Some info has been automatically translated. Show original language

Vacation rentals in Santo Domingo

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santo Domingo

Guests agree: these stays are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Guest favorite
A charming patio is visible, featuring colorful hammocks suspended beneath a traditional roof. Lush greenery frames the view, enhancing the serene outdoor space that encourages relaxation. The exterior of the home is simple yet inviting, with wooden accents and large windows.
Home in Playa El Agallito
4.94 out of 5 average rating, 17 reviews

El Refugio: Nature Escape in Chitre

El Refugio at Playa El Agallito, Chitré: Nature Escape: Just 7 minutes from downtown Chitré, El Refugio is a fully equipped countryside home, perfect for disconnecting in a natural setting. Surrounded by mangroves and accommodating up to 8 guests, it offers a unique experience for couples, families or digital nomads. Enjoy bird watching, the peaceful surroundings, and the comfort of our large gazebo. Ideal for those seeking simple relaxation and a close connection to nature. A unique experience

Guest favorite
Home in Playa Venao
5 out of 5 average rating, 6 reviews

Jungle Tiny House w/ Oceanview – Playa Venao

Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Guest favorite
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.87 out of 5 average rating, 62 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

Apartment in Las Tablas
4.61 out of 5 average rating, 70 reviews

2nd floor Beach Apartment with Amazing Views!

Enjoy beach life all year round in Panama at Uverito Beach! Go to the beach anytime you want, it is literally at your footsteps or relax in a hammock. This 2 bedroom 1 bath 2nd floor unit has all the amenities that will make your stay comfortable. Long-term rental is also available plus electricity (except long-term rental of 28 days or more you pay), you get a smart TV, unlimited bandwidth Wi-Fi internet, hot water shower, and brand new kitchen appliances to include a dishwasher.

Guest favorite
A refreshing swimming pool sits in the foreground, complementing the rustic building behind it. Lush greenery and potted plants surround the area, enhancing the natural setting. A shaded patio area with outdoor seating is visible, offering a serene environment for relaxation.
Guesthouse in La Enea
4.96 out of 5 average rating, 49 reviews

Country House with Pool in La Enea de Guararé

Far from the capital city, come and enjoy Panamanian folklore in a rustic but cozy space, living an indigenous experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Port of Guararé where you can enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian skirts.

Guest favorite
A charming structure is framed by lush greenery, showcasing a rustic exterior with a terracotta roof and red accents. A small porch features a table and two chairs, inviting relaxation in this serene environment.
Guesthouse in Guararé
4.88 out of 5 average rating, 17 reviews

La Casita del Abuelo

This private place with full private bathroom is perfect for solo adventurers or a couple, seeking peace and relaxation in an authentic environment near the beach and town. This cute hideaway is located minutes’ walks from town and bus stop and about two miles from the nearest beach. It is a new, very clean, private, secure place, and it includes private use of an adjacent bohio with hammocks, barbecue grill, and bar.

Top guest favorite
The exterior of a two-story adobe house is depicted, surrounded by lush green foliage and palm trees. A spacious porch extends from the house, featuring seating options under a lovely tiled roof. Natural materials blend seamlessly with the earthy landscape.
Earthen home in playa el arenal pedasi
4.96 out of 5 average rating, 166 reviews

Earth House Pedasi Experience

Welcome to the Earth House. This space is destined to give you the experience of spending your vacations in a Eco House with all the amenities and facilities of a ¨Regular Home¨. Why Eco? This house is made with 95% adobe and with natural materials from the surroundings like rock and wood. Everything is handmade for this unique space. It is a wonderful experience to share with family and friends.

Top guest favorite
Villa in El Ciruelo
4.95 out of 5 average rating, 19 reviews

Villa Almanglar - Tropical Home with Pool and View

Escape to 'Al Manglar', where tranquility meets luxury. Enjoy breathtaking views of the mangroves, beach, and ocean from your private infinity pool. This spacious 2-bedroom villa offers king beds, private bathrooms, and a fully equipped kitchen. Perfect for remote work with a dedicated co-working space. Just 7 minutes from Playa Venao, this is your ultimate coastal getaway.

Guest favorite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.95 out of 5 average rating, 20 reviews

Little home near to the beach -Las Tablas

10 min drive- Las Tablas Get away from it all when you stay under the stars. A room very close to the sea, with an open kitchen that will allow you to disconnect and enjoy the view and nature in Las Tablas. You can plan to visit nearby beaches or take a walk through Pedasí, 30 minutes from Las Tablas.

Guest favorite
Home in La Villa de los Santos
4.94 out of 5 average rating, 102 reviews

Spacious house in Villa de los Santos

Comfortable family accommodation in La Villa de Los Santos, with Wi-Fi, A/C, equipped kitchen, patio and parking. Located near supermarkets and plazas. Just 15 minutes from El Rompió y Monagre, 45 minutes from Isla Iguana and 1h 30 minutes from Playa Venao.

Superhost
The rustic wooden cottage features a welcoming front porch with a blue bench, set against a backdrop of lush greenery. Large windows are present, allowing natural light to enter the simple yet charming space. A well-maintained yard surrounds the cottage, adding to its tranquil rural setting.
Farm stay in Monagre
4.64 out of 5 average rating, 25 reviews

Cabaña Monagre

Cabaña de madera, puedes ver la cría de ovejas, montar a Caballo por la playa con un costo adicional y disfrutar de áreas verdes. Estamos a 20 minutos del centro urbano pero muy cerca de playas y lugares turísticos y folklore

A cozy living area features a wooden table at center with a vase of tropical flowers. Two tufted armchairs and a small sofa provide comfortable seating. Large windows allow natural light to fill the space, offering views of the surrounding greenery.
Cottage in Santo Domingo
4.86 out of 5 average rating, 21 reviews

Cozy cottage in Las Tablas

The house is very spacious and cozy. It is located in Santo Domingo, a small town located 10 minutes by car from the city of Las Tablas. Here you can enjoy the authentic experience of being in a traditional inland village.

Popular amenities for Santo Domingo vacation rentals