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Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness, and more.

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Guest favorite
An outdoor area features a private plunge pool surrounded by wooden decking and sun loungers. A blue shade sail offers protection from the sun. Lush greenery and a vibrant blue fence enhance the tropical ambiance, with glimpses of the water visible in the background.
Home in Bastimentos Island
4.82 out of 5 average rating, 130 reviews

Spacious, Over the Water Home with Plunge Pool

Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

Superhost
An outdoor pool area is framed by well-maintained gardens and palm trees, illuminated by warm lights. Multiple lounge beds under a shaded pergola provide relaxation spots. The pool features a circular design, surrounded by landscaped greenery, creating a serene atmosphere at dusk.
Condo in Buenaventura, El Chirú
4.97 out of 5 average rating, 129 reviews

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool

➡️ The highest rated w more than 60 reviews! ⬅️ Welcome to "The Gliding Damselfly," the MOST stylish 4BR 4Bath flat nestled in the majestic Buenaventura, perfect for escaping city crowds and enjoying mesmerizing views, stunning beaches (5 mins), and lavish pools (2 mins). Explore the area and its exciting attractions, and then retreat to the breathtaking sanctuary that will leave you in awe. ✔ 4 Comfy BRs ✔ Open Design Living ✔ Full Kitchen ✔ Terrace ✔ Smart TVs ✔ Fast Wi-Fi See more below!

Guest favorite
A tranquil view of the clear, shallow waters of the Caribbean Sea is displayed, with gentle waves lapping against the shore. Smooth stones are partially visible above the waterline, and a distant mountain range is seen against a backdrop of scattered clouds.
Apartment in Maria Chiquita
4.95 out of 5 average rating, 128 reviews

Spacious 4Br Beachside Getaway at Playa Escondida

Escape to Playa Escondida Resort & Marina for the ultimate luxury getaway. Our 4Br beachfront apartment is ideal for families and friends seeking relaxation in the Caribbean Sea. Indulge in plush rooms, white sand beaches, and unforgettable sunsets. Our fully equipped apartment provides everything you need for an exceptional stay, and our unparalleled service ensures you'll never want to leave. Best of all, it's just an hour away from Panama City. Book now for a truly unforgettable experience.

Guest favorite
Villa in Farallon
4.9 out of 5 average rating, 238 reviews

Costa Blanca Beach & Golf Villa by Decameron

Spacious Villa with Pool, Golf Views & Beach Access Relax in this stylish 4-bedroom villa overlooking the 7th putting green of Mantarraya Golf Course. All on one level, it offers 250 sq m of comfort, with en-suite bathrooms and space for up to 12 guests. Wow ! - Private 15 m pool with shallow area - 15-minute walk to Pacific beach - Access to Owners Beach Club (restaurant + parking) - Peaceful golf course setting Perfect for families, groups, or golf lovers seeking sun and serenity.

Top guest favorite
The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.
Home in San Carlos
4.94 out of 5 average rating, 140 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Top guest favorite
The image shows a bright outdoor area featuring a clear blue swimming pool bordered by light stone paths and lush green grass. A tall palm tree provides shade in the foreground, while the backyard includes a single-story house and an open patio area under a roof.
Villa in Punta Chame
4.97 out of 5 average rating, 135 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Las Colinas de Caceres de Arraijan
4.98 out of 5 average rating, 222 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Top guest favorite
A view of a vibrant turquoise lagoon surrounded by palm trees. In the background, modern high-rise buildings are visible, set against a clear sky with soft clouds. Lounge chairs are positioned along the sandy shore, inviting relaxation by the water.
Home in Rio Hato
4.98 out of 5 average rating, 129 reviews

Private House | Beach | Quiet Stays | Wi-Fi | A/C

Cozy & comfy villa with great illumination and natural ventilation located in the Playa Blanca Beach & Lagoon complex in Rio Hato, Cocle just 10 minutes away from Scarlett Martinez International Airport and 90 minutes from Panama City. Playa Blanca is an exclusive tourist residential beach complex with villas, apartments, big lush green areas, the largest pool in Central America, beach club, Playa Blanca Hotel Resort and much more.

Guest favorite
A stunning terrace is showcased, featuring a glass-enclosed pool with views of the skyline and sea. Comfortable lounge chairs are arranged around a dining table, all situated against a backdrop of bright blue skies and distant urban architecture.
Apartment in Panama City
4.9 out of 5 average rating, 79 reviews

Penthouse Deluxe, 360º views and glass pool

Welcome to a luxurious penthouse in the heart of Panama City's Old Town, where comfort and conviviality merge to offer you an unparalleled stay! With four private bedrooms, capacity for eight guests, and 300 square meters of elegance, enjoy a terrace with a glass-enclosed pool and 360° views of the sea and skyline. Bright spaces, impeccable design, and a comfortable, fully-equipped environment.

Guest favorite
The outdoor area features a large swimming pool surrounded by lounge chairs, with a separate jacuzzi nearby. Inside, a game room comprises a pool table and a ping pong table, with expansive glass doors allowing natural light and views of the greenery.
Villa in Costa Esmeralda
4.96 out of 5 average rating, 113 reviews

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.

Spectacular villa a few minutes from the beach by car, super spacious, ideal to share with family, friends or corporate meetings. The property is full of surprises and with many things to do including its swimming pool, jacuzzi, pool table, ping pong table, domino table, hammocks, large green areas, gas BBQ, variety of board games and a fully equipped kitchen.

Guest favorite
A spacious living area features large glass doors opening to a private terrace, allowing natural light to fill the room. A comfortable sectional sofa and stylish dining table are complemented by a large television on an accent wall. Tropical plants enhance the inviting ambiance.
Condo in Buenaventura, El Chirú
4.9 out of 5 average rating, 146 reviews

Modern | Steps to Beach Club & Shops | Sleeps 10

• Beautiful design • Excellent location • Steps to the La Mansa Beach Club! • Spacious & luxurious • Luxury Bedding • 75 inches TV • Beautiful views! • Half a block from restaurants & convenience store! • Fully equipped • High speed internet • Buenaventura, best luxury beach resort in Panama

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