
Apartment vacation rentals in Panama City
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Quick stats about apartment rentals in Panama City

Total vacation rentals
Explore 2,860 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at G$2,089 GYD per night before taxes and fees

Verified guest reviews
Over 88,500 verified reviews to help you choose

Family-friendly vacation rentals
920 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 1,130 rentals that welcome pets

Vacation rentals with a pool
1,940 properties feature pools

Rentals with dedicated workspaces
1,910 properties have a dedicated workspace

Wi-Fi availability
2,790 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated apartment rentals in Panama City
Guests agree: these apartments are highly rated for location, cleanliness, and more.

Apartment Av. Balboa, Yoo&Arts
Accommodation with the best ocean view in Panama, Yoo & Arts Building, 130 meters. You can enjoy various environments during your stay, have breakfast on our balcony with an exceptional ocean view, watch the sunrise from your bedroom, or even work in an excellent environment. You can have easy access to haute cuisine restaurants in the same building as the accommodation, supermarkets nearby, shopping malls. Luxury will be all around you as the building is one of the most exclusive in the area.

Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Best location - Unique and charming loft
Relax and enjoy the elegance of a bygone era when you stay in this charming Loft. Carefully built with wooden floors, calicanto walls, high beamed ceilings and antique details for a luxurious yet charming feel. Take an early morning walk and enjoy the ruins, churches, and museums of Casco Viejo. Stroll through the historic streets while the city sleeps, then return for morning coffee in this classic and elegant Loft with a dreamy terrace. This apartment is located in the heart of Casco Viejo!

Apartment with unique views to remember and a pool
Pasarás una Experiencia con estilo, alojamiento céntrico. acceso a líneas de buses y el Metro, restaurante , grocery store 24 horas, y una vida nocturna genial, casinos, cinta costera, iglesia del Carmen. casco antiguo a minutos en uber. compras. Soho Mall, Multi Plaza Mall y Albrook Mall. Piscina para adultos y niños. Bar, restaurante, rooftop vistas panorámicas, coworking, gym. Una habitación Con cama queen y un sofá cama en la sala para huéspedes extras (costo xtra 15.00 pp x noche)

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Luxury Mid-Century Apartment In Casco Viejo
Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

The View of Casco: Designer Loft with best Balcony
Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Impressive ocean and Panama City views
Enjoy a unique experience, a modern apartment with its own style, where every sunrise and sunset becomes a show. Enjoy breathtaking views of Panama City, the bay, and the Old Town from the comfort of your home. Unbeatable Location Located just 5 minutes from the charming Casco Viejo and the famous seafood market, and 10 minutes from the banking area. In addition, you will have a metro station and several bus stops just a few steps from the building

Studio apartment in the heart of Casco
Welcome to Casa Pérez, your retreat in the heart of the Old Town! Enjoy a prime location and the best views from a spectacular private balcony facing the most iconic square in the Casco. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, washing machine and elevator for your comfort. Enjoy an unforgettable stay in a warm and fully equipped atmosphere.

The best view of the Old Town
Welcome to this charming accommodation located in the heart of Casco Viejo, on the third floor facing one of the most iconic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Cozy Balcony •Pool Gym• Near Multiplaza

Luxury Centric 2BR Apartment in Casco Viejo

Lovely & Cozy central apartment in Casco Viejo

Private parking & rooftop | Studio Casco Center

Luxury apt in Panama City 2 Rooms 3 Baths

Luxury Balcony Stays + Pool Casco Viejo

2BR King Suite Ocean View, Casco, Canal 500MB WIFI

Tropicool Casco Loft w/King Bed & Rooftop
Private apartment rentals

Unique sunrises overlooking Panama Bay

A cozy Casco Viejo apartment

Centric - 2BDR Apt - Old Town

Comfortable oceanfront apartment

Modern apartment in Obarrio with pool and gym

Casco View: Comfortable and modern apartment in Panama

Apartment with home warmth

Beautiful Ocean View Studio on Ave Balboa
Apartment rentals with a hot tub

Suite Luxury 30th View Yoo Panamá & Arts Tower

Historic 2BR Loft at Casa del Horno, Old Town

Luxury 2BR Suite with Pool & Views

New Flat with Ocean + City Views

Tropical Paradise at Playa Bonita

Live the Wanders And Yoo Experience in Panama

PH The Gray | Balcony Views · Pool · Gym

Oceanview Apt Near Panama City w/ King Bed & More
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