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Vacation home rentals in Upstate South Carolina

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in Upstate South Carolina

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious living area features a comfortable sofa with a light-colored fabric, paired with a wooden coffee table adorned with greenery. A sloped ceiling adds dimension, while a warm neutral palette and natural light enhance the inviting feel of the space.
Vacation home in Pisgah Forest
4.99 out of 5 average rating, 97 reviews

Wake surrounded by views of the beautiful Blue Ridge Mountains in this lovely 1 bedroom vacation home.

Forget your worries in this spacious and serene space with indoor fireplace,full kitchen,laundry room,air, covered parking,large deck and outdoor fire pit/dining area. Minutes from hiking,biking,fishing,golf, 200+ waterfalls, dining, downtown Brevard, shopping,local breweries. Located between Pisgah National and DuPont State Forests. 30 minutes from Asheville airport and 20 minutes from historic Hendersonville. Brevard Music Center, Cradle of Forestry,Flat Rock Playhouse, Biltmore House nearby

Top guest favorite
The open living space features wood flooring and high ceilings. A modern kitchen island with bar seating provides a gathering spot, while eclectic decor and artwork adorn the walls. A comfortable seating area is positioned near a flat-screen TV, promoting relaxation.
Vacation home in Greenville
4.93 out of 5 average rating, 182 reviews

City Dream Weekdays 2BR 2BA Walk the Heart of GVL

A CITY FALL GETAWAY w 2 FULL BATHROOMS. Explore the best of the Upstate. Prime local to walk,trolley,bike downtown or to trail. West End gem is 5 min walk to Bcycle/trolley @Fluor Field.10 min walk to Falls.Uber friendly.See shops-art galleries-museums-tours-eateries-breweries-outdoor activities.Newly remodeled spacious historic bldg w 10’ ceilings, wood floors & new baths.1300 sq.ft entire 1st floor.1 King &1 Queen bed.Large private patio,full kitchen/living/dining. Games and records. PARK FREE

Guest favorite
An aerial view of a spacious estate is surrounded by lush forests and rolling mountains. The home is set on a green lawn, showcasing pathways and outdoor seating areas. Scenic hills and a variety of trees provide a tranquil and picturesque backdrop.
Vacation home in Marshall
5 out of 5 average rating, 6 reviews

Leaf Change Special Villa Stony Woods by Asheville

The Villa at Stony Woods Estate, 4-acre estate home in the splendor of Western North Carolina, centered on an 85 acre estate. Rent the Villa or the entire property (with luxury tree house rentals) for your next memorable vacation getaway or special event. Welcome to the tranquility that comes from elevation, calming and majestic views, and the breathtaking awe of spacious, well-built masterpiece of a home designed by renowned architect, Robert Griffin. This home creates memories of a lifetime.

Guest favorite
An efficiency kitchen is visible, featuring a convection microwave, refrigerator, and coffee maker on a smooth countertop. A small dining area with a table and four chairs is nearby. A cozy armchair occupies a corner, while a doorway leads to a bathroom space with a shower.
Vacation home in Seneca
4.93 out of 5 average rating, 55 reviews

Cozy cottage 15 mins Clemson, 7 mins lake Keowee

Has Stairs This efficiency apt has it all. Kitchen with convection micro, fridge, coffee maker & hot plate. Not a full size home, it’s an apartment. Space surrounded by Oconee County Country Club golf course. 1 mile to Walmart and shopping. 30 mins to the Blue Ridge Mountains. We are 7 mins to beautiful Lake Keowee. Please note 5 people should be family as it is tight. The person booking the property must be staying on the property. No construction equipment or trucks allowed on the property.

Top guest favorite
A cozy riverfront cabin with a green metal roof is visible, situated beside a gentle flow of water. An outdoor seating area features a wooden deck, with several chairs positioned for relaxation. The surrounding landscape includes trees and a rocky bank.
Vacation home in Bryson City
4.97 out of 5 average rating, 88 reviews

Nantahala River 2BR - Bear Cave Boat Parade

Closest rental to the Nantahala Outdoor Center! 1.5 miles upriver. Trains daily. Read this: NO SMOKING, NO PETS, no exceptions, please don't ask. Service animal excepted. Read CANCELLATION POLICY before booking and house rules before booking. NO TRASH SERVICE in area, guest must remove when checking out. NO TRAILERS. Parking too small Two vehicles MAX. NOT SAFE for small children due to powerful water. WI-FI provided. CELL Coverage: Verizon = Excellent. T Mobile = None. ATT = Outdoors only.

