Lake house vacation rentals in Santee

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Top-rated lake house rentals in Santee

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Guest favorite

A fire pit surrounded by several dark chairs is set on a grassy area by the water's edge. The calm lake reflects the trees and distant docks, creating a serene lakeside environment. A few boats can be seen anchored along the shore.

Home in Ridgeway

4.96 out of 5 average rating, 112 reviews

Hillside Haven on Lake Wateree- Entire House

Lake Wateree rental with 3 bedrooms, 2 bathrooms that will comfortably sleep 8 guests. It also has 2 sleeper sofas. It is located in Ridgeway, SC and less than 5 minutes to Buck Hill Landing. Upstairs, you will find a fully stocked kitchen, living\dining room and master bedroom. Downstairs, there is a second living area with second kitchen, bathroom and 2 bedrooms. Home includes private deep water dock. Perfect location for swimming, kayaking and fishing. Fire pit is perfect for cool nights.

Guest favorite

The exterior of the lakefront cottage features a green and brick facade, complemented by a red bench on the porch. A circular concrete path leads to the entrance, while surrounding greenery and trees add to the natural setting. Soft evening light enhances the inviting atmosphere.

Home in Manning

4.87 out of 5 average rating, 53 reviews

Cozy Church Branch Cabin

A cozy lakefront cottage made by family, for family. This was our parents home away from home, their favorite getaway. Now that they're gone, we want to share what they enjoyed. Traditionally constructed lake cabin with all the comforts of home. Large deck with awning, large pier for fishing, plenty of room to bring your boat, canoes, or kayaks. Extremely close proximity to large landings where national fishing tournaments are held on Lake Marion. Prime hunting, near great hunting clubs.

Top guest favorite

A wooden dock extends into calm waters, reflecting the vibrant colors of the sunset. Silhouetted trees frame the scene, which features a serene lake bordered by grassy areas, creating a tranquil lakeside atmosphere.

Home in Cross

5 out of 5 average rating, 13 reviews

Lakefront Hideaway | Peaceful, Private & Serene

Escape to our serene Lakehouse Hideaway on Lake Moultrie, the perfect retreat for family vacations, fishing trips, or peaceful getaways. This charming 3-bedroom, 2-bath home features a spacious family room, fully equipped kitchen, kids’ room, queen bedrooms, and a lakefront porch on nearly an acre of private property. Enjoy fishing, relaxing, and exploring Lowcountry dining nearby. Just over an hour from Charleston, this tranquil oasis offers the ideal blend of relaxation and adventure.

Guest favorite

A spacious backyard features a well-maintained lawn bordered by trees, providing a sense of privacy. A wooden deck is accompanied by a gazebo, creating a relaxing outdoor space. The brick house showcases large windows that invite natural light into the living areas.

Home in Columbia

4.95 out of 5 average rating, 177 reviews

Downtown Columbia 3/2 - Entire House

* Entire House on a large lot with no neighbors behind for added privacy * 3 Bedrooms 2 Full Baths * 1.4 miles from PRISMA Hospital (4-minute drive) * NEWLY RENOVATED * BLACKOUT CURTAINS in all the bedrooms * 15 minutes to Fort Jackson * 7 minutes to Riverbanks Zoo * 5 minutes to the Columbia Museum of Art and Soda City Market * Split floor plan with the main bedroom on the right side of the home with on-suite * Open kitchen adjacent to the dining room overlooking the living and sunroom

Guest favorite

A spacious living area showcases warm wooden walls and high ceilings with exposed beams. Natural light fills the room through large windows, revealing views of the outdoors. A stone fireplace is featured along one wall, while comfortable seating arrangements offer a cozy atmosphere.

Home in Summerton

4.97 out of 5 average rating, 155 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite

Home in Irmo

4.86 out of 5 average rating, 109 reviews

Lakefront w pool, dock and pool table, sleeps12

Location, location, location! 10 minutes to Lexington, 15 minutes to Chapin, 15 minutes to downtown Columbia, 8 minutes to Harbison shopping. Boat parking at the dock. No need to pay high docking fees. Gorgeous sunsets, calm cove. Swim in the lake or relax by the pool. The massive deck is great for family fun or unforgettable events with your friends. Close to Liberty’s /Lake Murray marina on the lake, and Cat Fish Johnnys/rusty anchor marina. Not your typical Lake Murray Airbnb!

Top guest favorite

A spacious covered porch offers a view of the lake through large screens. A grassy area extends toward the water, where a private dock can be seen. Pine trees frame the scene, providing a natural backdrop to the tranquil setting.

Home in Moncks Corner

4.81 out of 5 average rating, 146 reviews

Lake Moultrie, Lake front with private dock

Lake front living. Sandy beach and private dock. Children and pets welcome. Enjoy swimming and fishing at your private resort. Local attractions are Old Santee Canal Park, with boardwalk along the Tail Race Canal. Pinopolis Lock, take your boat through the locks and travel to Charleston via intercoastal waterway. Mepkin Abbey, a working monastery and Cypress Gardens with hiking trails and butterfly house are in the area. Or you can simply stay at the cabin to unwind and relax.

Guest favorite

The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.

Home in Summerton

4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Top guest favorite

A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.

Home in Summerton

4.99 out of 5 average rating, 110 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Superhost

A serene lakeside view captures the calm water reflecting the surrounding trees and a wooden dock. Gentle ripples can be seen as ducks glide across the surface. Lush greenery frames the scene, while a large rock and a light fixture are positioned in the foreground.

Home in Cross

4.91 out of 5 average rating, 45 reviews

Lakeside Getaway

Relax with your whole family at our lakeside getaway. Nestled steps away from the Diversion Canal connecting Lake Marion and Lake Moultrie, our recently renovated space welcomes you. Enjoy the screened-in porches, a cozy spot to unwind, perfect for peaceful moments away from the hustle and bustle. Bring your boat and make use of the nearby loading ramp for easy access to the water. It's an inviting place to disconnect and embrace the lake life.

Top guest favorite

A scenic view of Lake Marion is presented, featuring a wooden dock extending into the water. A picnic table is situated on the grassy shore, beneath a large tree. A flag waves gently in the breeze, adding a touch of patriotism to the serene landscape.

Home in Eutawville

5 out of 5 average rating, 19 reviews

Lake House at Lake Marion

Beautiful lakefront 3 Bedrooms/2 full baths with million dollar view of Lake Marion. -2 Queen beds/2 twins/1 futon -Private Dock so you can fish in “big water” -Canoe and Kayak -Firepit -Includes linens and beach towels and more! -Fully Furnished + grill and covered parking -One level open concept -75” Roku TV and WiFi -great safe neighborhood for walking and bike riding -public boat landing and county park with playground within 2 blocks.