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Hotel vacation rentals in Mississippi River

Find and book unique hotel rentals on Airbnb

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Popular amenities for Mississippi River hotel rentals

Family-friendly hotel rentals

Superhost
A well-lit bedroom features a spacious bed covered with a striped blanket. A wooden dresser with a television sits opposite the bed, while a comfortable chair is positioned nearby. A floor lamp provides additional illumination, and a door leads to a separate area.
Hotel room in Chetek
4.75 out of 5 average rating, 8 reviews

Inn Greener Pastures - Ground Floor Room

KyanneRating, 5 stars11 months ago
This place is beautiful! So peaceful out in the country! I would recommend this place to everyone!
Guest favorite
Aerial view captures the Great Lodge nestled alongside Little Hanging Horn Lake, surrounded by lush greenery. The calm water reflects the hues of sunset, while a wooden pier extends into the lake, offering a serene connection to nature.
Hotel room in Barnum
4.97 out of 5 average rating, 70 reviews

Hanging Horn Lakeside Resort #6 Woods View Room

BrianRating, 5 stars2 weeks ago
unfortunately we only spent one night at Hanging Horn. It was a beautiful setting and would have loved to spend more time exploring the area.
A round wooden dining table is surrounded by six matching chairs in a sunlit room. Large windows reveal a scenic view of the beach and gulf beyond, with natural light flooding the space. A ceiling fan provides a cooling breeze, enhancing comfort.
Hotel room in Grand Isle
4.9 out of 5 average rating, 30 reviews

Gulf Front Suite - 2 Bedrooms with Kitchen

EthanRating, 5 stars4 weeks ago
Place was in a great location with an awesome deck, check in was easy and host was very responsive. Great place to stay in Grand Isle.
Top guest favorite
The exterior of the Courtland Hotel showcases red brick architecture, featuring large windows with green trim. A sidewalk runs alongside, complemented by planters and benches, enhancing the inviting atmosphere of the surrounding downtown area.
Hotel room in Fort Scott
4.9 out of 5 average rating, 71 reviews

Charming Historic Hotel lodging

CharlesRating, 5 stars1 month ago
Had a great stay. Frank was very flexible with early check in….really appreciate that.
Guest favorite
The exterior of the Shepherd's Suite is characterized by a striking black facade, accented with red wooden paneling. A warm-toned door with a grid-patterned window is visible, alongside two large, bright windows that allow natural light into the room.
Hotel room in Hermann
4.95 out of 5 average rating, 44 reviews

Hermann Crown's New Pet Friendly Shepherd's Suite

CassieRating, 5 stars2 months ago
The place was just a described. We liked the location was walkable and that we had access to the hotel amenities, but felt like we had a private space.
Guest favorite
A resort map displays the layout of Wilderness Resort, featuring marked areas for cabins, campsites, and amenities, set within a wooded landscape. Paths are indicated, along with locations for electrical hookups, water access, and common facilities like showers and the office.
Hotel room in Lac La Belle
4.87 out of 5 average rating, 119 reviews

Motel C Wilderness Resort

TaylorRating, 5 stars3 months ago
This was my second time staying here, and it was great again. unfortunately the power went out in the area, and Rick even came and checked up on us. Really appreciated that. Would defintely recommend this simple place to stay.
Top guest favorite
A well-appointed guest room features a spacious bed with an array of decorative pillows. A flat-screen television is mounted on the wall. Large windows offer natural light and are dressed with blinds, while a small seating area includes a table and two chairs.
Hotel room in Gulfport
4.92 out of 5 average rating, 139 reviews

Melinda@ Almanett hotel & Bistro Aquarium & beach

KerriRating, 5 stars5 months ago
Michael was an amazing host! He met us in the lobby. Showed us our to our room and was an endless source of information. I will definitely be returning.
Top guest favorite
A cozy seating area is shown, featuring a white couch adorned with pastel green and yellow cushions. Framed artwork is displayed on the wall above the couch, complementing the light yellow walls. Soft lighting is provided by a lamp on a nearby side table.
Hotel room in Bay St. Louis
4.97 out of 5 average rating, 233 reviews

The Happy Place

AlexanderRating, 5 stars1 week ago
We thoroughly enjoyed our weekend in Bay St. Louis and our stay at this lovely place. There is a magical quality to the property, with its lush garden complete with a goldfish pond and the cats and dogs. The place was comfortable (for two people) and the location is great. It's an easy walk to the heart of the town and the beach.

