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Panama vacation rentals

Book unique homes, vacation rentals, and more on Airbnb

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Popular amenities for Panama vacation rentals

Other great vacation rentals in Panama

Superhost

Home in Playa Venao

4.9 out of 5 average rating, 115 reviews

Beautiful Home Directly on Playa Venao Sleeps 8-10

Mar 6 – 13

G$129,968 GYD per night
Guest favorite

Townhouse in Panamá

4.97 out of 5 average rating, 162 reviews

Casa Casco Amigos - The Only House in Casco.

Sep 18 – 25

G$75,280 GYD per night
Superhost

Home in Bocas del Toro Province

4.87 out of 5 average rating, 113 reviews

Casa Clearwater... Your Caribbean Dream

Mar 1 – 8

G$145,247 GYD per night
Guest favorite

Earthen home in playa el arenal pedasi

4.96 out of 5 average rating, 117 reviews

Earth House Pedasi Experience

Oct 10 – 17

G$14,060 GYD per night
Guest favorite

Apartment in Panamá

4.97 out of 5 average rating, 131 reviews

Angie’s Place Cozy n Comfy in the ❤️ of #CascoViejo

Sep 22 – 29

G$22,354 GYD per night
Guest favorite

Apartment in Panamá

4.85 out of 5 average rating, 104 reviews

Yoo Panama, comfortable and cozy 54th floor.

Feb 18 – 25

G$30,270 GYD per night
Superhost

Apartment in Panamá

4.82 out of 5 average rating, 136 reviews

Deluxe rooftop with pool Ab4

Jul 6 – 13

G$21,069 GYD per night
Guest favorite

Condo in Panamá

4.81 out of 5 average rating, 122 reviews

Cozy two bedroom apartment

Oct 17 – 24

G$18,766 GYD per night

House rentals in Panama

Superhost

Home in Altos del Maria

4.78 out of 5 average rating, 240 reviews

Modern House in Altos del Maria, Panama

Sep 27 – Oct 4

G$62,224 GYD per night
Guest favorite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 196 reviews

Tropical Haven with Yoga Platform

Apr 28 – May 5

G$65,559 GYD per night
Guest favorite

Home in Pedasí

4.94 out of 5 average rating, 116 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Apr 16 – 23

G$47,187 GYD per night
Guest favorite

Home in El Valle de Antón

4.93 out of 5 average rating, 118 reviews

Rustic family mountain home - 5 min walk to town!

