Lake house vacation rentals in Seneca

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Top-rated lake house rentals in Seneca

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Guest favorite
A serene view of the cove showcases calm blue waters bordered by lush greenery and trees. Several boats are docked at a wooden pier, with homes visible along the shoreline. Fluffy clouds drift in a clear blue sky above this tranquil scene.
Home in Seneca
4.89 out of 5 average rating, 79 reviews

Peaceful Lake Keowee Waterfront Home ~Near Clemson

Live out your lake dreams at this 3/3 conveniently located 5 minutes to downtown Seneca!! Swim in the beautiful Keowee water right off private dock with direct access from backyard. Bring your boat or explore Lake Keowee in 2 available kayaks. Enjoy outdoor dining on the deck overlooking the lake, cooking in the open kitchen, grilling out in the backyard, or enjoying the fire pit. Separate downstairs suite with private access. Only 7 miles from Clemson and down the street from the Keowee Marina

Top guest favorite
The image showcases a serene lakefront view featuring a newly renovated cottage framed by lush greenery. A wooden dock extends into the calm water, providing a peaceful area to relax. The cottage's warm exterior is complemented by the surrounding trees, enhancing the natural setting.
Home in Seneca
5 out of 5 average rating, 124 reviews

Modern Lake Vibes – Kayaks, Dock & Fireplace

The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Guest favorite
A shaded area features several dark adirondack chairs arranged around a central table, overlooking the serene lake. A large, soft-colored umbrella provides protection from the sun, enhancing the tranquil lakeside setting surrounded by lush greenery.
Home in Martin
4.88 out of 5 average rating, 129 reviews

Lake-House Escape w/Dock, Kayaks, Paddleboards

Gather family or friends for an unforgettable lakeside getaway in a spacious, amenity-loaded lake house in an ultra-private setting. Your group will have a great time on the dock using provided kayaks and paddleboards, fishing, swimming, and more. Bring or rent a boat. Relax on the lakefront screened porch and multiple indoor/outdoor gathering spots. Kids and adults will love watching movies and playing foosball in the game room. Make memories around your choice of beachside or stone firepit.

Superhost
A wooden dock extends across the calm water, leading toward a lush green shoreline. The surface of the lake reflects the blue sky, while gentle ripples are visible. Surrounding trees contribute to a serene natural setting.
Home in Seneca
4.84 out of 5 average rating, 255 reviews

Cozy Lake House 5 miles from Clemson w Dock

Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

Guest favorite
A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.
Home in Seneca
4.95 out of 5 average rating, 199 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Top guest favorite
A single-story home is showcased, featuring a smooth driveway that leads to a covered front porch. Brightly colored chairs are placed on the porch, surrounded by landscaped shrubs. Tall trees provide a lush backdrop, creating a serene and inviting setting.
Home in Seneca
4.97 out of 5 average rating, 160 reviews

Lake Hartwell house w/ dock 2 miles from Clemson.

This is a simple, comfortable, recently renovated home for Clemson fans and lake vacationers. Decor is vintage/antique. It is 3 1/2 miles to stadium entrance. We have a deep water cove with fire ring, decks, dock, and stairs to gangway, parking for 6 cars, woods and lake on 3 sides, a variety of restaurants nearby. Clemson Marina is next cove over. Clemson golf course across the lake. We are PET FRIENDLY with a max of 2 dogs. There is a $75 pet fee. Read the house rules concerning pets.

Guest favorite
Home in Seneca
5 out of 5 average rating, 14 reviews

Clemson Games + Lake Keowee

Come stay at this new construction home in a Lake Keowee neighborhood, only 8 miles from Clemson and to Death Valley. Whether you're seeking convenient access to Clemson for college activities, such as move-in move out for students, game weekends, or to enjoy Lake Keowee this house is the perfect fit! This house offers plenty of amenities during your stay such as blackout curtains in all the bedrooms, a privacy fence in the backyard for barbecuing, and a ping-pong table in the garage! 

Guest favorite
A spacious sunken living area features a large brick fireplace as a central focal point, flanked by two inviting seating arrangements. Natural wood beams extend across the ceiling, and light fills the space through multiple large windows, creating a warm and welcoming environment.
Home in Seneca
4.93 out of 5 average rating, 70 reviews

Lakefront Mid-Century Dream Home / 3 mi to Clemson

We excitedly invite you to come enjoy a one of a kind experience at our personal lakefront home. Originally designed and built in the 60s, this home now has all the modern necessities, yet still brims with endless midcentury charm. Located only 3 miles from Clemson, our large outdoor entertainment space and direct access to our private dock invite you to enjoy the many sights and sounds that the lake has to offer. Use our 2 kayaks and canoe, or use the dock to tie up your own boat!

Guest favorite
The exterior of the home is illuminated by string lights, creating a warm ambiance. A set of red adirondack chairs is positioned in the foreground, facing the entrance steps. Soft garden lighting highlights the landscaping, enhancing the inviting atmosphere of the outdoor space.
Home in Townville
4.98 out of 5 average rating, 150 reviews

Hartley’s Haven

Enjoy your stay in this cozy 1 bedroom and 1 bathroom home on Lake Hartwell. We are located 20 minutes from Clemson, 15 minutes to Anderson, and 40 minutes to Greenville, so there is plenty in the area to keep you busy. Located on a dead end street, the neighborhood is very quiet. Our home also has fast wifi and 2 smart TV’s to access any streaming service. We also provide cable. With plenty of parking space in the driveway for vehicles and a boat we can provide a peaceful getaway.

Top guest favorite
Home in West Union
4.93 out of 5 average rating, 137 reviews

Hidden Lake Sanctuary

Recently remodeled and boasting 3000 sq ft, this home offers comfort and serenity. Tucked away in a peaceful cove feeding into Lake Keowee, it’s the perfect escape for nature lovers-especially kayakers. The property comes fully equipped with kayaks and paddle boards. Please note: Access to the dock involves a very steep descent, and the return hike can be challenging—best suited for active guests. Unwind in the private hot tub on the deck or gather around the cozy fire pit.

Guest favorite
A serene lakeside area features a green lake surrounded by tall trees. Cozy seating is arranged around a fire pit, with a pathway leading to a private dock. The calm water reflects the greenery, creating a peaceful outdoor environment.
Home in Seneca
5 out of 5 average rating, 8 reviews

Sweet Tea Retreats

We're tickled pink that you are considering Sweet Tea Retreats, a Southern themed Lakefront duplex on Lake Keowee. Clemson Stadium is only 7 miles away! Two separate 2 bedroom 2 bath apartment suites total of 4 bedrooms with 4 en-suite bathrooms, accommodations up to 6 guests. This listing is for both apartment suites, they have been fully renovated with new kitchens and bathrooms, granite and marble countertops and stainless steel appliances.

Guest favorite
Aerial view of The Landing Spot surrounded by lush greenery and trees, with a glimpse of Lake Keowee in the background. The single-story home is situated on a spacious lot with a winding driveway, offering a sense of seclusion while remaining accessible to nearby roads.
Home in Seneca
4.93 out of 5 average rating, 41 reviews

The Landing Spot

As seen on House Hunters!!!The Landing Spot is your Lake Keowee getaway—just a short walk to the marina with boat rentals, a lakeside restaurant, bar, and more. Close to public beaches, hiking, and downtown Seneca, yet tucked away under dark, starry skies. Game room, digital check-in, and room to relax. Clemson is just 20 minutes away, perfect for visits and game days. A laid-back space for families and friends to enjoy lake life and unwind.

Popular amenities for Seneca lake house rentals