Superhost
A cottage with a metal roof is set against a backdrop of trees and rolling hills. A gravel pathway leads to the front porch, flanked by landscaped flower beds and a tall evergreen. A clear creek can be seen in the distance, enhancing the serene environment.
Vacation home in Bryson City
4.75 out of 5 average rating, 64 reviews

Bear Kottage

This cottage is so cozy, most people call it the "Honeymoon Kottage." Bear Kottage sits right on the beautiful Alarka Creek; you can walk out your door and fish right in your back yard. This is a great little cottage for those wishing to do a little fishing, wading in the creek, or simply relax beside the beauty of the water from the comfort of their porch rockers or hot tub. Bear Kottage is located about seven miles from downtown Bryson City, which is about a 20-minute drive. WIFI available

Guest favorite
A welcoming blue front door is set against light beige siding. Flanking the door are two decorative planters containing lush greenery. A vertical sign reading 'WELCOME' stands beside the door, enhancing the inviting entrance.
Vacation home in Roebuck
4.9 out of 5 average rating, 105 reviews

Patriot Point B, an inviting studio apartment

This patriot themed studio apartment sleeps 5. The apartment includes a queen, pull out queen sofa bed, optional roll out full bed, a full kitchen, 1 bathroom, full laundry area, with areas for relaxing, bonfire and a gas grill. The apartment offers cozy patriotic decor including several historic homes in the area. It's charming and includes a large room with designated areas for the bed and living area, a kitchen and separate bath. We are minutes from downtown Spartanburg. Kerri & Brian

Top guest favorite
A gravel driveway leads to a charming detached building surrounded by trees, with a rustic exterior and a welcoming pathway. Natural light filters through the leaves, creating a serene atmosphere that invites exploration.
Vacation home in Tryon
5 out of 5 average rating, 118 reviews

Sandy Plains Fountain Home | King Bed | 3 MI TIEC

2 Bedrooms - 1 king bed & 1 queen, 1 bath Efficiency kitchen ( we are testing an additional space that we have recently added as another bedroom as an extra bonus room ) there will be an extra 100$ added separately by the host for use of 3rd bedroom- 2 night minimum Detached Laundry facility on property where nature surrounds you with additional outside seating & dining . Peaceful and centrally-located 3 miles from Tryon International Equestrian Center TIEC & local wineries .

Top guest favorite
Two coasters with a personalized design are placed on a detailed map of the lake area. The map displays various waterways and terrain features, inviting exploration and adventure in the surroundings.
Vacation home in Anderson
4.99 out of 5 average rating, 112 reviews

Lake House and Dock Upscale and Immaculate

Our immaculate 2020 built water-themed home is a luxury furnished lakefront 1.1 acre property on Lake Hartwell with a large boat dock. Our house enjoys amazing lake views and is perfect for the tournament fisherman, the boating enthusiast, golfers, families and those just needing to relax. We are down the street from Stonecreek Cove Golf Course in a countryside atmosphere and are comfortably close to the renowned Green Pond Landing, host to many national fishing tournaments.

Guest favorite
The exterior of Lirio Woods features a rustic wooden structure with a covered porch supported by sturdy beams. Two wooden chairs are positioned on the porch, while flower pots and greenery adorn the space. A stone pathway leads to the private entrance, surrounded by a well-kept lawn.
Vacation home in Fletcher
4.87 out of 5 average rating, 69 reviews

Lirio Woods

Lirio Woods is located in a rural setting, 15 minutes from downtown Asheville. The spacious lower level of the house is reserved for guests and is completely private. Next door is Barn Door Ciderworks (on the web - barndoorcw.com) - guests are invited to stop by for a cider on the house and a bite to eat. Lirio Woods is perfect for exploring this spectacular part of Western North Carolina - the Blue Ridge Parkway, Biltmore Estate, Chimney Rock, hiking trails, and more.

Guest favorite
The living area features a cozy sofa and recliner, with a wooden coffee table positioned on a patterned rug. A stone fireplace is complemented by a flat-screen TV. Natural light floods in through the glass doors leading to the balcony, and an open-area Jacuzzi tub is visible in the corner.
Vacation home in Gatlinburg
4.77 out of 5 average rating, 126 reviews

Stream side condo*Peaceful views+sounds*

154 Village Stream in Chalet Village - A romantic getaway, perfect for couples who want a peaceful, natural setting with easy access to Gatlinburg and the Smokies. It’s one of my favorite places to be on the private back deck listening to the sounds of water & nature. Our space is clean & cozy. Nothing fancy. Perfectly meant for simple people:) We did do upgrades, new decor, and furnishings since photos! Brand new larger water heater installed Dec 2023.

Guest favorite
A spacious entryway is captured, featuring a staircase with white balusters leading to the second floor. The open living area displays a comfortable seating arrangement, natural light from ample windows, and a decorative wall with wood accents. A ceiling fan adds to the inviting ambiance.
Vacation home in Ashville
4.96 out of 5 average rating, 93 reviews

Large 3BR Asheville Home - Quiet Neighborhood!

Bring the whole family to our spacious home with lots of room to spread out! Only ten minutes from downtown Asheville and five minutes to shopping and restaurants in West Asheville. Twenty minutes from the Blue Ridge Parkway or the Biltmore Estate. Enjoy the full kitchen and dining room. Relax in one of the two living rooms equipped with smart TVs. Get some sun on the large private back deck or take a walk through the quiet neighborhood.

Popular amenities for Upstate South Carolina vacation home rentals

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