Jul 16 – 23

G$23,719 GYD per night
Guest favorite

Home in Los Algarrobos

4.99 out of 5 average rating, 118 reviews

New house! 5 min from David on the Boquete highway

Sep 12 – 19

G$15,124 GYD per night
Superhost

Home in Bocas del Toro District

4.82 out of 5 average rating, 106 reviews

Amazing over the water house

Feb 24 – Mar 3

G$40,527 GYD per night
Superhost

Home in playa coronado

4.8 out of 5 average rating, 111 reviews

Beach Villa in Coronado

May 8 – 15

G$44,270 GYD per night
Superhost

Home in El Valle de Antón

4.81 out of 5 average rating, 131 reviews

Casa Antares

Sep 15 – 22

G$8,749 GYD per night

Beach house rentals in Panama

Superhost

Home in contadora

4.85 out of 5 average rating, 192 reviews

villa in counter, pearls

Sep 8 – 15

G$27,648 GYD per night
Guest favorite

Home in Playa Venao

5.0 out of 5 average rating, 15 reviews

Casa Samambaia - sea view tropical paradise w pool

Jul 22 – 29

G$56,792 GYD per night
Guest favorite

Home in Playa Bluff

5.0 out of 5 average rating, 15 reviews

Jungle House 100m from the beach

Jun 18 – 25

G$53,850 GYD per night
Guest favorite

Home in San Carlos

4.93 out of 5 average rating, 87 reviews

Beach House-Ocean View Rooftop Jacuzzi & Pool

Sep 10 – 17

G$54,693 GYD per night
Guest favorite

Home in Bocas Del Toro

4.96 out of 5 average rating, 90 reviews

Wiona of Villa Paraiso | Beachfront Villa & Pool

Sep 17 – 24

G$103,586 GYD per night
Guest favorite

Home in Bocas del Toro

5.0 out of 5 average rating, 9 reviews

La Casita Barrbra BnB

Jun 17 – 24

G$40,235 GYD per night
Guest favorite

Home in Río Hato

4.95 out of 5 average rating, 75 reviews

Spectacular beachfront house in Buenaventura!

Jul 13 – 20

G$143,248 GYD per night
Guest favorite

Home in Nueva Gorgona

4.95 out of 5 average rating, 19 reviews

Stylish & Beachfront in Gorgona

May 15 – 22

G$18,801 GYD per night

Your guide to Panama

All About Panama

A narrow isthmus on the southern tip of Central America, Panama is the cultural gateway to South America and the geographical gateway between the Caribbean Sea and the Pacific Ocean. Panama City, its stunning capital city, juxtaposes old-quarter Casco Viejo against the shiny, soaring skyscrapers of the modern district — all surrounded by rolling green hills and vast blue ocean studded with tiny islands. The Metropolitan Natural Park, a wildlife refuge threaded through with hiking trails, is just 10 minutes away from downtown. And Taboga Island, a volcanic enclave featuring a rich array of plants as well as white-sand beaches, is easily reachable via a 30-minute ferry ride.

The terrain rises dramatically from white-sand Caribbean beaches to lush mountain jungles. Near the top of the country, altitude-wise, you’ll find Boquete, home to world-renowned coffee plantations, and the Quetzal Trail, one of Panama’s most scenic hiking trails. Leaving from Volcan Baru National Park, it passes through the Talamanca Mountain Range, where you’ll discover rare tropical wildlife including spider monkeys, tapir, and brightly colored frogs.


The best time to stay in a vacation rental in Panama

The lovely tropical climate makes the prospect of securing a vacation rental in Panama appealing all year long. The drier winter months are ideal for hitting the country’s hiking trails or visiting the beaches. Many of the country’s most significant religious festivals, including Carnaval and Semana Santa (Holy Week), occur in March and April. You’ll want to keep this in mind when booking your Panama house rental if you are headed to a city that hosts a big celebration.

Once Panama’s rainy season starts in May, the sunshine is interrupted with short bursts of heavy rain. It is also usually the quietest time of year for tourism, and you may find yourself alone in the country’s national parks or beaches. That all changes, of course, after the rainy season finishes in November and gorgeous, sunny weather returns.


Top things to do in Panama

Casco Viejo

As the oldest part of Panama City, settled in 1673, Casco Viejo is filled with beautifully restored French and Spanish-style buildings, with a touch of art deco flair. As you stroll down the cobblestone streets, past pastel-colored buildings housing trendy restaurants, upscale bars, and inviting coffee shops, time seems to shimmer between the 19th and 21st centuries. Explore the neighborhood during the day; return after dark for its lively nightlife.

Panama Canal

When the 51-mile Panama Canal opened in 1914, it provided a waterway through Central America and reduced the traveling distance between the Pacific and Atlantic Ocean by 8,000 miles. The impact that this had on global commerce is hard to underestimate. The Pacific mouth of the canal is 26 miles outside Panama City, making it easy to visit this engineering marvel and watch as enormous ships rise and descend through a series of locks.

Bocas Del Toro

Lying close to the border of Costa Rica, this collection of islands is Panama's most popular beach destination. Largely undeveloped, the islands are home to lush tropical rainforest. Great snorkeling and diving opportunities abound in the Isla Bastimentos National Park, which is home to a wide variety of Caribbean coral species as well as (gentle) nurse sharks, crab, and stingrays.

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