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Apartment vacation rentals in Santee

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Santee

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious studio room features a comfortable king bed with a patterned duvet and decorative pillows. A cozy seating area includes a wooden chair and a small side table. Two large windows provide natural light, enhancing the neutral tones of the decor.
Apartment in Columbia
4.91 out of 5 average rating, 174 reviews

*Tuscan Sun KING suite downtown FREE parking*

Perfectly situated in the heart of downtown! This studio is within walking distance of Main Street, The State House, USC campus and just a short drive to Williams Brice Stadium, Colonial Life Arena, medical facilities and so much more. The perfect stay for both long and short term guests. Wake up from a great night's sleep in our comfy KING bed to explore downtown, head out to see the Gamecocks play, or just sleep in! You’ll love staying at this stylish apartment! Permit No. STRN-004218-10-2023

Top guest favorite
A well-arranged bedroom features a spacious bed dressed in white linens and a grey throw blanket. Two reading lamps are positioned on either side of the headboard. Carpeting covers the floor, and natural light filters through a window dressed with white curtains.
Apartment in Columbia
4.97 out of 5 average rating, 118 reviews

Heathwood 2Br/1Bath Cozy Home

COC Permit STRN-001336-10-2026. Close to everything when you stay at this centrally located duplex. Close to the grocery store and restaurants. Five Points (1.5 miles), the Vista (2.5 miles), Township Auditorium (2 miles), USC (2 miles), and Ft Jackson (3 miles). This freshly renovated unit includes 2 bedrooms, 1 bath, fully equipped kitchen (including a k-cup coffee maker), washer and dryer. Both bedrooms have memory foam beds (1 King & 1 Queen). Keyless entry. Off street parking for 2 cars.

Top guest favorite
A wooden serving board displays a freshly sliced loaf of banana bread, positioned in the foreground. In the background, a spacious bed is visible alongside a cozy seating area, featuring a green couch and a comfortable chair, both complemented by natural light streaming through the windows.
Apartment in Columbia
4.99 out of 5 average rating, 157 reviews

The Studio in Forest Acres

A calm, stylish space, filled with sunlight - the Studio is a detached 2'nd floor apartment, nestled in the heart of Forest Acres... SC's best kept secret! Take a relaxing walk around our beautiful old neighborhood and find delicious eats at highly-rated restaurants, groceries, dessert shops and local cafes. Just minutes from Columbia's storied cultural/musical nightlife, USC, the Koger Center for the Arts, Fort Jackson, Main St., and The Vista! (Age limit: must be at least 23 y/o to book).

Guest favorite
A queen bed is centrally placed against a light-colored headboard, adorned with decorative pillows. Nightstands with lamps are positioned on either side, providing balanced lighting. Fresh towels are neatly arranged at the foot of the bed. Soft natural light enters through a nearby window, accented by blue curtains.
Apartment in Columbia
4.8 out of 5 average rating, 143 reviews

One SUITE Deal

The guest suite is located on the lower level of our tri-level home, with a private driveway, patio, and entrance. The queen bed and pull-out sofa sleep 4 guests comfortably. It is within 15 minutes of downtown, which is home to USC and the Colonial Life Arena. It is 10 minutes from Lake Murray, Riverbanks Zoo, shopping, movies, and great dining experiences. This suite is spacious and cozy. It's great for business travelers, traveling nurses, and small groups looking to enjoy local events.

Superhost
A bright living area is furnished with a light-colored sofa adorned with accent pillows. In front, a wooden coffee table rests on a soft area rug. The kitchen is visible in the background, showcasing modern appliances and an open layout that enhances the space's inviting feel.
Apartment in Florence
4.88 out of 5 average rating, 401 reviews

Kuker Carriage House-Sleeps 3-Downtown/Near I95&20

Kuker Carriage House was originally a barn that has been converted into apartments in the heart of the newly revitalized Florence downtown. This first floor unit was just fully renovated and is ready for you to enjoy, whether for a short overnight stop or a longer extended stay. This space is bright and open with lots of natural light and a fully enclosed private courtyard. Queen bed, twin daybed, full bath, Wifi and TV. Walkable to parks and restaurants. Just 4 miles from I95 and I20

Top guest favorite
The exterior of the property features a charming house with a light-colored façade and a green metal roof. A gravel driveway leads to the entrance, illuminated by soft outdoor lighting. Lush greenery surrounds the home, creating a serene and welcoming environment.
Apartment in Camden
4.96 out of 5 average rating, 320 reviews

Camden Carriage House on the Polo Field

This quaint and private one bedroom apartment is uniquely situated on a beautiful property surrounded by gardens, ponds and history. Camden is known for its Antebellum homes and from this location you can walk to some of its finest examples. The apartment is cozy with a comfortable queen size bed, a bathroom which features natural hardwoods and a claw-foot tub/shower and a modern Mitsubishi ductless heating and cooling system. Private deck overlooks historic polo field.