Hotel rentals with a pool

Guest favorite
A two-story yellow brick building is illustrated, featuring large windows and a prominent sign for the Riverbend Inn. A flight of steps leads to the entrance, while exterior lights enhance visibility. A parking area is visible to the right side of the building.
Hotel room in Hannibal
4.91 out of 5 average rating, 79 reviews

Honeymoon Suite 3

TshiaRating, 5 stars1 week ago
Second time staying here. One of our favorite places in Hannibal.
Guest favorite
The room contains two queen beds with white linens and wooden frames. A dining table with four white chairs is positioned near a window. A television is mounted on a wall, and an air conditioning unit is visible beneath the window.
Hotel room in Branson
4.83 out of 5 average rating, 36 reviews

Indian Point Walk-In Condo 124, FREE SDC Shuttle

LisaRating, 5 stars1 week ago
We were truly impressed with everything and would give our experience five stars! Before arriving, I had seen a review mentioning an issue with the hot water, so I was a little concerned. However, I'm happy to report that the hot water was instant and consistent throughout our stay, so it seems that issue has been completely resolved. We especially appreciated the convenience of being able to back our car right into the parking spot, making it just a couple of steps to the door. Being on the bottom floor and so close to the pool was also incredibly convenient, especially for our grandkids, who swam every day. Thanks again for a wonderful stay.
Superhost
A spacious outdoor courtyard area features comfortable seating arranged around a central fire table. The patio showcases a mix of greenery and landscaping, complemented by nearby glass doors leading into the building. Soft lighting from candles creates a welcoming ambiance.
Hotel room in Madison
4.8 out of 5 average rating, 10 reviews

Settle Into Comfort In Our East Madison Hotel

PhyllisRating, 5 stars3 weeks ago
It was very quiet. I loved it. Big room nicely furnished. Had a small fridge. The property had a pool, hot tub, exercise room, laundry, outdoor seating, and a bistro. We would stay again
Superhost
Hotel room in Hot Springs
4.86 out of 5 average rating, 28 reviews

Lakefront, Double Studio #16 on The Cove, Fishing Pier, Pool, Pet Friendly

JulieanneRating, 5 stars2 months ago
We had a lovely time and enjoyed the Canadian goose we saw on the lake. Beautiful.
Superhost
The spacious lobby area features a mix of comfortable seating arrangements, including circular ottomans and sleek lounge chairs. A long, curved sofa complements the modern design. The adjoining bar area is illuminated with blue lighting, enhancing the contemporary ambiance.
Hotel room in Itasca
4.8 out of 5 average rating, 364 reviews

King Bed at Chicago Northwest + PET Friendly

JenniferRating, 5 stars3 weeks ago
had a wonderful stay. would stay again.
Guest favorite
A warm living area features a dark wood piano positioned against a red accent wall. Sunlight filters through the window blinds, creating a soft glow on the hardwood floor. A comfortable sofa is complemented by decorative cushions and a modern chandelier hangs above.
Hotel room in Eureka Springs
4.84 out of 5 average rating, 37 reviews

The Grand Suite at Tradewinds

SherylRating, 5 stars1 month ago
Great location, easy to find, very clean and comfortable! Plenty of towels and both beds were very comfortable. Christopher checked on us after we arrived and was quick to respond when I had a question! The location was close to everything we did and parking was plentiful. This was a sister trip, we would stay here again, as would my sister and her husband at a later date.
A light-filled studio is depicted, featuring a spacious kitchen with black and stainless steel appliances. A comfortable seating area is provided with a plush sofa and decorative rug. Large windows open to a balcony with outdoor furnishings and greenery visible.
Hotel room in New Orleans
5 out of 5 average rating, 11 reviews

Luxury Studio Apt w Balcony in Memoir Building

ChloeRating, 5 stars2 weeks ago
I truly enjoyed my stay. The room was beautiful and clean. The concierge was so kind and helpful. We spent an amazing Sunday afternoon at the beautiful pool. The stay itself was really amazing. The one thing that chapped me was I wasn’t made aware of a $42 fee I would have to pay to use the pool and have access to their social club. The Airbnb was already pretty pricey so having to pay a fee when i arrived and not being made aware of said fee was a little annoying. Also the parking situation was nice because it’s across the street so very convenient but again pricey adding another 50 dollars to our trip. Overall the stay was lovely i just wish there was a little more price transparency especially since i figured the Airbnb was priced at that point to reflect the amenities you would enjoy.
Superhost
An outdoor swimming pool is positioned within a fenced area, surrounded by various lounge chairs and tables. Colorful seating options are visible, along with several potted plants. Nearby, a vehicle is parked next to a dock, and water can be seen beyond the enclosure.
Resort in Rockaway Beach
4.82 out of 5 average rating, 55 reviews

Expedition Cabin - On the Lake Fishing Cabin

SeanRating, 5 stars4 weeks ago
Wonderful peaceful stay right on the lake! Exactly what we were looking for. We loved it and will be back!

