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House vacation rentals in Cape Girardeau

Find and book unique houses on Airbnb

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Popular amenities for Cape Girardeau house rentals

House rentals with a hot tub

Top guest favorite
A spacious outdoor area features comfortable seating arranged around a fire pit, surrounded by a lush landscape. The home's exterior includes a large deck with decorative railings, enhancing the inviting ambiance of this retreat, nestled in natural surroundings.
Home in Carbondale
4.99 out of 5 average rating, 67 reviews

Hot Tub Overlooking Sunset Ridge | Sleeps 6

EllenRating, 5 stars6 days ago
What a beautiful home within a peaceful natural area with incredible views. Everything was immaculate and well-designed. The hot tub was lovely and just as pictures suggested. Allison was extremely responsive, as well. We had a great time hiking in Giant City park and kayaking at Crab Orchard Lake. Such a relaxing vacation.
Top guest favorite
A two-story cabin is positioned amidst greenery, featuring a welcoming porch and a large deck. The structure has multiple windows, allowing natural light to fill the interior. An American flag is displayed near the entrance, complementing the rustic charm of the surrounding forest.
Home in Alto Pass
4.95 out of 5 average rating, 66 reviews

Alto Cabin-1/2 mile from 3 wineries!

JasonRating, 5 stars1 week ago
This was our second visit to Alto Cabin and we love it! It was pretty new when we first went, and now they’ve added a lot more touches that make it great like yard games and more kitchen supplies. We enjoyed lots of day trips for hiking and lounging in the hot tub at night. This is a place to go relax, not a place to go if you want the big city. Carbondale & Marion are both pretty close by and there are stores and a good butcher in Marion. The cabin is well equipped for cooking and has good WiFi for all your screening needs. We needed to contact the host one time for a question and she answered immediately. We are lucky to have found Alto cabin!
Guest favorite
A cozy living area features a light-colored sofa and armchair arranged around a wooden side table with a lamp. A flat-screen television is mounted on the wall, while a glass-doored cabinet displays white dishware. Hardwood flooring enhances the warm and inviting space.
Home in Anna
5 out of 5 average rating, 18 reviews

Twin Maples 2

DevinRating, 5 stars5 months ago
If you are looking for cozy and quiet getaway this is definitely the place. Very well kept, the hosts were great, and there was a hot tub😎
Top guest favorite
A well-maintained white house is shown, featuring a covered porch with a swing and potted plants. The lawn is lush and green, surrounded by trees, creating a serene outdoor space. Natural light enhances the inviting appearance of the front facade.
Home in Cobden
4.97 out of 5 average rating, 38 reviews

The King's Quarters

AjRating, 5 stars1 week ago
We recently stayed at King’s Quarters, and it was truly an incredible experience! From the moment we arrived, we were impressed by how impeccably clean the cabin was. Every detail seemed to have been thoughtfully considered to ensure guest comfort. The high-quality towels and linens were a delightful touch, and we appreciated having an abundance of towels available. It was also a nice surprise to find snacks, hair dryers, and luxurious soap and shampoo provided. These little details made our stay feel extra special. The location of King’s Quarters is perfect for anyone looking for a peaceful retreat. It is very secluded, offering a serene atmosphere where it was hard to even notice a single neighbor. The climate control was excellent, keeping the cabin at a comfortable temperature throughout our stay. Overall, we had a fantastic time at King’s Quarters. It’s an ideal getaway for those seeking comfort and tranquility. We can’t recommend it highly enough.
Guest favorite
The exterior of the cabin is surrounded by lush greenery, featuring a spacious front porch with railing. Steps lead up to the entrance, providing easy access. The home is set on a raised foundation, enhancing views of the forested surroundings.
Home in Ste. Genevieve
4.96 out of 5 average rating, 75 reviews

The Roost

RobinRating, 5 stars1 month ago
We thoroughly enjoyed our stay at The Roost. The location is convenient to the venue for our son’s wedding. The home was exceptionally clean (inside & out) and the owners provided everything we needed with attention to little extras that made it so welcoming and comfortable. The rooms are spacious and the master bedroom is located on the main floor which was perfect for my parents. I will definitely recommend this place to my friends and family. Thanks so much to the Runyons!!! Robin
Guest favorite
An outdoor space is surrounded by twin maple trees, offering a relaxing atmosphere. White swinging chairs and a circular table are positioned on a stone patio. A comfortable seating area with plush cushions is visible, complemented by greenery and potted plants, providing a private retreat.
Home in Anna
4.96 out of 5 average rating, 28 reviews

Twin Maples

MollyRating, 5 stars3 months ago
We booked Kathy’s place to set up a ‘home base’ while we visited some of the nearby State Parks and Natural Areas, and it was clean, comfortable, and cozy. Kathy leaves clear instructions and helpful recommendations for your stay, and though we spent most of our time out exploring we were always happy to come back and relax. The all-seasons porch and backyard are absolutely dreamy!
Guest favorite
A charming exterior view of a blue house is presented, featuring white trim and multiple windows. A covered porch area includes two red chairs and a black barbecue grill. Flower beds with plants are positioned along the front, set against a gravel area and surrounding greenery.
Home in Cobden
4.96 out of 5 average rating, 74 reviews

Wine trail cozy cabin! Hot Tub!

