Guesthouse vacation rentals in San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A curving staircase is visible, flanked by white walls and adorned with vibrant blue tiles. Handrails provide support along the ascent, leading to a bright upper space. A potted plant enhances the serene ambiance at the top of the stairs.
Guesthouse in Mission Hills
5 out of 5 average rating, 237 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

*CHECK OUT OUR OTHER AIRBNB* Travel 16 steps up a Greek-inspired curving stairway with 2-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina.  With spectacular views, step onto the balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. European-inspired design & details, it'll be hard to believe you’re still in San Diego!

Top guest favorite
A private outdoor patio features a circular seating area arranged around a fire pit. Bamboo fencing encloses the space, with tropical plants and trees providing greenery. A decorative water fountain is visible, contributing to a serene setting ideal for relaxation.
Guesthouse in Bay Park
4.96 out of 5 average rating, 134 reviews

Upscale Studio

Stay just minutes from the sun-soaked shores, vibrant downtown San Diego, SeaWorld, and the world-famous San Diego Zoo. This thoughtfully designed retreat offers a seamless blend of comfort & convenience. ✨ Luxury Features Include: A massage bed with adjustable head and foot settings for ultimate relaxation A spacious, spa-inspired bathroom with a premium Toto toilet and oversized shower A kitchen equipped with a sink, fridge, toaster oven RIGHT CLICK ON MY PICTURE TO SEE ALL OF OUR PROPERTIES.

Top guest favorite
A private patio space surrounded by lush greenery features seating areas with wooden chairs and potted plants. Soft lighting is provided by outdoor string lights, and a cozy rug adds warmth. In the distance, a shaded area with an umbrella can be seen, enhancing the tranquil setting.
Guesthouse in Greater North Park
4.96 out of 5 average rating, 261 reviews

Sunny garden casita in vibrant North Park

Enjoy peaceful, sunny San Diego days as palms sway above this private garden retreat tucked behind a 1925 Craftsman. Designed with a love of nature and simple beauty, the guest house opens onto lush greenery and dappled light — a calm, creative hideaway in the heart of one of San Diego’s most charming neighborhoods. Just a short stroll brings you to great restaurants, world-class breweries, and cozy coffee shops, while Balboa Park, the Zoo, the beaches, and downtown are all only minutes away.

Top guest favorite
A cozy studio space features a spacious bed with patterned bedding, complemented by warm orange and neutral tones on the walls. A small dining area with two chairs and a table is visible, along with a kitchenette and a bathroom entrance in the background.
Guesthouse in Greater North Park
4.93 out of 5 average rating, 533 reviews

Private Cottage in Walkable North Park w/AC

Welcome to our charming private Airbnb in vibrant North Park! Enjoy the perfect blend of comfort and convenience for your San Diego stay. Walk to restaurants, coffee shops, art galleries, wine bars, breweries, yoga studios & various boutiques. Nature lovers will adore the nearby Balboa Park with its stunning gardens and cultural attractions. Downtown, Gaslamp Quarter, beaches, and the famous San Diego Zoo are easily accessible. Book and create lasting memories in this dynamic neighborhood.

Top guest favorite
A broad view captures the coastal landscape of La Jolla, featuring the shimmering ocean, serene bay, and city lights under a clear sky. The horizon displays the iconic pier, with the vibrant residential area blended into the backdrop of rolling hills.
Guesthouse in La Jolla
4.98 out of 5 average rating, 247 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

Escape to your private 1000 sq. ft La Jolla studio with expansive ocean, bay and city views. This quiet guest retreat features private entrance, full kitchen, and a private scenic patio to watch the Sea World fireworks. Relax in a modern, open concept retreat perched on a hill in a prestigious multimillion-dollar neighborhood, minutes from Windansea Beach, the village of La Jolla, downtown San Diego and top attractions. The space comfortably sleeps up to four guests. Small pets welcome.

Top guest favorite
Guesthouse in San Diego
4.95 out of 5 average rating, 209 reviews

Clean Cozy Private Guesthouse | Central San Diego

Centrally located, this cozy spot is professionally cleaned, well maintained & managed by a responsive host. Safe & secure it’s close to urban centers yet discretely nestled in a residential neighborhood, within 15 minutes to: The airport Petco Park SD Convention Center Gas Lamp District SD Zoo Balboa Park Seaport Village beaches, major freeways & much more. Keyless entry for self-check, well-lit approach, generously-sized private, fenced yard, washer/dryer & filtered RO water on tap.

Top guest favorite
The tiny cabin is illuminated by soft lighting, showcasing its wooden exterior and welcoming design. Surrounding cacti and plants enhance the natural setting, while steps lead up to a private deck. The evening sky provides a serene backdrop, highlighting the cabin's cozy atmosphere.
Guesthouse in Spring Valley
4.98 out of 5 average rating, 205 reviews

Loft Cabin •SoakTub•Cinema•View +Zoo add-on

Tucked into a quiet hillside canyon, this very private, nature-immersed retreat is just a short drive outside of downtown San Diego. Features include: ✦Private Hot Soaking Tub under the stars ✦Custom outdoor theatre ✦Queen bed - always white sheets ✦Fast Wi-Fi ✦New quiet AC & Heat ✦Gated, off street parking Relax on your private patio with panoramic views, unwind in the outdoor hot soaking tub or rain shower, and end the night with a movie at your very own "Cinema Under the Stars"!

