Vacation rentals in Santee

4.94 out of 5 average rating, 163 reviews

The rustic cabin features weathered wooden siding and a metal roof partially covered by overhanging branches. A front porch with railings leads to a small entry door, surrounded by grass and shrubs. The serene natural setting complements the cabin's quaint charm.

Cabin in Rowesville

Mulberry Cabin, a rustic tiny house cabin

Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.

4.97 out of 5 average rating, 470 reviews

The cottage is surrounded by greenery, showcasing a welcoming front porch with white railings. Two planters are placed at the entrance, and a swing is visible on the side. The entrance is accessible from a paved pathway leading to the door.

Cottage in Sumter

Restful Lakeside Getaway Cottage -Dogs allowed

This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

4.88 out of 5 average rating, 188 reviews

A charming log home is set on a grassy lot, surrounded by trees. The façade showcases large windows that invite natural light inside. A wooden deck extends from the entrance, providing a space for outdoor seating. A paved pathway leads to the front steps.

Cabin in Vance

Log home on Lake Marion inlet w/private dock.

Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

4.77 out of 5 average rating, 111 reviews

A spacious bedroom features a large bed dressed in white linens, complemented by decorative pillows. Nightstands with soft lamps are placed on either side. Wooden walls provide a rustic backdrop, with two windows adorned by patterned curtains allowing gentle light to filter in.

Bungalow in Summerton

The Turtle's Nest

Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

4.97 out of 5 average rating, 157 reviews

A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.

Home in Santee

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Farm stay in Timmonsville

The cozy interior features rustic wooden beams and a blend of warm tones. A spacious bed is positioned against a wall with a peacock artwork. A kitchenette area is visible, alongside a small dining table and a television, providing a comfortable, multifunctional living space.

4.95 out of 5 average rating, 645 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

4.97 out of 5 average rating, 128 reviews

An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.

Home in Santee

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

4.93 out of 5 average rating, 853 reviews

A charming poolside cottage is surrounded by lush palm trees and vibrant plants. The outdoor space features a dining set on a paved patio, providing a tranquil area for relaxation. The entrance to the cottage is easily accessible, enhancing the inviting ambiance.

Guesthouse in Florence

The Cottage by the Pool: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

Vacation home in Summerton

An aerial view captures a spacious home surrounded by greenery, featuring a turquoise pool in the foreground. Relaxing lounge chairs line the poolside, while colorful plants add vibrancy against the evening sky transitioning into warm hues.

4.97 out of 5 average rating, 104 reviews

Lakefront Paradise W/Pool/hot tub/outdoor kitchen

Brand new, hot tub, outdoor kitchen area, heated saltwater pool to be completed spring 2025. This upgraded home is ready to host your family or large group! Enjoy breathtaking sunsets year round from your private beach directly on the big waters of Lake Marion. Spends evenings out on the dock fishing or pull your boat right up to the beach. Ping pong and bumper pool tables, fast wifi and big screen tv's make for the perfect entertaining space for large groups.

4.96 out of 5 average rating, 684 reviews

A charming cottage features a sloped roof and rustic brick exterior, surrounded by lush greenery. Natural light filters through the trees, enhancing the serene setting. A hammock and seating area are visible in the background, inviting relaxation in the natural surroundings.

Cottage in Gaston

Congaree Vines - Woodland Cottage by a Vineyard!

-Enjoy a Quiet Country Stay! This charming European style cottage is set by a Hobby Vineyard! Enjoy complimentary port wine from our vineyard, a fire pit and hammock under the stars! -Congaree Vines also has the Log Cabin and Barn Bungalow. Pets are welcome for fee. If service dog, bring paperwork. -We are near Congaree National Park (33 min), Columbia, USC, Ft. Jackson, Airport I-26 & Hwy 77. -15% off Guided Kayak in CNP w/Carolina Outdoor Adventures.

Tiny home in Moncks Corner

A field of blooming yellow flowers is displayed in the foreground, with delicate petals and green stems. In the background, a white farmhouse is visible, providing a serene country setting. The scene captures the tranquility of the flower field adjacent to the cottage.

4.98 out of 5 average rating, 119 reviews

The Goose Cottage at Wild Goose Flower Farm

Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed but the sofa also extends into a queen-sized sleeper. Please reach out with further questions or if you would like to inquire about an extended stay.

A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.

4.99 out of 5 average rating, 111 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Vacation rentals for every style

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Popular amenities for Santee vacation rentals

Self check-in

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Santee house rentals

Superhost

A serene lakeside view captures the calm water reflecting the surrounding trees and a wooden dock. Gentle ripples can be seen as ducks glide across the surface. Lush greenery frames the scene, while a large rock and a light fixture are positioned in the foreground.

Home in Cross

4.91 out of 5 average rating, 47 reviews

Lakeside Getaway

The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.

4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

A serene view of Lake Marion is presented, featuring a well-maintained grassy area with four curved adirondack chairs arranged around a fire pit. A private dock extends into the water, providing boat access, under a clear blue sky dotted with soft clouds.

5 out of 5 average rating, 24 reviews

The Heron Lake House

5 out of 5 average rating, 13 reviews

The exterior of the lakehouse is showcased, featuring a welcoming porch with a ceiling fan and ample seating. A gentle slope leads to the entrance, surrounded by a well-maintained lawn and mature trees, emphasizing the property’s connection to nature.

Home in Cross

Lakefront Fishing + Grilling | Home Sweet Home!

A private sandy beach area is highlighted, featuring a wooden dock with a blue umbrella providing shade. Two black chairs are positioned on the sand, overlooking a calm lake with clear blue waters and a bright sky.

5 out of 5 average rating, 24 reviews

Almost Heaven on Lake Marion, SC

4.94 out of 5 average rating, 81 reviews

A spacious bedroom features a large, elegantly crafted bed adorned with patterned bedding and decorative pillows. Soft lighting is provided by two bedside lamps on matching nightstands. Natural light enters through a window covered by light curtains, contributing to a warm ambiance.

Home in Pinewood

Ultimate Hideaway in the pines next to Lake Marion

4.96 out of 5 average rating, 69 reviews

A serene view of Lake Marion is captured, featuring calm waters reflecting blue skies and lush greenery. A wooden dock is visible on the left, surrounded by grass and trees, creating a tranquil natural setting.

Home in Eutawville

Heated Indoor Pool on Lake Marion with Dock

4.87 out of 5 average rating, 53 reviews

The exterior of the lakefront cottage features a green and brick facade, complemented by a red bench on the porch. A circular concrete path leads to the entrance, while surrounding greenery and trees add to the natural setting. Soft evening light enhances the inviting atmosphere.

Home in Manning

Cozy Church Branch Cabin

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Other great vacation rentals in Santee

Superhost

A cozy room features a spacious bed with soft linens, surrounded by natural light filtering through layered curtains. Artwork adorns the walls, while exposed wooden beams add character. A small table is set near a window, and a television is mounted on the nearby wall.

Guest suite in Elloree

4.87 out of 5 average rating, 83 reviews

Private entrance charming room with clawfoot tub.

Cabin in Dorchester County

The cabin features a wide porch with rocking chairs and a swing, framed by lush green grass. A brick pathway leads to the entrance, while trees provide a natural backdrop, enhancing the sense of privacy and tranquility.

4.99 out of 5 average rating, 86 reviews

Cabin in the country

A tranquil view of Lake Marion is captured, featuring calm waters reflecting the sky and surrounding greenery. In the foreground, a wooden dock post is visible, with the shoreline and tree line defining the horizon. Fluffy clouds dot a bright blue sky.

4.88 out of 5 average rating, 48 reviews

Santee/Lizzie's Creek Lakefront

Superhost

The image showcases a private dock extending into the lake, with a small platform at the end. Behind the dock, a spacious home is visible, surrounded by trees and an expansive yard, creating a tranquil lakeside setting.

4.84 out of 5 average rating, 57 reviews

Lakefront home with boat ramp and game room

Guest suite in Eutawville

A spacious covered deck provides views of the lake through large trees, featuring two striped chaise loungers and a dining table with four chairs. The wooden flooring enhances the outdoor space, inviting relaxation and enjoyment of the serene surroundings.

4.78 out of 5 average rating, 86 reviews

Relaxing Comfortable Waterfront Family Dock Suite

5 out of 5 average rating, 14 reviews

The front exterior of the house is presented, featuring light-colored siding and a welcoming blue front door. A small porch is visible with white railings, and large windows allow natural light into the interior. The surrounding yard is grassy with scattered trees and landscaping.

Home in Eutawville

Fisherman’s stay! Lake Getaway!

5 out of 5 average rating, 19 reviews

A serene lake view is presented, featuring a wooden pier extending into calm waters surrounded by lush trees. The vibrant green grass leads to the water's edge, reflecting the clear blue sky above.

Cottage in Manning

Big Mama's Lakeside Cottage Lake Marion