Guesthouse vacation rentals in Port St. Lucie

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Top-rated guesthouse rentals in Port St. Lucie

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

The image features a designer-decorated bedroom with a comfortable bed adorned in soft linens. A decorative table holds fresh flowers, almonds, and apples, while a cozy area rug enhances the room's warmth.

Guesthouse in Fort Pierce

5 out of 5 average rating, 59 reviews

Casita Luna - Sunny boho retreat with a pool

One of the most beloved homes on Airbnb, fall in LOVE with Casita Luna! * Stand alone Casita Luna is designer decorated, a perfect base to explore Treasure Coast & beaches! * Enjoy your organic coffee or get work done in the window alcove * Bask in the the sun or swim in the pool * Sink into comfortable queen bed with luxurious linens, enjoy fully stocked kitchenette & a spacious bath * Watch Prime & Netflix, play games, browse through books * Convenience for long stays * Lovely private patio

Guest favorite

A scenic view of the beach and water features a wide wooden boardwalk leading to the Atlantic Ocean. Lush greenery accompanies the path, with sandy areas visible in the foreground. Another section showcases a fishing dock extending over calm waters, with blue skies framed by clouds.

Guesthouse in Hutchinson Island

4.9 out of 5 average rating, 187 reviews

Private Detached Guesthouse Oasis

Special reduced summer rates 6/1/2025-8/31/2025. *Two night weekend minimum* Enjoy the sea and lagoon. Hutchinson Island locale a two minute walk to private beach/Indian River Lagoon/fishing dock. Preserve, and, park surroundings, great hiking trails, and, awesome fishing spots. Guest house, with bedroom, living room, and bathroom, includes an alcove with small fridge, Keurig, toaster oven, and microwave. -Never a cleaning fee. -No pre check-out chores. -This is a private property listing.

Superhost

A tranquil canal scene is depicted at sunset, with a thatched-roof hut and lush palm trees framing the waterway. A lounge chair is positioned on the dock, inviting relaxation while reflecting the vibrant colors of the sky.

Guesthouse in Port St. Lucie

4.82 out of 5 average rating, 51 reviews

Cozy River Retreat

Conveniently located within a short driving distance from the beach 'Cozy River Retreat,' offers an oasis in Florida that seamlessly combines retreat, comfort, adventure, relaxation, and outdoor cooking. Whether kayaking and fishing by the river, unwinding by the fire pit, or cooking outdoors on the BBQ, discover your perfect escape where tranquility meets excitement." Enjoy the gentle rustle of palms and the soothing breeze as you step into our cozy accommodation, designed with you in mind.

Top guest favorite

An open-concept living area is depicted, featuring a leather sofa opposite a dining table with four chairs. The kitchen showcases modern appliances, including a stainless steel refrigerator. A washer and dryer are visible within cabinetry. Light-colored walls and wood flooring enhance the spacious feel.

Guesthouse in Port St. Lucie

4.95 out of 5 average rating, 83 reviews

Private apt. for 4, king bed, laundry inside.

Feel at home in our totally private apartment, in a quiet neighborhood with all you need for a relaxing stay. Relax in the comfort of a spacious King bed and a cozy queen sofa bed providing ample space for additional guests. Newly added washer and dryer inside the unit for a quick wash. With its own private entrance, and safe and free parking you'll enjoy the freedom to come and go as you please. Stay connected with free high-speed WiFi, and smart tvs on the bedroom and the living room.

Top guest favorite

An outdoor shared patio area is shown, featuring a wooden table surrounded by four wicker chairs. String lights create a warm ambiance above, and a hammock hangs nearby. The space is adorned with potted plants and a decorative star-shaped light fixture.

Guesthouse in Stuart

4.95 out of 5 average rating, 154 reviews

Comfy and Cozy

Comfy for one and Cozy for two - efficiency apartment. 9 min. drive to public beaches and 20 min. leisurely walk to downtown Stuart -full of inviting shops, restaurants, and music. Laundry facilities available for guests who are here at least a week. One of House Beautiful Magazine's Top Ten charming USA towns: #10 - Stuart, Florida The "sailfish capital of the world" is best for those who love the perfect climate during the winter but want a less touristy destination to soak up some sun.

Top guest favorite

A serene studio space features a plush king-size bed with white bedding and blue accent pillows. A light wooden dining table accompanies white chairs, and natural light enters through windows dressed with light curtains. Tropical plants are placed near a cozy armchair in the corner.

Guesthouse in Stuart

5 out of 5 average rating, 13 reviews

Historic Studio Retreat | Renovated & Walkable

Welcome to The Parakeet, a centrally located, newly renovated historic cottage in downtown Port Salerno—a charming fishing village on Florida’s coast. Just a short stroll to waterfront restaurants, live music, marinas, and scenic beauty. Designed with comfort and style in mind, this private retreat blends Old Florida charm with modern convenience. Walk to breakfast, enjoy music by the water, or spot parakeets in the trees—this is Florida at its most relaxing.