Top guest favorite
The poolside area features a well-maintained saltwater pool reflecting the colors of the sunset. Comfortable seating arrangements, including lounge chairs and a cozy fire pit, are visible. Large umbrellas provide shade, and lush greenery adds to the serene ambiance.
Guesthouse in Lake Murray
4.96 out of 5 average rating, 142 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

This is your perfect Guest House with a salt & heated pool & hot tub. We are located in a super quiet & very safe neighborhood in beautiful San Diego, 15 minutes drive to beaches, Downtown, La Jolla, Zoo, Stadiums, Sea World, Convention Center + more. Hike next door at Mission Trails & Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo and top quality finishes and furniture. Everything you need for memorable vacation! No smoking or vaping on the property.

Top guest favorite
The living area features natural wood paneling and a warm color palette. Large windows allow ample light, framed by woven shades. A comfortable white sofa and a stylish entertainment unit with a television are visible, along with a decorative chair and a small side table.
Guesthouse in Mission Beach
4.9 out of 5 average rating, 811 reviews

South Mission Beach Zen-Like Studio

This fully furnished second story South Mission bayside studio offers relaxed beach living. This studio sleeps 2 (Queen Bed) & 2 Boogie Boards are provided; private off street parking on premise. Bbq grill on small balcony. The unit is steps to the bay and short three minute stroll to the beach. Two beach cruiser bicycles provided which is one great way to get around the area. Please note, access to the second story is via an outdoor spiral staircase.

Guest favorite
A light-filled studio apartment is presented, featuring a dining table with two chairs and a kitchenette equipped with modern appliances. The space boasts a ceiling fan and large mirror, while a bathroom area is visible with a blue rug. Neutral-toned walls create a clean atmosphere.
Guesthouse in San Diego
4.87 out of 5 average rating, 1,072 reviews

Private Garden Studio

Enter through a hidden garden filled with plants into a cute, clean, recently refurbished studio apartment. Although the house sits on a quiet street with abundant free street parking, it is within easy walking distance of craft breweries, cocktail bars, cafes, and some of San Diego's best restaurants, as well as Trolley Barn Park. We're also an easy shot to the zoo, Balboa Park museums, downtown, and the beaches.

Guest favorite
A spacious studio room features warm wooden walls and contemporary furnishings. A queen-sized bed is accompanied by accent pillows. Large double doors open to a private deck with garden views, while a work desk and chair are positioned near the entrance.
Guesthouse in Greater North Park
4.9 out of 5 average rating, 1,162 reviews

Safe Hip Quiet GARDEN STUDIO / Northpark

Come to a quiet and stylish studio to relax. Check-in contactless and enjoy! Cozy, hip and private garden studio with private entrance, private full bathroom, and private deck. The Studio house is in a large garden adjoining a craftsman-style house in the historic Northpark/ Morley Field District. Minutes away from coffee shops, breweries, Zoo, Balboa Park.

Guest favorite
A landscaped outdoor space is highlighted by a soothing water fountain and comfortable seating area, surrounded by lush greenery. Wooden decking provides a pathway leading through the garden, complemented by decorative plants and stones adding texture to the serene environment.
Guesthouse in Greater North Park
4.91 out of 5 average rating, 580 reviews

North Park Guest House

Our remodeled, modern guest house is located in a landscaped oasis in the heart of North Park. The private patio with guest studio has easy access to downtown, the San Diego Convention Center, Balboa Park, The San Diego Zoo, Hillcrest, and North Park's vibrant dining and craft beer scene.

Popular amenities for San Diego guesthouse rentals

When is the best time to visit San Diego?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$24,439 GYDG$25,065 GYDG$25,274 GYDG$25,065 GYDG$25,901 GYDG$27,572 GYDG$29,870 GYDG$27,363 GYDG$24,856 GYDG$25,065 GYDG$25,065 GYDG$24,648 GYD
Avg. temp15°C15°C16°C17°C18°C20°C21°C22°C22°C20°C17°C14°C

Quick stats about guesthouse rentals in San Diego

  • Total vacation rentals

    Explore 970 vacation rentals in San Diego

  • Nightly prices starting at

    San Diego vacation rentals start at G$6,266 GYD per night before taxes and fees

  • Verified guest reviews

    Over 100,480 verified reviews to help you choose

  • Family-friendly vacation rentals

    120 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 240 rentals that welcome pets

  • Vacation rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    530 properties have a dedicated workspace

  • Wi-Fi availability

    960 of San Diego vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across San Diego rentals

  • 4.9 Average rating

    San Diego stays are highly rated by guests—averaging 4.9 out of 5!

  • Nearby attractions

    San Diego's top spots, include Balboa Park, San Diego Zoo Safari Park, and La Jolla Cove

Destinations to explore