Vacation rentals in Seneca

4.98 out of 5 average rating, 105 reviews

A length of coiled yellow rope is neatly hung beside a light fixture on a gray exterior wall. The ground features small gray rocks, contrasting with the white lower edge of the building.

Tiny home in Salem

The Meadow #4

Take it easy at this unique and tranquil getaway. We ask you to not bring pets during to allergies. We are 4 miles from Fall Creek Landing on Lake Keowee and 8 miles from Lake Jocassee Devils Fork StatePark. The bed is comfortable and the futon is also great for that extra person or children.Grab a drink or a cup of coffee and Sit on the porch or relax in the hammock. Play some corn hole. Hike our many waterfalls. Come enjoy our area. Self check in anytime after 1:00 pm. Check out is 11:00. Am

4.96 out of 5 average rating, 137 reviews

A spacious hot tub is situated on a wooden deck, surrounded by lush green trees. Soft string lights are visible overhead, adding a cozy touch. A potted fern adds a natural element to the inviting space, perfect for relaxation.

Camper/RV in West Union

Hot Tub, Firepit, Projector, No Extra Fees/Chores

Escape to this enchanting bear themed camper, nestled on a cozy one acre wooded lot. While another camper is nearby, a privacy fence creates your own peaceful haven. Soak in the hot tub on the covered deck, with a towel warmer and movie projector adding to the fun. Ideally located between three cities, you’re just minutes from shopping, dining, lakes, waterfalls, and scenic hiking trails. Cap off your evening by the firepit, roasting marshmallows under a starlit sky. Your serene getaway awaits!

4.87 out of 5 average rating, 134 reviews

Cottage in Townville

Waterfront cottage w/deep dock 17 miles to Clemson

Welcome to the Queen of Harts, our 2BR/1BA, waterfront cottage on Lake Hartwell w/private, deep water dock. The house is located on a quite street 25 min to Clemson. Interior has been remodeled including farmhouse kitchen sink, butcher block countertops, dishwasher, large bathroom, washer/dryer, and new furnishings. Enjoy beautiful sunsets on the dock or explore the cove on stand-up paddle boards included with rental. Other amenities include wi-fi, 55" Smart TV, charcoal grill, and fire pit.

4.99 out of 5 average rating, 105 reviews

Cottage in Seneca

Destination Keowee

A rustic industrial style Lake Keowee lakefront escape that places you right on a panoramic point in a private cove. Welcome the outdoors in with the 6ft kitchen hinge bar window to the upper deck or enjoy the 6-seat hot tub on lower deck. Deep water dock tie off space is available. Guests enjoy the use of 2 standup paddle boards, and lakeside fire pit (guest provide firewood). Great cove sunsets! 15 minutes to Clemson and 1 min Lighthouse Restaurant. Please read all details prior to booking!

4.95 out of 5 average rating, 168 reviews

A wall-mounted shelf holds four white mugs, each with a textured design. An artificial flower in a small vase rests beside the mugs. A coffee maker is positioned on the counter below, along with a compact refrigerator.

Apartment in Seneca

Clemson Mom Apartment

Roomy 1 bedroom, 1 bath apartment in Seneca, SC. Approximately 2.5 miles from Wal-Mart and 2 miles from Waffle House. 9 miles from Clemson football stadium. Excellent location with a short drive to restaurants, shopping, 3 24-hour gyms, and grocery stores. Located in a quiet subdivision with minimal traffic. This is the perfect spot, close to Seneca, but away from highly trafficked areas. Great for a working adult and quiet enough during the day for someone working third shift to sleep.

Superhost

A wooden dock extends across the calm water, leading toward a lush green shoreline. The surface of the lake reflects the blue sky, while gentle ripples are visible. Surrounding trees contribute to a serene natural setting.

4.85 out of 5 average rating, 221 reviews

Cozy Lake House 5 miles from Clemson w Dock

Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

A well-maintained backyard area features a lush green lawn, bordered by a decorative stone wall. A hanging swing adds a relaxing touch, while the backdrop of tall, vibrant pine trees creates a tranquil natural setting. Clear blue skies stretch overhead.