Top guest favorite
An A-frame structure is pictured, elevated on a brick foundation. Sturdy wooden stairs lead to the entrance, flanked by a deck with railings. The surrounding area is filled with tall trees, and a car is parked underneath the apartment, offering a rustic country setting.
Apartment in Orangeburg
4.99 out of 5 average rating, 156 reviews

Elevated Country Apartment

Discover the charm of country-living in our cozy 1-bedroom elevated apartment, just a short drive from Orangeburg, Bamberg, and Neeses. Wake up to the sound of roosters crowing and enjoy your morning coffee with views of our picturesque homestead, or enjoy a glass of wine while watching the sun set below the majestic pines. Perfect for those seeking tranquility without sacrificing convenience, our apartment offers a fully-equipped kitchen and laundry.

Top guest favorite
A charming brick exterior features a welcoming entrance with steps leading to a covered porch adorned with plants. Large windows allow natural light to brighten the interior. Surrounding greenery provides a tranquil setting in a peaceful residential neighborhood.
Apartment in Earlewood
4.93 out of 5 average rating, 333 reviews

The Toad Abode Studio

Relax and unwind in this cozy, centrally located studio. Perfect for travelers, the space features a comfortable double bed, work desk, cozy reading chair, and TV for your downtime. The kitchenette area includes a microwave & mini fridge with ample coffee & tea supplies, while the bright bathroom offers plenty of natural light. All the essentials you need for a comfortable stay. **Checkout on a Monday for more options at a discounted Sunday rate.

Guest favorite
A spacious living area is depicted, featuring a comfortable couch adorned with cushions, a wooden coffee table, and a flat-screen TV. Natural light streams through the wooden-blind-covered windows, casting soft shadows on the warm wooden floor and exposed brick wall.
Apartment in Arsenal Hill
4.94 out of 5 average rating, 188 reviews

Apartment in heart of Columbia

This NEWLY RENOVATED apartment in the heart of Columbia's Vista neighborhood is the perfect spot for your stay. Bright and spacious with a comfortable queen-sized bedroom with flat-screen smart TV; large and spacious living area with full kitchen and big screen smart TV, AND a super comfortable couch that can be used as second bed. Located in the heart of The Vista, you'll have access to scores of restaurants, bars, and retail. Plenty of parking!

Guest favorite
A bright kitchen features wooden countertops and white cabinetry. A dual sink is positioned under a decorative light fixture with hanging bulbs. Wall-mounted shelves display plants and kitchen essentials. Mirrors are framed above the bar area, enhancing light and space.
Apartment in Summerville
4.91 out of 5 average rating, 231 reviews

Full Kitchen, 2 Bed, 2 Bath W/ Laundry & Fish Pond

Hosted by a Superhost with multiple listings in Summerville, this charming, two bedroom, two bathroom apartment features a full kitchen, a washer/dryer combo, and a picturesque 1 acre fishing pond. Resting on a small farm on the outskirts of Summerville, this one-of-a-kind shabby-chic suite will have you in a southern state of mind in no time. Just don't be surprised if you see a chicken or two running around...

Superhost
A modern kitchenette features gray cabinetry complemented by brass hardware and a white marble countertop. Appliances such as a microwave and mini fridge are neatly arranged, with light streaming from an adjacent room. Open shelving displays decorative items enhancing the space's functionality.
Apartment in Earlewood
4.92 out of 5 average rating, 289 reviews

The Traveler's Apartment | 1BR 1BA + Kitchenette

The #travelersapt is a 1919 Queen Anne Victorian style duplex home in the Earlewood Park neighborhood of Columbia, SC and the two sides are rented out via AirBnB. This is a private unit and only YOU will have access to all spaces listed during your stay. The rear door in the backyard serves as your private entrance and you also have private off-street parking for 2 cars.

Top guest favorite
A spacious bed is dressed with a light patterned duvet and decorative pillows. A black nightstand is positioned beside the bed, topped with a textured lamp and a small potted plant. The backdrop features green wainscoting, adding a calming touch to the room.
Apartment in Barnwell
4.99 out of 5 average rating, 135 reviews

Ellzey Place

Ellzey Place is a peaceful spot where you can relax and unwind. Enjoy having a cup of coffee on the deck facing a spacious private back yard. There are lots of azaleas that bloom in season and pines swaying in the breeze. It is a charming apartment attached to the owner's house but has a private deck and entrance. It has been newly remodeled and delightfully decorated.

Popular amenities for Santee apartment rentals

Quick stats about apartment rentals in Santee

  • Total vacation rentals

    Explore 10 vacation rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at G$31,332 GYD per night before taxes and fees

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    10 of Santee vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santee rentals