
House vacation rentals in Seneca
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Top-rated house rentals in Seneca
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Seneca house rentals
House rentals with a pool

VIEWS! 100+MB WIFI! firepit, private, convenient

Keowee Key Luxury Condo - Stunning Views!

Lake Hartwell: Private Pool, Dock, Pets, Fire Pit

Big House with Big Mtn Views, Golf & Pool Access

Peninsula Sunset View of Keowee

Lake Keowee Home near Clemson, boating, and hiking

Mountain Laurel Retreat

Enchanting 1906 Farmhouse
Weekly house rentals

The Skyline Way Lake House w/ Hot Tub & Dock!

Sunset Point-Best view on Broadway - HOT TUB!

Red Door Retreat on the Lake

Clemson ,Lake Hartwell, Waterfront, pontoon rental

lakefront Home with million dollar view

6+BR home with Mountain Views

Westwind Retreat Lake House

Happy Trails: Jacuzzi, Lookout Tower, Views!
Private house rentals

*Gorgeous Mtn Views, Fire Pit & Wine Cellar*

aunt helen's house

Relaxing On Riviera

<10 min to Main St~Hot Tub Coming May 2025~Pets

Peaceful Panorama, Breathtaking views, Firepit

Jess & Bailey's Easley Escape

Lake Hartwell Hideaway

Tugaloo Hideaway
Quick stats about house rentals in Seneca
Total rentals
30 properties
Nightly prices starting at
G$8,393 GYD before taxes and fees
Total number of reviews
1.5K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Destinations to explore
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- Black Rock Mountain State Park
- Table Rock State Park
- Tallulah Gorge State Park
- Gorges State Park
- Bell Mountain
- Jump Off Rock
- Tugaloo State Park
- Mountaintop Golf & Lake Club
- Don Carter State Park
- Ski Sapphire Valley
- Helen Tubing & Waterpark
- Old Edwards Club
- Funopolis Family Fun Center
- Anna Ruby Falls
- Wade Hampton Golf Club
- Haas Family Golf
- Discovery Island
- Victoria Bryant State Park
- Victoria Valley Vineyards
- Carl Sandburg Home National Historic Site