Lake house vacation rentals in Seneca

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Top-rated lake house rentals in Seneca

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Top guest favorite
The image showcases a serene lakefront view featuring a newly renovated cottage framed by lush greenery. A wooden dock extends into the calm water, providing a peaceful area to relax. The cottage's warm exterior is complemented by the surrounding trees, enhancing the natural setting.
Home in Seneca
5 out of 5 average rating, 124 reviews

Modern Lake Vibes – Kayaks, Dock & Fireplace

The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Superhost
A wooden dock extends across the calm water, leading toward a lush green shoreline. The surface of the lake reflects the blue sky, while gentle ripples are visible. Surrounding trees contribute to a serene natural setting.
Home in Seneca
4.84 out of 5 average rating, 255 reviews

Cozy Lake House 5 miles from Clemson w Dock

Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

Guest favorite
A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.
Home in Seneca
4.95 out of 5 average rating, 199 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Superhost
Home in Six Mile
4.83 out of 5 average rating, 268 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Top guest favorite
A single-story home is showcased, featuring a smooth driveway that leads to a covered front porch. Brightly colored chairs are placed on the porch, surrounded by landscaped shrubs. Tall trees provide a lush backdrop, creating a serene and inviting setting.
Home in Seneca
4.97 out of 5 average rating, 160 reviews

Lake Hartwell house w/ dock 2 miles from Clemson.

This is a simple, comfortable, recently renovated home for Clemson fans and lake vacationers. Decor is vintage/antique. It is 3 1/2 miles to stadium entrance. We have a deep water cove with fire ring, decks, dock, and stairs to gangway, parking for 6 cars, woods and lake on 3 sides, a variety of restaurants nearby. Clemson Marina is next cove over. Clemson golf course across the lake. We are PET FRIENDLY with a max of 2 dogs. There is a $75 pet fee. Read the house rules concerning pets.

Guest favorite
Home in Seneca
5 out of 5 average rating, 14 reviews

Clemson Games + Lake Keowee

Come stay at this new construction home in a Lake Keowee neighborhood, only 8 miles from Clemson and to Death Valley. Whether you're seeking convenient access to Clemson for college activities, such as move-in move out for students, game weekends, or to enjoy Lake Keowee this house is the perfect fit! This house offers plenty of amenities during your stay such as blackout curtains in all the bedrooms, a privacy fence in the backyard for barbecuing, and a ping-pong table in the garage! 

Guest favorite
Home in Seneca
4.96 out of 5 average rating, 23 reviews

Lakefront Home w/Deep Water Dock 20 min to Clemson

Welcome to the King of Harts! Our 4 BR/2BA home on Lake Hartwell has a deep water, covered dock with electricity that is only 20 minutes to Clemson, 15 minutes to Seneca, and less than 1 hour from many amazing waterfalls and hiking trails in the blue ridge. Two kayaks included for exploring the cove! The house has been updated with cozy furnishings, fast wi-fi, and a 70 inch TV in the living room so can feel like you're at the game when you're actually just steps away from the lake!

Guest favorite
A spacious sunken living area features a large brick fireplace as a central focal point, flanked by two inviting seating arrangements. Natural wood beams extend across the ceiling, and light fills the space through multiple large windows, creating a warm and welcoming environment.
Home in Seneca
4.93 out of 5 average rating, 70 reviews

Lakefront Mid-Century Dream Home / 3 mi to Clemson

We excitedly invite you to come enjoy a one of a kind experience at our personal lakefront home. Originally designed and built in the 60s, this home now has all the modern necessities, yet still brims with endless midcentury charm. Located only 3 miles from Clemson, our large outdoor entertainment space and direct access to our private dock invite you to enjoy the many sights and sounds that the lake has to offer. Use our 2 kayaks and canoe, or use the dock to tie up your own boat!

Top guest favorite
Home in West Union
4.93 out of 5 average rating, 137 reviews

Hidden Lake Sanctuary

Recently remodeled and boasting 3000 sq ft, this home offers comfort and serenity. Tucked away in a peaceful cove feeding into Lake Keowee, it’s the perfect escape for nature lovers-especially kayakers. The property comes fully equipped with kayaks and paddle boards. Please note: Access to the dock involves a very steep descent, and the return hike can be challenging—best suited for active guests. Unwind in the private hot tub on the deck or gather around the cozy fire pit.

Guest favorite
Home in Seneca
4.95 out of 5 average rating, 19 reviews

Lakefront Getaway~Dock~Fire Pit~Kayak & Games!

This 4-bedroom home is in a prime location & has EVERYTHING you need for an amazing vacation in Seneca, SC! • Screened-in Porch w/ Fireplace + Outdoor TV • Dock, Kayak & Paddles! • Fire Pit • Outdoor Patio/Dining • BBQ Grill • Board Games • Fully Stocked Kitchen • Keurig & Drip Coffee Maker • Indoor Fireplace • Family Friendly- Pack n Play & High Chair • Ample Parking • Washer & Dryer • No trailers or boats allowed to be parked on site for more than 5 hours.

Guest favorite
A serene lakeside area features a green lake surrounded by tall trees. Cozy seating is arranged around a fire pit, with a pathway leading to a private dock. The calm water reflects the greenery, creating a peaceful outdoor environment.
Home in Seneca
5 out of 5 average rating, 8 reviews

Sweet Tea Retreats

We're tickled pink that you are considering Sweet Tea Retreats, a Southern themed Lakefront duplex on Lake Keowee. Clemson Stadium is only 7 miles away! Two separate 2 bedroom 2 bath apartment suites total of 4 bedrooms with 4 en-suite bathrooms, accommodations up to 6 guests. This listing is for both apartment suites, they have been fully renovated with new kitchens and bathrooms, granite and marble countertops and stainless steel appliances.

Guest favorite
Aerial view of The Landing Spot surrounded by lush greenery and trees, with a glimpse of Lake Keowee in the background. The single-story home is situated on a spacious lot with a winding driveway, offering a sense of seclusion while remaining accessible to nearby roads.
Home in Seneca
4.93 out of 5 average rating, 41 reviews

The Landing Spot

As seen on House Hunters!!!The Landing Spot is your Lake Keowee getaway—just a short walk to the marina with boat rentals, a lakeside restaurant, bar, and more. Close to public beaches, hiking, and downtown Seneca, yet tucked away under dark, starry skies. Game room, digital check-in, and room to relax. Clemson is just 20 minutes away, perfect for visits and game days. A laid-back space for families and friends to enjoy lake life and unwind.

Popular amenities for Seneca lake house rentals