Hotel rentals with a patio

Top guest favorite
A cozy seating area is highlighted by a decorative chair upholstered in deep blue fabric. A patterned cushion enhances the comfort. A small table holds a lamp and a floral arrangement, while a round mirror reflects light, adding depth to the space.
Hotel room in Ocean Springs
4.95 out of 5 average rating, 177 reviews

Mockingbird Inn- Fern Suite

KristaRating, 5 stars3 days ago
Second time booking this place. It is so beautiful, peaceful, and cozy. You feel right at home!
Top guest favorite
A well-lit private bedroom features a spacious bed adorned with a textured green throw. The room is complemented by decorative oars on the wall and two modern lamps. Natural light enters through large windows, showcasing views of the outside greenery.
Hotel room in Cotter
5 out of 5 average rating, 26 reviews

Best Value! Historic B&B in Cotter - Room 101

AndreaRating, 5 stars3 weeks ago
Our favorite place to stay when we visit Cotter! You won’t be disappointed with the location, price and amenities either! Thank you again for another great stay! ❤️
Top guest favorite
A comfortable bedroom features a queen bed with a light-colored quilt and decorative pillows. A wooden dresser and a mirror stand against one wall. Natural light enters through a nearby window, illuminating the warm tones of the furnishings.
Hotel room in Preston
5 out of 5 average rating, 27 reviews

Front Motel Room

CindyRating, 5 stars3 weeks ago
Simple, clean, beautiful country surroundings, and oh so friendly and hospitable from start to finish!! The location was quiet and lovely, and perfectly situated from Ballpark National complex where we watched lots of baseball! We will likely be back if Kerry & Pam will have us! We also got our first look at Lake Pomme de Terre just minutes away!! Beautiful body of water! Thank you for everything, Kerry & Pam!
Top guest favorite
The exterior of a historic Victorian house is presented, featuring a light-colored facade with decorative motifs around the windows. Lush greenery frames the entrance, with manicured hedges leading to the front steps. The building showcases multiple stories and distinctive architectural details.
Hotel room in St. Louis
4.97 out of 5 average rating, 58 reviews

Napoleon's Retreat - Lafayette Room

LeAaronRating, 5 stars2 weeks ago
Matthew’s hotel suite was precisely what my partner and I were hoping to find for our day trip to St. Louis for the Kendrick Lamar concert. The suite was spacious, clean, well-located, and felt like a home away from home. This suite was the kind of place that gets right what hotels often have a hard time with, like making a space feel like a home, mostly because of its unique decor choices and artwork. And Lafayette Square is quite the charming place. Highly recommend!
Top guest favorite
The room features two spacious beds with wooden frames and a neutral color palette. A large area rug with vibrant colors adds contrast to the stone wall backdrop. Natural light enhances the room's inviting atmosphere, while bedside lamps provide additional illumination.
Hotel room in Pawhuska
5 out of 5 average rating, 41 reviews

The Cross Bell Downtown 204

KRating, 5 stars1 week ago
A great place to stay! Super cute and clean. I Love, LOVE this location! Would highly recommend.
A cozy living area features a comfortable gray sofa adorned with decorative pillows. A simple coffee table sits in front, accompanied by a small plant. A ceiling fan and wall clock add functional elements, while light from the adjacent entryway brightens the space.
Casa particular in Waveland
4.61 out of 5 average rating, 49 reviews

Homey Hideaway

LasaunRating, 5 stars2 weeks ago
It was a very nice setup and close to the gulf. Really enjoyed ourselves.
Top guest favorite
A cozy sleeping area is illuminated by a bedside lamp, creating a comfortable setting. The bed is adorned with a colorful quilt featuring intricate patterns. Soft curtains frame the window, allowing natural light to brighten the room.
Hotel room in Mead
4.97 out of 5 average rating, 35 reviews

Reel ‘Em Inn 2: Cozy & Clean | Convenient location

EricaRating, 5 stars1 week ago
We absolutely loved our stay at this super cute, charming vintage motel! It was spotless, full of personality, and such a great value. The space was cozy and well cared for, with fun retro touches that made it feel special. What really stood out was the host’s kindness—she went above and beyond to make my daughter’s 12th birthday extra memorable. She surprised her with the sweetest little basket filled with candy, a cute cup, fun socks, and other birthday goodies. It was such a thoughtful and personal touch, and my daughter was over the moon! Highly recommend this place if you’re looking for something clean, unique, and hosted by someone who genuinely cares about your stay. We’ll definitely be back!
Guest favorite
A modern suite is equipped with a practical coffee station and a decorative mirror. Two green sofas are positioned next to a bedside table and lamp, providing a cozy lounging area. The spacious bed is visible in the background, contributing to a comfortable atmosphere.
Hotel room in Laurel
4.88 out of 5 average rating, 120 reviews

Hotel Pinehurst- Jean Theatre, Suite 103

NatalieRating, 5 stars5 days ago
Always a great stay at Cindy’s place! Have stayed multiple times and will continue to! Thanks Cindy!!

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