Guesthouse vacation rentals in San Diego County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in San Diego County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for San Diego County guesthouse rentals
Family-friendly guest house rentals
Guesthouse in San Diego
4.93 out of 5 average rating, 447 reviewsPrivate Cottage in Walkable North Park w/AC
Jun 4 – 11
Guesthouse in Chula Vista
4.95 out of 5 average rating, 476 reviewsPrivate Casita in Great Eastlake Neighborhood
Oct 20 – 27
Guesthouse in San Diego
4.97 out of 5 average rating, 292 reviewsPrivate Guest House with a View
Aug 6 – 13
Guesthouse in El Cajon
4.98 out of 5 average rating, 190 reviewsFletcher Hills - modern 1 BR.Easy, no step access.
Apr 24 – May 1
Guesthouse in La Mesa
4.92 out of 5 average rating, 206 reviewsFig Tree Bungalow
Jul 9 – 16
Guesthouse in San Diego
4.97 out of 5 average rating, 507 reviewsCentral & Serene Secret Garden Guesthouse
Oct 14 – 21
Guesthouse in San Diego
4.94 out of 5 average rating, 333 reviewsThe BEST NEST Clean, peaceful, private, affordable
Apr 18 – 25
Guesthouse in San Diego
4.92 out of 5 average rating, 316 reviewsUrban Cottage Getaway
May 7 – 14
Guest house rentals with a patio
Guesthouse in San Diego
4.99 out of 5 average rating, 151 reviewsAdorable cottage in Talmadge
Sep 17 – 24
Guesthouse in San Diego
5.0 out of 5 average rating, 107 reviewsSantorini-Inspired Cottage #1 w/ Hot Tub + Views
Jan 12 – 19
Guesthouse in La Mesa
4.97 out of 5 average rating, 130 reviewsDa Hui Hut-Beachy home/La Mesa’s best view and spa
Sep 12 – 19
Guesthouse in Poway
4.99 out of 5 average rating, 117 reviews⭐️Garden studio guesthouse, resort living with pool
Guesthouse in San Diego
4.98 out of 5 average rating, 124 reviewsPrivate Studio Cottage with Outdoor Patio
Dec 10 – 17
Guesthouse in San Diego
4.92 out of 5 average rating, 149 reviewsCentral studio w/ private outdoor space & parking
Apr 9 – 16
Guesthouse in San Diego
4.85 out of 5 average rating, 124 reviewsPrivate, beautiful 1-bedroom 2 story guest house
May 17 – 24
Guesthouse in Oceanside
4.94 out of 5 average rating, 155 reviewsDetached, Private Cottage! Fenced, PET friendly!
Sep 16 – 23
Guest house rentals with a washer and dryer
Guesthouse in San Diego
4.95 out of 5 average rating, 108 reviewsRelax in a Centrally Located, Modern Guest House
Jan 1 – 8
Guesthouse in San Diego
4.96 out of 5 average rating, 208 reviewsPrivate beach guesthouse w/ private parking
Sep 5 – 12
Guesthouse in San Diego
4.98 out of 5 average rating, 117 reviewsCasita Hermosa - Close to everything in San Diego
Dec 16 – 23
Guesthouse in San Diego
4.91 out of 5 average rating, 114 reviewsCharming Granny Flat Near SDSU & Transit Center
Jun 6 – 13
Guesthouse in Encinitas
4.96 out of 5 average rating, 347 reviewsCardiff by the Sea Beach Bungalow
Apr 10 – 17
Guesthouse in San Diego
4.9 out of 5 average rating, 192 reviewsSTUNNING Casita with a View!!
Oct 19 – 26
Guesthouse in La Mesa
4.99 out of 5 average rating, 133 reviewsStunning Guest House 15 min. from Zoo, Downtown
Sep 28 – Oct 5
Guesthouse in San Diego
4.98 out of 5 average rating, 117 reviewsPrivate Guest House for 2 with Kitchen + Laundry
Jun 5 – 12
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