
Family-friendly vacation rentals in Santee
Find and book unique family-friendly homes on Airbnb
Top-rated family-friendly rentals in Santee
Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

Mulberry Cabin, a rustic tiny house cabin
Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.

Restful Lakeside Cottage -Dogs allowed
This pond-side cottage is a peaceful place to relax & unwind. Sit in the sunroom and enjoy watching the birds & the water or enjoy the front porch rockers where you can listen to the birds & frogs. We are 12 min. from downtown Sumter & 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens, Poinsett State Park & Congaree Nat. Park. It's only 2 hrs to Myrtle Beach or Charleston & 3 hrs to the mtns. While it's conveniently located, this cottage offers a quiet place to relax.

Archie's Lake Daze Cottage No pets
Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

The Turtle's Nest
Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

3 bd, 2ba, near ShawAFB, Game Rm
Welcome to our newly renovated 3 Bed, 2 Bath, home in Sumter. Our modern decor home has the following: - Master bdrm with King bed/ ensuite bath - Queen beds other rooms - Full equipped kitchen, coffee station - 65", 55", 43" TVs in rooms - Game Room, w/ pool table, table tennis, arcade games - Work area, wifi, 32" monitor, printer, adj height desk - Private backyard, BBQ grill ,gazebo, fire table, games. - Centrally located near Shaw AFB, Tuomey Hospital, food, parks and more

Relaxing Comfortable Waterfront Family Dock Suite
Bring your family or group to this 3 bedroom 1+ bath place in the large trees with lots of room for relaxing and fun (….if you are a jeans and sweatshirt kind of person. It is not the Hilton!) TVs in each room, and 2 covered decks. Fish, or just sit out on the dock, watch the boats run by, and appreciate the lake. We rarely use the dock ourselves. 600’ from our public boat ramp with a park and small beach. Please also note that we do have cameras installed that monitor outside only.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Stylish Lakefront Group Getaway Sleeps 8
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Perfect Family Retreat at Lake Marion
Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

A Great Lake house. Near Manning, SC and I-95.
Secluded and serene, our private lakefront property in South Carolina's Lake Marion region offers a community feel with minimal traffic and noise. The fenced-in property has 2 cozy bedrooms, a large open floor plan, and a screen porch with a beautiful lake view. Enjoy the private dock, kayaks, and floats, and relax with a bonfire and grill. Conveniently located just 20 minutes from Manning and I-95, our retreat is perfect for travelers looking to unwind and recharge.
Popular amenities for Santee family-friendly rentals
Family-friendly home rentals with a hot tub

Sunset Serenity Pool/Swim Spa

Welcome to The Days End-Farmstay w/ Animals

KING, 4 beds, 5 minutes to I-26

Lake Moultrie retreat

Lakeview Leisure-Face to the Sun

The Merry Inn @ Lake Marion

Glamping Tent Stay

3-Bedroom Dlx @ Lake Marion Resort
Family- and pet-friendly home rentals

Welcome! a relaxing retreat...home away from home

Santee/Lizzie's Creek Lakefront

Jay’s Upstairs Suite

Congaree Vines - Woodland Cottage by a Vineyard!

Almost Heaven on Lake Marion, SC

Fisherman's Dream at Low Falls Landing-Lake Marion

Shotgun Cabins-#3-Beretta

Charming Octagon Cabin for a Peaceful Escape
Family-friendly home rentals with a pool

Colonial Farmhouse - 6 bedroom with a pool

The Sunset Chaser

Lakefront Farmhouse Retreat+Pool

Eagle Point Retreat W/Pool

Wyboo Retreat at Lake Marion W/Pool

Lake Marion "Penthouse" at Club Wyndham Resort

Quiet Retreat:Secluded & Idyllic

Lovely Condo w/pool, balcony, and lakeside view!
Quick stats about vacation rentals that are family-friendly in Santee

Total vacation rentals
Explore 20 vacation rentals in Santee

Nightly prices starting at
Santee vacation rentals start at G$20,879Â GYD per night before taxes and fees

Verified guest reviews
Over 160 verified reviews to help you choose

Vacation rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
20 of Santee vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santee rentals

4.8 Average rating
Santee stays are highly rated by guests—averaging 4.8 out of 5!
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- Rentals with pools Santee
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- Pet-friendly rentals Santee
- Rentals with lake access Santee
- Rentals with a patio Santee
- House rentals Santee
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- Family-friendly rentals Orangeburg County
- Family-friendly rentals South Carolina
- Family-friendly rentals United States
- Riverbanks Zoo and Garden
- University of South Carolina
- North Charleston Coliseum & Performing Arts Center
- Middleton Place
- Magnolia Plantation & Gardens
- South Carolina State House
- Congaree National Park
- West Columbia Riverwalk Park and Amphitheater
- Cypress Gardens
- Williams Brice Stadium
- South Carolina State Museum
- Columbia Museum of Art
- Charleston Southern University
- Sesquicentennial State Park
- Colonial Life Arena
- Edventure
- Columbia Metropolitan Convention Center
- Wannamaker County Park
- Riverfront Park
- Soda City Market
- Whirlin' Waters Adventure Waterpark
- Koger Center for the Arts
- Segra Park
- Frankie's Fun Park





