Santee vacation rentals

Apartment in Downtown Columbia

The image captures the exterior of Colonial Life Arena, featuring a modern architectural design. Bright lights illuminate the entrance, and palm trees line the walkway. Light trails from passing vehicles suggest a lively atmosphere, with a vibrant sky transitioning from sunset to twilight.

4.89 out of 5 average rating, 112 reviews

*Tuscan Sun KING suite downtown FREE parking*

Perfectly situated in the heart of downtown! This studio is within walking distance of Main Street, The State House, USC campus and just a short drive to Williams Brice Stadium, Colonial Life Arena, medical facilities and so much more. The perfect stay for both long and short term guests. Wake up from a great night's sleep in our comfy KING bed to explore downtown, head out to see the Gamecocks play, or just sleep in! You’ll love staying at this stylish apartment! Permit No. STRN-004218-10-2023

4.85 out of 5 average rating, 136 reviews

Home in Park Circle

Walk to Playground & Dining|Game Room|Pet Friendly

Across the street from the largest adaptive playground in the US and a frisbee golf course - an incredible location and home for families. This charming, park-front home sits on a quiet street under a beautiful live oak tree in the heart of Park Circle. Plenty of play space for the kids in the game room and bunk room, while the adults can relax in the backyard or rest of the cozy home. A short walk to restaurants, only 15 min drive to Historic Downtown Charleston, and 20 minutes to the beaches.

4.93 out of 5 average rating, 15 reviews

A compact bathroom features a sleek toilet and a modern sink with a stylish black faucet. The walls are adorned with decorative tiles and framed wall art. A plush bathroom rug with a playful message is positioned in front of the toilet, enhancing the space's character.

Apartment in Florence

“Cozy Escape | Relax & Recharge”

Discover your perfect getaway in this beautifully furnished 2-bedroom, 1.5-bathroom retreat. Featuring sleek, updated appliances and the convenience of an in-unit washer and dryer, this space blends style and comfort effortlessly. Nestled in a prime, sought-after neighborhood, you’ll enjoy both tranquility and easy access to local hotspots. Conveniently located near Magnolia Mall. A perfect blend of shopping, dining. Book your stay and experience the best of home living with a touch of luxury!

4.78 out of 5 average rating, 103 reviews

A laundry area features a chrome rack displaying neatly rolled towels on a rustic wooden wall. A laundry basket stands beside the rack, providing additional storage. The warm tones of the wood enhance the cozy ambiance of the space.

Bungalow in Summerton

The Turtle's Nest

Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

A charming blue house showcases a welcoming front porch with white railings. Lush greenery surrounds the home, enhancing its inviting facade. The yellow door adds a pop of color, while well-maintained landscaping provides a pleasant entrance.

4.97 out of 5 average rating, 115 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

4.93 out of 5 average rating, 43 reviews

A modern kitchen features white cabinetry and stainless steel appliances. A large window with multiple panes allows natural light to illuminate the space, highlighting the sleek countertops. Two black stools are positioned at a small breakfast bar, creating a cozy dining area.

Home in Charleston

Newly Renovated Charleston Colonial Sleeps 10

Our spacious 4 bedroom 2.5 bath getaway is your home away from home. Located in a quiet community but close to everything. Short drive from the airport, restaurants & shops w/ lots of entertainment nearby. Amenities include: ✔ Quiet Neighborhood ✔ 4 Comfortable Bedrooms with memory foam mattresses ✔ Fully stocked kitchen ✔ Patio with lots of seating and a fenced in yard for safety ✔ High-Speed Internet ✔ Completely renovated throughout! ✔ Sleeps up to 10 people ✔ Pack & play available

Condo in North Charleston

A horse-drawn carriage is seen traveling along a charming street, with passengers seated comfortably. The carriage is embellished with a canopy, offering shade. Historic buildings, adorned with balconies and greenery, create a scenic backdrop, reflecting the character of the area.

4.87 out of 5 average rating, 247 reviews

Southern Sophistication at the Park

When you visit the city voted "No. 1 City in the World" and "No. 1 City in the U.S. & Canada" by Travel + Leisure magazine, you'll want to stay at Southern Sophistication. Quiet, secluded, and serene, Southern Sophistication at the Park is a hidden gem nestled in a quaint, well kept gated community—offering the natural beauty, warm hospitality, and cozy comforts of the Lowcountry, all just minutes from the energy and excitement of King Street, Restaurant District, and the Airport.

