
Vacation rentals in Panama City
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Top-rated vacation rentals in Panama City
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CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES
Spectacular duplex penthouse in Panama's old town, 265 square meters with balconies, private outdoor terraces, it has an interior garden lounge, a dining room, 3 bedrooms (+ sofa bed in studio), recently renovated with a loft concept, unique and comfortable exclusive design, in the best area of the old town, perfect for relaxing and unwinding, kitchen, dishwasher, living room with washing machine, swimming pool, elevator, 24-7 doorman, children who cannot swim are not allowed, a wide variety of leisure activities in the area.

Comfortable and spectacular old town - parking
Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Modern apt ocean view in heart of Panamá yoo tower
Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Cozy 2 Bedroom w/ Splash Pool
Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Yoo Panama, 54th floor, comfortable and cozy.
Beautiful apartment located on the 54th floor of the most luxurious building in Panama. Areas designed by designer Philip Stark. It is 134 square meters, fully furnished, has a bedroom, walk-in closet, full bathroom, open living room and kitchen, half bathroom, terrace, and laundry room. The building is a unique place, with special and luxurious communal areas; 2 elegant restaurants; 2 swimming pools; gym; spa; 2 squash courts; poker room, lobby with pool table, etc.

Jacuzzi & Private Rooftop recently refurbished D11
Welcome to Casa Diez, the most romantic spot in the Old Town! Enjoy a unique experience in this room for two, featuring an exclusive outdoor Jacuzzi overlooking the starry sky. Relax in a comfortable queen-size bed, with a private bathroom, air conditioning, Smart TV, and Wi-Fi. You'll also have access to a beautiful shared pool and laundry center, exclusively for our guests. Enjoy an unforgettable stay in a cozy, intimate, and fully equipped setting.

Loft 3b Old Town Best! It is 150 m2 (492 feet)
Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wood floors radiating warmth and an openly designed modern kitchen ideal for sharing, this space guarantees a memorable vacation. Located on A Avenue A, you'll be just a few steps from exquisite restaurants, museums, colonial churches, and the coveted rooftops of Casco, turning every day into an adventure.

k*| Delightful 1 BR w/King Bed in Calle 50
Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Exceptional three-story building with sea view
This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Patty’s Cozy Studio with K bed in Casco Viejo
Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!
Popular amenities for Panama City vacation rentals
Other great vacation rentals in Panama City

