House vacation rentals in Orangeburg County

5 out of 5 average rating, 28 reviews

Home in Manning

Lakeside Hideaway

The perfect place for a family vacation or peaceful getaway! Walking distance to White Oak III boat launch on beautiful Lake Marion, along with 2 beautiful golf courses 1 mile away! Enjoy 2 acres of wooded property with a stocked pond right in the backyard! Large house sleeps 10-11 comfortably, perfect for multi-family, bachelor/bachelorette party, golf/hunting/fishing trips, or a peaceful couples getaway! Home is filled with everything you need to make some of the best Lake vacation memories!

4.98 out of 5 average rating, 45 reviews

Home in Springfield

Historic home in small town

Built in 1909 this home is historic and beautiful to look at. Being 4,000sq ft you’ll have plenty of room to stretch out. Bring the whole family or have the place to yourself. It’s located in the middle of our beloved small town, Springfield on 1.4 acres. 35 minutes from Aiken, SC. 36 minutes from Orangeburg, Sc 1 hr from Columbia, SC. Bedroom info: King and 1 full bed located downstairs. 1 queen, another queen and 2 single beds located upstairs. All showers are walk in. One upstairs & 1 down

5 out of 5 average rating, 111 reviews

Home in Orangeburg

The Marshall

Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

4.96 out of 5 average rating, 157 reviews

Home in Olar

The Pond House at Salkehatchie Farms

The Pond House is a secluded getaway in the woods with double glass doors throughout the house so you can enjoy nature, even while you are inside. It sits at the end of the winding drive through dogwoods in the spring, green trees in summer and colored leaves in autumn. There is a small pond on the edge of the property. Outdoor patios are a wonderful place to breathe in the early morning air, watch a sunset, or grill. There is plenty of room for walks and the property is yours to explore.

5 out of 5 average rating, 36 reviews

Large Lakefront Home w/360 view, beaches, & dock

This family-friendly spacious lakefront home with dock is located on a peninsula and boasts water access on three sides of the property. Park your boat at your own personal dock using the boat ramp located directly across from the property. This property has room for 13 people, but there is also access to an air mattress. Enjoy the 3 huge porches, fire pit, paddle boat, hammocks and swings, fishing, drop in your kayak or paddle board straight off the property and head out to Lake Marion.

4.97 out of 5 average rating, 147 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

4.97 out of 5 average rating, 115 reviews

Home in Santee

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

4.83 out of 5 average rating, 108 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

5 out of 5 average rating, 15 reviews

Almost Heaven on Lake Marion, SC

Enjoy a serene getaway at our lake front spacious 3-bedroom, 2-bathroom lake house. Features include a king-size master bedroom with en-suite bathroom, queen and two full-size beds in other rooms, fully equipped kitchen, winter-only fireplace, screened porch with ample seating, smart TVs in all rooms, high-speed Wi-Fi, gas BBQ, private sandy beach, covered dock with power and seating, boat ramp, and ample parking. Dog-friendly (no cats). location provided after booking.

5 out of 5 average rating, 21 reviews

Home in Orangeburg

Columbia Road Escape

Great in town location, recently renovated kitchen and bath, Luxury Vinyl Plank floors, and nicely appointed with dedicate workspace, off street parking, convenient to shopping and restaurants. We host Travelers for the local hospital and other medical facilities. Pet Notes: Pets are to be approved in advance, Pets are welcome but there is a pet fee based on number of dogs and breed. Some breed are restricted by insurance company. Contact me before booking please.

4.99 out of 5 average rating, 106 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.