Boutique hotel vacation rentals in Panama

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Panama

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Hotel room in Bastimento

5.0 out of 5 average rating, 11 reviews

Dream stay at Villa F&B in Bocas del Toro

Situe sur l ile de Solarte a 10 mn de Bocas centre, la Villa F&B est un lieu qui inspire a la detente au calme et a la sérénité. La Villa F&B offre une vue exceptionnel sur la mer et la sierra. Fabienne sera vous ravir par sa cuisine a base de produits locaux, brioches, pains, gateaux crepes et meme le ketchup et la mayo, tout est fait maison!!! Soucieux de votre bien être, que vous soyez farniente ou Kayak ,venez découvrir et séjourner a la Villa F&B une experience que vous n oublierez pas....

Dec 12 – 19

G$33,336 GYD per night

Superhost

Boutique hotel in Bajo Boquete

4.92 out of 5 average rating, 107 reviews

Villa Alejandro - Tastefully Furnished Room

Just 5 minutes walk to centre, calmly situated and close to town located in an extraordinary mansion. Lovely furnished bedroom (King-Size/Orthopedic mattress) with private bathroom and walk-in closet . Affectionately decorated living room with spectacular view to the Boquete valley by large windows and large, full equipped kitchen can be shared with other guests. Lot of space for dining/reading in the living room. Lovely garden and terrace can be used. Gated carport. Fast WiFi, CableTV, Netflix

Jul 17 – 24

G$18,720 GYD per night

Superhost

Boutique hotel in PA

4.84 out of 5 average rating, 43 reviews

Rancho Cabaña- Private Porch, Loft, 1 min to beach

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Aug 20 – 27

G$17,228 GYD per night

Superhost

Boutique hotel in PA

4.9 out of 5 average rating, 29 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

Oct 8 – 15

G$34,038 GYD per night

Boutique hotel in Cambutal

5.0 out of 5 average rating, 3 reviews

Zen Sanctuary & Spa

Breathe is a Zen designed healing and wellness retreat sanctuary, with your boutique stay we offer an all-inclusive cuisine package that can be added. The nourishment plan includes three vital plant based meals, desserts, teas and infusions designed for you to have a holistic healing experience. Our Spa offerings consist of massage, IR saunas, hydrotherapy whirlpool, bodywraps, scrubs, facials, and sound therapy. We instruct movement classes, cooking and cacao classes. Details below.

Sep 26 – Oct 3

G$31,566 GYD per night

Guest favorite

Hotel room in Bocas del Toro Province

4.92 out of 5 average rating, 71 reviews

Economy Oceanview Room - Bird Island Bungalows

Bird Island Bungalows is a hidden, secluded beach hotel surrounded by pristine private beaches, jungle and a 3.5ha lush tropical garden. From breathtaking sunsets from our 360 degree view roof top bar, silent meditation on our oceanview yoga deck, kayak tours to the bird watcher's paradise Bird Island to educational jungle walks to explore all the unique tropical flora and fauna - there is something for everyone or you just enjoy the beautiful silent sounds of nature and waves.

Nov 24 – Dec 1

G$18,183 GYD per night

Boutique hotel in Isla Colon

5.0 out of 5 average rating, 8 reviews

Hotel Palma Royale - 1 bedroom suite w/ kitchen

Luxury suite with separate bedroom with queen size bed, kitchen, and living area, balcony with spectacular sea views, bathroom with rain water shower, office desk, air conditioning, coffee pot with grinder and panamanian coffee beans, flat screen tv with cable, upper floors, free wifi, large quality windows and doors, pillow top mattresses, marble or coral tile, bamboo flooring, non-smoking rooms, beach towels, umbrellas, blow dryers, laundry service, board games.

Jan 8 – 15

G$37,379 GYD per night

Guest favorite

Boutique hotel in Playa Venao

5.0 out of 5 average rating, 8 reviews

Brisa - Ocean Views, Calm Vibes, King/Twin beds

Brisa is the perfect family room on the ground floor, made for relaxing after a fun day in the sun. Equipped with a mini fridge, AC, TV (ready for you to sign into all your online viewing accounts), hot/cold water and beautiful breezy covered seating area outside with ocean views. Steps from our pool! *Additional guest, available to kids up to 12 year old* *A 10% tax will be collected separately as Airbnb do not collect tax in behalf of the host. * !!PROMO BELOW!!

Jan 19 – 26

G$36,455 GYD per night

Boutique hotel in San Carlos

4.82 out of 5 average rating, 94 reviews

B) Beach, surf and Relax with King size bed

Manglar Lodge is a small beach Hotel located at El Palmar beach on the Pacific coast on the town of San Carlos, If you like nature and comfort, you'll enjoy your stay at Manglar Lodge We are small beach hotel that offers the visitor four cozy and clean rooms, WiFi, restaurant (open form 8.30am until 9pm) with great food and a great selection of craft beer and live music on some weekends from 7pm to 9.30pm The Room is on a 1 floor you have to walk up the stairs

Aug 31 – Sep 7

G$14,189 GYD per night

Guest favorite

Boutique hotel in Playa Morillo, Mariato

4.97 out of 5 average rating, 33 reviews

Double room IXORA with partial ocean view balcony

Boutique hotel near Playa Morrillo with pool, whirlpool, private beach and garden. The 8 rooms, a combination of aesthetics, authentic decor and functionality, offer warmth with a subtlety that focuses on the ocean view; an oasis for your next Pacific Ocean retreat. Most rooms have floor-to-ceiling panoramic windows and stunning ocean views. They have a private balcony, ideal to enjoy the tropical breezes and the breathtaking views.

May 26 – Jun 2

G$20,031 GYD per night

Boutique hotel in Contadora Island

4.83 out of 5 average rating, 23 reviews

Luxury "LaRomantica" B&B A/C Jacuzzi Island-Tour !

The guest house "La Romantica" welcomes you to Contadora in Panama. Newly renovated and modern and funkionell expanded. La Romantica is just a 10-minute walk from the nearest beach. Flat screen Smart TV Large terrace Strong free Wi-Fi Free shuttle service to the ferry or airport. Good snorkeling possibilities We speak your language! (German English and Spanish) Our motto: Arrive as a guest and leave as a friend

Oct 27 – Nov 3

G$21,815 GYD per night

Hotel room in Bajo Boquete

4.77 out of 5 average rating, 66 reviews

Buena Vista Boquete Quadruple Room

This quadruple room is furnished with one double bed and two twin beds, all with semi-orthopedic mattresses. The room has a WiFi access, a Smart TV, large windows to enjoy the mountain view and a private bathroom. Features: Large windows / Bathroom / Access to rooftop patio with 360° views / Access to kitchen / WiFi / Smart TV / Standing fan / Parking

Sep 22 – 29

G$8,868 GYD per night