
Vacation rentals in Santee
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Top-rated vacation rentals in Santee
Guests agree: these stays are highly rated for location, cleanliness, and more.

Mulberry Cabin, a rustic tiny house cabin
Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.

Restful Lakeside Getaway Cottage -Dogs allowed
This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Archie's Lake Daze Cottage No pets
Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

The Turtle's Nest
Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

The Little Cottage, Stateburg
Take it easy at this unique and tranquil getaway. The Little Red Cottage features a small bedroom with a double size bed and a closet, a spacious living room with sofa/roku TV and computer desk, and a bathroom with shower. It is nestled on 6 serene acres, among massive windswept Live Oaks dripping with Spanish moss, Palmettos, azaleas, camellia, magnolias and creape myrtle, yet so conveniently close to Shaw Air Force base, 30 mins to Columbia and Camden, close to all Sumter's attractions.

Congaree Vines - Rustic Log Cabin by a Vineyard!
-Enjoy a Quiet Stay in the Country! An authentic Rustic Log Cabin on the edge of a Hobby Vineyard with Port Wine from our own vineyard! An outdoor fire pit and hammock to enjoy under the stars! -Congaree Vines also has a Barn Bungalow and Woodland Cottage. Pets welcome for fee! If service pet, bring paperwork. -We are near Congaree Natl Park (33 min), Columbia, USC, Ft. Jackson, Airport, 1-26 & Hwy 77. -15% off Guided Kayaking Congaree National Park, Carolina Outdoor Adventures.

The Cabin at Minehill
Our cabin is located in Stateburg, SC between Columbia and Sumter and within a 5-15 minute commute to Shaw AFB and Sumter. It is a convenient stop between I-77 and I-95 and has close proximity to Poinsett and Congaree Parks and The Palmetto Trail. It sits on top of a hill offering panoramic views, quiet, and privacy. Mine Hill sunrises and sunsets are stunning. Reserve as a stopover, a retreat from the workday, or a romantic getaway and enjoy our cabin as a home away from home.

Lizzi & Scott’sTiny Guest House secluded USC-Vista
Welcome to our tiny guest cottage hidden in the heart of the city. It's within blocks of restaurants, coffee shops, an art movie house, and a lovely river walk. The Lace House/Governor’s Mansion, business district, MiLB & UofSC are a short walk or bike ride away. At the rear of our home, it’s private, secure & quiet. A partition & movable screen separate the bathroom area. There’s a smart tv, small fridge, microwave, coffeemaker & work-table.24 hr self check-in. STRO-000579-03-2024

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

The Goose Cottage at Wild Goose Flower Farm
Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed but the sofa also extends into a queen-sized sleeper. Please reach out with further questions or if you would like to inquire about an extended stay.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.
Popular amenities for Santee vacation rentals
Santee house rentals

The Parkside Retreat

Jewel on the Lake

Lake House Retreat

Anchor Out Lake Marion

Santee lakefront home, big water right off I-95

Ultimate Hideaway in the pines next to Lake Marion

Quiet 2BR Near Shaw AFB

2 BR Near Ft Jackson & Downtown
Other great vacation rentals in Santee

Old Man’s Fishing Hole (Lake Front-Lake Marion)

Skylight Spa Cottage - USC, FT. J, Williams- Brice

Lake House Getaway

The Boho Barndo

Relaxing 1-Bedroom Lakeview Escape

Renovated Camper Farm Stay

Adorable 2 bedroom guesthouse in Bowman, SC.

Luxe Lake Marion Oasis with Pool/Hot Tub/Dock
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in Santee?
Yes! Work meets play with ease at over 10 vacation rentals in Santee featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there Santee vacation rentals on Airbnb with pools?
Yes! Dive into the perfect getaway at one of over 20 vacation homes with pools in Santee, available on Airbnb. Make a splash and soak up the sun in style!
How much does it cost to stay in apartment rentals in Santee?
Experience the best of Santee with our apartment rentals, starting at about $150 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Do apartment rentals in Santee have a gym?
Absolutely! We offer over 10 apartment rentals with a gym in Santee. Enjoy a tailored experience with all the comforts you desire.
Do apartment rentals in Santee have wifi?
Absolutely! We offer over 10 apartment rentals with wifi in Santee. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly vacation rentals in Santee?
Santee has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.
Quick stats about vacation rentals in Santee

Total vacation rentals
Explore 30 vacation rentals in Santee

Nightly prices starting at
Santee vacation rentals start at G$20,882 GYD per night before taxes and fees

Verified guest reviews
Over 220 verified reviews to help you choose

Family-friendly vacation rentals
30 properties offer extra space & kid-friendly amenities

Vacation rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
30 of Santee vacation rentals include wi-fi access

Popular amenities for guests
Guests love Self check-in, Gym, and BBQ grill across Santee rentals

4.8 Average rating
Santee stays are highly rated by guests—averaging 4.8 out of 5!
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- Riverbanks Zoo and Garden
- Middleton Place
- Congaree National Park
- South Carolina State House
- Columbia Museum of Art
- South Carolina State Museum
- Whirlin' Waters Adventure Waterpark
- University of South Carolina
- Colonial Life Arena
- Magnolia Plantation & Gardens
- North Charleston Coliseum & Performing Arts Center
- Columbia Metropolitan Convention Center
- Edventure
- Riverfront Park
- West Columbia Riverwalk Park and Amphitheater
- Charleston Southern University
- Cypress Gardens
- Soda City Market
- Williams Brice Stadium
- Sesquicentennial State Park
- Wannamaker County Park