4.99 out of 5 average rating, 210 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

4.95 out of 5 average rating, 258 reviews

A wooden bridge traverses a narrow stream, surrounded by lush greenery. Trees and foliage create a natural canopy, contributing to the serene environment. The scene is accessed from a deck area, with stairs leading down to the path towards the water.

Tiny home in West Union

Holliday's Inn Tiny Tree-house

Tiny Treehouse is a ‘container’ house set in a private wooded locale at the foothills of the mountains. Find yourself hiking at Oconee State park or Caesar's Head mountain along with a multitude of waterfalls within our county. 5 minutes from downtown historic Walhalla, 10 minutes to city of Seneca, and 20 minutes from Clemson University where tailgaters unite before the big football game! Explore the artistic venues and cultural scenes of Greenville just an hour away!

4.97 out of 5 average rating, 164 reviews

An open living area features a modern garage door that transitions the space to the outdoors. Neutral-toned seating arrangements create a comfortable atmosphere, while a dining area with stylish chairs is positioned alongside a view of the greenery outside.

Cottage in Anderson

Lakefront dock *hot tub* Anderson Clemson King bed

Relax & enjoy the beautiful views of lake Hartwell from the front porch daybed swing, hot tub, or private dock. Sleep in a king size bed wrapped in cool cotton linens, a towel warmer, soaking tub with TV, & a breville espresso maker. Located w/i 10 minutes of many restaurants. Less than 20 min. to downtown Anderson Pendleton or Clemson. This prime location on lake Hartwell is a 10 minute boat ride to Portman Shoals Marina, the Galley restaurant, & Green Pond Landing.

4.96 out of 5 average rating, 110 reviews

A tranquil outdoor setting features a fire pit surrounded by two red adirondack chairs, nestled among tall trees. Soft evening light casts a warm glow, and a nearby pathway leads to the lake, where a dock is visible in the distance.

Guest suite in Seneca

Hartwell Escape 6 mi to Clemson Beautiful views

We recently purchased this gorgeous home on Lake Hartwell, in a secluded cul-de-sac in a quiet neighborhood (6 miles to Clemson..ALL BACKROADS) You will have the entire bottom floor with separate entrance . Enjoy beautiful lake views on the covered porch or from our dock. A Private Neighborhood Boat ramp is 25 feet from our home. Bring your boat, use our dock, space for multiple trailers. Driveway parking. Dogs Welcome! ($25 pet fee/entire stay)

4.97 out of 5 average rating, 560 reviews

An open-plan kitchen area features a spacious island with two brown bar stools. A modern washing machine and dryer are positioned across from a stainless steel refrigerator. A wooden ladder leads up to a loft area, adding height and character to the space.

Cottage in Westminster

Tiny house

BRAND NEW 490 sq ft tiny house/cottage nestled in the woods in a country setting. Complete with a queen bedroom, a twin/day bed and then a queen bed in loft ( comfortably sleeps 4 adults and one child). We are conveniently located 10 miles from I-85 exit 1 on S Hwy 11. 20 minutes from Clemson, 8 minutes from Seneca, and just a short drive to many hiking trails, lakes and parks in the beautiful foothills of the Blue Ridge mountains.

4.93 out of 5 average rating, 111 reviews

A white picket fence encloses a green yard adorned with colorful flowers in pots, including red and white blooms. A flag gently flutters in the breeze near the entrance steps leading to the house, surrounded by lush greenery.

Home in Westminster

Shady Rest

As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Vacation rentals for every style

Get the amount of space that is right for you

Houses

A space thats all yours, with room for everyone

Cabins

Kick off your hiking boots at these rustic lodgings

Hotels

Stylish accommodations and amenities

Popular amenities for Seneca vacation rentals

Self check-in

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Other great vacation rentals in Seneca

4.98 out of 5 average rating, 43 reviews

A new cottage is depicted nestled among the trees, featuring a welcoming front porch with rocking chairs. The structure exhibits a gabled roof and is surrounded by a concrete driveway, creating an inviting entrance illuminated by warm light from the windows.

