
Family-friendly vacation rentals in Seneca
Find and book unique family-friendly homes on Airbnb
Quick stats about vacation rentals that are family-friendly in Seneca

Total vacation rentals
Explore 50 vacation rentals in Seneca

Nightly prices starting at
Seneca vacation rentals start at G$16,702 GYD per night before taxes and fees

Verified guest reviews
Over 1,560 verified reviews to help you choose

Pet-friendly vacation rentals
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
50 of Seneca vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Seneca rentals

4.9 Average rating
Seneca stays are highly rated by guests—averaging 4.9 out of 5!
Top-rated family-friendly rentals in Seneca
Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

Hanover Haven 3 BR/2 Bath
Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.
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Farm Geodome Near Lake Jocassee, Hot Tub, Zip Line
Glamping: where luxury meets the outdoors. This geodesic structure offers a rare opportunity to experience the outdoors without the elements. Complete with kitchen, AC & heat, dual control heated mattress pad, fully functioning bathroom, and sunrise views over the pasture. Whether you are looking to relax and enjoy feeding the farm animals, have an adventure riding the zip line, or indulge in a romantic evening sipping wine in the hot tub under the stars, you will leave with lasting memories.
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Clemson Mom Apartment
Roomy 1 bedroom, 1 bath apartment in Seneca, SC. Approximately 2.5 miles from Wal-Mart and 2 miles from Waffle House. 9 miles from Clemson football stadium. Excellent location with a short drive to restaurants, shopping, 3 24-hour gyms, and grocery stores. Located in a quiet subdivision with minimal traffic. This is the perfect spot, close to Seneca, but away from highly trafficked areas. Great for a working adult and quiet enough during the day for someone working third shift to sleep.
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Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.
KitchenIndoor spacesBiking

Lake Keowee Cabin: Peaceful and Bright
Welcome to Lizard Lodge. Relax in this quaint lake cabin with a mountain home vibe nestled in Northern Seneca on Lake Keowee. Enjoy the serenity of a beautifully modern 3-bedroom, 2.5 bath vacation cabin in a quiet gated cul-de-sac with scenic surroundings. On early mornings you can spot wildlife including deer and wild turkeys. Excellent location on the lake a few hundred feet away from a boat ramp. Come to relax, have fun on the lake or even enjoy a romantic escape.
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Clemson- 5 Min | Hot Tub | Game Room | 5 King Beds
5 minutes to Clemson University & Lake Keowee with a private saltwater hot tub, full arcade-style game room and stocked bar—perfect for families or game-day groups! 4 spacious bedrooms, 7 total beds High-speed Wi-Fi & smart TVs in every room Outdoor deck with grill, fire-pit & cornhole Fully equipped kitchen + coffee bar Rated 4.9★ by 171 guests and hosted by a local husband/wife team who lives nearby for quick help. Book your Clemson retreat today—dates fill fast!
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Singing Pines Cottage
Right among the pines of South Carolina you will find our cottage. It's 5 minutes from the Historic Ram Cat Alley with Live Outdoor music every Thursday Night (Apr.-Oct.), Shopping, Boutiques, Restaurants, Breweries, and Coffee Shops. It's only 12 minutes from Clemson University, and a short drive to Lake Keowee, Lake Jocassee, and Lake Hartwell. This area is home to numerous Waterfalls, Hiking Trails, and good southern barbecue. We do not host work crews.
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Oak Hill Getaway
Right between Seneca and Clemson you will find our getaway. It's 5 mins from Historic Ram Cat Alley with shopping, restaurants, and breweries with Jazz on the Alley music every Thursday night (April - Oct.) It's only 10 minutes from Clemson University. Surrounded by 3 different lakes Jocassee, Keowee, and Hartwell with just a short drive away. You can ride 30 mins up to the mountains where you can hike trails and see waterfalls the foothills have to offer.
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The Cottage
Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.
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Tiny house
BRAND NEW 490 sq ft tiny house/cottage nestled in the woods in a country setting. Complete with a queen bedroom, a twin/day bed and then a queen bed in loft ( comfortably sleeps 4 adults and one child). We are conveniently located 10 miles from I-85 exit 1 on S Hwy 11. 20 minutes from Clemson, 8 minutes from Seneca, and just a short drive to many hiking trails, lakes and parks in the beautiful foothills of the Blue Ridge mountains.
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5 Min to Clemson | Large Driveway & Self Check-In
Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.
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Perfect Lake Hartwell Getaway! Gorgeous Views!
Lake living at its best: Amazing views, deep water with a perfect location steps from the shoreline and for you Tiger fans this property is ten minutes from Clemson. Waterfront point lots that are this close to the water are extremely rare. This house is only a very short ride from Clemson Marina and the Walker Course. Gorgeous Sunsets from the dock!
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Popular amenities for Seneca family-friendly rentals
Family-friendly home rentals with a hot tub

Keowee Key Luxury Condo - Stunning Views!
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Lake Keowee, Waterfront Cabin, 2-Story Dock!
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Hidden Lake Sanctuary
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YOUR OWN Waterfall+Hot Tub+Fire Pit+Sauna
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A Lakefront Tiny Cabin • Hot Tub • Kayaks • Canoe
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Shady Rest
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Hardystone LakeHouse Hot Tub & Double Decker Dock!
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A-Frame Lake Hartwell Cottage w/ Hot Tub
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Family- and pet-friendly home rentals

Hartwell Escape 6 mi to Clemson Beautiful views
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The House on Oak Grove
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Getaway on Lake Hartwell: Pontoon Rental, Clemson
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Perfect 2 bed, remodeled home in quaint Pendleton
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Lake Hartwell house w/ dock 2 miles from Clemson.
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Beautiful Lake Keowee Condo with great Amenities
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Renfrow's Retreat
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Clemson Lake Hartwell Waterfront, Pontoon Rental
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Family-friendly home rentals with a pool

Quiet 3-bedroom Cottage at Lake Hartwell
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Clemson Cedarwood Condo with a Deck
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Lakefront 2BR+/2BA w/ a Dock On Lake Hartwell
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Pet-Friendly Retreat • Hot Tub • Fenced Yard
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Lisa’s Lodge
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Close to campus Clemson Condo
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Perfect Tigertown Condo
Indoor spacesFamilyComfort

Clemson Getaway with Sunset Views of Lake Keowee
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- Clemson University
- Table Rock State Park
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- Black Rock Mountain State Park
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- Bell Mountain
- DuPont State Forest
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- Jump Off Rock
- Fred W Symmes Chapel
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