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Apartment vacation rentals in Panama City

Find and book unique apartments on Airbnb

Quick stats about apartment rentals in Panama City

  • Total vacation rentals

    Explore 3,150 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at G$2,090 GYD per night before taxes and fees

  • Verified guest reviews

    Over 97,220 verified reviews to help you choose

  • Family-friendly vacation rentals

    1,010 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,180 rentals that welcome pets

  • Vacation rentals with a pool

    2,170 properties feature pools

  • Rentals with dedicated workspaces

    2,060 properties have a dedicated workspace

  • Wi-Fi availability

    3,090 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in San Felipe
4.96 out of 5 average rating, 260 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Superhost
Apartment in Panama City
4.92 out of 5 average rating, 170 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Superhost
Apartment in Panama City
4.79 out of 5 average rating, 123 reviews

New Flat with Ocean + City Views

Brand new apartment in a high rise in the middle of downtown Panama. Very centrally located. Two fully furnished rooms and fully equiped kitchen. Gorgeous views of the city and Pacific ocean. Guests will have access to all the building's amenities such as a pool, gym, coworking space and game room. 15 minutes walking distance to Casco Viejo. 5 minute walking distance to Mercado de Mariscos, Cinta Costera and to the 5 de Mayo Metro Station. Airport Pickup and Dropoff Services Also Available.

Guest favorite
A spacious living room features a comfortable brown sofa and an armchair beside a decorative coffee table. Natural light enters through large glass doors draped with sheer curtains, illuminating the warm wood floors and elegant decor.
Apartment in San Felipe
4.97 out of 5 average rating, 117 reviews

Luxury Mid-Century Apartment In Casco Viejo

Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Top guest favorite
Apartment in San Felipe
4.98 out of 5 average rating, 130 reviews

The View of Casco: Designer Loft with best Balcony

Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! ​Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. ​You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Guest favorite
A modern living area is presented with a light-colored sofa and stylish accent cushions. A glass coffee table is paired with a white armchair and a vibrant blue side table. Floor-to-ceiling windows provide a clear view of the ocean and allow natural light to brighten the space.
Apartment in Bella Vista
4.8 out of 5 average rating, 143 reviews

Ocean View Apt in Panama, Yoo&Arts

Iconic luxury at Yoo&Arts Panama. This spectacular 130m² (1,400 sq ft) apartment offers sophisticated design and a breathtaking panoramic view of the Pacific Ocean. Enjoy breakfast on the balcony with an exceptional breeze, watch the sunrise from your bedroom, or work in an inspiring environment. Located on Avenida Balboa, the city's most exclusive area, you’ll have direct access to fine dining inside the building, premium supermarkets, and shopping malls nearby.

Superhost
Apartment in San Felipe
4.78 out of 5 average rating, 200 reviews

Studio apartment in the heart of Casco

Welcome to Casa Pérez, your retreat in the heart of the Old Town! Enjoy a prime location and the best views from a spectacular private balcony facing the most iconic square in the Casco. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, washing machine and elevator for your comfort. Enjoy an unforgettable stay in a warm and fully equipped atmosphere.

Guest favorite
Apartment in Panama City
4.9 out of 5 average rating, 108 reviews

Moderno, céntrico y cómodo (104)

Moderno y acogedor estudio en el corazón de Panamá. Perfecto para explorar el Casco Antiguo, la Cinta Costera y más. Cocina completa, cama queen, sofá cama doble, aire acondicionado, WiFi rápido y baño privado. Ideal para 1–4 personas. Acceso privado, ascensor y check-in autónomo. Rodeado de restaurantes, transporte y sitios turísticos. ¡Tu base ideal para conocer la ciudad! 🧳 Estancias largas bienvenidas (descuentos aplicables)

Guest favorite
A cozy sitting area is highlighted by a large window offering views of the vibrant plaza and cathedral. Two comfortable armchairs are positioned beside a small coffee table on a textured rug. Natural light fills the space, enhancing the warm tones of the wooden floor.
Apartment in San Felipe
4.91 out of 5 average rating, 127 reviews

The best view of the Old Town

Welcome to this charming accommodation located in the heart of Casco Viejo, on the third floor facing one of the most iconic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Guest favorite
Apartment in San Felipe
4.92 out of 5 average rating, 66 reviews

Casa del Horno | A Piece of Panamanian History

Enjoy a different experience in the center of the Old Town. Casa del Horno is a historic building created from the restoration of an old mid-19th century structure, which retains the character of its calicanto walls. Today, this space combines history, comfort and a very prime location. You will be surrounded by restaurants, cafes, and bars, and you will have very easy access to Panama's most iconic sites.

Guest favorite
Apartment in San Francisco
4.98 out of 5 average rating, 163 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Top guest favorite
Apartment in San Felipe
4.97 out of 5 average rating, 36 reviews

Luxury Centric 2BR Apartment in Casco Viejo

Welcome to our charming and spacious apartment in the heart of Casco Viejo. We are located directly across the street from the landmark Hotel La Compañia. From the balcony you can look at the remaining structure of the centuries-old La Compañia de Jesus, a former Jesuit temple and convent. In the apartment, you can relax in the spacious and comfortable space.

Popular amenities for Panama City apartment rentals

Destinations to explore