Villa vacation rentals in Panama

Find and book unique villas on Airbnb

Top-rated villa rentals in Panama

Guests agree: these villas are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Villa in Playa Venao

5.0 out of 5 average rating, 22 reviews

Villa Verde - Luxury&Cozy Villa 1BR #26 BlueVenao

Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows

Sep 19 – 26

G$46,439 GYD per night

Guest favorite

Villa in Chame

4.83 out of 5 average rating, 124 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide.

Jul 2 – 9

G$23,741 GYD per night

Guest favorite

Villa in Río Hato

5.0 out of 5 average rating, 38 reviews

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Welcome to one of the nicest villas in Buenaventura, Panama's most luxurious beach resort community. This meticulously kept, spacious, 4 bedroom vacation paradise with additional private guest house and pool will make for unforgettable getaways with family and loved ones. Private baths, multiple dining areas, Sonos indoor/outdoor sound system, gorgeous outdoor areas and high end finishes, furnishings, and appliances throughout make every moment spent in Las Portales one to treasure.

Jun 30 – Jul 7

G$102,577 GYD per night

Guest favorite

Villa in Playa Venao

4.98 out of 5 average rating, 61 reviews

Casa Aqua: Amazing beach front house - Playa Venao

Exceptional beach front property, Casa Aqua sits right on the beach of Playa Venao Bay where you can enjoy great surfing, fishing, whale watching and many other outdoor activities. Casa Aqua is a very spacious 3,500ft home with all amenities you could dream of. You will love to eat/lounge outside in the spacious covered terrasse or swim in the large infinity pool. And if you don't feel like cooking, there are some quality restaurants close by a short walk on the beach from Casa Aqua.

Apr 1 – 8

G$128,898 GYD per night

Guest favorite

Villa in Panamá

4.98 out of 5 average rating, 47 reviews

Beautiful House in Panama w/ King Beds + Pool

Welcome to our stunning home located in the heart of Punta Paitilla, Panama. This beautiful property boasts 4 bedrooms, 3.5 bathrooms, 7 beds, and can comfortably accommodate up to 11 guests, making it the perfect choice for families or groups of friends. This property also features a private outdoor pool, where you can soak up the sun and cool off on hot days. For those who like to stay active, there is a gym on-site where you can work out and stay in shape during your stay.

Aug 20 – 27

G$108,400 GYD per night

Guest favorite

Villa in Portobelo

5.0 out of 5 average rating, 42 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Apr 11 – 18

G$51,406 GYD per night

Superhost

Villa in Bocas del Toro

4.84 out of 5 average rating, 32 reviews

Bocas del toro - Villa over the water- Bahia Coral

Come and live a unique experience, in our Ecolodge on stilts, you will experience dream moments in the bay of Punta Caracol, a heavenly place between sky and sea. Our EcoBungalow 4-5 people, offers two bedrooms with King size bed, two bathrooms, an equipped kitchen, the lounge area turns into a third sleeping area. 15 minutes by boat from the center of Bocas, 10 minutes by boat from Playa Estrella, you can easily enjoy the treasures of the archipelago.

Nov 22 – 29

G$90,468 GYD per night

Guest favorite

Villa in Bajo Boquete

4.97 out of 5 average rating, 158 reviews

VILLA YOLO, Walk To Town

This beautiful two-unit villa is located in the spectacular 5 Star resort of Valle Escondido. Guests occupy the entire lower level which includes their own private entrance and patio over looking the garden. It is an 8 minute walk down to the town of Boquete which boasts a wide variety of restaurants, bars & shops. Boquete is at an elevation of 3800 ft ( 1160 meters) in the lush Panama rain forest & is called the Valley of Rainbows.

Aug 24 – 31

G$18,895 GYD per night

Guest favorite

Villa in Maria Chiquita

4.9 out of 5 average rating, 49 reviews

Villa en Playa Escondida Resort

Playa hidden Resort & Marina, is a jewel of the Caribbean , one of the most beautiful and exclusive beaches, one hour from Panama City or the Airport , located in Maria Chiquita, Columbus. The project is growing , currently there are constructions in development. Our exclusive Villa , has a terrace with BBQ, natural temperature Jacuzzi and low pumping system, direct access to the pool and a 1 mint walk to the beach .

Jul 8 – 15

G$72,367 GYD per night

Guest favorite

Villa in Cacique

5.0 out of 5 average rating, 23 reviews

CARA AL MAR Cacique

In the middle of the Parque National de Portobello (access only by 4x4), nestled at the top of the hill, between sky and sea, away from all eyes, at the first lodges, a small cozy love nest to rest and disconnect (as a couple or with friends), comfortable, bright (large and high windows), spacious, cool (central air conditioning), witness of a grandiose show... awaits you...!

Mar 31 – Apr 7

G$79,292 GYD per night

Guest favorite

Villa in Pedasí District

4.84 out of 5 average rating, 158 reviews

Charming beach villa Pedasi, Panama

Villa in the Destiladeros Beach Pedasi (3min walk), private garden and private pool only for the guests of the villa. Very quiet place, secure. For people who are looking for a hidden place, far from the crowd but with all the commodities around (markets in Pedasi village 10min driving, several beaches , little restaurants...). Just to enjoy nature with all the comfort.

May 18 – 25

G$35,963 GYD per night

Guest favorite

Villa in Farallon

4.92 out of 5 average rating, 193 reviews

4 Bedroom Costa Blanca Golf & Beach Villa

Spacious 4 bedroom, 4.5 bathroom, 250m detached villa overlooking the 7th putting green on Mantaraya Golf Course. Accommodation provided for up to 12 people within 4 bedrooms. The 15m long swimming pool plus shallow area in rear garden is totally private. Villa guests have access to the Property Owners Beach Club and Restaurant.

Jul 15 – 22

G$46,439 GYD per night