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Vacation rentals in Panama City

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Top-rated vacation rentals in Panama City

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Guest favorite
An indoor garden is showcased, featuring lush greenery and soft lighting. A glass roof allows natural light to illuminate the space, which is accented by warm-toned stone walls. Two stylish chairs are positioned nearby, creating a comfortable seating area.
Condo in Panamá
4.91 out of 5 average rating, 118 reviews

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES

Spectacular duplex penthouse in Panama's old town, 265 square meters with balconies, private outdoor terraces, it has an interior garden lounge, a dining room, 3 bedrooms (+ sofa bed in studio), recently renovated with a loft concept, unique and comfortable exclusive design, in the best area of the old town, perfect for relaxing and unwinding, kitchen, dishwasher, living room with washing machine, swimming pool, elevator, 24-7 doorman, children who cannot swim are not allowed, a wide variety of leisure activities in the area.

Top guest favorite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Apartment in Panama City
5 out of 5 average rating, 37 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Superhost
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Apartment in Panamá
4.87 out of 5 average rating, 355 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favorite
A modern living area features a large wave mural that enhances the space's vibrant decor. Comfortable seating arrangements include a sleek white sofa and a pair of stylish armchairs. A glass coffee table is centered among the furnishings, with tastefully arranged decorative accents.
Apartment in Panamá
4.93 out of 5 average rating, 262 reviews

Modern apt ocean view in heart of Panamá yoo tower

Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Superhost
An open living space features a large gray sectional sofa paired with a round wooden coffee table. A patterned rug lies beneath, complementing the light wooden flooring. The kitchen area is visible in the background, showcasing modern appliances and a breakfast bar with stools.
Apartment in Panamá
4.94 out of 5 average rating, 152 reviews

Cozy 2 Bedroom w/ Splash Pool

Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Guest favorite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 146 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Guest favorite
A modern living area is showcased, featuring a light gray sofa positioned across from a flat-screen TV on a wooden console. Two abstract art pieces adorn the walls. Floor-to-ceiling windows offer views of the city skyline, enhancing natural light in the space.
Condo in Panamá
4.95 out of 5 average rating, 129 reviews

Beautiful Apartment 3 guests

Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Top guest favorite
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Apartment in Panamá
4.97 out of 5 average rating, 118 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Guest favorite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.93 out of 5 average rating, 129 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 118 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Top guest favorite
Condo in Panama
4.99 out of 5 average rating, 256 reviews

Patty’s Cozy Studio with K bed in Casco Viejo

Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!

Guest favorite
A private terrace features a jacuzzi surrounded by lush greenery against an exposed stone wall. Wooden decking creates a warm ambiance, complemented by two lounge chairs designed for relaxation, offering an inviting outdoor space for guests.
Apartment in Panama City
4.9 out of 5 average rating, 153 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Popular amenities for Panama City vacation rentals

Quick stats about vacation rentals in Panama City

  • Total rentals

    4.7K properties

  • Nightly prices starting at

    G$2,092 GYD before taxes and fees

  • Total number of reviews

    114K reviews

  • Family-friendly rentals

    1.5K properties are a good fit for families

  • Pet-friendly rentals

    1.7K properties allow pets

  • Rentals with a pool

    2.6K properties have a pool

Frequently Asked Questions

  • How is the weather in Panama City?

    Panama City has a tropical climate with high temperatures throughout the year, usually ranging from 75°F to 88°F (24°C to 31°C). Rainy season occurs between May and December, while the dry season extends from January to April.

  • What are some of the best things to do in Panama City?

    Popular activities in Panama City include exploring the historic Casco Viejo district, visiting the Panama Canal Museum, and strolling along the Cinta Costera. Birdwatching in the Metropolitan Natural Park and shopping in the Mercado de Mariscos are also often recommended.

  • What is the best time of year to visit Panama City?

    The most frequented time to visit Panama City is between January and April. This period coincides with Panama's dry season, which enables more comfortable exploration of the city's many attractions. During this time, the vibrant and lively Carnival of Panama, typically held in February, draws a sizable crowd.

  • What are the best places to stay in Panama City?

    Casco Viejo, the city's historic district, is a popular area to stay in Panama City due to its colonial architecture and range of dining options. The modern neighborhood of Punta Paitilla is often recommended for its skyscrapers and shopping centers, while Costa del Este appeals to those seeking a quieter, residential ambiance.

  • What are the best places to visit in Panama City?

    Many visitors to Panama City enjoy the historic district of Casco Viejo, the Panama Canal, and the Metropolitan Natural Park. Other frequently suggested places include the Amador Causeway for its stunning views, and the Biomuseo for its distinct architecture and exhibits on biodiversity.

  • What are some hiking trails in Panama City?

    The Metropolitan Natural Park, located within Panama City, has several hiking trails, such as the Mono Titi Road and the Los Momotides trail. Just outside the city, you can explore the trails of the Soberania National Park, including the Pipeline Road, known for its diverse birdlife.

  • What are some family activities to do in Panama City?

    Families in Panama City often enjoy a visit to the Biomuseo, a museum renowned for its exhibits on biodiversity. The Panama Canal, particularly the Miraflores Locks, provides an educational experience. The Metropolitan Natural Park and Summit Botanical Gardens and Zoo are also popular destinations for families.

  • What are some of the best day trip ideas in Panama City?

    A day trip to the Panama Canal, specifically the Miraflores Locks, is frequently suggested. The beautiful Pearl Islands are also accessible for a day trip from the city. Within the city, exploring the historic district of Casco Viejo, or the biodiversity of the Metropolitan Natural Park, make for enjoyable day trips.

  • Are there family-friendly apartment rentals in Panama City?

    Panama City has more than 870 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in bed and breakfast rentals in Panama City?

    Experience the best of Panama City with our bed and breakfast rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City