Some info has been automatically translated. Show original language

Apartment vacation rentals in Panama City

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 233 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Top guest favorite
Apartment in Panamá
4.94 out of 5 average rating, 108 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favorite
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Apartment in Panamá
4.87 out of 5 average rating, 375 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favorite
A balcony features two red chairs on a patterned tile floor, overlooking the vibrant Main Plaza. The wrought-iron railing provides a classic touch, while trees and buildings can be seen in the background, under a partly cloudy sky.
Apartment in Panamá
4.94 out of 5 average rating, 145 reviews

Elegant Apt - View to Main Plaza of Casco Viejo

Experience the charm of Casco Viejo with this beautiful apartment, located in the heart of the historic neighborhood - close to many dining options, cafes, supermarkets and attractions. Enjoy the stunning views of the Main Plaza from the comfort of your balcony or rest easy inside with the soundproof doors and strong WIFI connection. We provide a water biden throughout your stay for hydration and Panamanian coffee renowned as one of the best in the world, at the moment of check in.

Guest favorite
An open living space features a large gray sectional sofa paired with a round wooden coffee table. A patterned rug lies beneath, complementing the light wooden flooring. The kitchen area is visible in the background, showcasing modern appliances and a breakfast bar with stools.
Apartment in Panamá
4.94 out of 5 average rating, 170 reviews

Cozy 2 Bedroom w/ Splash Pool

Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Superhost
A modern living area is featured with a neutral-toned sofa adorned with accent pillows. Natural light floods the space through large windows, showcasing views of the city. A circular coffee table sits in front of the sofa, complemented by a decorative plant and wall art.
Apartment in Panamá
4.82 out of 5 average rating, 111 reviews

Modern Cozy Apartment · Pool, Gym & Coworking

Welcome to our charming apartment in the heart of Panama City! Perfect for digital nomads who take their office with them. At LIVING 73 you will enjoy a wide range of amenities, such as swimming pool, a coworking space and gym. Located in the San Francisco area, it's the perfect starting point for exploring the city. You will find within a 5 minute walk a wide range of restaurants, supermarkets and the Multiplaza Mall, the largest and most varied in the city.

Guest favorite
A modern living space features a flat-screen TV mounted on a textured wall, paired with a stylish coffee table and a floor lamp. Soft natural light filters through sheer curtains, illuminating the adjacent bedroom, which contains a cozy bed and bedside tables.
Apartment in Panamá
4.97 out of 5 average rating, 33 reviews

Beauty Balcony •Remote Working • Near Multiplaza

➤ Stylish and beautiful apartment, tailored for remote workers with balcony, minutes away from Multiplaza Mall . ★ Perfect for Remote Workers, desktop and 150 MB speed internet. ★ Walk 5-10 mins to Restaurants, Supermarkets, Multiplaza Mall, Cafes & Shopping ➤ Urban Escape - Building Highlights: ★ Gym ★ 2 Co-Working Space with 500 MB speed internet ★ Pool on the Rooftop Terrace ➤ Located in San Francisco: Explore the City Easily | Uber-Friendly

Top guest favorite
Apartment in Panama City
4.97 out of 5 average rating, 101 reviews

Amazing loft with an iconic view of Casco Viejo

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Guest favorite
A modern dining area features a white table set for four, surrounded by stylish chairs. Large windows allow natural light to fill the space, revealing views of the city skyline. A sleek kitchen is visible in the background, showcasing a gas stove and granite countertops.
Apartment in Panamá
4.94 out of 5 average rating, 116 reviews

k*| Delightful 1 BR w/King Bed in Calle 50

Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Guest favorite
A rooftop terrace features a wooden hot tub surrounded by potted plants and a stone pathway. In the background, historical ruins are visible, complementing the vibrant atmosphere of the area. Seating areas and greenery contribute to a relaxing outdoor space.
Apartment in Panamá
4.94 out of 5 average rating, 102 reviews

Beautiful apartment in Casco Viejo ST. George D

Welcome to our spacious and charming apartment in Casco Viejo. Located in a vibrant and historic neighborhood. You will love the warm atmosphere created by the lime and pebble walls, in perfect harmony with our modern and elegant decor. The space is large and comfortable, ideal for relaxing after a day exploring the city. As a host, I'm available 24/7 to answer questions and make sure you make the most of your stay.

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 138 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Superhost
A private terrace features a jacuzzi surrounded by lush greenery against an exposed stone wall. Wooden decking creates a warm ambiance, complemented by two lounge chairs designed for relaxation, offering an inviting outdoor space for guests.
Apartment in Panama City
4.9 out of 5 average rating, 165 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Popular amenities for Panama City apartment rentals

Quick stats about apartment rentals in Panama City

  • Total vacation rentals

    Explore 2,890 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at G$2,091 GYD per night before taxes and fees

  • Verified guest reviews

    Over 79,200 verified reviews to help you choose

  • Family-friendly vacation rentals

    900 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,090 rentals that welcome pets

  • Vacation rentals with a pool

    1,840 properties feature pools

  • Rentals with dedicated workspaces

    1,770 properties have a dedicated workspace

  • Wi-Fi availability

    2,760 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore