
Apartment vacation rentals in Panama City
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Quick stats about apartment rentals in Panama City

Total vacation rentals
Explore 3,150 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at G$2,092 GYD per night before taxes and fees

Verified guest reviews
Over 97,220 verified reviews to help you choose

Family-friendly vacation rentals
1,010 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 1,180 rentals that welcome pets

Vacation rentals with a pool
2,170 properties feature pools

Rentals with dedicated workspaces
2,060 properties have a dedicated workspace

Wi-Fi availability
3,090 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated apartment rentals in Panama City
Guests agree: these apartments are highly rated for location, cleanliness, and more.

Luxury Mid-Century Apartment In Casco Viejo
Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

The View of Casco: Designer Loft with best Balcony
Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Ocean View Apt in Panama, Yoo&Arts
Iconic luxury at Yoo&Arts Panama. This spectacular 130m² (1,400 sq ft) apartment offers sophisticated design and a breathtaking panoramic view of the Pacific Ocean. Enjoy breakfast on the balcony with an exceptional breeze, watch the sunrise from your bedroom, or work in an inspiring environment. Located on Avenida Balboa, the city's most exclusive area, you’ll have direct access to fine dining inside the building, premium supermarkets, and shopping malls nearby.

Walk to Everything | Luxury Stay in Casco Viej
Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Casco Antiguo Apartment with Balcony & Stone Wall
Elegant apartment in the heart of the Historic District. Enjoy a colonial-style space with exposed stone walls, warm lighting, and a charming balcony overlooking vibrant streets. Located on Avenida B, within walking distance of restaurants, coffee shops, rooftop bars, and historic sites. Sleeps up to 5 guests. Perfect for experiencing the culture and energy of Casco Viejo. Due to the lively atmosphere in the area, noise may be heard at night on weekends.

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Private parking & rooftop | Studio Casco Center
This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

The best view of the Old Town
Welcome to this charming accommodation located in the heart of Casco Viejo, on the third floor facing one of the most iconic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Most Beautiful Loft in the Heart of Casco Viejo
Discover Casco Viejo from this beautiful loft, perfectly located. Casco Viejo, UNESCO World Heritage Site, known for its colonial buildings, and iconic streets. This vibrant neighborhood offers many restaurants, coffee places, museums, and an exciting night life. Just steps from Fonda Lo Que Hay, ranked among Latin America's Top 50 culinary destinations. Close to MYKA Greek Yogurt and the iconic La Compañía Hotel.

Cozy Balcony •Remote Working• Near Multiplaza
✨ Bright and charming apartment with balcony and an unbeatable location 🌇 🚶♂️Walk 5–10 mins to Restaurants, Supermarkets, Multiplaza Mall, Cafes. ☕🛍️🍽️ 💻 Ideal for remote workers — 750 MB internet speed, 100 Up⚡📶 Building Highlights: 🏋️♂️ Gym 💻 2 Co-Working Spaces 500 MB internet speed 🏊 Rooftop Terrace Pool 📍Located in San Francisco, Panama City | 🧭 Explore the city easily | 🚗 Uber-Friendly

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Modern, central and comfortable (001)
Modern and cozy studio in the heart of Panama. Perfect for exploring the Old Town, the Coastal Strip and more. Full kitchen, full bed, double sofa bed, air conditioning, fast WiFi and private bathroom. Ideal for 1–4 people. Private access, elevator and self check-in. Surrounded by restaurants, transportation, and tourist sites. Your ideal base to explore the city!
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Gorgeous Flat in the best location in Casco Viejo

Panoramic Casco Viejo Lookout in The Sands

Villas La Fontana Spacious ApartaSuite - Pool 102

Peaceful Stay in the Heart of Casco

Apartment with Home Warmth and City View

Lovely & Cozy central apartment in Casco Viejo

Elegant Apt in Costa del Este. Premium Amenities

Luxury Centric 2BR Apartment in Casco Viejo
Private apartment rentals

The Sands | Modern 1BR w/ Partial Ocean View

Ocean View Luxury | 4 Guests | 1 BR | 1 Bath

Old Town & Ocean View

Apartment Casco Antiguo Panamá

Amazing loft with Casco charm in the best location

Charming Casco Viejo Flat with Parking and Pool

A warm and cozy flat in Casco Viejo

Ocean View, Panama City
Apartment rentals with a hot tub

New Flat with Ocean + City Views

Tropical Paradise at Playa Bonita

Apartment in Obarrio with Rooftop | Pool and View

Vive la Experiencia Wanders And Yoo en Panamá

Premium APT | Downtown | Design, Comfort, Parking

Luxurious apartment in Marbella

PH The Gray | Balcony Views · Pool · Gym

Historic 2BR Loft at Casa del Horno, Casco Antiguo
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