Apartment vacation rentals in Cape Girardeau

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Regal Rustic Retreat

Take it easy at this unique and tranquil getaway. Close to SIU Carbondale and also Murphysboro. We offer a quiet, simple apartment to relax and recharge. Free local over the air television. We have broadband/smart monitor for your HDMI stick . Bring your own Roku or Firestick with your subscriptions. The second bedroom is an open loft area, not a separate room. We offer a large storage space for bicycles and mudroom with washer/dryer for cleaning up after a hike or bike race. Full kitchen.

Historical Kage House

The Building is reminiscent of eighteenth-century New Orleans architecture, and was built sometime before 1883. The Kage House is located at 120 Broadway in the historical district and is less than a minutes walk to Main Street and less than a 10 minutes walk to the Isle of Capri Casino. On Main Street you will find many fine shops and restaurants, or just enjoy the scenic area as you walkabout. This is by far one of the best places in Cape. Additional reviews can be read on the VRBO website.

Earnhart Carriage House

Standalone, 2 BR, light, airy, upstairs apartment for 4 guests. Full kitchen, coffee bar, washer/dryer. In our small village, there is a grocery store, bank, post office, Dollar Store, library, gas station, and a park are within walking distance. I-57 is one mile. We live near a railroad crossing. If you are a very light sleeper, they may wake you. Each bedroom has a desk and sitting area and the bedside table lamp bases have outlets to charge your phone or tablet.

The Windbreak

Forget your worries in this spacious apartment, the lower/first level of a 3-level house, a peaceful place at the woodsy end of a country lane, not far from two state parks, five lakes, wine trail, Southern Illinois University and other interesting features of this area. The 1st level apartment is large, has a kitchen, dining room, 2 bedrooms, living room/bedroom, a full bath, and a utility room, 2 exterior doors, one to a patio with a fire pit and charcoal cooker.

Fresh & Cozy Retreat w/ King Bed · By KeenStays

This fresh apartment offers a unique blend of chic style and cultural charm, nestled in a freshly rehabilitated building in Downtown Cape Girardeau. Enjoy a vibrant stay by being in walking distance to shopping, dining, and downtown entertainment! The apartment features a spacious, light-filled layout with chic finishes and appliances. Enjoy a comfortable & spacious living area. Don't forget to visit the viral mac & cheese bar, Roni's Mac Bar, downstairs!

Downtown 4BR with 2 King Beds! Off-street parking

- Massive two story 2,400 sq ft historic apartment on Broadway - Recently renovated - Downtown location - Free off-street parking - Walking distance to SEMO and River Front - 2 King beds! - 3 Bathrooms - 2 futons and one couch for extra sleepers - Self check-in with smart lock - Full kitchen - Washer/Dryer included - Formal dining area - Second cozy living room upstairs - Room darkening shades in all bedrooms - Note: narrow staircase at entrance

Lovely 2 bedroom apartment with luxury shower.

This special home away from home has 800 sq. ft. and is on 1st floor. Less than one mile from grocery, a few eateries and park. There is little traffic on our one-block street with an old graveyard across the street. We are just minutes away from a beautiful lake and rivers. Explore historic sites, visit antique shops and enjoy fishing, kayaking, hunting, visiting family or just relaxing.

Riverwalk 2BR | Easy, Walkable Stay

Enjoy easy, single-level living just steps from the River Campus and Riverwalk. This updated first-floor 2-bedroom home sits on the southeast side of Cape Girardeau — a short 5-minute walk to downtown while still tucked into a quiet residential street. Renovated in 2023, the home blends historic character with practical updates, offering a clean, functional space with no interior stairs.

Lennon's Garden 2BR with KING bed, Carterville

2 Bedroom apartment with 1 king sized bed, 1 full bed. Smart TVs in each bedroom and 55" smart tv in the living room. Comfy recliners and couch. Dining area in the open kitchen as well as an eating area under the covered patio. The kitchen is well stocked with pots, pans and dishes. Washer and Dryer available for guest use. Designated parking.

Modern Queen Suite Near SIU Carbondale

Stay in Suite 3 at Wall Street Suites, a modern queen suite near SIU Carbondale. This newly renovated micro-suite blends industrial charm with stylish urban design. Enjoy a full kitchen, Smart TV, queen bed & updated bath, plus a shared lobby workspace. Perfect for mid-term or monthly stays near SIU East Campus. Note: Access via stairwell.