
Vacation rentals in Panama City
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Top-rated vacation rentals in Panama City
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CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES
Spectacular duplex penthouse in Panama's old town, 265 square meters with balconies, private outdoor terraces, it has an interior garden lounge, a dining room, 3 bedrooms (+ sofa bed in studio), recently renovated with a loft concept, unique and comfortable exclusive design, in the best area of the old town, perfect for relaxing and unwinding, kitchen, dishwasher, living room with washing machine, swimming pool, elevator, 24-7 doorman, children who cannot swim are not allowed, a wide variety of leisure activities in the area.

Luxury apt in Panama City 2 Rooms 3 Baths
El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Modern apt ocean view in heart of Panamá yoo tower
Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Cozy 2 Bedroom w/ Splash Pool
Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Escape to the Heart of Casco with a Private Balcony
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Beautiful Apartment 3 guests
Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Exceptional three-story building with sea view
This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Patty’s Cozy Studio with K bed in Casco Viejo
Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!

Jacuzzi in colonial ruins in beautiful apartment
Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.
Popular amenities for Panama City vacation rentals
Other great vacation rentals in Panama City

The Waterfall House

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

Elegant apartment with a view & the warmth of home

Spacious oceanfront apartment

New apartment on 50th Street

Chic & Modern 1BD Yoo Panama City

Unique Luxury 3-story Loft at the Yoo

Amazing2bed’s2bath/stunning cityview
Quick stats about vacation rentals in Panama City
Total rentals
4.7K properties
Nightly prices starting at
G$2,092 GYD before taxes and fees
Total number of reviews
114K reviews
Family-friendly rentals
1.5K properties are a good fit for families
Pet-friendly rentals
1.7K properties allow pets
Rentals with a pool
2.6K properties have a pool
Frequently Asked Questions
How is the weather in Panama City?
Panama City has a tropical climate with high temperatures throughout the year, usually ranging from 75°F to 88°F (24°C to 31°C). Rainy season occurs between May and December, while the dry season extends from January to April.
What are some of the best things to do in Panama City?
Popular activities in Panama City include exploring the historic Casco Viejo district, visiting the Panama Canal Museum, and strolling along the Cinta Costera. Birdwatching in the Metropolitan Natural Park and shopping in the Mercado de Mariscos are also often recommended.
What is the best time of year to visit Panama City?
The most frequented time to visit Panama City is between January and April. This period coincides with Panama's dry season, which enables more comfortable exploration of the city's many attractions. During this time, the vibrant and lively Carnival of Panama, typically held in February, draws a sizable crowd.
What are the best places to stay in Panama City?
Casco Viejo, the city's historic district, is a popular area to stay in Panama City due to its colonial architecture and range of dining options. The modern neighborhood of Punta Paitilla is often recommended for its skyscrapers and shopping centers, while Costa del Este appeals to those seeking a quieter, residential ambiance.
What are the best places to visit in Panama City?
Many visitors to Panama City enjoy the historic district of Casco Viejo, the Panama Canal, and the Metropolitan Natural Park. Other frequently suggested places include the Amador Causeway for its stunning views, and the Biomuseo for its distinct architecture and exhibits on biodiversity.
What are some hiking trails in Panama City?
The Metropolitan Natural Park, located within Panama City, has several hiking trails, such as the Mono Titi Road and the Los Momotides trail. Just outside the city, you can explore the trails of the Soberania National Park, including the Pipeline Road, known for its diverse birdlife.
What are some family activities to do in Panama City?
Families in Panama City often enjoy a visit to the Biomuseo, a museum renowned for its exhibits on biodiversity. The Panama Canal, particularly the Miraflores Locks, provides an educational experience. The Metropolitan Natural Park and Summit Botanical Gardens and Zoo are also popular destinations for families.
What are some of the best day trip ideas in Panama City?
A day trip to the Panama Canal, specifically the Miraflores Locks, is frequently suggested. The beautiful Pearl Islands are also accessible for a day trip from the city. Within the city, exploring the historic district of Casco Viejo, or the biodiversity of the Metropolitan Natural Park, make for enjoyable day trips.
Are there family-friendly apartment rentals in Panama City?
Panama City has more than 870 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
How much does it cost to stay in bed and breakfast rentals in Panama City?
Experience the best of Panama City with our bed and breakfast rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
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