
House vacation rentals in Cape Girardeau
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Top-rated house rentals in Cape Girardeau
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Cape Girardeau house rentals
House rentals with a hot tub

Hot Tub Overlooking Sunset Ridge | Sleeps 6
What a beautiful home within a peaceful natural area with incredible views. Everything was immaculate and well-designed. The hot tub was lovely and just as pictures suggested. Allison was extremely responsive, as well. We had a great time hiking in Giant City park and kayaking at Crab Orchard Lake. Such a relaxing vacation.

Alto Cabin-1/2 mile from 3 wineries!
This was our second visit to Alto Cabin and we love it! It was pretty new when we first went, and now they’ve added a lot more touches that make it great like yard games and more kitchen supplies. We enjoyed lots of day trips for hiking and lounging in the hot tub at night. This is a place to go relax, not a place to go if you want the big city. Carbondale & Marion are both pretty close by and there are stores and a good butcher in Marion. The cabin is well equipped for cooking and has good WiFi for all your screening needs. We needed to contact the host one time for a question and she answered immediately. We are lucky to have found Alto cabin!

Twin Maples 2
If you are looking for cozy and quiet getaway this is definitely the place. Very well kept, the hosts were great, and there was a hot tub😎

The King's Quarters
We recently stayed at King’s Quarters, and it was truly an incredible experience! From the moment we arrived, we were impressed by how impeccably clean the cabin was. Every detail seemed to have been thoughtfully considered to ensure guest comfort. The high-quality towels and linens were a delightful touch, and we appreciated having an abundance of towels available. It was also a nice surprise to find snacks, hair dryers, and luxurious soap and shampoo provided. These little details made our stay feel extra special. The location of King’s Quarters is perfect for anyone looking for a peaceful retreat. It is very secluded, offering a serene atmosphere where it was hard to even notice a single neighbor. The climate control was excellent, keeping the cabin at a comfortable temperature throughout our stay. Overall, we had a fantastic time at King’s Quarters. It’s an ideal getaway for those seeking comfort and tranquility. We can’t recommend it highly enough.

The Roost
We thoroughly enjoyed our stay at The Roost. The location is convenient to the venue for our son’s wedding. The home was exceptionally clean (inside & out) and the owners provided everything we needed with attention to little extras that made it so welcoming and comfortable. The rooms are spacious and the master bedroom is located on the main floor which was perfect for my parents. I will definitely recommend this place to my friends and family. Thanks so much to the Runyons!!! Robin

Twin Maples
We booked Kathy’s place to set up a ‘home base’ while we visited some of the nearby State Parks and Natural Areas, and it was clean, comfortable, and cozy. Kathy leaves clear instructions and helpful recommendations for your stay, and though we spent most of our time out exploring we were always happy to come back and relax. The all-seasons porch and backyard are absolutely dreamy!

Wine trail cozy cabin! Hot Tub!
The place was beautiful and exactly what my Fiancee and my mother needed to enjoy a quick weekend trip to the wine trail. The place was spotless and the hot tub was the best! Patrick and Jennifer were very helpful and made sure the check in and check out process ran smoothly! We highly recommend this property and we will be back!

Peacock On Poplar
Laura was always very responsive and so helpful. The house was lovely. Clean, easy to find, centrally located to beautiful vineyards. Laura thought of EVERYTHING when she stocked her beautiful Victorian house on Poplar in Cobden. So many beautiful dishes. She even had champagne flutes!! There wasn’t an oven but she had a wonderful toaster oven that did anything you would want. The beds were so comfortable. Two of the rooms had room darkening curtains which was so appreciated by the ones who stayed in them. It was so fun to try to find all the peacocks she has decorated with. Everyday one of us found ones we didn’t catch the day before. It was so clean and comfortable. She even screened in the back porch which was quite lovely. I would highly recommend Laura and her house!
House rentals with a pool

Large Home, 2 King Beds, HotTub, Air Hockey, Games
We had a team of 9 for a week and the place had everything we needed! Abbie was a responsive host and the location was fantastic. Memories to be made and non stop conversation starters. One of the most fun air bnbs that I’ve been a part of over the years. Thank you!

Wine trail, views, hot tub, pool…
Four of us stayed in Lisa's place for the weekend and we had more than enough space. The outdoor area was definitely our favorite amenity. Sitting outside anytime of the day with a beautiful view of the bluffs was special. I highly recommend staying here if you're in the area. It was a wonderful time.

3+ acre:King Bed, Hot Tub, Mini Golf, Pool Table
Beautiful home - we felt very comfortable and enjoyed our time there.

Peaceful Custom Carbondale Home w/ Pool, Near SIU!
The pictures did not do any justice of how beautiful this place was! I would come back again and I recommend this spot 1000000 percent! So private and perfect for a getaway!

Champagne Domain
We absolutely recommend! A beautiful location and a beautiful home! It was so relaxing and peaceful! The host went out of their way to make us feel at home. The home has a beautiful location and plenty of privacy. It was very clean and comfortable! Would absolutely book again.
Weekly house rentals

Twisted Sister's Retreat
A wonderful little place! Quaint & tucked away; only a 10-15m ride into town. Candace made the two of us feel right at home and had great recommendations. The backyard is a birders paradise! Great home base for multiple Shawnee sights & wineries; would definitely revisit.

Big Sky Cabin! On The WineTrail! Hot Tub! Fire Pit
When 6 guests ranging from 13-79 all love the place, it’s a win!! It was so peaceful and we felt right at home! We had a blast with the arcade, pool table, & the hot tub! We highly recommend! Thanks to the host for going above expectations!

Gem in Heart of Altenburg
beds are comfy, bathrooms were spacious and clean, cozy home and ample parking

Hilltop Retreat 2: Spacious, pondfront home for 12
Our group had a wonderful time! Great location with approximately 15-30 minutes to most nearby attractions including Little Grand Canyon Trail and Alto Pass Vineyard. The house appeared well kept and accommodated our group perfectly. The back deck was peaceful. Ashley responded promptly to all of my messages and was very nice and professional. We hope to return in the future!

Mary and Snooks' Cozy Country Farm House.
This Airbnb was EXACTLY what we needed for a stay near friends and family for a family occasion. This listing far exceeded our expectations and we are already planning to book again this summer! The place is beautiful, comfortable, and made us feel right at home. 10/10 recommend!

Located near downtown and casino
Great house, great location. Quiet neighborhood. Beds were comfortable. Plenty of room for my son to play. He loved playing in the basement.

Cottage Near Casino
Had a great stay. Was there for work and it was a quick drive to everywhere in town. Quiet and peaceful just what was needed for my off hours.

Brewer House
We stayed at the Brewer House while in town for a family reunion. The home was clean and very comfortable. Amy is an exceptional host, and made herself available to us. We had an unexpected family emergency and needed extra accommodations, and Amy was so gracious in fulfilling our need and giving us local suggestions and support. Our kids loved playing in the outside area, and it reminded me of my childhood growing up in Peach Tree City, Georgia. Thank you Amy!
Quick stats about house rentals in Cape Girardeau
Total rentals
70 properties
Nightly prices starting at
G$6,273 GYD before taxes and fees
Total number of reviews
3K reviews
Family-friendly rentals
40 properties are a good fit for families
Pet-friendly rentals
20 properties allow pets
Rentals with dedicated workspaces
40 properties have a dedicated workspace
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