Vacation rentals in Santee

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Top-rated vacation rentals in Santee

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A view from the balcony captures a serene landscape featuring a pool adjacent to Lake Marion. Lush greenery and palm trees frame the scene, while guests enjoy the pool area. The tranquil waters of the lake are visible in the background under a clear sky.
Condo in Santee
4.96 out of 5 average rating, 93 reviews

Lovely Condo w/pool, balcony, and lakeside view!

Relax on the balcony overlooking the pool and lake Marion or go down and relax at the pool, or launch your boat at the boat ramp for the day and go fishing or cruising. There is also a myriad of golf courses near by. For dinner with a great view head over to the other side of the lake to the Lake House bar and grill for adult beverages on the lake with great food. For upscale dining Clark’s restaurant is a good choice. Bike,hike,or cook out over at Santee state park which is only 10 minutes away

Top guest favorite
A serene view from a screened porch is shown, featuring two wooden rockers facing the tranquil lake. Green grass and trees surround a private dock visible in the distance, creating a peaceful outdoor setting.
Cottage in Manning
4.97 out of 5 average rating, 129 reviews

Archie's Lake Daze Cottage No pets

Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Top guest favorite
A charming log home is set on a grassy lot, surrounded by trees. The façade showcases large windows that invite natural light inside. A wooden deck extends from the entrance, providing a space for outdoor seating. A paved pathway leads to the front steps.
Cabin in Vance
4.9 out of 5 average rating, 230 reviews

Log home on Lake Marion inlet w/private dock.

Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Guest favorite
A spacious covered deck provides views of the lake through large trees, featuring two striped chaise loungers and a dining table with four chairs. The wooden flooring enhances the outdoor space, inviting relaxation and enjoyment of the serene surroundings.
Guest suite in Eutawville
4.8 out of 5 average rating, 100 reviews

Relaxing Comfortable Waterfront Family Dock Suite

Bring your family or group to this 3 bedroom 1+ bath place in the large trees with lots of room for relaxing and fun (….if you are a jeans and sweatshirt kind of person. It is not the Hilton!) TVs in each room, and 2 covered decks. Fish, or just sit out on the dock, watch the boats run by, and appreciate the lake. We rarely use the dock ourselves. 600’ from our public boat ramp with a park and small beach. Please also note that we do have cameras installed that monitor outside only.

Guest favorite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 170 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Top guest favorite
An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.
Home in Santee
4.97 out of 5 average rating, 172 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 125 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Top guest favorite
Home in Summerton
5 out of 5 average rating, 22 reviews

Sunset Serenity Pool/Swim Spa

Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.

Top guest favorite
A scenic view of Lake Marion is presented, featuring a wooden dock extending into the water. A picnic table is situated on the grassy shore, beneath a large tree. A flag waves gently in the breeze, adding a touch of patriotism to the serene landscape.
Home in Eutawville
4.97 out of 5 average rating, 29 reviews

Lake House at Lake Marion

Beautiful lakefront 3 Bedrooms/2 full baths with million dollar view of Lake Marion. -2 Queen beds/2 twins/1 futon -Private Dock so you can fish in “big water” -Canoe and Kayak -Firepit -Includes linens and beach towels and more! -Fully Furnished + grill and covered parking -One level open concept -75” Roku TV and WiFi -great safe neighborhood for walking and bike riding -public boat landing and county park with playground within 2 blocks.

Guest favorite
A modern two-story home is depicted, featuring a blue front door adorned with a wreath. The exterior is clad in gray siding, and the driveway is spacious, bordered by young trees. A well-maintained lawn surrounds the property, and the sky is bright with scattered clouds.
Townhouse in Santee
5 out of 5 average rating, 7 reviews

Sunny Santee Stay / Patio Haven at Lake Santee

Brand new 2025 modern, cozy home near interstate I95, golf courses, markets, local restaurants (Cracker Barrel Old Country Store, Starbucks, etc) and Lake Marion. Santee is right in the middle distance between Miami and New York. Clean, stylish space with Wi-Fi, full amenities, and easy self check-in. Relax with the whole family at this new clean, quiet, safe and peaceful neighborhood. View our profile to explore more homes in the area.

Guest favorite
Vacation home in Summerton
4.95 out of 5 average rating, 121 reviews

Lakefront Paradise W/Pool/hot tub/outdoor kitchen

Brand new heated saltwater pool, hot tub and outdoor kitchen area. This upgraded home is ready to host your family or large group! Enjoy breathtaking sunsets year round from your private beach directly on the big waters of Lake Marion. Spends evenings out on the dock fishing or pull your boat right up to the beach. Ping pong and bumper pool tables, fast wifi and big screen tv's make for the perfect entertaining space for large groups.

Guest favorite
Home in Santee
5 out of 5 average rating, 16 reviews

Beautiful Lake Marion Townhome

Forget your worries in this spacious and serene space. Enjoy the beautiful lake view from our patio. 3 large bedrooms and 3 spacious bathrooms, along with a fully equipped kitchen and comfortable family room make this townhome an outstanding family retreat. 3 golf courses and beautiful Lake Marion make this a fine place to visit on a yearly basis.

Popular amenities for Santee vacation rentals

When is the best time to visit Santee?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$48,494 GYDG$50,159 GYDG$52,864 GYDG$52,656 GYDG$51,824 GYDG$57,443 GYDG$48,702 GYDG$57,651 GYDG$59,524 GYDG$60,357 GYDG$57,443 GYDG$59,108 GYD
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Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Santee?

    Yes! Work meets play with ease at over 10 vacation rentals in Santee featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there Santee vacation rentals on Airbnb with pools?

    Yes! Dive into the perfect getaway at one of over 20 vacation homes with pools in Santee, available on Airbnb. Make a splash and soak up the sun in style!

  • How much does it cost to stay in apartment rentals in Santee?

    Experience the best of Santee with our apartment rentals, starting at about $150 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do apartment rentals in Santee have wifi?

    Absolutely! We offer over 10 apartment rentals with wifi in Santee. Enjoy a tailored experience with all the comforts you desire.

  • Do apartment rentals in Santee have a gym?

    Absolutely! We offer over 10 apartment rentals with a gym in Santee. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly vacation rentals in Santee?

    Santee has more than 30 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

Quick stats about vacation rentals in Santee

  • Total vacation rentals

    Explore 30 vacation rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at G$20,813 GYD per night before taxes and fees

  • Verified guest reviews

    Over 220 verified reviews to help you choose

  • Family-friendly vacation rentals

    30 properties offer extra space & kid-friendly amenities

  • Vacation rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    30 of Santee vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Self check-in, Gym, and BBQ grill across Santee rentals

  • 4.8 Average rating

    Santee stays are highly rated by guests—averaging 4.8 out of 5!