House vacation rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Superhost

Home in Panama oeste

5 out of 5 average rating, 6 reviews

Cómoda casa en la Naturaleza de Panamá Pacifico

La casa tiene mucha luz y ventilación natural. En la planta baja encontraras la cocina completamente equipada, muy luminosa y lista para cocinar las mejores recetas. La casa esta justo frente al bosque, asi que todos los días podrás ver loros, tucanes, pequeños monitos, ñeques y otros animalitos. El vecindario es privado tiene ciclovias que te permiten llegar desde la casa hasta el supermercado, ferreteria, farmacia, restaurantes y más. Ademas a solo 10 minutos en auto está la playa Veracruz

Top guest favorite

Home in Panama City

5 out of 5 average rating, 30 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Superhost

Home in Punta Pacifica

4.74 out of 5 average rating, 88 reviews

Amplia Residencia Privada en Excelente Zona

Casa en las mejores zona del país. Calle muy tranquila, céntrico, cerca de Restaurantes, Farmacias, Mall entre otros. Amplia Residencia cómoda para grupos o Familias. Estacionamiento Privado de hasta 2 autos 4 Recamaras espaciosas , 2 cómodos estudios, Sala Comedor, Desayunador, Amplia Terraza. *Opcion Kosher Disponible* House in one of the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

Superhost

Home in Panamá

5 out of 5 average rating, 3 reviews

Airbnb - Tropical Vacation!

Welcome to the private tropical Villa | Jardín del Edén, which is located in the center of the country resort - "Quintas de Cabuya" - one of the unique ecological and geographical places of Panama🇵🇦. Our guests have the opportunity to spend a wonderful vacation close to sunny beaches 🏖, mountains 🗻, rivers🌊 , forests 🌴, national parks 🌳, hot springs and many other interesting places to visit. 60 miles (100км) away from airport Tocumen (PTY) and downtown of city of Panama.

Superhost

Home in Panamá

4.88 out of 5 average rating, 8 reviews

Charming House in Casco Viejo

This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

Guest favorite

Home in Panama City

4.92 out of 5 average rating, 12 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Superhost

Home in Panamá

4.89 out of 5 average rating, 9 reviews

Cómodo y lujoso apartamento

Disfruta de una experiencia con estilo en nuestro alojamiento en el Casco Antiguo, aprovecha la ubicación cercana a galerías de arte, restaurantes, artesanías,etc. Nuestra casa cuenta con tres habitaciones cada una con balcón, baño y closet, con una bonita cocina contemporánea equipada; una amplia sala y comedor , zona de labores. Cuentas con un area total de 326 mts² Toda la casa rodeada de balcónes donde puedes disfrutar de las vistas panorámicas.

Top guest favorite

Home in Panama City

4.8 out of 5 average rating, 103 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Top guest favorite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 210 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favorite

Home in Panamá

4.92 out of 5 average rating, 109 reviews

Spacious accommodation with ocean views

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Superhost

Home in Panamá

4.89 out of 5 average rating, 47 reviews

Unique 4 room house - direct access to the beach

Incredible newly renovated villa with the best location and views of the entire Old Town. There is no villa that is better located, with the sea at your feet and being able to enjoy the beach. Enjoy the best property in all of Casco Viejo, on the golden mile, on the beachfront. You will enjoy the best sunrises and sunsets, turning the sky completely pink and seeing the Panama Canal.

Superhost

Home in San Miguelito

4.83 out of 5 average rating, 12 reviews

Gorgeous 3bed near panama city & airport

This memorable place is anything but ordinary. This stylish place is perfect for group of persons or family trips. Conveniently located next to shopping malls and supermarkets you’re literally minutes from the train station and just minutes to the city. San Antonio is a safe place for families. Enjoy a cozy silent place with everything you can need for your stay.