everything we needed and more. The neighborhood is beautiful and it was easy to get to downtown Charleston (~15 min away) and other locations via Uber/Lyft. She was so easy to communicate with and quick to respond. I'd highly recommend!
Guest favorite
A bright dining area features a light-colored wooden table surrounded by two white chairs. A coastal-themed painting hangs on the wall, depicting sailboats on a serene ocean. Natural light enters through a nearby door with multiple paned windows.
Guesthouse in Bluffton
4.93 out of 5 average rating, 256 reviews

Beautiful Carriage House! Your Home Away from Home

CathyRating, 5 stars1 week ago
Very cute place in a nice location! Definitely recommend!
Top guest favorite
Guesthouse in Mountain Rest
5 out of 5 average rating, 105 reviews

The Guest House By The River

ChristyRating, 5 stars1 month ago
Thank you so much Kay!! It was a beautiful place!! Enjoyed it so much!! The charcuterie board was amazing!! I look forward to staying there again!!
Top guest favorite
A small outdoor balcony is shown with two striped chairs positioned at a round table. A potted plant with bright pink flowers adds a pop of color to the wooden decking. Sunlight filters through greenery in the background.
Guesthouse in Charleston
5 out of 5 average rating, 260 reviews

James Island "La Casita" Nestled btw Beach & City

CallieRating, 5 stars3 weeks ago
We enjoyed our stay so much! The space was very clean and neat. I quick drive to the beach and to the city! The James Island area was amazing! We will definitely stay again if we are in the area!
Top guest favorite
A white horse is depicted wearing a harness with various attachments. The animal stands on a paved surface, while a blurred background reveals a bridge and people engaging in conversation. The soft evening light casts a subtle glow on the horse's features.
Guesthouse in Summerville
4.97 out of 5 average rating, 263 reviews

Summerville’s Tiny Oak Hideaway

DanielleRating, 5 stars1 week ago
Our stay in Summerville was wonderful. I loved being able to walk out our door to take a walk downtown or to the park. It was such a restful weekend away.
Guest favorite
A fully equipped kitchen area displays a coffee maker and a single-serve brewing machine on a black countertop. Various storage containers and kitchen utensils are neatly arranged, with decorative items and plants positioned on open shelves above.
Guesthouse in Mount Pleasant
4.96 out of 5 average rating, 309 reviews

Shem Creek Bungalow: Coastal Comfort Redefined

NathanRating, 5 stars1 week ago
Stayed here on a recommendation and the place was perfect. Would recommend it to anyone interested in private little getaway.
Guest favorite
A spacious living area features a comfortable blue sofa and a stylish glass coffee table atop a textured area rug. A sleek television is mounted on the wall, while natural light enters through large windows adorned with light curtains. A dining table is situated in the background.
Guesthouse in Columbia
4.91 out of 5 average rating, 161 reviews

Brand New Studio Guest House with Full Kitchen.

EbonyRating, 5 stars1 week ago
I really enjoyed my stay here! It’s the perfect spot for a getaway of any kind. I definitely booked AGAIN!!!

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