AshleyRating, 5 stars2 weeks ago
The place was beautiful and exactly what my Fiancee and my mother needed to enjoy a quick weekend trip to the wine trail. The place was spotless and the hot tub was the best! Patrick and Jennifer were very helpful and made sure the check in and check out process ran smoothly! We highly recommend this property and we will be back!
Top guest favorite
A charming Victorian house showcases a well-maintained exterior with a turret and decorative trim. A vibrant garden featuring a variety of flowers, including marigolds and petunias, surrounds a pathway leading to the entrance. A pumpkin and decorative elements add seasonal touches to the inviting landscape.
Home in Cobden
4.96 out of 5 average rating, 25 reviews

Peacock On Poplar

JulieRating, 5 stars3 days ago
Laura was always very responsive and so helpful. The house was lovely. Clean, easy to find, centrally located to beautiful vineyards. Laura thought of EVERYTHING when she stocked her beautiful Victorian house on Poplar in Cobden. So many beautiful dishes. She even had champagne flutes!! There wasn’t an oven but she had a wonderful toaster oven that did anything you would want. The beds were so comfortable. Two of the rooms had room darkening curtains which was so appreciated by the ones who stayed in them. It was so fun to try to find all the peacocks she has decorated with. Everyday one of us found ones we didn’t catch the day before. It was so clean and comfortable. She even screened in the back porch which was quite lovely. I would highly recommend Laura and her house!

House rentals with a pool

Superhost
Home in Cape Girardeau
4.29 out of 5 average rating, 7 reviews

Large Home, 2 King Beds, HotTub, Air Hockey, Games

BrandenRating, 5 stars2 months ago
We had a team of 9 for a week and the place had everything we needed! Abbie was a responsive host and the location was fantastic. Memories to be made and non stop conversation starters. One of the most fun air bnbs that I’ve been a part of over the years. Thank you!
Top guest favorite
A private pool area is surrounded by a wooden fence, featuring a circular blue pool and a spacious deck. Two orange umbrellas provide shade over lounge chairs. The natural landscape is visible in the background, with trees and rolling hills under a cloudy sky.
Home in Cobden
4.94 out of 5 average rating, 68 reviews

Wine trail, views, hot tub, pool…

ErikaRating, 5 stars3 weeks ago
Four of us stayed in Lisa's place for the weekend and we had more than enough space. The outdoor area was definitely our favorite amenity. Sitting outside anytime of the day with a beautiful view of the bluffs was special. I highly recommend staying here if you're in the area. It was a wonderful time.
Superhost
Home in Cape Girardeau
4.72 out of 5 average rating, 232 reviews

3+ acre:King Bed, Hot Tub, Mini Golf, Pool Table

ChristyRating, 5 stars1 month ago
Beautiful home - we felt very comfortable and enjoyed our time there.
A spacious living area features a mix of comfortable seating, including a sectional sofa and armchairs. Large windows allow natural light to illuminate the warm, rustic interior. A central coffee table and a desk are present, enhancing the functional layout.
Home in Carbondale
4.49 out of 5 average rating, 87 reviews

Peaceful Custom Carbondale Home w/ Pool, Near SIU!

PriscillaRating, 5 stars3 weeks ago
The pictures did not do any justice of how beautiful this place was! I would come back again and I recommend this spot 1000000 percent! So private and perfect for a getaway!
Top guest favorite
The master suite features a spacious bed adorned with colorful bedding, complemented by a cozy seating area. Large windows provide natural light and views of the surrounding landscape. Tile flooring and warm-colored walls enhance the inviting atmosphere of the room.
Home in Cobden
5 out of 5 average rating, 17 reviews

Champagne Domain

LauraRating, 5 stars1 month ago
We absolutely recommend! A beautiful location and a beautiful home! It was so relaxing and peaceful! The host went out of their way to make us feel at home. The home has a beautiful location and plenty of privacy. It was very clean and comfortable! Would absolutely book again.