Home in Westminster

Mountain Road Cottage

DanielRating, 5 stars2 weeks ago

Great place to stay and very clean. Esther even had a plate full of cookies waiting on us. Loved it!

5 out of 5 average rating, 15 reviews

A modern bathroom is displayed, featuring a sleek white vanity with a sink and black fixtures. A mirror hangs above the vanity, with soft lighting provided by two pendant lights. A walk-in shower is enclosed with glass, and towels are neatly arranged on a rack nearby.

Tiny home in Seneca

Cozy Clemson Tiny House Cabin

AndyRating, 5 stars1 month ago

Jim's place was perfect. There for my daughter's graduation and decided to stay a couple extra nights. We will return!

A hallway is visible leading into a light-filled living space. A ceiling fan is positioned overhead, and a cream-colored sofa is partially seen along with a dresser and decorative wall mirror. Natural light filters through sheer curtains, adding to the welcoming atmosphere.

4.88 out of 5 average rating, 16 reviews

No cleaning fee farmhouse lake keowee near Clemson

TerryRating, 5 stars1 month ago

We stayed here for a couple of months while our home was being built and it was a perfect place for us...Private, peaceful and such a charming home..We loved our evenings outside on the porch and morning walks with our dog...This place feels like home and the wildlife is amazing..(deer, foxes many birds and geese and turkey) I highly recommend this place it is close to the lake and to town...Hunter is so attentive and respond quickly to any questions...

A spacious outdoor area is shaded by large trees, featuring a picnic table surrounded by natural greenery. Two Adirondack chairs are positioned nearby, inviting relaxation. A grill is visible in the background, contributing to the outdoor cooking experience.

5 out of 5 average rating, 25 reviews

Tween 2 Cats the perfect spot

RachelleRating, 5 stars1 month ago

This was our second time staying at Debbie’s. She’s a dream to work with. Very flexible and accommodating. Her home is very close to Clemson, so it was perfect for graduation weekend. Debbie is a great host! Left us snacks, and even a little gift for my daughter’s graduation, which was just the sweetest! Thank you so much Debbie. This is our go to spot for any future visits.

4.97 out of 5 average rating, 34 reviews

Place to stay in Seneca

Lake Keowee Serene Cove Getaway

WilliamRating, 5 stars6 months ago

This is a great place to stay for a football weekend. Short ride to the game and restaurants. It was very clean and had what we needed for the weekend. We will definitely stay here again if we come back. Marta was very friendly and responsive to our needs. Perfect for 2 couples or a small family.

Treehouse in Mountain Rest

A charming treehouse retreat is nestled among lush greenery, surrounded by tall trees. The exterior features warm wooden tones, illuminated by soft lights. A spacious deck extends from the structure, blending seamlessly with the natural surroundings.

5 out of 5 average rating, 16 reviews

StellaVista Romantic Treehouse - Waterfall Feature

LauraRating, 5 stars2 weeks ago

Absolutely beautiful place to stay! Very romantic and private but not too far away that you have to drive a long distance to get to town. Dee is an absolutely wonderful host! 🩷She is thoughtful and had wonderful suggestions of places to visit. I had the honor or meeting her in person before we left and she's just as lovely in person as she is through messages. We can't wait to book again!

5 out of 5 average rating, 30 reviews

A wooden staircase is seen descending towards a bright entryway. The steps feature a rich, dark stain and are framed by exposed brick walls. A modern light fixture is visible at the top of the stairs, illuminating the path with natural light.

Apartment in Seneca

The Nest- The Wren Suite Downtown Seneca

KennethRating, 5 stars1 month ago

Great place to stay much larger and nicer than a hotel room. The location was great in the old town area and you can walk to shops bars and great restaurants. Would definitely stay again!

The entrance to the Un-Sweetened apartment features a white door with multiple glass panes set within a stone facade. Two lantern-style wall lights flank the door, providing illumination. A small sign reads 'Sweet Tea Retreats Un-Sweetened' next to the entrance.