
Guesthouse vacation rentals in South Carolina
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals

New Loft in Historic Summerville
Absolutely lovely. Cozy space, plenty of room for 2 people! Jacquelynn was great at responding and was very kind!

The Wren Guest House
This was a great Airbnb! Exactly as described. We ubered most places due to the weather so I’m not sure about walkability, but all Ubers to restaurants and shopping took under 10 minutes. Space was very clean and we had an extremely easy check in with clear instructions. Definitely recommend for a party of 2!

Executive Suite on a farm @GSP Airport
This was by far our favorite!!! This home is absolutely lovely! Decorated so well, cozy and inviting and the bed very comfy! The grounds are gorgeous! Honestly I can’t say enough the only problem we had was not getting to spend enough time there to really enjoy it as we were there for work :( However would most definitely book again! Joey is a fabulous host and always so responsive! THANK YOU!!!

Cozy Park Circle, Charleston Guest House
Our second stay here. The place had everything we needed. She lives next door and I can tell she is making thoughtful upgrades over time.

Cozy studio apartment, convenient location
A wonderful place to stay. Sharon has everything decorated beautifully. All the amenities are so appreciated. We will definitely plan to stay here again our next time we visit the area. Thank you Sharon for everything.

Home on the farm
This was our 3rd time there. It is the most relaxing place to stay. Ruth thinks of everything, you don’t want for anything. You will not find any better hosts than Ruth and Bob. We absolutely love our stays, have stayed in both the apartment and the cabin and we’ve been extremely happy in both. If we could live there we would! I highly recommend staying in either place. Ruth is the sweetest person you will ever meet and makes you feel like family.

Spacious Daniel Island Apartment
We had an amazing stay. Everything was extremely clean, bed and living room furniture are so comfortable. David and Shirlie are super responsive, very clear with all communication and gave excellent restaurant recommendations. The nearby park and lake were a dream. We caught several fish and enjoyed the peaceful scenery on Daniel Island. Highly recommended 100/10!

Mother in Law in James Island Riverland Terrace
This was a very cute and quiet place. It is in the backyard of the host and the host were quiet. We felt very safe and it was nice parking in the driveway and not the road. The location is perfect. It is easy and quick to get to about anywhere you want to go. There is a very cute movie theater and pizza place down the road.
Guest house rentals with a patio

Quaint Cottage Studio in Ashley Forest (Avondale).
Great place for an individual or couple to use as homebase when visiting Charleston. Has just what you need for a weekend.

Bungalow on a 3 acre mini farm
Great place, really private and wonderful atmosphere. Went with my spouse and our two daughters and the loft sleeping arrangements worked amazing. We were worried at first since our youngest is 2 years old but there was an extremely Sturdy gate for the top of the stairs waiting for us which was a great touch, host even had some basic items in the fridge which was great and saved us some time in the morning. It is definitely private and away from the hussle and bustle which worked great for us. My daughters even got to chase lightning bugs which was a new experience for them (we live in an area where lightning bugs aren’t around)

Foothills Favorite
This is a great airbnb for exploring Landrum, the foothills, and surrounding areas. It's not far from the freeway, but feels like it is out in the country. Phyllis is very friendly and extremely helpful. She has extra touches such as some continental breakfast items, real cream for the coffee, etc. The airbnb is spotless. Lots of natural light, an amazing shower, and a very comfortable bed. Great stay!

Driftwood Cottage
Very clear and simple instructions, would stay here again!

Alli B's Air B and B-Great Country access off 278
Clean and exactly as described. Good communication responds quickly. Was able to have early check In.

Finished Room over Garage (FROG) on Reedy River
Enjoyed, as always. Thanks Brett,

Restful Refuge
Thoroughly enjoyed this cozy Airbnb while on a business trip. Very clean and private. Very peaceful spot on the water. Loved the extra little items to make it feel like home such as the spices, all the dishes/ cook items you could need, chocolates by the pillow, water in the fridge, coffee and creamers. Truly appreciated how they go above and beyond for the guest. I would highly reccomend and will be back!

Cozy Cottage! 5 mins from Kiawah!
My husband and I thoroughly enjoyed our stay in Lucy’s super cute cottage. It was clean, well appointed, and with the perfect amount of space for a couple. Although we didn’t get a chance to try it out (a little too chilly), the outdoor bathtub was a charming feature, in addition to the other outdoor spaces available. We loved the close proximity to the beach and to downtown Charleston. We felt very comfortable and rested really well. We would absolutely come back to Lucy’s cottage, and I’m sure you will feel the same way!
Guest house rentals with a washer and dryer

Amazing Studio Guesthouse in COLA suburb.
It was a wonderful place to stay in. Exactly like the pictures. The bed was super comfortable. He made it super welcoming when we came in. Raul was extremely responsive and communicative. He provided clear instructions for checking in and out. Would definitely stay again.

Cozy Apartment in Mount Pleasant
Dorothy's stay was perfect! It's such a cozy apartment and had everything we needed and more. The neighborhood is beautiful and it was easy to get to downtown Charleston (~15 min away) and other locations via Uber/Lyft. She was so easy to communicate with and quick to respond. I'd highly recommend!

Beautiful Carriage House! Your Home Away from Home
Very cute place in a nice location! Definitely recommend!

The Guest House By The River
Thank you so much Kay!! It was a beautiful place!! Enjoyed it so much!! The charcuterie board was amazing!! I look forward to staying there again!!

James Island "La Casita" Nestled btw Beach & City
We enjoyed our stay so much! The space was very clean and neat. I quick drive to the beach and to the city! The James Island area was amazing! We will definitely stay again if we are in the area!

Summerville’s Tiny Oak Hideaway
Our stay in Summerville was wonderful. I loved being able to walk out our door to take a walk downtown or to the park. It was such a restful weekend away.

Shem Creek Bungalow: Coastal Comfort Redefined
Stayed here on a recommendation and the place was perfect. Would recommend it to anyone interested in private little getaway.

Brand New Studio Guest House with Full Kitchen.
I really enjoyed my stay here! It’s the perfect spot for a getaway of any kind. I definitely booked AGAIN!!!
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