Vacation rentals with lake access in Santee

Find and book unique lake access rentals on Airbnb

Top-rated lake access rentals in Santee

Guests agree: these lake access rentals are highly rated for location, cleanliness, and more.

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Guest favorite

A well-maintained outdoor space features a gazebo surrounded by lush green grass. A wooden path leads to a serene cove with boats anchored nearby, framed by trees providing a sense of privacy. The setting encourages relaxation and connection to nature.

Cabin in Chapin

4.85 out of 5 average rating, 153 reviews

Lakefront Cabin with Scenic Views

A quiet 1500 ft2 log cabin on a small cove of Lake Murray with beautiful views and room for the whole family. The back porch has an attached gazebo, another gazebo is at lakefront. The interior is wide open with magnificent cathedral ceilings, fireplace in the family room and master bedroom. Spiral staircase up to the loft with a study/extra sleeping. Public boat ramp & dock is approximately 3 miles away, making a short boat ride to be able to beach your boat at the cove. No pets or smoking.

Guest favorite

A charming log home is set on a grassy lot, surrounded by trees. The façade showcases large windows that invite natural light inside. A wooden deck extends from the entrance, providing a space for outdoor seating. A paved pathway leads to the front steps.

Cabin in Vance

4.88 out of 5 average rating, 171 reviews

Log home on Lake Marion inlet w/private dock.

Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Top guest favorite

A spacious lakefront home is visible from the water, surrounded by lush green trees. The two-story structure features porches on each level. A sandy beach area and grassy yard lead up to the house, with white lounge chairs placed nearby, inviting relaxation by the water.

Home in Summerton

5 out of 5 average rating, 36 reviews

Large Lakefront Home w/360 view, beaches, & dock

This family-friendly spacious lakefront home with dock is located on a peninsula and boasts water access on three sides of the property. Park your boat at your own personal dock using the boat ramp located directly across from the property. This property has room for 13 people, but there is also access to an air mattress. Enjoy the 3 huge porches, fire pit, paddle boat, hammocks and swings, fishing, drop in your kayak or paddle board straight off the property and head out to Lake Marion.

Guest favorite

A spacious lakefront home is set amid trees, featuring an expansive deck overlooking the water. A private dock is visible with steps leading to it. Vibrant flowers line the property, adding color to the landscape, while a basketball hoop stands ready for outdoor activities.

Home in Lexington

4.97 out of 5 average rating, 154 reviews

Lakefront home on Lake Murray with private dock

Lakefront home on Lake Murray in Lexington, SC on over 1/2 an acre, 166 feet of waterfront with deep water, private dock, and entertainment space- perfect for an unforgettable vacation or weekend. Entire home for rent-4BR, 3 Bath +2 half baths, 2 sofa sleepers, sleeps 12. Breathtaking kitchen & large living space, perfect for the entire family. 2 single person kayaks, outdoor grill, 65 inch and 55 inch TV, washer/dryer, and fast wifi. Master suite with a lavish bathroom and soaking tub.

Top guest favorite

An aerial view reveals a serene point lot surrounded by water, with multiple docks extending into the lake. Lush greenery and trees frame the area, creating a tranquil atmosphere. Several nearby structures and boats are visible along the shoreline, enhancing the natural setting.

Home in Chapin

4.92 out of 5 average rating, 26 reviews

"Serenity Now"-Sunsets/ Beach/ Water On 3 Sides

"SERENITY NOW" -Sunset views / Point lot / Deep water / Mid-lake / Peaceful cove / Close to marinas & big water / Private beach / Private dock & boat ramp / Fire pit / Multi-generational & pet friendly / High speed internet / Spacious screen porch with TV & dining for 8 / Lots of parking / Loft / On site laundry / Great kids' bedroom / Indoor & outdoor games / fully remodeled with lake vibe. High end features like stone fireplace, bidet toilet seat, Bosch Dishwasher and Grohe faucets

Guest favorite

Home in Summerton

4.97 out of 5 average rating, 147 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite

A spacious house is positioned near the edge of a calm lake. A wooden dock extends into the water, with a walking path leading to the home. The outdoor area features a deck with seating and landscaping including trees and shrubs.

Home in Irmo

4.87 out of 5 average rating, 106 reviews

Lakefront w pool, dock and pool table, sleeps12

Location, location, location! 10 minutes to Lexington, 15 minutes to Chapin, 15 minutes to downtown Columbia, 8 minutes to Harbison shopping. Boat parking at the dock. No need to pay high docking fees. Gorgeous sunsets, calm cove. Swim in the lake or relax by the pool. The massive deck is great for family fun or unforgettable events with your friends. Close to Liberty’s /Lake Murray marina on the lake, and Cat Fish Johnnys/rusty anchor marina. Not your typical Lake Murray Airbnb!

Guest favorite

A spacious covered porch offers a view of the lake through large screens. A grassy area extends toward the water, where a private dock can be seen. Pine trees frame the scene, providing a natural backdrop to the tranquil setting.

Home in Moncks Corner

4.8 out of 5 average rating, 143 reviews

Lake Moultrie, Lake front with private dock

Lake front living. Sandy beach and private dock. Children and pets welcome. Enjoy swimming and fishing at your private resort. Local attractions are Old Santee Canal Park, with boardwalk along the Tail Race Canal. Pinopolis Lock, take your boat through the locks and travel to Charleston via intercoastal waterway. Mepkin Abbey, a working monastery and Cypress Gardens with hiking trails and butterfly house are in the area. Or you can simply stay at the cabin to unwind and relax.

Guest favorite

An aerial view captures the property nestled among trees in a neighborhood with proximity to Lake Moultrie. The surrounding homes and streets are visible, along with patches of green lawns and calm water in the distance, illustrating a serene environment.

Home in Bonneau

4.91 out of 5 average rating, 22 reviews

A Peace A Paradise

Life is better at the Lake! Easy 2-5 min drive to the beach and public boat landing. All sport Lake Moultrie at your disposal for boating, fishing, tubing, kayaking and more. Huge U-shaped drive makes storing your large boat or RV a southern breeze. Screened in porch lets you enjoy the private back yard. While board games, giant checkers, corn hole and poker table are available for some competitive fun. An outdoor fish cleaning station makes it easy to trim up the days catch.

Guest favorite

A lush green yard features a shaded gazebo with seating, overlooking a serene lake. In the distance, a dock extends into the water, surrounded by trees. The scene captures a tranquil outdoor space ideal for relaxation and family gatherings.

Home in Summerton

4.83 out of 5 average rating, 108 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Top guest favorite

A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.

Home in Summerton

4.99 out of 5 average rating, 106 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Guest favorite

A large, two-story house with a sloped roof is set against a clear blue sky. The exterior features light-colored siding and numerous windows. A spacious wrap-around porch is visible, complemented by a flagpole displaying the American flag. Grassy surroundings add to the picturesque setting.

Home in Manning

4.91 out of 5 average rating, 23 reviews

Spacious home with lake access on Lake Marion

Welcome to the lake! You will have lake access for your boat or water toys with dock space to tie up during your stay. You are free to swim & fish from the community dock located just steps from the wrap around porch where you're sure to enjoy your morning coffee and evening sunsets. Located a short drive from several golf courses, boat rentals, state parks and nature trails. Grocery, restaurant and retail options are a short drive into town.