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Apartment vacation rentals in Panama City

Find and book unique apartments on Airbnb

Quick stats about apartment rentals in Panama City

  • Total vacation rentals

    Explore 3,150 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at G$2,091 GYD per night before taxes and fees

  • Verified guest reviews

    Over 97,220 verified reviews to help you choose

  • Family-friendly vacation rentals

    1,010 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,180 rentals that welcome pets

  • Vacation rentals with a pool

    2,170 properties feature pools

  • Rentals with dedicated workspaces

    2,060 properties have a dedicated workspace

  • Wi-Fi availability

    3,090 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Superhost
Apartment in Panama City
4.78 out of 5 average rating, 125 reviews

New Flat with Ocean + City Views

Brand new apartment in a high rise in the middle of downtown Panama. Very centrally located. Two fully furnished rooms and fully equiped kitchen. Gorgeous views of the city and Pacific ocean. Guests will have access to all the building's amenities such as a pool, gym, coworking space and game room. 15 minutes walking distance to Casco Viejo. 5 minute walking distance to Mercado de Mariscos, Cinta Costera and to the 5 de Mayo Metro Station. Airport Pickup and Dropoff Services Also Available.

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Guest favorite
A modern living area is presented with a light-colored sofa and stylish accent cushions. A glass coffee table is paired with a white armchair and a vibrant blue side table. Floor-to-ceiling windows provide a clear view of the ocean and allow natural light to brighten the space.
Apartment in Bella Vista
4.8 out of 5 average rating, 144 reviews

Ocean View Apt in Panama, Yoo&Arts

Iconic luxury at Yoo&Arts Panama. This spectacular 130m² (1,400 sq ft) apartment offers sophisticated design and a breathtaking panoramic view of the Pacific Ocean. Enjoy breakfast on the balcony with an exceptional breeze, watch the sunrise from your bedroom, or work in an inspiring environment. Located on Avenida Balboa, the city's most exclusive area, you’ll have direct access to fine dining inside the building, premium supermarkets, and shopping malls nearby.

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Top guest favorite
Apartment in Panama City
4.96 out of 5 average rating, 24 reviews

5B • 5 Bedroom Apt • 4 Baths • Great for Groups

Apartment 5B is a modern 5-bedroom, 4-bath home designed for comfortable group stays, accommodating up to 10 guests with one king, three queens, and two single beds. It features a fully equipped kitchen, bright living area, fast WiFi, and spaces to relax or work. Centrally located in Panama City near restaurants, supermarkets, parks, and the waterfront. Guests enjoy full privacy, shared amenities including pool, gym, sauna, spa, and on-site support when needed.

LocationFamilyCondition

Top guest favorite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Apartment in San Francisco
5.0 out of 5 average rating, 87 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

The Wanders by yoo building is located in the heart of the city. It is an extraordinary project where every corner has a story to tell. 24/7 reception, many recreation areas, hydration station. Outside the lobby, there is the Cafetería cafe con teclas and a Popino Carnes restaurant. In the social area, bar service in the pools, children's park, games room with screens on the ceiling bathrooms, function room, kitchen for events, fully equipped gym and more

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Top guest favorite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in San Felipe
4.99 out of 5 average rating, 206 reviews

The apartment of a legendary Panamanian footballer

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

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Superhost
Apartment in Panama City
4.75 out of 5 average rating, 121 reviews

Apartment in the Causeway Amador

Forget your worries in this spacious and serene space. Where you can enjoy the views of the Panama Canal and see the boats that pass through it, a space full of amenities with a perfect location, you can walk through the streets of the Causeway, visit the Biodiversity Museum, restaurants of various specialties, amusement park, bike rides etc, everything comes together to make this vacation an unforgettable experience for your whole family

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Top guest favorite
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Apartment in Bella Vista
4.92 out of 5 average rating, 176 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

ValueFamilyCheck-in

Guest favorite
A cozy sitting area is highlighted by a large window offering views of the vibrant plaza and cathedral. Two comfortable armchairs are positioned beside a small coffee table on a textured rug. Natural light fills the space, enhancing the warm tones of the wooden floor.
Apartment in San Felipe
4.91 out of 5 average rating, 129 reviews

The best view of the Old Town

Welcome to this charming accommodation located in the heart of Casco Viejo, on the third floor facing one of the most iconic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

ValueFamilyBathroom

Guest favorite
Apartment in San Francisco
4.98 out of 5 average rating, 164 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

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Guest favorite
Apartment in Panama City
4.89 out of 5 average rating, 9 reviews

Luxury Apartment | Walk to Restaurants & Shops

✔️ Superhost | Yoo Panama 🇵🇦 🏙️ Enjoy an exclusive apartment designed by Philippe Starck, with spectacular views of the bay and a prime location on Av. Balboa. 🌊 ✨ It has Wi-Fi, Smart TV, equipped kitchen, A/C, queen-size bed and private bathroom. 🏊‍♀️ Access to resort-style pool, gym, spa, restaurant, parking, and 24/7 security. 🆔 Only pre-registered guests with ID may enter.

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Guest favorite
Apartment in Panama City
5.0 out of 5 average rating, 15 reviews

Ocean View, Panama City

Stunning views of the ocean and the Old Town, with direct access to the Poin Panamá resort, as well as a variety of dining options and bars, for an unparalleled vacation experience. ⚠️ Important notice: The building's pool and gym will be temporarily closed for maintenance from August 24 to September 15, 2026. Thank you for your understanding.

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Top guest favorite
Apartment in Panama City
4.96 out of 5 average rating, 179 reviews

LUXURY APT/Ocean View & Rooftop

Modern luxury apartment on the Cinta Costera, ideal for executives, couples or families. Large bedroom with ocean view, private bathroom, kitchen and appliances. Elegant design with 24/7 security, gym, swimming pools, 4 restaurants, bar and Sky Lounge. Prime location near supermarkets and excellent cuisine in Panama City. PANAMA

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Popular amenities for Panama City apartment rentals

Destinations to explore