Private suite vacation rentals in Upstate South Carolina

Find and book unique private suite rentals on Airbnb

Top-rated private suite rentals in Upstate South Carolina

Guests agree: these private suite rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A private patio area features two striped chairs positioned around a circular table. Sliding glass doors provide access to the guest suite, framed by a well-maintained green lawn and lush trees in the background.

Guest suite in Brevard

4.94 out of 5 average rating, 585 reviews

Private guest suite in heart of Cedar Mountain

NO CLEANING FEE Newly constructed private guest suite conveniently located in the heart of Cedar Mountain. 8 miles from Pretty Place Chapel. Queen bed, tiled shower, kitchenette that includes convection oven, sink, microwave, small refrigerator, coffee pot, tea kettle, small table and chairs, private patio and fire pit(advanced notice required & bring your own wood please). Room is very well stocked with coffee, snacks & toiletries. If you’re planning to visit Pretty Place- check website first

ValueLocationBiking

Top guest favorite

A serene bedroom features a spacious bed dressed in light linens, flanked by a bedside table with a soft lamp. A modern hanging light fixture adds a stylish touch, while a decorative plant and a cozy area rug complete the inviting atmosphere.

Guest suite in Greenville

5 out of 5 average rating, 111 reviews

The Peaceful Retreat Estate in Greenville, SC.

The Peaceful Retreat Estate offers guests a beautifully designed and European modern living experience in Greenville, South Carolina. The five acre property is nestled in a variegated wooded environment with a gentle running stream allowing for a space to truly enjoy healthy living. The superb location provides convenient access to key points of interest and areas in the city. Come and enjoy a place where you can pause--enjoy a simple rest, work with clarity, or refocus on what matters in life.

LocationFamilyAccuracy

Top guest favorite

A classic brick two-story house is showcased, featuring a covered front porch with decorative columns. Green landscaping surrounds the home, complemented by well-maintained grass and trees. A pathway leads to the house, inviting guests to explore the entrance further.

Guest suite in Anderson

4.99 out of 5 average rating, 177 reviews

Backyard Hideaway - Anderson, SC

Enjoy a stylish comfy experience at this lovely private suite w/king bed. Located in the Linley Park Historic District of Anderson, SC. One block from acres of green space, walking paths, playground, and shopping. Enter the gated courtyard with an inviting covered porch and lush outdoor space. Less than one mile to downtown restaurants, breweries, and shopping. One mile to Anderson University, AnMed Health. 15 miles to Clemson University. Includes private suite and access to back porch/yard.

LocationValueQuiet

Top guest favorite

A tranquil bedroom features a spacious bed covered in soft, layered linens and decorative pillows. Warm lighting is provided by two bedside lamps, and artwork hangs above the bed. Large windows with wooden blinds allow for natural light, complementing the calming blue walls.

Guest suite in Athens

4.98 out of 5 average rating, 203 reviews

River Bottom Bungalow

Pamper yourself with a very private Bungalow in the peaceful woods of west Athens (approx. 15 min from UGA). This newly renovated SPA-like space is a haven for wellness and relaxation. Situated on the Oconee River in the lovely River Bottom neighborhood, you'll enjoy the rejuvenating benefits of your own private custom-built cedar sauna, spacious marble shower, outdoor Jacuzzi, king bed & more. The Bungalow is part of the main house with a separate, PRIVATE entrance through the backyard.

LocationValueNearby

Top guest favorite

The studio features a spacious bed with a light-colored coverlet, accompanied by a decorative pillow. Two chairs are positioned beside a small table, and a kitchenette with a refrigerator, microwave, and coffee maker is visible in the corner. Natural light enters through the door leading to the outside.

Guest suite in Simpsonville

4.96 out of 5 average rating, 167 reviews

Upstate Bungalow @ Five Forks

Small modern rustic studio located in a quiet neighborhood in the heart of Five Forks. Less than 1 mile from Woodruff Road for endless restaurant and shopping options. Also, just a quick drive to downtown Greenville, Simpsonville, and Mauldin. Perfect for locals or tourists to enjoy and explore all the Upstate has to offer! (Please note- there is an in-ground swimming pool that is not included in the listing/stay. It’s fenced and locked at all times. Signed liability waiver required).

LocationFamilySolo travel

Top guest favorite

A cozy living room is highlighted by a brick fireplace and a flat-screen TV mounted above it. A wicker loveseat and chairs provide comfortable seating. A dining table for four is visible beyond large glass doors that lead to the outside, surrounded by greenery.

Guest suite in Travelers Rest

5 out of 5 average rating, 180 reviews

Privacy/Sleeps 4/Furman/TR/Gorgeous Yard/Wildlife

So much to love! Private, restful downstairs with separate entrance. Magical wooded area and lush private backyard. Birds & squirrels galore. Porch swing. Great attn. to detail. Crisp ironed sheets, fresh baked goods. We love to pamper! Comfortable Murphy bed. Paris Mountain, Swamp Rabbit Trail access, Furman 5 min. Greenville 15 min. Blue Ridge Mountain gateway! Kitchenette Fire Pit (ask). Asheville & Biltmore Estates 1 hr. Check our reviews! Lots of return guests!