4.9 out of 5 average rating, 166 reviews

Two individuals relax in a hot tub, surrounded by lush greenery. The hot tub water glistens under natural light, enhancing the tranquil environment. The setting invites relaxation and social interaction, perfect for unwinding after a day of exploring.

Home in Ladson

Charleston HotTub FirePit FirePlace Patio Hammock

👍PRIME CENTRALIZED LOCATION to explore all Charleston has to Offer! ✅ NO Cleaning Fees! ✅ 2 mins to Summerville Medical Center ✅ Featured in Relative Race Reality TV show! ✅ 10 mins from I26 ✅ 35 mins from downtown Charleston and beaches🏖 ✅ 18 mins to Airport/Convention Center/Performing Arts ✅ 3 mins to Publix Grocery/restaurants ✅ Hot Tub 💦 ✅ Fire🔥Pit ✅ BBQ 🍔 Grill ✅ Fire🔥Place ✅ Hammock 🌴 ✅ High Chair & Pack n Play 🍼 ✅ Air Hockey Table 🏒 ✅ K Cup/Coffee Pot ✅ EV plug

4.83 out of 5 average rating, 108 reviews

A wooden dock extending over calm water invites outdoor activities. The pathway leading to the dock is flanked by lush green grass, with soft shadows cast by nearby trees. Gentle waves reflect the clear sky, creating a serene lakeside environment.

Home in Summerton

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

4.98 out of 5 average rating, 124 reviews

A wooden rocking chair is positioned on a spacious porch overlooking a lush, wooded area. A peaceful yard is visible with trees surrounding the space, complementing the tranquil outdoor setting. Natural light gently illuminates the wooden flooring.

Cottage in Hopkins

Charming Country Cottage Nestled in the Woods

Cedar Creek Cottage is conveniently located to everything Columbia & Sumter, SC has to offer, while nestled in a wooded setting for a peaceful stay. Newly renovated with lots to offer: comfy beds & linens, fully stocked kitchen, Wi-Fi, keyless entry, fire pit, back-up generator & 2 large porches. Master bedroom has a queen bed and private full-bath. Two additional bedrooms (1 queen, 1 full) with shared full-bath. Washer, dryer, iron, ironing board and steamer are available.

Townhouse in North Charleston

A modern kitchen features granite countertops and stainless steel appliances, including a microwave and oven. A kitchen island with a sink is visible, accompanied by cabinets providing storage space. The area is well-lit, enhancing the functionality of the space.

4.99 out of 5 average rating, 110 reviews

*The Lazy Seahorse* 3/3 Townhouse w/ King Bed

Large 3 Bedroom 2.5 baths townhouse in a Centralized location. This spacious townhouse has a living room, fully stocked kitchen, dinning room, half bath, and laundry room downstairs. Upstairs you will find the primary suite with a king size bed and full bathroom, a queen bedroom(tv), a bedroom with 2 twin beds, and another full bath. This townhouse is located in a lively and diverse neighborhood with lots of families and kids, free parking, and convenient shopping.

Place to stay in Columbia

A cozy studio room features a spacious bed with decorative pillows, a sunlight-filled reading chair, and a small work desk. The green front door adds a vibrant touch, while natural light pours in through two windows, enhancing the inviting ambiance of the space.

4.94 out of 5 average rating, 242 reviews

The Toad Abode Studio

Relax and unwind in this cozy, centrally located studio. Perfect for travelers, the space features a comfortable double bed, work desk, cozy reading chair, and TV for your downtime. The kitchenette area includes a microwave & mini fridge with ample coffee & tea supplies, while the bright bathroom offers plenty of natural light. All the essentials you need for a comfortable stay. **Checkout on a Monday for more options at a discounted Sunday rate.

Vacation rentals for every style

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Popular amenities for Santee vacation rentals

Self check-in

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Stay near Santee's top sights

Clark's Restaurant11 locals recommend

Captains Quarters Seafood and Steak11 locals recommend

Lonestar BBQ & Mercantile10 locals recommend

Armando’s Mexican Restaurant10 locals recommend

Lake Marion Golf Course7 locals recommend

Food Lion7 locals recommend

Santee house rentals

A cozy living area features a light-colored sectional sofa adorned with colorful throw pillows, accompanied by two wooden chairs. A vibrant red patterned rug covers the floor, while a wooden sideboard and a large flat-screen TV are positioned along the wall.

