Hotel vacation rentals in Panama

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

A furnished bedroom features a spacious bed with white linens, flanked by bedside tables with lamps. Soft artwork adorns the wall above, while a bench rests at the foot of the bed. A cozy throw drapes over the bench, completing the inviting arrangement.

Hotel room in Boquete

4.89 out of 5 average rating, 114 reviews

Villa Alejandro - Tastefully Furnished Room

Just 5 minutes walk to centre, calmly situated and close to town located in an extraordinary mansion. Lovely furnished bedroom (King-Size/Orthopedic mattress) with private bathroom and walk-in closet . Affectionately decorated living room with spectacular view to the Boquete valley by large windows and large, full equipped kitchen can be shared with other guests. Lot of space for dining/reading in the living room. Lovely garden and terrace can be used. Gated carport. Fast WiFi, CableTV, Netflix

Guest favorite

A spacious bedroom features a wooden platform bed with a blue patterned mattress. Large glass doors open to a private patio, surrounded by lush greenery. Two chairs are positioned on the terrace, and a colorful framed artwork adorns the wall near a window.

Hotel room in PA

4.9 out of 5 average rating, 29 reviews

Treetop views of the Pacific in a boutique cabaña

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Guest favorite

Hotel room in PA

4.91 out of 5 average rating, 35 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

Guest favorite

The bungalow features a screened-in porch, framed by lush greenery and colorful plants. Warm sunlight casts shadows across the wooden structure, creating a serene and inviting atmosphere amidst the surrounding foliage.

Hotel room in Bastimentos Island

4.95 out of 5 average rating, 64 reviews

Casa Florecer- bungalow at the edge of the sea

Welcome to Casa Florecer, a bungalow at the edge of the sea. Your space is simple and elegant. A studio apartment with plenty of room to enjoy a quiet & peaceful time on the island. The bungalow boasts a screened in porch, gorgeous views, and pristine coral reef for your front yard. All stays include a locally sourced vegetarian breakfast served in our over the water eatery, Juntos. For fun closer to home: we have snorkel gear, paddle boards, and yoga mats available for your enjoyment.

Guest favorite

A shared swimming pool is surrounded by tropical palm trees and lush greenery. Two vibrant bean bag chairs are placed beside the pool on a wooden deck, providing a relaxing spot to enjoy the ocean view in the distance during twilight.

Private room in Bastimentos Island

4.94 out of 5 average rating, 47 reviews

The Firefly B&B oceanfront bungalow w/ pool

Our b&b is a little off the beaten path but we love it that way. Listing is for one of our two private, oceanfront bungalows. We can let you know which one is available at time of booking. We are an eco lodge & describe our vibe as "hip, rustic beach house". Our rooms are fan cooled & have in room safes. Pool is shared by all five rooms. Breakfast is included. If a "resort" or 4 star place is your vibe, we are probably not for you :) We accept guests 15 and up.

Superhost

A round wooden dining table is set for four, surrounded by light-colored chairs. A chandelier hangs above, casting a warm glow. Light enters through open doors, highlighting wall art and plants, creating a welcoming dining space.

Casa particular in Dolega District

5 out of 5 average rating, 4 reviews

Wanakaset Forest Haven 2BR, River & shared Pool

Casa Quetzal is a serene 2-bedroom retreat nestled in the lush forest of Wanakaset Panama, perfect for up to 4 guests. With its open-plan living space, modern bathrooms, and fully equipped kitchen, it offers comfort in a natural setting. Relax on the private terrace or enjoy the shared pool, just a short walk away. Surrounded by rivers and tropical greenery, it’s an ideal escape for nature lovers seeking tranquility and a peaceful getaway.

Top guest favorite

The exterior of the B&B is softly illuminated at night, with warm lights highlighting the roof and entrance areas. Surrounding lush greenery is visible, along with a meandering path leading to the entrance. Comfortable outdoor seating is arranged in the garden area, inviting relaxation.

Private room in Chame District

5 out of 5 average rating, 7 reviews

VillaHermosa B&B

This is an unparalleled B&B in Panama and is focused on architecture and landscape lovers. Visiting it will transport them to countries or places that evoke the pleasure of living. The way in which the structures are arranged and their night lighting will allow them to feel like a true dream cottage, where the sounds of nature will give peace and quiet to the spirit and rejuvenate the energies of the body.

Superhost

The villa is situated amidst lush greenery, showcasing a modern design that blends with the surrounding jungle. Spacious outdoor areas are visible, with seating arrangements under the shade of trees, inviting a relaxed atmosphere for guests to enjoy their surroundings.

Hotel room in Cambutal

4.95 out of 5 average rating, 20 reviews

Boutique Inn_The Hill 2_Private Entry_Tripple_+16

The Hill Panama, our Boutique Inn Adult Only (16+) is proud to be featured on Architectural Digest Magazine, located in the heart of enchanted Cambutal Beach, just a 5 five-minute walk to the beach, surrounded by several surf spots, balance between mountain and sea, hidden amongst the jungle canopy. This listed Room 2 was designed as a boutique hotel room with separated private entry and communal kitchen.

Superhost

A serene outdoor seating area is featured on a wooden dock above the water, illuminated by soft string lights. Guests are seen relaxing under thatched umbrellas, with a picturesque sunset reflecting on the calm surface of the sea.

Hotel room in Bocas del Toro

4.99 out of 5 average rating, 69 reviews

BarrBra / Double Bed / Priv. Bath. / Ac

- house built right over the Caribbean sea - bedroom with double sized bed & balcony - private bathroom (hot water shower) - air conditioning included - a la carte breakfast included (between 8 - 9:30 a.m.) - guest kitchen - sunset orientated (yes, we're facing west! :)) - ocean access from our private dock - in-house kayak, bike and snorkel gear rentals - gay-friendly place

A wooden cabana sits elevated on stilts, topped with a thatched roof. Steps lead up to the open side, revealing a cozy interior. Surrounding foliage includes a variety of trees and plants, contributing to the natural setting of the community.

Nature lodge in Darién Province

4.7 out of 5 average rating, 20 reviews

La Chunga

La Chunga is in a difficult access indigenous community without electricity or roads. Come see this gem of a community and the indigenous way of life. You’ll love this place because of the nature walks, the wildlife, the gastronomy, and the people. We have a number of guided tours and adventures. My place is good for adventurers trying to see something new and exciting.

Guest favorite

A comfortable bedroom features a spacious bed with layered bedding, including throw pillows in various patterns. The nightstands are equipped with pendant lighting, adding to the inviting ambiance. Fresh towels are neatly arranged at the foot of the bed, while natural light filters through a nearby window.

Hotel room in Boquete

4.77 out of 5 average rating, 137 reviews

Private Room in Boquete

Enjoy the simplicity of this quiet and central accommodation in town, just a few steps from grocery stores, restaurants, bars, coffee shops, with easy access to public or private transportation. This room has a comfortable bed, private bathroom with hot water ample space, the kitchen is perfectly equipped to share with two other rooms, the garden is beautiful.

Superhost

Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.

Hotel room in Panamá

4.86 out of 5 average rating, 104 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.