FamilyLocationParks

Top guest favorite

A custom-built farmhouse is set among lush greenery, featuring a combination of wood and stone elements. The driveway leads to the main entrance and garage, where welcoming flowers are planted along the path. A spacious outdoor area invites exploration, surrounded by gentle hills.

Guest suite in Arden

5 out of 5 average rating, 202 reviews

The Guesthouse at Deer Crossing

Our home is a custom built unique farm house which used materials off the property for much of its structure. We call it our “ barn house.” It is located down a private drive surrounded by beautiful horses and other animals. We are close to I-26 and the airport. Restaurants and theaters are 5 minutes away. **Due to the beginning of a housing construction project in the acreage behind us, there could be possible noise from Monday thru Friday. Be aware of this before you book.

ValueLocationHospitality

Top guest favorite

A spacious living area features a large entertainment center with a flat-screen TV, a comfortable leather sofa, and a decorative area rug. A dining table and chairs are positioned nearby, with the kitchenette visible in the background, showcasing a full-size fridge and microwave.

Guest suite in Chapin

4.99 out of 5 average rating, 508 reviews

LAKE FRONT SWEET - Dog Friendly

We hope you will find everything you need in our clean, comfortable basement suite. On beautiful Lake Murray and only 8 mins to Chapin with 3 great grocery stores and plenty of restaurants. We are off Amicks Ferry Road @10 mins out of Chapin. Enjoy the lake view from your shady patio or on the dock. There's room for your boat and trailer, and we are dog friendly -1 dog if you agree to our rules. Lexington Cty #2500883. Sorry, 2 guests max, no extra guests day or night.

ValueLocationHiking

Top guest favorite

A cozy porch area overlooks the Pigeon River, featuring rustic wooden beams and a natural rug. Two red chairs and a wicker sofa provide comfortable seating. Greenery surrounds the space, enhancing the tranquil outdoor experience.

Guest suite in Canton

4.98 out of 5 average rating, 309 reviews

Studio on the River

This is a great little efficiency by the river that offers a great porch overlooking the Pigeon River. This is the perfect getaway for two, in the mountains of Western North Carolina, who want somewhere to stay that is affordable but with all the amenities. We are located approximately 20 minutes from the Blue Ridge Parkway, 20 minutes to the quaint town of Waynesville and 3 miles from Springdale at Cold Mountain Golf course. Asheville is a 30 minute drive.

FamilyLocationAccess

Top guest favorite

A well-maintained walkway leads to a fenced yard featuring a circular arrangement of red Adirondack chairs, set against a backdrop of lush trees. A swimming pool is visible, along with lounge chairs and umbrellas, all under a colorful sunset sky.

Guest suite in Clayton

4.96 out of 5 average rating, 162 reviews

Little Red Door, a poolside guest suite

The Little Red Door is a newly renovated stylish place centrally-located to everything Rabun County has to offer. Just minutes from downtown Clayton and close to stores, hiking, horseback riding, zip lining, whitewater rafting, Tallulah Gorge & Black Rock Mountain State Parks, Lake Burton, Lake Rabun, and more… Sit poolside while it’s warm or under your personal covered patio sipping coffee in the morning & wine in the evening under the stars.

FamilyValueSleep quality

Top guest favorite

The open layout of Studio B features a cozy queen-sized bed with plush pillows, complemented by a stylish brown sofa in the living area. Light fixtures add brightness to the modern decor, while patterned wall art enhances the inviting atmosphere.

Guest suite in Greenville

5 out of 5 average rating, 263 reviews

Backyard guest suite near downtown

Welcome to our charming guest suite, Studio B, near the heart of downtown Greenville, South Carolina! Nestled in a quiet neighborhood, our Airbnb offers the perfect blend of comfort, convenience, and Southern hospitality. Whether you're in town for a weekend getaway, a business trip, or exploring all Greenville has to offer, Studio B is the ideal home away from home. Studio B is a private oasis designed with your comfort in mind.

ValueFamilyHeating

Guest favorite

A sunset view is captured through the silhouette of tall trees, with warm hues of orange and pink filling the sky. The mountains are visible in the background, creating a peaceful, natural setting that encourages relaxation.

Guest suite in Hendersonville

4.94 out of 5 average rating, 140 reviews

Soaking in the views a romantic getaway for 2

You will love the space and the beautiful views you have from every window, this is a quiet residential home with a private apartment below. Enjoy the jacuzzi with a nice glass of wine and the sweeping views. Sleep in or get out and enjoy the many waterfall hikes, brewery’s and wineries in the area, the Biltmore is 13 miles away. We provide fresh coffee w/cream and sugar, we also have a selection of Teas as well.

LocationFamilyGrill