Weekly house rentals

Top guest favorite
A welcoming living room features comfortable seating, including a large, light-colored sofa and armchairs. A decorative area rug lies on the dark wooden floor. Natural light filters through windows, highlighting the rustic wood beam overhead and a cozy wood stove in the corner.
Home in Makanda
5 out of 5 average rating, 26 reviews

Twisted Sister's Retreat

JosephRating, 5 stars3 weeks ago
A wonderful little place! Quaint & tucked away; only a 10-15m ride into town. Candace made the two of us feel right at home and had great recommendations. The backyard is a birders paradise! Great home base for multiple Shawnee sights & wineries; would definitely revisit.
Superhost
The kitchen area features grey cabinets and stainless steel appliances. A spacious island with seating for three is complemented by a large farm table that accommodates up to 12 guests. Natural light floods the space through sliding glass doors leading to a deck.
Home in Alto Pass
5 out of 5 average rating, 11 reviews

Big Sky Cabin! On The WineTrail! Hot Tub! Fire Pit

RachelRating, 5 stars1 month ago
When 6 guests ranging from 13-79 all love the place, it’s a win!! It was so peaceful and we felt right at home! We had a blast with the arcade, pool table, & the hot tub! We highly recommend! Thanks to the host for going above expectations!
Guest favorite
A two-story home is showcased at night, featuring a gabled roof and green shutters. The porch is adorned with white chairs and a bench, illuminated by moonlight. Lush greenery surrounds the property, contributing to a calming evening scene.
Home in Altenburg
4.92 out of 5 average rating, 12 reviews

Gem in Heart of Altenburg

LauraRating, 5 stars2 months ago
beds are comfy, bathrooms were spacious and clean, cozy home and ample parking
Superhost
A spacious living area features a large sectional couch adorned with yellow accent pillows. A coffee table is positioned in front, complemented by a woven basket. Soft lighting highlights the wooden floor and tasteful wall decor, creating a comfortable gathering space.
Home in Murphysboro
4.87 out of 5 average rating, 76 reviews

Hilltop Retreat 2: Spacious, pondfront home for 12

ErikaRating, 5 stars3 weeks ago
Our group had a wonderful time! Great location with approximately 15-30 minutes to most nearby attractions including Little Grand Canyon Trail and Alto Pass Vineyard. The house appeared well kept and accommodated our group perfectly. The back deck was peaceful. Ashley responded promptly to all of my messages and was very nice and professional. We hope to return in the future!
Top guest favorite
A recently remodeled farmhouse is set on a ridge top, featuring a welcoming porch with seating. The white exterior is complemented by rich maroon shutters. Grassy areas and established trees surround the home, creating a serene countryside setting.
Home in Murphysboro
4.99 out of 5 average rating, 69 reviews

Mary and Snooks' Cozy Country Farm House.

BobbiRating, 5 stars3 weeks ago
This Airbnb was EXACTLY what we needed for a stay near friends and family for a family occasion. This listing far exceeded our expectations and we are already planning to book again this summer! The place is beautiful, comfortable, and made us feel right at home. 10/10 recommend!
Guest favorite
The exterior of a charming brick house is presented, surrounded by manicured green grass and shrubs. Large windows invite natural light, while the roof features a small chimney. A clear blue sky and scattered clouds create a pleasant backdrop to the home.
Home in Cape Girardeau
4.96 out of 5 average rating, 24 reviews

Located near downtown and casino

HeatherRating, 5 stars1 month ago
Great house, great location. Quiet neighborhood. Beds were comfortable. Plenty of room for my son to play. He loved playing in the basement.
Superhost
A living area features a blend of floral wallpaper and hardwood flooring. A light-colored sofa and an armchair are arranged around a circular coffee table, with a patterned area rug underneath. Natural light enters through window drapes, enhancing the cozy ambiance.
Home in Cape Girardeau
4.82 out of 5 average rating, 11 reviews

Cottage Near Casino

MelissaRating, 5 stars3 months ago
Had a great stay. Was there for work and it was a quick drive to everywhere in town. Quiet and peaceful just what was needed for my off hours.
Top guest favorite
A bright living area features a comfortable gray sofa adorned with patterned throw pillows. A round area rug in soothing colors lies on the floor. A wooden coffee table is centrally positioned, and a small side table with a lamp complements a nearby armchair. Large windows allow natural light to fill the space.
Home in Perryville
4.96 out of 5 average rating, 53 reviews

Brewer House

LukeRating, 5 stars2 days ago
We stayed at the Brewer House while in town for a family reunion. The home was clean and very comfortable. Amy is an exceptional host, and made herself available to us. We had an unexpected family emergency and needed extra accommodations, and Amy was so gracious in fulfilling our need and giving us local suggestions and support. Our kids loved playing in the outside area, and it reminded me of my childhood growing up in Peach Tree City, Georgia. Thank you Amy!

Quick stats about house rentals in Cape Girardeau

  • Total rentals

    70 properties

  • Nightly prices starting at

    G$6,273 GYD before taxes and fees

  • Total number of reviews

    3K reviews

  • Family-friendly rentals

    40 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with dedicated workspaces

    40 properties have a dedicated workspace

Destinations to explore