House vacation rentals in Santee

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Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
A serene lakeside view captures a wooden dock extending into calm waters, surrounded by trees. Buildings are visible in the background, subtly illuminated by dusk light. The sky displays gentle hues of blue and pink, reflecting the tranquil atmosphere of the location.
Home in Vance
4.96 out of 5 average rating, 23 reviews

Lakefront w/ dock at Mill Creek

Nestled between Santee & Eutawville, Vance is less than an hour from Downtown Charleston. Experience lake life w/ a front row seat to live music, dancing & karaoke at the Mill Creek Marina! Float over to grab a bite or drink at the Barefoot Lakeside Bar & Mill Creek Food & Spirits! Community hosts golf cart parades, Halloween bash, & a spectacular 4th of July fireworks show. Launch your pontoon a few doors down, tie up at your dock & conveniently fuel up at the marina. Campground store on site!

Top guest favorite
A spacious living area features a large blue sectional sofa adorned with patterned cushions. A light wooden coffee table sits on a soft area rug, complemented by a small potted plant. Natural light filters through the windows, creating a bright and welcoming environment.
Home in Orangeburg
5 out of 5 average rating, 144 reviews

The Grand Marshall

Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Guest favorite
The home features a classic two-story design with an inviting porch supported by tall columns. Green shrubs surround the property, and windows showcase black shutters. A red roof and a brick foundation accentuate the traditional architecture of the estate located on expansive grounds.
Home in Orangeburg
4.95 out of 5 average rating, 105 reviews

Colonial Farmhouse - 6 bedroom with a pool

This private estate 4,355 s.f. (2,800 1st floor, 1,555 2nd floor) home was originally built around the year 1900 and features 6 bedrooms (3 upstairs, 3 downstairs) and 2.5 bathrooms (1.5 downstairs, 1 upstairs). It has 12 ft ceilings throughout, a large dining room, living room, and kitchen area, a beautiful foyer and large staircase, an office, laundry room, large porches, a fireplace, a carport, and a basketball court. You can conveniently walk on a paved walkway to the fenced pool area.

Guest favorite
A charming house is featured, with a well-maintained front yard and stone walkway leading to a welcoming porch. Lush greenery surrounds the entrance, and the architectural details include gabled roofs and decorative elements on the facade. Sunlight casts a warm glow over the exterior.
Home in Eutawville
4.9 out of 5 average rating, 29 reviews

Lakeview Leisure-Face to the Sun

At this unique and tranquil getaway, your day can be whiled away on the porch, poolside or in the hot tub. Or pack a cooler and spend the day on Lake Marion. Tie your boat off on the dock and head just down the road to Santee for a round or two at Santee National Golf Club. Located conveniently between Columbia and Historic Charleston you are never out of options to stay as busy as you like. End the day with a cocktail on the back porch, steaks on the grill and a game of pool. Enjoy life!

Top guest favorite
A single-story house with a combination of brick and siding exterior is situated in a spacious yard. Surrounding trees provide shade, and the gravel driveway leads to the entrance. The structure features multiple windows, allowing natural light to fill the interior.
Home in Moncks Corner
4.98 out of 5 average rating, 167 reviews

Your home away from home in Pinopolis

Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Guest favorite
Home in Summerton
4.94 out of 5 average rating, 173 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 173 reviews

Stylish Lakefront Group Getaway Sleeps 8

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Guest favorite
The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.
Home in Summerton
4.83 out of 5 average rating, 112 reviews

Perfect Family Retreat at Lake Marion

Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Guest favorite
An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.
Home in Santee
4.96 out of 5 average rating, 179 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Top guest favorite
A scenic view of Lake Marion is presented, featuring a wooden dock extending into the water. A picnic table is situated on the grassy shore, beneath a large tree. A flag waves gently in the breeze, adding a touch of patriotism to the serene landscape.
Home in Eutawville
4.97 out of 5 average rating, 31 reviews

Lake House at Lake Marion

Beautiful lakefront 3 Bedrooms/2 full baths with million dollar view of Lake Marion. -2 Queen beds/2 twins/1 futon -Private Dock so you can fish in “big water” -Canoe and Kayak -Firepit -Includes linens and beach towels and more! -Fully Furnished + grill and covered parking -One level open concept -75” Roku TV and WiFi -great safe neighborhood for walking and bike riding -NO HOUSE PARTIES or events. -public boat landing and county park with playground within 2 blocks.

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 128 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Superhost
Home in Eutawville
4.78 out of 5 average rating, 18 reviews

Cypress shores cottage. Lake Marion Sc

Relax and recharge in this cozy 2BR/1BA home just one row back from Lake Marion. Enjoy an equipped kitchen, bright living area, large streaming TV, and private yard and outdoor seating. Slight water views add to the charm, with marinas, boat landings, and fishing spots just minutes away. Perfect for families, couples, anglers, small groups, or remote workers seeking a peaceful retreat in Eutawville and the Lowcountry.

Popular amenities for Santee house rentals

Quick stats about house rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at G$20,914 GYD per night before taxes and fees

  • Verified guest reviews

    Over 40 verified reviews to help you choose

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santee rentals

  • 4.9 Average rating

    Santee stays are highly rated by guests—averaging 4.9 out of 5!