Top guest favorite

An aerial view captures the oceanfront estate's layout, with a spacious main house surrounded by lush greenery and palm trees. A sandy beach path is visible leading to the ocean, highlighting the property's serene coastal setting.

Guesthouse in Fort Pierce

4.98 out of 5 average rating, 202 reviews

Extraordinary location, private, beach path, cozy

Location, privacy, ocean. Due to health concerns, pool seen from aerial shots not available Nov-May because owners will be in residence in the main house. Welcome to Nova Beach Cottage, the guest house on the oceanfront estate of famous sculptor, Mihai Popa, a.k.a. “Nova”. Located on the south tip of North Hutchinson Island directly next to the Fort Pierce Inlet State Park. Garden and beach path a few steps from the cottage. Screened patio from bedroom.

Top guest favorite

A lush garden area features green grass, surrounded by tropical foliage and flowers. A covered patio offers a cozy seating space with soft lighting, creating an inviting atmosphere in the evening. Lanterns add a touch of warmth to the serene outdoor setting.

Guesthouse in Hutchinson Island

4.96 out of 5 average rating, 224 reviews

Cottage Efficiency on South Hutchinson Island

Welcome to our cozy efficiency on South Hutchinson Island, Florida! Our one bedroom is perfect for singles or couples, with a queen Murphy bed and private ground-level entrance. an induction cooktop, convection oven, full-size refrigerator, Smart TV, and a full bathroom. Located in a friendly neighborhood, we're close to beaches, jetties, restaurants, and historic downtown. Come stay with us and enjoy all that the Treasure Coast has to offer!

Guest favorite

The exterior of a well-maintained home is displayed, featuring a neatly landscaped lawn with lush green grass and decorative plants. A paved driveway leads to a dark garage door. The white facade is accented by a gray metal roof and surrounded by a tidy white fence.

Guesthouse in Port St. Lucie

4.9 out of 5 average rating, 363 reviews

Port St Lucie - Peaceful home away from home.

Defined as a dwelling attached to my private home with its own private entrance, containing all the essentials of a home. Lovely, safe, quiet, family neighborhood, decorated with blackout drapes. Host only 1 person or 1 couple max at a time. Freshly renovated with private patio, independent with full kitchen. Mini fridge, coffee maker, microwave, Iron, hair dryer available. 42” LCD tv/premium channels, WiFi, streaming.

Guest favorite

The exterior of a quaint cottage is captured, featuring light-colored siding and blue accents. A pathway made of stone leads to the entrance, bordered by lush green grass and small shrubs. A blue canopy is positioned over part of the entrance area.

Guesthouse in Hobe Sound

4.8 out of 5 average rating, 160 reviews

Sandee's Cottage

Cute little cottage in a quiet small beach town neighborhood. One and a half miles to beautiful Hobe Sound Beach, an easy walk or bike ride.! Plenty of little shops and grocery stores within a mile of the cottage. If you like fishing bring your poles, lots of good spot Animals under 40lbs. are welcome; we do have a nice fenced in yard.! No cats! Highly allergic!!! A 25.00 fee 1 time will be charged for all pets

Top guest favorite

A private outdoor area is laid out with a stone pathway leading to a circular patio featuring a glass-top table and four green chairs. Lush greenery and trees surround the space, contributing to a serene outdoor setting.

Guesthouse in Vero Beach

4.95 out of 5 average rating, 156 reviews

Private 1 Bedroom Hideaway

Keep it simple at this peaceful and centrally-located in-law suite. 2 private outdoor areas that are not shared with the homeowner. Separate entrance means you can enjoy your privacy. Compact full kitchen to prepare meals while you enjoy your stay. Living area has a loveseat, bedroom has a queen size bed. 1.5 miles to downtown Vero and just 11 minutes to the beach

Superhost

A bright sleeping area features a spacious bed dressed in white linens, complemented by decorative pillows. A textured throw is laid across the foot of the bed. Two folding chairs are positioned at the foot, with a woven storage unit and wall art enhancing the cozy ambiance.

Guesthouse in Port St. Lucie

4.81 out of 5 average rating, 26 reviews

Private entrance,1bdroom, kitchen,sitting area

Enjoy a cheerful 1-bedroom guest apartment with AC, Wi-Fi, and a workspace. Use the kitchen and private patio to relax. Less than 15 mins from beaches, and close to restaurants, shopping, nightlife, Mets Stadium, and Botanical Gardens. Perfect for exploring Port St. Lucie like a local. Have questions? Message me anytime—I’m happy to share my favorite spots!