5 out of 5 average rating, 68 reviews

The Oasis

4.98 out of 5 average rating, 96 reviews

A spacious patio area features a round dining table surrounded by metal chairs. Nearby, a swing chair and a lawn are visible, framed by trees with hanging Spanish moss. A shed is situated in the background, complementing the tranquil outdoor setting.

Home in Goose Creek

Charming Ranch House

4.91 out of 5 average rating, 105 reviews

Home in North Charleston

NEAR HISTORIC DOWNTOWN | LAKE ACCESS + BALCONY

4.77 out of 5 average rating, 151 reviews

A cozy living room is presented with red walls and hardwood flooring. Two comfortable sofas and a coffee table with a decorative surface are arranged, complemented by a floor lamp and an entertainment center. Natural light flows through multiple windows, enhancing the welcoming ambiance.

Home in Cayce

3/1.5 house in Cayce Close to USC, Ft Jackson, CAE

A spacious living area features a high ceiling, two lamps providing warm lighting, and a comfortable seating arrangement that includes a large sofa and armchairs. A coffee table occupies the center, adorned with decorative items. Natural light enters through a nearby window.

4.95 out of 5 average rating, 43 reviews

LODGING @ OLD TOWNE LANDING SUITE A

4.88 out of 5 average rating, 256 reviews

A living room features natural light flowing through large windows, illuminating a cozy seating arrangement with a white sofa adorned with colorful cushions. A glass coffee table sits atop hardwood flooring, accompanied by a decorative plant. A comfortable chair and gray couch add to the inviting atmosphere.

Home in Park Circle

Island House Blue

4.86 out of 5 average rating, 21 reviews

A single-story brick home is featured, showcasing large blue shutters on the front windows. A green lawn leads to a covered porch with steps. An attached garage is visible on the right, with vehicles parked inside.

Home in Dalzell

Beautiful Home Away from Home Near Shaw AFB

4.95 out of 5 average rating, 216 reviews

The exterior of a single-story brick house is depicted, featuring a covered carport and a concrete driveway. Large windows provide natural light to the interior. The surrounding grass and landscaping are well-maintained, contributing to a neat appearance in a quiet residential area.

Home in North Charleston

FANTASTIC PRICE!! FOR CHARLESTON 2 BEDROOM HOUSE

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Other great vacation rentals in Santee

The kitchen features gray cabinetry complemented by light-colored countertops. A sink is positioned between the countertop and a white oven. A refrigerator and a microwave are also visible. The floor is laid with tiled patterns, and a small mat is placed in front of the sink.

4.93 out of 5 average rating, 100 reviews

Welcome! a relaxing retreat...home away from home

4.96 out of 5 average rating, 144 reviews

A scenic view from the balcony shows a tranquil lake and adjacent pool area. Palm trees and lush landscaping frame the space, creating a relaxing outdoor environment. The calm water reflects the sky, enhancing the serene lakeside atmosphere of the property.

Condo in Santee

Beautiful lakefront condo overlooking Lake Marion.

4.99 out of 5 average rating, 106 reviews

The image showcases a scenic view of a calm lake from a deck area. Several outdoor chairs are positioned along a railing, with lush green grass and trees framing the water. A private dock is visible, extending into the lake.

Home in Summerton

Cheerful 3 bedroom home on the lake

Condo in North Charleston

An electric fireplace is framed by a black surround, featuring glowing blue and orange flames. A decorative log piece lies within the firebox, and a sign reading 'HOME SWEET HOME' rests below, adding a touch of warmth to the living area.

4.96 out of 5 average rating, 50 reviews

2 Beautiful Master Suites

4.88 out of 5 average rating, 34 reviews

A view of several homes along the shoreline, surrounded by trees, is captured from the water. The calm surface of the lake reflects the clear blue sky and lush greenery. Various docks and boats are visible near the water's edge.

Home in Chapin

Summerset The Heart of Lake Murray

4.97 out of 5 average rating, 147 reviews

The exterior of a modern log home is visible by the water, surrounded by tall trees. A wooden fishing pier extends toward the water, leading to a sandy area with seating. The sky exhibits shades of purple and pink during sunset, creating a serene atmosphere.

Home in Summerton

Luxurious Lakefront Log Home W/Pool & hot tub

4.69 out of 5 average rating, 103 reviews

The exterior of a two-story house is displayed, featuring light siding and dark shutters. A two-car garage is visible, along with a manicured lawn and landscaping. The driveway is spacious, leading to the entrance, while additional homes are seen in the background.

Home in Summerville

Low Country Living by Low Country BNB