Lake house vacation rentals in Santee

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Top-rated lake house rentals in Santee

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Irmo

5 out of 5 average rating, 8 reviews

The Herons Nest

Escape to tranquility at our charming lakefront getaway, where breathtaking views and serene surroundings await you. This home offers a blend of comfort, style, and nature. Whether you're looking to unwind with a cup of coffee on the deck or enjoy water activities just steps away, our home has something for everyone. While you’ll feel worlds away in this serene retreat, you’re just a short drive from local shopping, dining, and entertainment options. Recently upgraded w/ Starlink Internet.

Guest favorite

A spacious living area is highlighted by a modern sectional sofa with decorative pillows in shades of green and gold. Neutral walls create a bright atmosphere, while an elegant coffee table complements the contemporary decor. The open floor plan leads to a dining area in the background.

Home in Columbia

5 out of 5 average rating, 10 reviews

Lakeside Oasis: Fort Jackson Family Retreat

Escape to this luxurious Lake House, where every corner invites relaxation and rejuvenation. This stunning property is designed for family fun, featuring spacious rooms each adorned with elegant furnishings and en-suite bathrooms. The expansive balconies and patios offer a picturesque backdrop for every moment of your stay. With direct access to the lake from the lower level, indulge in a variety of outdoor activities right at your doorstep, creating unforgettable memories with loved ones.

Top guest favorite

A spacious lakefront home is visible from the water, surrounded by lush green trees. The two-story structure features porches on each level. A sandy beach area and grassy yard lead up to the house, with white lounge chairs placed nearby, inviting relaxation by the water.

Home in Summerton

5 out of 5 average rating, 36 reviews

Large Lakefront Home w/360 view, beaches, & dock

This family-friendly spacious lakefront home with dock is located on a peninsula and boasts water access on three sides of the property. Park your boat at your own personal dock using the boat ramp located directly across from the property. This property has room for 13 people, but there is also access to an air mattress. Enjoy the 3 huge porches, fire pit, paddle boat, hammocks and swings, fishing, drop in your kayak or paddle board straight off the property and head out to Lake Marion.

Guest favorite

A spacious lakefront home is set amid trees, featuring an expansive deck overlooking the water. A private dock is visible with steps leading to it. Vibrant flowers line the property, adding color to the landscape, while a basketball hoop stands ready for outdoor activities.

Home in Lexington

4.97 out of 5 average rating, 154 reviews

Lakefront home on Lake Murray with private dock

Lakefront home on Lake Murray in Lexington, SC on over 1/2 an acre, 166 feet of waterfront with deep water, private dock, and entertainment space- perfect for an unforgettable vacation or weekend. Entire home for rent-4BR, 3 Bath +2 half baths, 2 sofa sleepers, sleeps 12. Breathtaking kitchen & large living space, perfect for the entire family. 2 single person kayaks, outdoor grill, 65 inch and 55 inch TV, washer/dryer, and fast wifi. Master suite with a lavish bathroom and soaking tub.

Guest favorite

Home in Columbia

4.95 out of 5 average rating, 170 reviews

Downtown Columbia 3/2 - Entire House

* Entire House on a large lot with no neighbors behind for added privacy * 3 Bedrooms 2 Full Baths * 1.4 miles from PRISMA Hospital (4-minute drive) * NEWLY RENOVATED * BLACKOUT CURTAINS in all the bedrooms * 15 minutes to Fort Jackson * 7 minutes to Riverbanks Zoo * 5 minutes to the Columbia Museum of Art and Soda City Market * Split floor plan with the main bedroom on the right side of the home with on-suite * Open kitchen adjacent to the dining room overlooking the living and sunroom

Top guest favorite

Home in Chapin

5 out of 5 average rating, 20 reviews

R&R Lake Retreat with Hot Tub

Beautiful home on Lake Murray with extraordinary lake views! New hot tub! 4 BR,3 bath. Cook in Gourmet kitchen with lake views, dining and living room with fire place. Relax on the large porch overlooking the lake. Bring your boat, or rent ours, enjoy our dock and use the kayaks. Our cove is great for swimming and fishing right from our dock. We are located on a quiet street and only about 6 miles from town, grocery stores, and restaurants. We are about 30 miles from downtown Columbia!

Guest favorite

An aerial view reveals a serene point lot surrounded by water, with multiple docks extending into the lake. Lush greenery and trees frame the area, creating a tranquil atmosphere. Several nearby structures and boats are visible along the shoreline, enhancing the natural setting.

Home in Chapin

4.92 out of 5 average rating, 26 reviews

"Serenity Now"-Sunsets/ Beach/ Water On 3 Sides

"SERENITY NOW" -Sunset views / Point lot / Deep water / Mid-lake / Peaceful cove / Close to marinas & big water / Private beach / Private dock & boat ramp / Fire pit / Multi-generational & pet friendly / High speed internet / Spacious screen porch with TV & dining for 8 / Lots of parking / Loft / On site laundry / Great kids' bedroom / Indoor & outdoor games / fully remodeled with lake vibe. High end features like stone fireplace, bidet toilet seat, Bosch Dishwasher and Grohe faucets

Guest favorite

Home in Summerton

4.97 out of 5 average rating, 148 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite

A spacious covered porch offers a view of the lake through large screens. A grassy area extends toward the water, where a private dock can be seen. Pine trees frame the scene, providing a natural backdrop to the tranquil setting.

Home in Moncks Corner

4.81 out of 5 average rating, 144 reviews

Lake Moultrie, Lake front with private dock

Lake front living. Sandy beach and private dock. Children and pets welcome. Enjoy swimming and fishing at your private resort. Local attractions are Old Santee Canal Park, with boardwalk along the Tail Race Canal. Pinopolis Lock, take your boat through the locks and travel to Charleston via intercoastal waterway. Mepkin Abbey, a working monastery and Cypress Gardens with hiking trails and butterfly house are in the area. Or you can simply stay at the cabin to unwind and relax.

Guest favorite

A lush green yard features a shaded gazebo with seating, overlooking a serene lake. In the distance, a dock extends into the water, surrounded by trees. The scene captures a tranquil outdoor space ideal for relaxation and family gatherings.

Home in Summerton

4.83 out of 5 average rating, 108 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Top guest favorite

Home in Summerton

5 out of 5 average rating, 15 reviews

Almost Heaven on Lake Marion, SC

Enjoy a serene getaway at our lake front spacious 3-bedroom, 2-bathroom lake house. Features include a king-size master bedroom with en-suite bathroom, queen and two full-size beds in other rooms, fully equipped kitchen, winter-only fireplace, screened porch with ample seating, smart TVs in all rooms, high-speed Wi-Fi, gas BBQ, private sandy beach, covered dock with power and seating, boat ramp, and ample parking. Dog-friendly (no cats). location provided after booking.

Guest favorite

A wooden dock extends along the calm water, featuring several black outdoor chairs and tables outlined beneath red umbrellas. The spacious home is visible in the background, complemented by lush greenery and evening light reflecting from the windows.

Home in Bonneau

5 out of 5 average rating, 39 reviews

Lake Moultrie retreat

Relax with the whole family at this peaceful oasis on the water. This home offers a private boat ramp, with 40' dock to tie off multiple boats, kayaks,canoe, paddle board, log & gas fire pits, corn hole boards, hot tub, beautiful 12x28 covered porch to enjoy the water and listen to the birds, swimming for the kiddoes, and plenty of yard space for entertainment and barbecue's for the entire family and friends to enjoy. Inside is beautiful & very accommodating.