House vacation rentals in Upstate South Carolina

The Greenville Nest - Retreat & Relaxation Home

This beautifully one-level home offers 3 queen beds and 2 baths, accommodating up to 6 guests. Centrally located in a peaceful neighborhood. 8-minute drive to GSP airport, 15-minute drive to downtown Greenville, minutes from I-85/385, and minutes from Woodruff and Pelham Rd. You'll appreciate the easy access to food delivery and restaurants. Enjoy a stylish Experience for entertaining, working, and relaxing with high-speed Wi-Fi. Quiet and safe with an enjoyable private screened porch and Grill.

Atrium House - Spa Retreat

Come unwind and breathe at our couples mountain spa retreat. Atrium House has been designed to feel open to the lovely mountain surroundings yet let you relax in privacy. Our outdoor therapy hot tub, indoor/outdoor gas fireplace, and spacious two-person, walk-in shower make for a getaway so tranquil, you may never make it in to nearby Asheville! We're out in the country but just over a 15-minute drive from downtown Asheville, Biltmore, Hendersonville, Asheville Airport, and dozens of breweries.

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Cabin I Private hiking trails | Hot Tub I Sauna

Welcome to your private mountain escape in Lake Toxaway, NC! This 1-bedroom, 2-bathroom cabin is a one-of-a-kind retreat, offering breathtaking sunset views, a peaceful wooded setting, and unique architectural details. Unwind in the hot tub under the stars, relax in the sauna, challenge your partner to air hockey, or cozy up by the fire pit—all while enjoying the beauty of nature. Plus, enjoy exclusive access to 3 miles of private hiking trails, perfect for exploring the great outdoors!

3BR Retreat Near Augusta Rd & Downtown w/ Patio

Tucked away just off Augusta Rd near Downtown Greenville, Flora Sanctuary is your custom oasis to relax and recharge. At our home, you are less than 2 miles from I-85 for easy access to all the upstate has to offer. Our home is thoughtfully designed to provide an upscale experience for our guests both inside and out. We are: ~Less than a mile from Greenville Country Club Chanticleer Golf Course ~Less than 5 miles from N Main St and Falls Park ~5 miles from Bon Secours Wellness Arena

The Little White House

Kick back and relax in our newly built guest house. We have put a lot of thought and effort into our space for you to have a comfortable stay. Enjoy a country living feel while being just minutes from shopping, restaurants, and the hospital. The host also live behind the property should you need anything. No pets. No smoking. This space is for paying guest only. No parties! We also have a 2nd listing in Greenwood- The Cottage @ Hill & Dale. *OWNER IS A LICENSED REAL ESTATE AGENT.

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Ultra Luxury Downtown House, Voted GVL's #1 AirBnb

Walking distance to everything, yet quiet at night. Luxury downtown living. Gourmet kitchen with chef appliances and wine fridge, living area with flat screen TV, one king bedroom and twin bedroom (2 beds) and bath. Ample parking for guest (Rare for downtown). Perfect accommodation for couples or business travelers. Walking distance to restaurants and bars, grocery store and drug store in central business district. Half bath is located in the garage.

Lana’s Cottage

Welcome to our cozy cottage in historic Abbeville. We are in a quiet and family friendly neighborhood. This home comfortably sleeps six adults. The kitchen is fully stocked and is perfect for making a cup of coffee to cooking a full meal! There’s a smart TV with fast internet to be able to access your favorite streaming service. We are 1 mile from groceries and your choice of local restaurants. We are delighted to host you in our home.