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Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious living area offers a direct view of the ocean, framed by large openings. A private pool sits in the foreground, with the horizon and distant islands visible beyond. Natural light fills the space, and outdoor lounging areas are positioned alongside.
Villa in Boca Chica
5 out of 5 average rating, 23 reviews

On the Beach Villa in Boca Chica!

Contemporary on the beach Villa with 180° Panoramic Ocean & island views of the Gulf of Chiriqui National Park. Open concept, indoor/outdoor living with private pool & spacious terraces for lounging, sunsets & stargazing. Perched on a cliff with direct beach access. Ocean breezes, tropical birds, exotic monkeys, iguanas & dolphins in the Bay. Private gated community. Large sand beach, perfect for swimming, boogie boarding, long walks, bocce ball or just relaxing & enjoying the sounds of nature.

Guest favorite
An outdoor area features a private plunge pool surrounded by wooden decking and sun loungers. A blue shade sail offers protection from the sun. Lush greenery and a vibrant blue fence enhance the tropical ambiance, with glimpses of the water visible in the background.
Home in Bastimentos Island
4.83 out of 5 average rating, 134 reviews

Spacious, Over the Water Home with Plunge Pool

Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

Top guest favorite
A view of a vibrant turquoise lagoon surrounded by palm trees. In the background, modern high-rise buildings are visible, set against a clear sky with soft clouds. Lounge chairs are positioned along the sandy shore, inviting relaxation by the water.
Home in Rio Hato
4.98 out of 5 average rating, 135 reviews

Private House | Beach | Quiet Stays | Wi-Fi | A/C

Discover the pleasure of staying in a private, elegant, and light-filled villa within the exclusive Playa Blanca Beach & Lagoon. Start your day with the tropical breeze on the terrace, relax by the pool, and enjoy a short 10-minute walk to the beach. Perfect for families and travelers seeking rest, security, and resort-style comfort. Ideally located 10 minutes from Scarlett Martínez Airport and 2 hours from Panama City, it's the perfect place for an unforgettable getaway by the sea.

Top guest favorite
The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.
Home in San Carlos
4.94 out of 5 average rating, 145 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Guest favorite
A serene swimming pool is depicted surrounded by lush palm trees, with the tranquil sea visible in the background. The water's clear blue tiles reflect the sky and nearby greenery, while the gentle curvature of the pool edge invites relaxation.
Villa in Portobelo
4.97 out of 5 average rating, 78 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Top guest favorite
The image shows a bright outdoor area featuring a clear blue swimming pool bordered by light stone paths and lush green grass. A tall palm tree provides shade in the foreground, while the backyard includes a single-story house and an open patio area under a roof.
Villa in Punta Chame
4.97 out of 5 average rating, 139 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 186 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Las Colinas de Caceres de Arraijan
4.98 out of 5 average rating, 225 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Top guest favorite
A bright dining area features a round wooden table surrounded by six turquoise chairs. Large windows allow natural light to fill the space, showcasing a cozy atmosphere. A wooden dresser and potted plants add touches of comfort. Arched openings lead to other rooms.
Home in El Valle de Antón
4.95 out of 5 average rating, 175 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Guest favorite
Home in Playa Coronado
4.77 out of 5 average rating, 137 reviews

Coronado. Bright pool and jacuzzi, entire house

Have fun with your whole family in this family and fun space within Coronado with security gate. The house has a beautiful bright swimming pool with a beach, a jacuzzi without a heater accompanied by its kiosk and barbecue. The house has 4 bedrooms and 4 remodeled bathrooms 2 bedrooms have pool access Modern kitchen and spacious dining room Close to the beach, restaurants, and supermarkets

Top guest favorite
The outdoor area features a large swimming pool surrounded by lounge chairs, with a separate jacuzzi nearby. Inside, a game room comprises a pool table and a ping pong table, with expansive glass doors allowing natural light and views of the greenery.
Villa in Costa Esmeralda
4.97 out of 5 average rating, 118 reviews

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.

Spectacular villa a few minutes from the beach by car, super spacious, ideal to share with family, friends or corporate meetings. The property is full of surprises and with many things to do including its swimming pool, jacuzzi, pool table, ping pong table, domino table, hammocks, large green areas, gas BBQ, variety of board games and a fully equipped kitchen.

Top guest favorite
Home in Nueva Gorgona
5 out of 5 average rating, 26 reviews

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

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