
Hotel vacation rentals in Mississippi River
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Top-rated hotel rentals in Mississippi River
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
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Popular amenities for Mississippi River hotel rentals
Family-friendly hotel rentals

Inn Greener Pastures - Ground Floor Room
This place is beautiful! So peaceful out in the country! I would recommend this place to everyone!

Hanging Horn Lakeside Resort #6 Woods View Room
unfortunately we only spent one night at Hanging Horn. It was a beautiful setting and would have loved to spend more time exploring the area.

Gulf Front Suite - 2 Bedrooms with Kitchen
Place was in a great location with an awesome deck, check in was easy and host was very responsive. Great place to stay in Grand Isle.

Charming Historic Hotel lodging
Had a great stay. Frank was very flexible with early check in….really appreciate that.

Hermann Crown's New Pet Friendly Shepherd's Suite
The place was just a described. We liked the location was walkable and that we had access to the hotel amenities, but felt like we had a private space.

Motel C Wilderness Resort
This was my second time staying here, and it was great again. unfortunately the power went out in the area, and Rick even came and checked up on us. Really appreciated that. Would defintely recommend this simple place to stay.

Melinda@ Almanett hotel & Bistro Aquarium & beach
Michael was an amazing host! He met us in the lobby. Showed us our to our room and was an endless source of information. I will definitely be returning.

The Happy Place
We thoroughly enjoyed our weekend in Bay St. Louis and our stay at this lovely place. There is a magical quality to the property, with its lush garden complete with a goldfish pond and the cats and dogs. The place was comfortable (for two people) and the location is great. It's an easy walk to the heart of the town and the beach.
Hotel rentals with a pool

Honeymoon Suite 3
Second time staying here. One of our favorite places in Hannibal.

Indian Point Walk-In Condo 124, FREE SDC Shuttle
We were truly impressed with everything and would give our experience five stars! Before arriving, I had seen a review mentioning an issue with the hot water, so I was a little concerned. However, I'm happy to report that the hot water was instant and consistent throughout our stay, so it seems that issue has been completely resolved. We especially appreciated the convenience of being able to back our car right into the parking spot, making it just a couple of steps to the door. Being on the bottom floor and so close to the pool was also incredibly convenient, especially for our grandkids, who swam every day. Thanks again for a wonderful stay.

Settle Into Comfort In Our East Madison Hotel
It was very quiet. I loved it. Big room nicely furnished. Had a small fridge. The property had a pool, hot tub, exercise room, laundry, outdoor seating, and a bistro. We would stay again

Lakefront, Double Studio #16 on The Cove, Fishing Pier, Pool, Pet Friendly
We had a lovely time and enjoyed the Canadian goose we saw on the lake. Beautiful.

King Bed at Chicago Northwest + PET Friendly
had a wonderful stay. would stay again.

The Grand Suite at Tradewinds
Great location, easy to find, very clean and comfortable! Plenty of towels and both beds were very comfortable. Christopher checked on us after we arrived and was quick to respond when I had a question! The location was close to everything we did and parking was plentiful. This was a sister trip, we would stay here again, as would my sister and her husband at a later date.

Luxury Studio Apt w Balcony in Memoir Building
I truly enjoyed my stay. The room was beautiful and clean. The concierge was so kind and helpful. We spent an amazing Sunday afternoon at the beautiful pool. The stay itself was really amazing. The one thing that chapped me was I wasn’t made aware of a $42 fee I would have to pay to use the pool and have access to their social club. The Airbnb was already pretty pricey so having to pay a fee when i arrived and not being made aware of said fee was a little annoying. Also the parking situation was nice because it’s across the street so very convenient but again pricey adding another 50 dollars to our trip. Overall the stay was lovely i just wish there was a little more price transparency especially since i figured the Airbnb was priced at that point to reflect the amenities you would enjoy.

Expedition Cabin - On the Lake Fishing Cabin
Wonderful peaceful stay right on the lake! Exactly what we were looking for. We loved it and will be back!
Hotel rentals with a patio

Mockingbird Inn- Fern Suite
Second time booking this place. It is so beautiful, peaceful, and cozy. You feel right at home!

Best Value! Historic B&B in Cotter - Room 101
Our favorite place to stay when we visit Cotter! You won’t be disappointed with the location, price and amenities either! Thank you again for another great stay! ❤️

Front Motel Room
Simple, clean, beautiful country surroundings, and oh so friendly and hospitable from start to finish!! The location was quiet and lovely, and perfectly situated from Ballpark National complex where we watched lots of baseball! We will likely be back if Kerry & Pam will have us! We also got our first look at Lake Pomme de Terre just minutes away!! Beautiful body of water! Thank you for everything, Kerry & Pam!

Napoleon's Retreat - Lafayette Room
Matthew’s hotel suite was precisely what my partner and I were hoping to find for our day trip to St. Louis for the Kendrick Lamar concert. The suite was spacious, clean, well-located, and felt like a home away from home. This suite was the kind of place that gets right what hotels often have a hard time with, like making a space feel like a home, mostly because of its unique decor choices and artwork. And Lafayette Square is quite the charming place. Highly recommend!

The Cross Bell Downtown 204
A great place to stay! Super cute and clean. I Love, LOVE this location! Would highly recommend.

Homey Hideaway
It was a very nice setup and close to the gulf. Really enjoyed ourselves.

Reel ‘Em Inn 2: Cozy & Clean | Convenient location
We absolutely loved our stay at this super cute, charming vintage motel! It was spotless, full of personality, and such a great value. The space was cozy and well cared for, with fun retro touches that made it feel special. What really stood out was the host’s kindness—she went above and beyond to make my daughter’s 12th birthday extra memorable. She surprised her with the sweetest little basket filled with candy, a cute cup, fun socks, and other birthday goodies. It was such a thoughtful and personal touch, and my daughter was over the moon! Highly recommend this place if you’re looking for something clean, unique, and hosted by someone who genuinely cares about your stay. We’ll definitely be back!

Hotel Pinehurst- Jean Theatre, Suite 103
Always a great stay at Cindy’s place! Have stayed multiple times and will continue to! Thanks Cindy!!
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