
House vacation rentals in Seneca
Find and book unique houses on Airbnb
Quick stats about house rentals in Seneca

Total vacation rentals
Explore 40 vacation rentals in Seneca

Nightly prices starting at
Seneca vacation rentals start at G$10,460 GYD per night before taxes and fees

Verified guest reviews
Over 1,930 verified reviews to help you choose

Family-friendly vacation rentals
30 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 20 rentals that welcome pets

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wi-Fi availability
40 of Seneca vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Seneca rentals

4.9 Average rating
Seneca stays are highly rated by guests—averaging 4.9 out of 5!
Top-rated house rentals in Seneca
Guests agree: these houses are highly rated for location, cleanliness, and more.

Lakeside Retreat • Pet friendly • Fire Pit
Wake up to peaceful lake views, sip coffee on the screened porch, and end your day in the hot tub under the stars. Dream Weaver Cottage is a private, pet-friendly lakeside retreat designed for families, friends, and four-legged travelers with a fenced yard, beach access, kayaks, and cozy gathering spaces. It’s the perfect place to relax and reconnect. Guest favorites: • Sandy beach & lake access • Luxury Hot Tub • Fully fenced yard for kids & dogs • Screened porch with lake views • Fire pit

Hanover Haven 3 BR/2 Bath
Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.

Hartwell Hideaway – Dock, Kayaks & Fire Pit
The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Cozy Lake House 5 miles from Clemson w Dock
Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

The Cozy Cottage
Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

The Cottage
Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.

Keowee Key Luxury Condo - Stunning Views!
Freshly renovated condo at the sought after Tall Ship condos in Keowee Key. This is hands down the best unit the complex has to offer with amazing views. Enjoy grilling out on the patio overlooking the marina, walking on the trail, or relax in the pool which is only a short walk away. This is truly a paradise. Guest boat slip is available at the marina for boats or jet skis. Slip is $50 per day. Recommended to book one month in advance.

Shady Rest
As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Getaway on Lake Hartwell: Pontoon Rental, Clemson
Our 3 bedroom house is located on Lake Hartwell and is just a 15 min drive to Clemson University. You can enjoy access to the dock and beach which are a quick golf cart ride away. We have paddle boards on the dock and kayaks, coolers, bagged ice, fishing poles etc upon request. Off the back of the detached garage there’s a furnished screened-in deck with a grill that overlooks the end of the cove and fire pit below.

5 Min to Clemson | Large Driveway & Self Check-In
Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.

The House on Oak Grove
Enjoy your time spent in this spacious and peaceful pet friendly space. Nicely appointed with everything you need for a short or long term stay. Ten easy miles to Clemson and 3 miles to SWU. Besides the open living space the house has a screened porch and accomodates 4 with 2 bedroom & 2 adjoining baths. The home includes washer & dryer, coffee bar, granite countertops, and microwave.
Popular amenities for Seneca house rentals
House rentals with a pool

Lakeside Retreat - 4BR/4BA Home

Hartwell Hideaway

Lakefront, Private Pool, Dock, Dog, Boats, FirePit

Lakeside Haven- Lake Hartwell, Sleeps 8

Pool + Hot Tub Oasis | Coastal Vibes Near AU

Golf view, lake access, 3 pools!

* Keowee Key* Lake* Fireplace*Golf*Tennis*Gym*

New Construction w/ Pool!
Weekly house rentals

Tee House... waterfront on beautiful Lake Keowee

Lakefront+Near Clemson+Dock+Kayaks+Putting Green

Cozy 2 bedroom in Walhalla

Johnsons Cove - Lakefront Retreat With EV Charger

Lake House Retreat Near Clemson

Frankie’s Place

Lake house

Coffee and Kayaks - 5 Bedroom Lakefront Retreat
Private house rentals

Pet-Friendly 5BR Getaway near Lake Keowee

Waterfall Cove - Prime

New Waterfront House with Big Views & Private Dock

The Black Brick

Mountain Rest Lake Becky Retreat

Anchor Point, Lake Retreat - Clemson, 2-story dock

Keowee Lakefront Home | Hot Tub, Kayaks, Dock!

3 BR House Near Clemson
When is the best time to visit Seneca?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | G$30,335 GYD | G$28,661 GYD | G$29,080 GYD | G$31,590 GYD | G$40,377 GYD | G$34,728 GYD | G$34,101 GYD | G$49,163 GYD | G$45,398 GYD | G$40,586 GYD | G$48,536 GYD | G$37,657 GYD |
| Avg. temp | 6°C | 8°C | 12°C | 16°C | 21°C | 25°C | 27°C | 26°C | 23°C | 17°C | 11°C | 7°C |
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- Pet-friendly rentals Seneca
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- Black Rock Mountain State Park
- Gorges State Park
- Table Rock State Park
- Tallulah Gorge State Park
- Clemson University
- Helen Tubing & Waterpark
- Bell Mountain
- Jump Off Rock
- Bon Secours Wellness Arena
- Anna Ruby Falls
- Unicoi State Park and Lodge
- Chattooga Belle Farm
- Carl Sandburg Home National Historic Site
- Falls Park On The Reedy
- Jones Gap State Park
- Dillard House Restaurant
- Fred W Symmes Chapel
- Devils Fork State Park
- DuPont State Forest
- Peace Center
- Paris Mountain State Park
- Looking Glass Falls
- Georgia Mountain Coaster
- Fluor Field at the West End




