Lake house vacation rentals in Seneca

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Top-rated lake house rentals in Seneca

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

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Top guest favorite
A single-story home is showcased, featuring a smooth driveway that leads to a covered front porch. Brightly colored chairs are placed on the porch, surrounded by landscaped shrubs. Tall trees provide a lush backdrop, creating a serene and inviting setting.
Home in Seneca
4.96 out of 5 average rating, 164 reviews

Lake Hartwell house w/ dock 2 miles from Clemson.

This is a simple, comfortable, recently renovated (2019) home for Clemson fans and lake vacationers. Decor is vintage/antique. It is 3 1/2 miles to stadium entrance. We have a deep water cove with fire ring, decks, dock, and stairs to gangway, parking for 6 cars, woods and lake on 3 sides, a variety of restaurants nearby. Clemson Marina is 1 cove away. Clemson golf course is across the lake. We are PET FRIENDLY with a max of 2 dogs. There is a $75 pet fee. Read the house rules concerning pets.

Guest favorite
A serene view of the cove showcases calm blue waters bordered by lush greenery and trees. Several boats are docked at a wooden pier, with homes visible along the shoreline. Fluffy clouds drift in a clear blue sky above this tranquil scene.
Home in Seneca
4.88 out of 5 average rating, 83 reviews

Peaceful Lake Keowee Waterfront Home ~Near Clemson

Live out your lake dreams at this 3/3 conveniently located 5 minutes to downtown Seneca!! Swim in the beautiful Keowee water right off private dock with direct access from backyard. Bring your boat or explore Lake Keowee in 2 available kayaks. Enjoy outdoor dining on the deck overlooking the lake, cooking in the open kitchen, grilling out in the backyard, or enjoying the fire pit. Separate downstairs suite with private access. Only 7 miles from Clemson and down the street from the Keowee Marina

Top guest favorite
The image showcases a serene lakefront view featuring a newly renovated cottage framed by lush greenery. A wooden dock extends into the calm water, providing a peaceful area to relax. The cottage's warm exterior is complemented by the surrounding trees, enhancing the natural setting.
Home in Seneca
5.0 out of 5 average rating, 130 reviews

Modern Lake Vibes – Kayaks, Dock & Fireplace

The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Guest favorite
A private dock extends over a calm lake, illuminated by lights reflecting off the water's surface. The moon hangs in the sky, casting a gentle glow. Surrounding trees provide a natural backdrop, enhancing the serene evening atmosphere.
Home in Townville
4.93 out of 5 average rating, 188 reviews

Zoey’s Cottage on Lake Hartwell w/dock- Secluded

This cozy charming and quiet lake property is the perfect getaway for families & friends . Located 5 minutes off I-85 and is 10 minutes to Green pond Landing, 20 minutes to Clemson, Anderson and Seneca. Perfect place to enjoy fishing, shopping and Clemson football games, Enjoy using the back porch to view the sunrise over lake Hartwell and the wildlife as it pass through. The porch is a nice relaxing cozy place where you can enjoy your coffee or a glass of wine while watching the lake glisten.

Guest favorite
A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.
Home in Seneca
4.95 out of 5 average rating, 204 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Top guest favorite
Home in Seneca
5.0 out of 5 average rating, 56 reviews

Johnsons Cove - Lakefront Retreat With EV Charger

Welcome to Johnsons Cove - Lakeside Retreat! Home with over 400 feet of deep water, private lake frontage. This listing comes equipped with a full-sized dock, four kayaks, and a lily pad. Life vests are supplied in a variety of sizes for your safety. A unique boat ramp is on the property only for non-motorized watercrafts. There is a small sandy beach for easy access to walk into the lake. This quiet cove is perfect for swimming around the dock. Don't miss out on this special location!

