House vacation rentals in Santee

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Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
Home in Kingstree
4.94 out of 5 average rating, 122 reviews

magical 1840s farm house getaway

Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Superhost
A spacious living room features a large sectional sofa adorned with decorative pillows. Natural light enters through the windows, and a ceiling fan enhances airflow. A modern coffee table rests atop a soft area rug, while a TV is mounted on the wall, providing entertainment options.
Home in Summerville
4.78 out of 5 average rating, 129 reviews

Chas Summerville House w/ Games!

Home with Games, Space, King Bed and a great location! ✔ Fenced in yard! ✔ Firepit! ✔ Deck with Table and Chairs! ✔ Convenient to shopping, dining, and local attractions! ✔ Fully Stocked Kitchen! ✔ Lightning Fast Wifi! ✔ Games for everyone to enjoy! (Ping Pong, X-Men Arcade, Board Games!) ✔ Washer and Dryer on site! ✔ BBQ Grill! ✔ Near the Beach? 35 minutes! ✔ Near downtown Charleston? 30 minutes! ✔ Smart Tvs! Pets are allowed upon approval for an additional cost of $25 per night, per pet.

Top guest favorite
A bright living area features a cozy seating arrangement with two plush armchairs and a sectional sofa. A modern coffee table sits in the center, while a large wall-mounted television is positioned above an elegant fireplace. Natural light filters through large windows adorned with light curtains.
Home in Rembert
4.98 out of 5 average rating, 223 reviews

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Built in March 2022 single story home is full of amenities. High speed internet Upgraded cable 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/printer, desk/ monitor and futon (can sleep 2 kids or 1 adult). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Guest favorite
A charming blue house showcases a welcoming front porch with white railings. Lush greenery surrounds the home, enhancing its inviting facade. The yellow door adds a pop of color, while well-maintained landscaping provides a pleasant entrance.
Home in Sumter
4.97 out of 5 average rating, 137 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Top guest favorite
The exterior of the little house is framed by a welcoming porch with wooden posts. A light blue umbrella provides shade over a seating area. The surrounding trees and natural landscape enhance the peaceful atmosphere of the property.
Home in Columbia
4.95 out of 5 average rating, 121 reviews

Private home | 7 Acres Near Lake | Tucked away

The little house on Lincreek is tucked away down a hidden drive on 7 acres of beautiful wooded land with a creek, historic covered bridge and plenty of wildlife. Private one bedroom, one bath home with a full kitchen, breakfast nook, family room and spacious bedroom. Relax on the large front porch and enjoy being immersed in nature. The home is located less than 2 minutes from Lake Murray Dam. There is parking on site for a boat/trailer. 15 min to Columbia. *No smoking / No parties.

Superhost
The spacious screened-in porch features comfortable seating, a circular table, and ceiling fans. Soft lighting enhances the area, with panoramic views of Lake Marion visible through large screens. Vibrant sunset colors are seen in the sky, reflecting off the water in the background.
Home in Summerton
4.94 out of 5 average rating, 167 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite
A stand-alone apartment building is shown, featuring a low brick exterior and a gabled roof. There are several windows framed with white shutters, allowing natural light to enter. The well-maintained lawn is bordered by neatly trimmed bushes, complementing the overall tidy appearance.
Home in Lake City
4.93 out of 5 average rating, 264 reviews

Home Away From Home Apt 3 - A Hidden Gem

Stand Alone (not a part of the main house) 1 Bed-Room Apt. with Full furnished Kitchen, Full Bath, Private Entrance, private bedroom with door, Private Parking. Living Room- Dining Combo. Fully Furnished. High-Speed WI-Fi, 2 ROKU TVs, 1 in BR & 1 in LR, 1/2 way from New York to Miami, Hablamos Espanol, Fresh Brewed In-Room Coffee. Easy 1-mile walk on Main St. to uptown. 23 miles from I-95, 60 miles to Myrtle Beach, 23 miles to Florence, 1&1/2 hours to Charleston and Columbia.

Guest favorite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 166 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Top guest favorite
The exterior of the villa is shown, featuring a light-colored stucco façade contrasted by large windows. Surrounding landscaped areas include planters with vibrant greenery and flowers. A gravel pathway leads to the entrance, framed by the natural beauty of trees in the background.
Home in Summerville
4.93 out of 5 average rating, 133 reviews

Guest House/Villa

Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Guest favorite
An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.
Home in Santee
4.97 out of 5 average rating, 148 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 121 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Guest favorite
The living area features comfortable grey sofas adorned with decorative pillows. A round wooden coffee table is centered on a patterned area rug. Natural light streams through two large windows, enhanced by light curtains, while a small potted plant adds a touch of greenery.
Home in Dalzell
4.92 out of 5 average rating, 204 reviews

Near SHAW, Pet Friendly, Big Fenced Yard, King Bed

This home is ideal for ALL short and long term tenants. It is conveniently located near SHAW AFB. It has a KING size bed in the master bedroom with a walk in closet. A LARGE fenced in back yard. A new 55'' inch flat screen TV with Disney+, Amazon Prime, HBO MAX and HULU. Wifi is available for all guests as well as a built-in desk/office space. Appliances include: Washer, Dryer, Refrigerator, Oven, Stove, Microwave, and Coffee Maker.

Popular amenities for Santee house rentals

Quick stats about house rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at G$20,932 GYD per night before taxes and fees

  • Verified guest reviews

    Over 20 verified reviews to help you choose

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santee rentals

  • 4.9 Average rating

    Santee stays are highly rated by guests—averaging 4.9 out of 5!