
Hotels in Panama City
Find and book unique hotels on Airbnb
Top-rated hotels in Panama City
Guests agree: these hotels are highly rated for location, cleanliness, and more.

4. Heart of the Old Town: Boutique Apart-Hotel
La Isabela Suites is a Boutique apart-hotel built on the concept of space, elegance and comfort. Located in the heart of Casco Antiguo, only steps from culture, markets, dining, and bars, and with a unique quality of service. La Isabela Suites offers an alternative type of travel, away from the small, standardized and impersonal massive hotel rooms without the inconvenience of a self-catering apartment. Because we understand that the true luxury means not having to worry about anything.

La Husseyenda- Birdwatcher Haven
A Birdwatcher’s and Jungle Paradise nestled in Los Altos de Cerro Azul, this 3-level villa offers breathtaking Lake Alajuela views, stunning sunsets, and endless birdwatching opportunities! Spot hummingbirds, tanagers & toucans from the terrace while howler monkeys call in the distance. Family & pet-friendly with a fenced garden, spacious BBQ, & a fully equipped kitchen. Relax in nature’s paradise—your jungle escape awaits! Make some memories at this unique and family-friendly place.

Very Nice Downtown Panamá Hotel Free Parking
Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

Cuarto de hotel #3 a una cuadra del Metro.
Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

Habitaciones privadas Sofia's B&B Hostal Boutique
Alojamiento tipo hostal boutique, contamos con 7 cómodas habitaciones privadas con baño, para una capacidad total de 18 huéspedes. La tarifa mostrada por Airbnb para tu reserva distribuye 2 huéspedes por habitación, es decir, los huéspedes deberan compartir camas y/o habitaciones. Si requieres una distribución especial de habitaciones para tu grupo, contacta primero con el anfitrión, ya que la tarifa podría variar.

Desk & Dream Room in flat for work and rest
Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

Marinn Place | Deluxe King | Cozy Work & Rest
Located in Panama City’s upscale Financial District near Via España and Bella Vista, Marinn Place offers modern comfort, a rooftop pool, and free valet parking in a vibrant urban setting. The spacious Deluxe Double features two plush queen beds, a separate living/sleeping area with a sofa bed, a work desk, and a walk-in glass shower—perfect for families or professionals.

Corcho rooms #2 - king room with balconies
Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

Tu segundo hogar en Panamá.
Nuestras habitaciones están ubicadas en una zona privilegiada en el corazón del sector Financiero y Bancario de la ciudad. Tenemos a dos cuadras de distancia, dos estaciones del sistema de transporte Metro. 15 minutos de algunos Centros Comerciales.

Spacious and lovely room meters from the sea - Ztz
Lovely spacious private room with a new brand bed, with great lightning and a workspace inside it. Shared bathroom. Shared kitchen with your private kitchenware and utensils needed to cook. Shared laundry room, with a washing machine

The Corner Suite #110 | La Résidence Panamá
Contemporary comfort for the modern traveler. This 35–37 m² suite features a king-size bed, full kitchen, washer/dryer, Coffe machine, and A/C — designed with thoughtful touches to make you feel at home.

Pool side, Family suite, two bedroom one bath.
This trendy spot offers lots of charming details. Centrally located with many amenities, come enjoy our pool and spa. Dirección Crotón 818, Ancon, Panamá Wifi Red: cascadas Pass: 7636cascadas
Popular amenities for Panama City hotels
Family-friendly hotels

Room with private bathroom

Rainforest Suite with Breakfast! 15 min from city

Dormitorio con baño privado en el centro de Panamá

Habitación privada con 1 cama doble y baño

Habitación y baño privado en Panamá Centro

Habitación con 3 camas individuales y baño privado

Alojamiento entero Sofia's B&B Hostal Boutique

Habitación con baño privado para 2 personas
Hotels with a pool

Jr. Suite Rm #3- Cerro Azul

Suite Doble-Apartamento Hotel Príncipe

Hacienda el eden el valle de cerro azul

Habitación privada 2 camas twin

Double Studio - Viajero Hostels

Excelente habitación privada

El Canal

Tropical Tranquility - Coconut Lodge
Hotels with a patio

Harpy Eagle Room in Treehouse

Suite Room in the ORHO Hotel

Kakún Hab 12, Cable Tv, Nevera, Aire/A.

Eshel Panama Suites, Atlantic suite 04

Charming Studio w Two Double Beds

Private Twin | Shared Bathroom

cinta costera

Comfort and privacy, Casa Orquídea
Quick stats about hotels in Panama City

Total vacation rentals
Explore 130 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at G$2,092 GYD per night before taxes and fees

Verified guest reviews
Over 3,620 verified reviews to help you choose

Family-friendly vacation rentals
10 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 20 rentals that welcome pets

Vacation rentals with a pool
30 properties feature pools

Rentals with dedicated workspaces
90 properties have a dedicated workspace

Wi-Fi availability
120 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Destinations to explore
- Cartagena Vacation rentals
- San Andrés Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Uvita Vacation rentals
- Boquete Vacation rentals
- Coveñas Vacation rentals
- Playa Blanca Vacation rentals
- Bahía Ballena Vacation rentals
- Ancón Vacation rentals
- Limón Vacation rentals
- Valle de Antón Vacation rentals
- David Vacation rentals
- Rentals with lake access Panama City
- Rentals with a home theater Panama City
- Rentals with a fire pit Panama City
- Rentals with a sauna Panama City
- Fitness-friendly rentals Panama City
- Rentals with a hot tub Panama City
- Family-friendly rentals Panama City
- Rentals with a fireplace Panama City
- Rentals with pools Panama City
- Condo rentals Panama City
- Bed and breakfasts Panama City
- Ski-in/ski-out rentals Panama City
- Rentals with an accessible height bed Panama City
- Cabin rentals Panama City
- Rentals with a patio Panama City
- Smoking-friendly rentals Panama City
- Guesthouse rentals Panama City
- Villa rentals Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Boutique hotels Panama City
- House rentals Panama City
- Rentals with beach access Panama City
- Rentals with an EV charger Panama City
- Private suite rentals Panama City
- Loft rentals Panama City
- Rentals with a washer and dryer Panama City
- Hostel rentals Panama City
- Townhouse rentals Panama City
- Rentals with outdoor seating Panama City
- Waterfront rentals Panama City
- Serviced apartment rentals Panama City
- Rentals with breakfast Panama City
- Pet-friendly rentals Panama City
- Hotel rooms Panama
- Things to do Panama City
- Tours Panama City
- Sports activities Panama City
- Sightseeing Panama City
- Art and culture Panama City
- Food and drink Panama City
- Nature and outdoors Panama City
- Things to do Panama
- Sports activities Panama
- Food and drink Panama
- Tours Panama
- Sightseeing Panama
- Nature and outdoors Panama
- Art and culture Panama
- Entertainment Panama




