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Guesthouse vacation rentals in Panama

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Panama

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite
A charming cottage with a red metal roof is surrounded by lush greenery and colorful flowers. A few small trees and plants frame the image, highlighting the tranquil garden setting and the natural beauty of the hillside location.
Guesthouse in Los Naranjos
4.92 out of 5 average rating, 257 reviews

Sunshine Cottage at Finca Katrina

Sunshine Cottage is a little cottage in the back garden of Finca Katrina. It is set on a hill with views of Palo Alto and Jaramillo with a coffee plantation in the foreground. There is a full (double) bed, room to hang your clothes and to store your belongings. You have a small fridge, toaster oven, sink, coffee maker, and cupboard space for food, but no stove top. If you are looking for more bedrooms, there are additional units on Finca Katrina that compliment Sunshine Cottage. Send us a note!

Top guest favorite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 125 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Guest favorite
A traditional bohio with a thatched roof is set amidst lush greenery. A pathway leads to a serene pool, flanked by vibrant tropical plants and flowers. The surrounding landscape features distant mountains, softly illuminated by the warm light of dusk.
Guesthouse in El Valle de Antón
4.93 out of 5 average rating, 102 reviews

The Retreat in El Valle - Garden House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favorite
A charming apartment building is nestled among lush greenery and tall trees. The exterior features a welcoming porch with railings and is surrounded by tropical plants, creating a serene environment. Natural sunlight filters through the leaves, highlighting the vibrant foliage.
Guesthouse in Gamboa
4.94 out of 5 average rating, 85 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Top guest favorite
An aerial view showcases a spacious guesthouse with a blue roof surrounded by lush green mountains. A tranquil pool reflects the sky, and outdoor seating is visible on the patio, inviting relaxation amidst nature.
Guesthouse in Torio
4.92 out of 5 average rating, 153 reviews

Torio guesthouse with panoramic view; Kokomo

Our private guesthouse is suspended over the Torio River, on the west coast of the Azuero Peninsula. It is a paradise for hikers, bird watchers, surfers and beach goers. Marked trails with posted maps begin at our place. Hike to a beautiful waterfall, mountain or beach. Photograph birds from the porch. Surf, body board and swim safely (no strong currents). Walk to good restaurants, and a small grocery. Experienced Surfers have Morrillo Beach and Playa Reina. Watch sun and moon rise.

Top guest favorite
The property is illuminated at night, showcasing a spacious terrace with comfortable furniture. Soft lighting highlights the structure's features, while stairs lead to the lower level. A serene atmosphere is created by the surrounding trees and dark sky.
Guesthouse in Mariato
4.97 out of 5 average rating, 91 reviews

Beachfront Nature Rentals, Full floor Studio

At Beachfront Nature Rentals we have a 1km beautiful sandy beach. STARLINK, Solar power, Peace & Quiet. 4 wheel drive car is not required. Soft rhythmic sound of the waves. Every week; new birds, turtles nesting, dolphins, whales or monkeys. See the stars without light pollution. Ocean is perfect for swimming and body-boarding. Swim in our pool anytime you like. We have walking or driving access to a surfing beach. For DIGITAL NOMADS, a desk, good wifi, work on the terrace, Rancho or beach.

Top guest favorite
Guesthouse in Cambutal
5 out of 5 average rating, 12 reviews

Casita Verde 411

Your private jungle hideaway by the ocean. Wake up to the sound of waves and tropical birds, just a 3-min walk from the surf. Step outside into lush greenery, slow down, and feel more present. A quiet place to surf, relax, and reconnect – far from crowds, surrounded by nature and ocean. Spend your mornings in the water, unwind in the hammock, and enjoy stargazing at night. Perfect for longer stays, remote work, or anyone looking for a slower, grounded way of living.

Guest favorite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guesthouse in Panamá Oeste
4.84 out of 5 average rating, 143 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Guest favorite
An outdoor patio features a small table with two chairs, surrounded by lush tropical foliage. A hammock is suspended nearby, inviting relaxation. The cabin door is wooden, and a window allows natural light to enter, complemented by a fire extinguisher mounted on the wall for safety.
Guesthouse in La Ermita de San Carlos
4.96 out of 5 average rating, 132 reviews

Small House/Rural/AC, WiFi, pool, hot water

The Small House is part of 5 cabins called “A Piece of Paradise” plus the House where the hosts live; Registered in the Panamanian Tourism Authority Bureau. ✸ Ideal for a couple or a single person ✸ Outdoor dining area and hammock ✸ Very quiet neighborhood ✸ Private and public transportation available, just ask and we will help you ✸ 7-10 minutes, by car, from Playa La Ermita and 10 minutes from Playa El Palmar (great spot for surfing)

Guest favorite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Panamá
4.84 out of 5 average rating, 122 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Top guest favorite
Guesthouse in El Valle de Antón
4.92 out of 5 average rating, 50 reviews

Flor del Aire Cabin

Welcome to our Flor del Aire cabin. A private and cozy retreat, for up to 3 people. The cabin is surrounded by a large garden where you can enjoy the local biodiversity. We have a well-equipped kitchen and shower with hot water. *Private parking. *Wi-Fi-free space, an ideal opportunity to disconnect. For those who need Wi-Fi there is an excellent coffee shop just a few meters away. *We are pet friendly.

Superhost
Guesthouse in Panama City
4.88 out of 5 average rating, 257 reviews

Boho Studio - Private Terrace 9 km from airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

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