Guesthouse vacation rentals in Panama City

4.76 out of 5 average rating, 240 reviews

Garden Cottage in city center

Cozy Private Cottage in Panama City Enjoy a comfortable stay in this charming garden cottage located in a central area of Panama City. With a private entrance, garden, and outdoor barbecue area, you'll have everything you need for a perfect getaway. The property features WiFi, smart TV, air conditioning, a double bed, and a sofa bed in the living room, as well as a fully equipped kitchen and bathroom. It also includes a washer and dryer for your convenience Perfect for an unforgettable escape

Airbnb - Wonderful Vacation!

Welcome to the private tropical Villa | Jardín del Edén, in the center of the country resort - "Quintas de Cabuya" - one of the unique ecological and geographical places of Panama🇵🇦 Our guests have the opportunity to spend a wonderful vacation surrounded by sunny beaches 🏖, mountains 🗻, rivers💦 , forests 🌴, national and bio parks🐒, hot springs, volcanic lakes and many other interesting places to visit. 100 km from Tocumen PTY airport and downtown of Panama City and 50m above sea level.

4.91 out of 5 average rating, 35 reviews

Home Harmony 15 min. Aeropuerto.

"Experimenta una estancia cómoda y conveniente en nuestro acogedor apartamento, ubicado a solo 10 minutos del aeropuerto Tocumen. Equipado con todas las comodidades necesarias para tu descanso, desde conexión WiFi hasta una cocina equipada, este espacio te ofrece la oportunidad de relajarte y recargar energías. Disfruta del confort del aire acondicionado, agua caliente/fria en el baño, una cama y sofá cama para tu comodidad, televisión con cable , y toallas y sobrecama para tu conveniencia.

Guesthouse in Panama City

4.73 out of 5 average rating, 82 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Trendy Tiny Apartment in Ancon

Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

4.75 out of 5 average rating, 4 reviews

The Black Studio near airport & city

This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Guesthouse in El Cangrejo

4.88 out of 5 average rating, 17 reviews

Charming Urban Retreat with Private Green Oasis

A peaceful, art-filled retreat in the heart of El Cangrejo. This ground-floor apartment features a private green yard — perfect for relaxing or spotting hummingbirds. There is an outdoor furniture dining set (available upon request). Steps from cafés, galleries, parks, and nightlife, yet quiet and tucked away. Only one neighbor on site. Thoughtfully decorated with pieces from local artisans. Watch the video: “El Cangrejo – Unique Oasis Apartment” on YouTube.

4.47 out of 5 average rating, 15 reviews

Convenient, centrally located suite with parking

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

4.93 out of 5 average rating, 41 reviews

CASA PINO, a forest in the city

Excellent independent studio apartment with everything you need, private bathroom, kitchenette, fridge, and WiFi. Very safe. You can use machines in the park to exercise. We are located in a privileged area on the banks of the Canal, with lots of vegetation and forests, but very close to all the recreational amenities of the City of Knowledge. Very central, 10 minutes by metro-bus to Albrook Mall, 10 minutes from the Panama Canal.

4.94 out of 5 average rating, 16 reviews

Guesthouse in Veracruz

2 bedrooms in tropical garden

Quiet sleep surrounded by lush greenery 20 minutes from Panama spacious accommodation suitable for 2 couples or family of 4 people 1 queen bed and 2 twins with each en-suite private bathroom, provision of an umbrella bed Rest room hammock , equipped kitchen dining room, a saltwater pool to entertain you facing the ocean whose only users you are surrounded by a large garden Workspace with fast wifi Water sports, hiking nearby

Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City

5 out of 5 average rating, 26 reviews

Apartment in a safe residential area

You will be Close to everything when you stay in this central home. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, on the way to Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether traveling for business, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We're available if you need any additional information.