
Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.

Spacious, Over the Water Home with Plunge Pool
Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

Costa Blanca Beach & Golf Villa by Decameron
Spacious Villa with Pool, Golf Views & Beach Access Relax in this stylish 4-bedroom villa overlooking the 7th putting green of Mantarraya Golf Course. All on one level, it offers 250 sq m of comfort, with en-suite bathrooms and space for up to 12 guests. Wow ! - Private 15 m pool with shallow area - 15-minute walk to Pacific beach - Access to Owners Beach Club (restaurant + parking) - Peaceful golf course setting Perfect for families, groups, or golf lovers seeking sun and serenity.

OceanView-Rooftop Jacuzzi&Pool | Concierge Service
Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Beach House with Pool/Gazebo in Punta Chame!
"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Beautiful House in Panama w/ King Beds + Pool
Beautiful home in Punta Paitilla featuring 6 bedrooms, 5.5 bathrooms, and 8 beds, comfortably accommodating up to 16 guests. Enjoy a private pool, in-home gym, and spacious, modern living areas designed for families, groups, or business travelers. The layout offers both privacy and comfort across two levels. Located in one of Panama City’s most exclusive neighborhoods, just minutes from restaurants, shopping centers, supermarkets, and the Cinta Costera.

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Cozy Lagoon View Apartment | BBQ
Un espacio amplio y tranquilo en buenaventura con capacidad para (10) personas, donde podrán disfrutar de una barbacoa en su amplia terraza y su hermosa vista al Lago. Con 190m este hermoso apartamento cuenta con: - 4 dormitorios. - 4 baños completos. - Cocina completa. - Sala. - Comedor. - Terraza con parilla para barcacoa, abanico, sillas y sillones exteriores. - Área de Lavandería. - Dos (2) Estacionamientos. - Área para bicicletas o motos.

Tropical Haven with Pickleball/Yoga Platform
Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

BirdHouse — Gamboa, Panama Canal Rainforest
BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.

Coronado. Bright pool and jacuzzi, entire house
Have fun with your whole family in this family and fun space within Coronado with security gate. The house has a beautiful bright swimming pool with a beach, a jacuzzi without a heater accompanied by its kiosk and barbecue. The house has 4 bedrooms and 4 remodeled bathrooms 2 bedrooms have pool access Modern kitchen and spacious dining room Close to the beach, restaurants, and supermarkets

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.
Spectacular villa a few minutes from the beach by car, super spacious, ideal to share with family, friends or corporate meetings. The property is full of surprises and with many things to do including its swimming pool, jacuzzi, pool table, ping pong table, domino table, hammocks, large green areas, gas BBQ, variety of board games and a fully equipped kitchen.

Infinity Pool Boutique Villa on The Point Break
Our Private Boutique Style Yoga and Surf Villa features comfortable rooms, many with unobstructed ocean views. Each room is airconditioned with a private bathroom. Our guests are like family, spend downtime between yoga, surf, and the infinity pool, relishing spectacular sunset views.
Popular amenities for Panama mansion rentals
Luxury mansion rentals

Breathtaking Views: Sleeps 13, Walk to Beach!

Luxury beachfront villa!

La Casa de la Cascada has a bbq, ping pong, and a gym

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool

Mansion on Organic Farm with Heated Pool

Villa Papagayo, Morrillo Beach, Veraguas

Amazing Catamaran Experience in San Blas

Modern Luxury Beach Front House in Coronado
Pet-friendly mansion rentals

Mountain Retreat

Entire Villa with pool in front of beach!

Exclusive Villa with pool, and beach minutes away

Wonderful House with Terrace and Ocean View

Villa GiGi - Beach Home Panama Santa Clara

Cerro Azul, Country House with Heated Pool.

Casa Coco - Beautiful Mountain Villa With AC

Spectacular Beachfront House
Mansion rentals with a pool

Private Beachfront Getaway

Playa Escondida with the Best Direct Ocean View

Escultura 2 — 4BR/4BA w/AC, near surf and beach

Nice duplex house with a swimming pool.

Beachfront Home | En-Suites + Chef & Tours Available

Your perfect mountain escape

Luxury Beachfront Escape | Playa Escondida Resort

Jungle House 100m from the beach
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