
Apartment vacation rentals in Panama City
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Top-rated apartment rentals in Panama City
Guests agree: these apartments are highly rated for location, cleanliness, and more.

In the heart of Casco, remodeled and with parking
Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Modern apartment in the heart of Obarrio
This apartment stands out for its prime location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The comfort of having two bathrooms makes it unique. Ideal for travelers looking for tranquility and functionality. Located within walking distance of Calle 50 and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area to walk and enjoy the city.

Elegant Apt - View to Main Plaza of Casco Viejo
Experience the charm of Casco Viejo with this beautiful apartment, located in the heart of the historic neighborhood - close to many dining options, cafes, supermarkets and attractions. Enjoy the stunning views of the Main Plaza from the comfort of your balcony or rest easy inside with the soundproof doors and strong WIFI connection. We provide a water biden throughout your stay for hydration and Panamanian coffee renowned as one of the best in the world, at the moment of check in.

Tropicool Loft w/rooftop steps from Casco
This historic 1941 loft is located at the entrance of Casco Viejo where you’re steps from the fish market and all the cool cafés, rooftops, and trendy restaurants that make up the neighborhood. Fully equipped kitchen, washer/dryer combo, 1.5 bath, bedroom on 2nd floor, 2 balconies + communal rooftop, projector w/Netflix, fast internet, and great AC. You’re also directly in front of the Cinta Costera park for running, biking, tennis courts. Near local airport for flights to Bocas!

Gorgeous Flat in the best location in Casco Viejo
This cute and stylish studio is perfectly located in the heart of Casco Viejo, Panama City’s most charming historic district. Recently renovated, it combines modern comfort with classic charm inside a beautiful colonial building—just steps from top restaurants, bars, monuments, and attractions. The space includes a comfortable sofa bed, making it ideal for a couple or a small family looking to enjoy the vibrant atmosphere of Casco right outside their door.

Private parking & rooftop | Studio Casco Center
This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Casa Arias with Pool, Rooftop and Great Location 2
Welcome to Casa Arias, your retreat in the heart of the Old Town! A cozy bedroom for two, with a fully equipped kitchen and a view of a spectacular pool surrounded by tropical vegetation. Access to a shared rooftop terrace with panoramic views of the Old Town, ideal for relaxing or sharing good times. The property offers tropical design, comfort, and privacy. Enjoy an unforgettable stay in a cozy and fully equipped environment.

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

k*| Delightful 1 BR w/King Bed in Calle 50
Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Beautiful apartment in Casco Viejo ST. George D
Welcome to our spacious and charming apartment in Casco Viejo. Located in a vibrant and historic neighborhood. You will love the warm atmosphere created by the lime and pebble walls, in perfect harmony with our modern and elegant decor. The space is large and comfortable, ideal for relaxing after a day exploring the city. As a host, I'm available 24/7 to answer questions and make sure you make the most of your stay.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Sky Lounge/ APT 1 BR-vista al Mar/Pool bar & GYM
Moderno apartamento de lujo en la Cinta Costera, ideal para ejecutivos, parejas o familias. Dormitorio amplio con vista al mar, baño privado, cocina y electrodomésticos. Diseño elegante con seguridad 24/7, gimnasio, piscinas, 4 restaurantes, bar y Sky Lounge. Ubicación privilegiada cerca de supermercados y excelente oferta gastronómica en Ciudad de Panamá. PANAMA
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Brand new spectacular 1B 1B Apartment

2BR King Suite Ocean View, Casco, Canal 500MB WIFI

Lovely & Cozy central apartment in Casco Viejo

Large Apartment in La Cuadra - Casco | By Alura

Modern apartment with sea view and pool

The Captain's Canal View Penthouse

Impressive ocean and Panama City views

Oceanview Paradise in Panama City!
Private apartment rentals

Cozy apartment in Panama

Nice apartment in Panama

Cozy Casco Viejo Apartment

Luminous apartment with great energy and taste.

Suite Luxury 30th View , Cinta Costera Panama

La Maison de Dave - Lovely 2- Bedroom rental apt.

Sea View in Panama City: BrisaMarina

Modern Cozy Apartment · Pool, Gym & Coworking
Apartment rentals with a hot tub

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

Luxury Beachfront Apartment Near Panama City

Beautiful colonial condo with a hot tub and balcony

PH Yoo 44i – Ocean View Apartment

New Flat with Ocean + City Views

Tropical Paradise at Playa Bonita

Panama Dream View Escape

Coastal Chic Executive Studio in Panama City
Quick stats about apartment rentals in Panama City

Total vacation rentals
Explore 2,890 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at G$2,091 GYD per night before taxes and fees

Verified guest reviews
Over 79,200 verified reviews to help you choose

Family-friendly vacation rentals
900 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 1,090 rentals that welcome pets

Vacation rentals with a pool
1,840 properties feature pools

Rentals with dedicated workspaces
1,770 properties have a dedicated workspace

Wi-Fi availability
2,760 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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