
Family-friendly vacation rentals in Santee
Find and book unique family-friendly homes on Airbnb
Top-rated family-friendly rentals in Santee
Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

Mulberry Cabin, a rustic tiny house cabin
Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.

Restful Lakeside Getaway Cottage -Dogs allowed
This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Archie's Lake Daze Cottage No pets
Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

The Little Cottage, Stateburg
Take it easy at this unique and tranquil getaway. The Little Red Cottage features a small bedroom with a double size bed and a closet, a spacious living room with sofa/roku TV and computer desk, and a bathroom with shower. It is nestled on 6 serene acres, among massive windswept Live Oaks dripping with Spanish moss, Palmettos, azaleas, camellia, magnolias and creape myrtle, yet so conveniently close to Shaw Air Force base, 30 mins to Columbia and Camden, close to all Sumter's attractions.

The Cottage at Dream Acres & Petting Zoo I-95/I-20
The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Lizzi & Scott’sTiny Guest House secluded USC-Vista
Welcome to our tiny guest cottage hidden in the heart of the city. It's within blocks of restaurants, coffee shops, an art movie house, and a lovely river walk. The Lace House/Governor’s Mansion, business district, MiLB & UofSC are a short walk or bike ride away. At the rear of our home, it’s private, secure & quiet. A partition & movable screen separate the bathroom area. There’s a smart tv, small fridge, microwave, coffeemaker & work-table.24 hr self check-in. STRO-000579-03-2024

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

The Goose Cottage at Wild Goose Flower Farm
Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed but the sofa also extends into a queen-sized sleeper. Please reach out with further questions or if you would like to inquire about an extended stay.

The Hideaway
Renovated stationary camper nestled in its own private space on 12 acres. This is around 200 square feet indoor living area but over 300 square feet outdoor space for your enjoyment. Secure 5 ft. Fence for your fur babies to be safe in. There are 2 other Airbnbs on this property with ample distance between the houses. Residental toliet with septic tank .Tankless hot water heater with endless hot water. Washer/dryer/dishwasher in its own space behind camper.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Elevated Country Apartment
Discover the charm of country-living in our cozy 1-bedroom elevated apartment, just a short drive from Orangeburg, Bamberg, and Neeses. Wake up to the sound of roosters crowing and enjoy your morning coffee with views of our picturesque homestead, or enjoy a glass of wine while watching the sun set below the majestic pines. Perfect for those seeking tranquility without sacrificing convenience, our apartment offers a fully-equipped kitchen and laundry.
Popular amenities for Santee family-friendly rentals
Family-friendly home rentals with a hot tub

Lake House Retreat

magical 1840s farm house getaway

Sunset Serenity Pool/Swim Spa

Santee lakefront home, big water right off I-95

The Farmhouse @ Goat Daddy's

Quiet spot on Lake Marion

Lakefront w pool, dock and pool table, sleeps12

Luxury Treehouse in the heart of Columbia
Family- and pet-friendly home rentals

Supersized Tiny House in Rest Haven MH Park

Jay’s Upstairs Suite

Kuker Cottage Downtown Florence-Near I95 & I20

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Bungalow on Bobs

Downtown Blue BoHo w/ outdoor spaces, grill & FP

Heart of the Vista Apartment

Comfy & Private Left Half of a Duplex
Family-friendly home rentals with a pool

The Cottage for Two

Updated 2BR condo with balcony

Lavish Home 4BR/3BA, King, Games, Grill, Pool!

Lake Marion Golf Villas Bldg#1

Splendorous Spoleto Ln.

Lake Marion "Penthouse" at Club Wyndham Resort

Retreat with Pool and Epic Game Room

Peaceful Retreat Two
Quick stats about vacation rentals that are family-friendly in Santee

Total vacation rentals
Explore 30 vacation rentals in Santee

Nightly prices starting at
Santee vacation rentals start at G$20,912 GYD per night before taxes and fees

Verified guest reviews
Over 150 verified reviews to help you choose

Vacation rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
20 of Santee vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests—averaging 4.9 out of 5!
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- Riverbanks Zoo and Garden
- Middleton Place
- Congaree National Park
- South Carolina State House
- Columbia Museum of Art
- South Carolina State Museum
- Whirlin' Waters Adventure Waterpark
- University of South Carolina
- Colonial Life Arena
- Magnolia Plantation & Gardens
- North Charleston Coliseum & Performing Arts Center
- Columbia Metropolitan Convention Center
- West Columbia Riverwalk Park and Amphitheater
- Riverfront Park
- Edventure
- Charleston Southern University
- Cypress Gardens
- Soda City Market
- Williams Brice Stadium
- Wannamaker County Park
- Sesquicentennial State Park




