House vacation rentals in Santo Domingo

Find and book unique houses on Airbnb

Top-rated house rentals in Santo Domingo

Guests agree: these houses are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1

Guest favorite

A private pool is framed by a stone patio, surrounded by lush greenery and tropical plants. A shaded area features outdoor seating and a grill, while the enclosed space provides a sense of tranquility. The home is visible in the background, set against a clear blue sky.

Home in Pedasí

4.92 out of 5 average rating, 199 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

FamilyValueSleep quality

Superhost

A welcoming entrance is framed by vibrant tropical plants, with a pathway leading to a covered porch. The structure features a tiled roof and red steps, providing an inviting transition from the outdoors to the interior space.

Home in Pedasi

4.86 out of 5 average rating, 22 reviews

Peaceful Pedasi

Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

FamilyLocationCondition

Guest favorite

A modern living area features a spacious white sofa facing a flat-screen TV mounted on the wall. Large windows allow natural light to fill the space, with soft drapes framing the view. A round coffee table sits atop a woven area rug, accompanied by a decorative plant.

Home in Playa Venao

4.87 out of 5 average rating, 30 reviews

Steps from Ocean: Couple's Getaway Private Villa

Escape to Villa 37! A romantic casita in Blue Playa Venao, 1 min walk from the ocean. This charming 1 bedroom is perfect for two. Enjoy an ensuite bathroom, fully equipped kitchen, cozy living space, WiFi, A/C, dreamy bedding, laundry closet, toiletries, and a comfortable terrace. You will have full access to the Blue oceanfront pool, beach club and restaurant, the perfect spot to enjoy a cold beverage and an unforgettable sunset. Villa 37 is your perfect Playa Venao getaway!

LocationKitchenLaundry

Superhost

The house exterior features a warm peach-colored facade with a large white-framed window. Tropical palm trees and vibrant flowering shrubs border the front, providing a refreshing touch to the entrance.

Home in Chitre

4.82 out of 5 average rating, 82 reviews

NinaHouse, spacious and cool house in Chitré.

House just for you, now with a water tank! Up to 7 people, spacious and in one of the best areas of Chitré, quiet and family-friendly, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with fast internet. We now have air conditioning in the living room for your comfort.

LocationValueCondition

Superhost

A private pool is surrounded by outdoor loungers, providing a spacious area for relaxation. The modern house features large glass doors that invite natural light, showcasing a harmonious blend of indoor and outdoor living spaces. Lush greenery is visible in the background.

Home in Punta Mala

4.82 out of 5 average rating, 22 reviews

Pedasi Coast, Casa Calma / 3BR

❤ Welcome to Casa Calma, enjoy this beautiful house ideal for groups of up to 6 people. With 3 comfortable and bright rooms, each equipped to guarantee your rest and comfort. The jewel of the house is its direct access to the sea, perfect for cooling off at any time of the day. In addition, you will have access to a private pool with a large terrace where you can enjoy spectacular sunrises and relax to the sound of the waves. Embark on this unique new adventure! ✿

LocationFamilyBeach

Guest favorite

A modern tropical home is set amid lush greenery, featuring an expansive deck that connects to a serene pool. Large glass doors provide a view of the inviting interior and allow natural light to fill the space. Mountains and trees frame the backdrop.

Home in Playa Venao

4.98 out of 5 average rating, 82 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

LocationFamilyAmenities

Guest favorite

Home in Playa Venao

4.9 out of 5 average rating, 81 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

FamilyLocationOutdoor spaces

Guest favorite

The outdoor area features a spacious infinity pool surrounded by a sun deck, complete with lounge chairs. Lush greenery and palm trees can be seen in the background, under a bright blue sky with fluffy clouds, creating a serene outdoor retreat.

Home in Pedasí

4.96 out of 5 average rating, 25 reviews

Villa La Jungla featuring a New Pool

Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.

ValueFamilyIndoor spaces

Guest favorite

Home in Chitre

5 out of 5 average rating, 11 reviews

Casa Blu Central Chitre| Sleeps 6| Private Parking

Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.

FamilyLocationNearby

Guest favorite

Home in Las Escobas del Venado

5 out of 5 average rating, 10 reviews

Tropical Cozy Cabin / Playa venao

Welcome to our tropical & cozy private cabin, fully furnished and equipped with everything you need for a comfortable stay in Playa Venao. Central location (2 min drive from the beach) Features two bedrooms with 2 single beds each, cozy living room with TV and sofa, fully equipped kitchen, AC in all the rooms, one bathroom and outdoor shower. Also have a nice terrace area with a deck and a comfy dining lounge.

ValueLocationAmenities

Top guest favorite

The exterior of a casita is displayed, featuring a light-colored facade with a red-tiled roof. A silver SUV is parked on a stone pathway that leads to a wooden front door. Lush greenery and palm trees are visible in the background under a partly cloudy sky.

Home in Pedasi

4.91 out of 5 average rating, 33 reviews

A minimalist Casita in Pedasi

Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

FamilyLocationSleep quality

Guest favorite

A colorful hammock hangs between two posts on a wooden terrace, overlooking a vast landscape. The sun sets in the distance, casting a warm glow over the scene, framed by lush greenery and bamboo fencing that adds privacy.

Home in Provincia de Los Santos

4.95 out of 5 average rating, 20 reviews

Casa Inito - Romantic Getaway

Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****

LocationGetting aroundKitchen