Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in Panama

4.96 out of 5 average rating, 138 reviews

Villa Isabella in Coronado Beach Panama

Villa Isabella is a private beach property located in Playa Coronado with a mini soccer field, Half basketball court, playground for children with swing, slider and monkey bars and a large swimming pool with deep for children's (1mts). For adults we have Domino Table, also we have a gazebo with 3 hammocks for your relaxation. We include 55" TV in the living room with CABLE TV and HIGH-SPEED INTERNET. Fully furnished and fully equipped kitchen, Linens and towels, BBQ. OUR HOUSE IS PET FRIENDLY.

Sep 24 – Oct 1

G$65,572 GYD per night

Guest favorite

Condo in Buenaventura, El Chirú

4.99 out of 5 average rating, 100 reviews

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool

➡️ The highest rated w more than 60 reviews! ⬅️ Welcome to "The Gliding Damselfly," the MOST stylish 4BR 4Bath flat nestled in the majestic Buenaventura, perfect for escaping city crowds and enjoying mesmerizing views, stunning beaches (5 mins), and lavish pools (2 mins). Explore the area and its exciting attractions, and then retreat to the breathtaking sanctuary that will leave you in awe. ✔ 4 Comfy BRs ✔ Open Design Living ✔ Full Kitchen ✔ Terrace ✔ Smart TVs ✔ Fast Wi-Fi See more below!

Sep 24 – Oct 1

G$60,161 GYD per night

Superhost

Earthen home in El Cope, Penonome

4.91 out of 5 average rating, 145 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Aug 3 – 10

G$44,360 GYD per night

Guest favorite

Home in San Carlos

4.93 out of 5 average rating, 87 reviews

Beach House-Ocean View Rooftop Jacuzzi & Pool

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 7.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base price covers 4 guests (additional charge $40 per person). Sleeps up to 25 guests.

Jul 30 – Aug 6

G$55,719 GYD per night

Guest favorite

Villa in Panamá

4.98 out of 5 average rating, 47 reviews

Beautiful House in Panama w/ King Beds + Pool

Welcome to our stunning home located in the heart of Punta Paitilla, Panama. This beautiful property boasts 4 bedrooms, 3.5 bathrooms, 7 beds, and can comfortably accommodate up to 11 guests, making it the perfect choice for families or groups of friends. This property also features a private outdoor pool, where you can soak up the sun and cool off on hot days. For those who like to stay active, there is a gym on-site where you can work out and stay in shape during your stay.

Aug 20 – 27

G$108,558 GYD per night

Guest favorite

Cottage in Punta Chame

4.99 out of 5 average rating, 103 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Jul 16 – 23

G$44,421 GYD per night

Guest favorite

Condo in Panamá

4.96 out of 5 average rating, 157 reviews

Los Diamantes Maximo. Prepare to be stunned.

A penthouse apartment, "Maximo" is in an ancestral home of a famous Panamanian family. 2 levels, 4 bedrooms, 3 of which have en-suite bathrooms, 5 meter ceilings, a huge rooftop terrace overlooking the ocean, and also with an enormous balcony overlooking Plaza Herrera, the heart of Casco Viejo. Need more space in the same building? We also have these properties. Add the path to airbnb.com to view: /h/terraza2 /h/herrera3 /h/cuteroomdiamantes

Jul 26 – Aug 2

G$52,531 GYD per night

Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 19 reviews

Top Floor Condo 6 bedroom with amazing views

Elegant and cozy Penthouse located in the exclusive sector of El Cangrejo where you will have the entire top floor of the building to yourself distributed in 2 completely independent, spacious and very comfortable apartments with impressive views of the City. The penthouse has everything you need for your group of friends or family as it is fully equipped. We have a shuttle private service to the airport with a special rate for our guests.

Jan 5 – 12

G$111,600 GYD per night

Guest favorite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 196 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Aug 6 – 13

G$65,577 GYD per night

Superhost

Home in Playa Venao

4.9 out of 5 average rating, 115 reviews

Beautiful Home Directly on Playa Venao Sleeps 8-10

This is our personal home and we take good care to make sure you thoroughly enjoy your stay! This home is located on the best surfing beach in the entire country. Walk out of your back door onto the sandy beach filled with wildlife and the best beach break for beginners to pros. This home offers luxury accommodations. This home is for families and respectful renters only. We do not accept groups who want to use the home to party.

Feb 18 – 25

G$136,092 GYD per night

Guest favorite

Home in El Valle de Antón

4.93 out of 5 average rating, 117 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Aug 3 – 10

G$23,726 GYD per night

Superhost

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 224 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets.

Jul 28 – Aug 4

G$147,168 GYD per night