House vacation rentals in Santee

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Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
An outdoor deck features a hot tub, surrounded by trees and comfortable seating arrangements. A gas fire table is located nearby, creating a cozy atmosphere. The picturesque lake view extends beyond the railing, with a vibrant sunset painting the sky in warm hues.
Home in Lake Murray
4.95 out of 5 average rating, 115 reviews

Panoramic Lakefront with Hot Tub

Welcome to 'Sunshine and Naptime' - This newly renovated home is located on the Chapin side of Lake Murray. The entire house is newly furnished and full of amenities. This 3 bedroom lakefront cottage sits on a point with 180 degree panoramic views. Vaulted rustic pine ceilings showcase the wall to wall windows for a view that will take your breath away. You can watch the sunrise AND sunset from the living room or 600 sq ft deck. There is a hot tub, 2 kayaks, shuffle board & private dock.

Guest favorite
A charming single-story brick home is shown with a welcoming entrance featuring a circular window and black door. The front yard is landscaped with grass and bushes, while large trees provide shade in the background. A concrete pathway leads to the front steps.
Home in Sumter
4.89 out of 5 average rating, 217 reviews

Bungalow on Bobs

This charming 3 bedroom, 2 bathroom brick home features an updated kitchen with granite countertops and stainless steel appliances. The great backyard space is fully-fenced, with a large deck, charcoal grill, and fire pit. The spacious master bedroom has a private bathroom and a large walk-in closet. The master bedroom and living room both have Smart TVs. Log in to your own streaming accounts, or enjoy the complimentary Hulu account. The split floor plan allows for easy separation of guests.

Top guest favorite
A single-story house with a combination of brick and siding exterior is situated in a spacious yard. Surrounding trees provide shade, and the gravel driveway leads to the entrance. The structure features multiple windows, allowing natural light to fill the interior.
Home in Moncks Corner
4.97 out of 5 average rating, 155 reviews

Your home away from home in Pinopolis

Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Guest favorite
A two-story house is shown, featuring a sloped metal roof and white exterior walls. Large windows are displayed at the front, surrounded by a well-maintained yard with green grass and various plants. Mature trees provide shade, creating a serene outdoor setting.
Home in Ladson
4.96 out of 5 average rating, 121 reviews

Gorgeous 2 bed Farmhouse 15 mins from downtown

Forget your worries in this spacious and serene space. Our home welcomes you with 2 beds, 2 baths, a gorgeous fenced in yard, a screened in porch, and a beautiful fountain to calm your mind. All of your day to day conveniences are available in our home allowing you to settle in like it’s yours. Located 15 mins to downtown Summerville, 25 mins to downtown Charleston, and 30 mins to multiple beautiful beaches. For more space check out my other listing: https://www.airbnb.com/h/chucktowneapt

Top guest favorite
A charming blue house showcases a welcoming front porch with white railings. Lush greenery surrounds the home, enhancing its inviting facade. The yellow door adds a pop of color, while well-maintained landscaping provides a pleasant entrance.
Home in Sumter
4.98 out of 5 average rating, 160 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Top guest favorite
The exterior of the little house is framed by a welcoming porch with wooden posts. A light blue umbrella provides shade over a seating area. The surrounding trees and natural landscape enhance the peaceful atmosphere of the property.
Home in Columbia
4.96 out of 5 average rating, 135 reviews

Private home | 7 Acres Near Lake | Tucked away

The little house on Lincreek is tucked away down a hidden drive on 7 acres of beautiful wooded land with a creek, historic covered bridge and plenty of wildlife. Private one bedroom, one bath home with a full kitchen, breakfast nook, family room and spacious bedroom. Relax on the large front porch and enjoy being immersed in nature. The home is located less than 2 minutes from Lake Murray Dam. There is parking on site for a boat/trailer. 15 min to Columbia. *No smoking / No parties.

Guest favorite
Home in Summerton
4.94 out of 5 average rating, 170 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 170 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Top guest favorite
The exterior of the villa is shown, featuring a light-colored stucco façade contrasted by large windows. Surrounding landscaped areas include planters with vibrant greenery and flowers. A gravel pathway leads to the entrance, framed by the natural beauty of trees in the background.
Home in Summerville
4.92 out of 5 average rating, 143 reviews

Guest House/Villa

Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Top guest favorite
An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.
Home in Santee
4.97 out of 5 average rating, 168 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Top guest favorite
A bright living area features a cozy seating arrangement with two plush armchairs and a sectional sofa. A modern coffee table sits in the center, while a large wall-mounted television is positioned above an elegant fireplace. Natural light filters through large windows adorned with light curtains.
Home in Rembert
4.98 out of 5 average rating, 243 reviews

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Built in March 2022 single story home is full of amenities. High speed internet Upgraded cable 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/printer, desk/ and futon (can sleep 1 person). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Superhost
The exterior of a single-family house is presented, featuring a white brick façade and a dark shingle roof. Two windows with black shutters flank the front door, which is centered. The surrounding yard is landscaped with patchy grass and nearby trees providing shade.
Home in West Columbia
4.81 out of 5 average rating, 111 reviews

Little WeCo Cottage

Centrally located one bed one bath house. This 700 sqft house is perfect for a weekend getaway or a week working remote. Completely remodeled and ready for your next trip. Quiet street with only a couple of neighbors but still close to town. Within a 10 minute drive from the airport, downtown and 5-points - there really couldn't be a more prime location. Ft. Jackson is a quick 15 minute drive away too. Come stay at this cute cottage for your next trip to Cola.

Popular amenities for Santee house rentals

Quick stats about house rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at G$20,907 GYD per night before taxes and fees

  • Verified guest reviews

    Over 30 verified reviews to help you choose

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santee rentals

  • 4.9 Average rating

    Santee stays are highly rated by guests—averaging 4.9 out of 5!