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

Elegant apartment with a view & the warmth of home

2BR King Suite Ocean View, Casco, Canal 500MB WIFI

Chic & Modern 1BD Yoo Panama City

Unique Luxury 3-story Loft at the Yoo

Luxury apt in Panama City 2 Rooms 3 Baths

Amazing2bed’s2bath/stunning cityview

The Captain's Canal View Penthouse
Frequently Asked Questions
What are the best places to stay in Panama City?
Panama City has stays in vibrant neighborhoods like Casco Viejo, known for historic charm, and Punta Pacifica, often suggested for modern towers and city views. Many visitors also enjoy options around El Cangrejo for its mix of cafes and local culture.
What are the best things to do in Panama City with kids?
Explore the Biomuseo’s interactive exhibits, walk the Amador Causeway for city and canal views, or visit parks like Parque Natural Metropolitano to spot wildlife. Many families enjoy boat tours or learning about the canal’s history.
What are some of the best things to do in Panama City?
Wander historic streets in Casco Viejo, explore exhibits at the Panama Canal Museum, and stroll the Cinta Costera waterfront. Food and markets, canal tours, and cultural centers are frequently suggested for first-time visitors.
How is the weather in Panama City?
Panama City has a tropical climate with warm temperatures year-round, often around 75–88°F (24–31°C). Visitors can expect higher humidity, with occasional rain, especially during the wet season.
What are the best places to visit in Panama City?
Casco Viejo’s historic architecture, the Panama Canal, and the Biomuseo are often highlighted for visitors. The Amador Causeway is also suggested for scenic walks and views over the bay.
What are some hiking trails in Panama City?
Parque Natural Metropolitano has trails through tropical forest with city vistas and wildlife. The Sendero El Gaital path and walking routes around Cerro Ancón are also frequently suggested for those who want a nature escape near urban sights.
What are some family activities we can do in Panama City?
Families often enjoy the interactive displays at Biomuseo, relaxing on the Amador Causeway, and wildlife spotting in Parque Natural Metropolitano. Parks with playgrounds and canal boat tours are also popular with kids.
What are some of the best day trip ideas from Panama City?
Day trips from Panama City often include hiking in nearby rainforest reserves, visiting Gamboa for canal views and nature tours, or relaxing on beaches around the Pearl Islands. Guided excursions introduce travelers to indigenous cultural sites as well.
Are there any pet friendly accommodations available in Panama City?
Panama City has pet-friendly stays, especially in neighborhoods like El Cangrejo and San Francisco, where parks and walkable streets make it easy to enjoy the city with your pet. Many hosts welcome dogs and cats with advance notice.
What are some local tips for visiting Panama City?
When exploring Panama City, lightweight clothing helps with humidity, and a reusable water bottle is useful. Street murals around Casco Viejo show local talent, while trying fresh seafood in city markets gives a taste of regional flavors.
What is Panama City known for?
Panama City is known for the Panama Canal, mix of colonial and modern architecture, and vibrant culinary scene. Its waterfront walks and lively festivals celebrate a crossroads of cultures.
What are the best hidden gems to explore in Panama City?
Panama City has tucked-away art galleries in Casco Viejo, quiet gardens at Mi Pueblito, and street food stands in Santa Ana that attract locals. Seek out small museums and indie coffee shops for a neighborhood experience.
What are the best foods to try in Panama City?
Local favorites include sancocho chicken stew, patacones (fried plantains), and ceviche from city markets. Panamanian seafood, fresh tropical fruits, and pastries filled with local flavors are frequently suggested.
What should I bring for a trip to Panama City?
Bring lightweight, breathable clothing for the tropical climate, comfortable walking shoes, and sun protection like hats and sunscreen. A rain jacket and an adapter for electronics are also practical for your stay.
What is the nightlife in Panama City like?
Panama City has a vibrant nightlife scene, with lively rooftop bars, salsa venues, and music lounges in Casco Viejo. Neighborhoods like Calle Uruguay and El Cangrejo are known for dance clubs, craft cocktail spots, and casual pubs. Visitors often explore a mix of local rhythms and international influences after dark.
What are the most popular events or festivals in Panama City?
Carnival is one of the most popular celebrations, filling Panama City with music, parades, and color before Lent. Jazz festivals, local art fairs, and folklore events also draw crowds throughout the year.
Are there family friendly vacation rentals in Panama City?
Panama City has family-friendly vacation rentals, especially in areas near parks and cultural attractions like El Cangrejo, San Francisco, and Casco Viejo. Many hosts provide amenities for children and groups traveling together.
When is the best time to visit Panama City?
The drier season is often recommended for clearer skies and outdoor activities. Many travelers prefer visiting when major cultural events and festivals enliven the city’s atmosphere.
Quick stats about vacation rentals in Panama City

Total vacation rentals
Explore 4,740 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at G$2,092 GYD per night before taxes and fees

Verified guest reviews
Over 114,280 verified reviews to help you choose

Family-friendly vacation rentals
1,480 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 1,680 rentals that welcome pets

Vacation rentals with a pool
2,570 properties feature pools

Rentals with dedicated workspaces
2,880 properties have a dedicated workspace

Wi-Fi availability
4,490 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Gym, BBQ grill, and Laptop-friendly workspace across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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- Things to do Panama
- Nature and outdoors Panama
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- Tours Panama
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- Food and drink Panama
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