Guest favorite
Home in Seneca
4.96 out of 5 average rating, 28 reviews

Lakefront Home w/Deep Water Dock 20 min to Clemson

Welcome to the King of Harts! Our 4 BR/2BA home on Lake Hartwell has a deep water, covered dock with electricity that is only 20 minutes to Clemson, 15 minutes to Seneca, and less than 1 hour from many amazing waterfalls and hiking trails in the blue ridge. Two kayaks included for exploring the cove! The house has been updated with cozy furnishings, fast wi-fi, and a 70 inch TV in the living room so can feel like you're at the game when you're actually just steps away from the lake!

Guest favorite
A spacious sunken living area features a large brick fireplace as a central focal point, flanked by two inviting seating arrangements. Natural wood beams extend across the ceiling, and light fills the space through multiple large windows, creating a warm and welcoming environment.
Home in Seneca
4.93 out of 5 average rating, 73 reviews

Lakefront Mid-Century Dream Home / 3 mi to Clemson

We excitedly invite you to come enjoy a one of a kind experience at our personal lakefront home. Originally designed and built in the 60s, this home now has all the modern necessities, yet still brims with endless midcentury charm. Located only 3 miles from Clemson, our large outdoor entertainment space and direct access to our private dock invite you to enjoy the many sights and sounds that the lake has to offer. Use our 2 kayaks and canoe, or use the dock to tie up your own boat!

Guest favorite
Home in Seneca
4.95 out of 5 average rating, 21 reviews

Lakefront Getaway~Dock~Fire Pit~Kayak & Games!

This 4-bedroom home is in a prime location & has EVERYTHING you need for an amazing vacation in Seneca, SC! • Screened-in Porch w/ Fireplace + Outdoor TV • Dock, Kayak & Paddles! • Fire Pit • Outdoor Patio/Dining • BBQ Grill • Board Games • Fully Stocked Kitchen • Keurig & Drip Coffee Maker • Indoor Fireplace • Family Friendly- Pack n Play & High Chair • Ample Parking • Washer & Dryer • No trailers or boats allowed to be parked on site for more than 5 hours.

Guest favorite
A serene lakeside area features a green lake surrounded by tall trees. Cozy seating is arranged around a fire pit, with a pathway leading to a private dock. The calm water reflects the greenery, creating a peaceful outdoor environment.
Home in Seneca
4.92 out of 5 average rating, 13 reviews

Sweet Tea Retreats

We're tickled pink that you are considering Sweet Tea Retreats, a Southern themed Lakefront duplex on Lake Keowee. Clemson Stadium is only 7 miles away! Two separate 2 bedroom 2 bath apartment suites total of 4 bedrooms with 4 en-suite bathrooms, accommodations up to 6 guests. This listing is for both apartment suites, they have been fully renovated with new kitchens and bathrooms, granite and marble countertops and stainless steel appliances.

Guest favorite
Aerial view of The Landing Spot surrounded by lush greenery and trees, with a glimpse of Lake Keowee in the background. The single-story home is situated on a spacious lot with a winding driveway, offering a sense of seclusion while remaining accessible to nearby roads.
Home in Seneca
4.93 out of 5 average rating, 42 reviews

The Landing Spot

As seen on House Hunters!!!The Landing Spot is your Lake Keowee getaway—just a short walk to the marina with boat rentals, a lakeside restaurant, bar, and more. Close to public beaches, hiking, and downtown Seneca, yet tucked away under dark, starry skies. Game room, digital check-in, and room to relax. Clemson is just 20 minutes away, perfect for visits and game days. A laid-back space for families and friends to enjoy lake life and unwind.

Guest favorite
Home in West Union
4.93 out of 5 average rating, 143 reviews

Hidden Lake Sanctuary

Recently remodeled with over 3,000 sq ft of comfortable living space, this peaceful retreat is tucked away in a quiet cove. Enjoy a large, fully stocked kitchen, spacious private deck, and relaxing hot tub. The property includes 2 kayaks and 2 paddleboards for exploring the cove. The path to the private dock is steep and best suited for active guests. Bringing a boat? A nearby public launch makes it easy to get out on the lake.

Popular amenities for Seneca lake house rentals