House vacation rentals in Rochester

A cozy living area is featured, highlighting a brick fireplace with a warm glow. A marble countertop is positioned in the foreground, accompanied by two glasses of red wine and a plate of assorted fruit garnished with a purple flower. Natural light accentuates the scene.

4.92 out of 5 average rating, 193 reviews

The BEST Stay in Town: See Pics+Reviews to Believe

One level living/no stair. 2 bedrooms with 3 beds One-side of a duplex home: 1,200 Squarefeet w/ your own private entry, parking, laundry, kitchen.. 2.5 miles to Mayo, Target, Hyvee, gas stations...Fully furnished home. Smart TV & Fridge w/ Superfast internet & NetFlix included. Easy self-check-in keypad. A few blocks to the bus stop. Modern/spacious interior. Fully equipped kitchen w/ dishwasher, pots, pans, and washer/dryer at no additional cost. Fireplace & private deck. 3 parking spaces

A spacious living area features warm wood beam ceilings and large windows, allowing natural light to fill the room. Modern furniture, including a comfortable white sofa and a glass dining table, is arranged to create an inviting space. Double doors lead to a backyard patio.

4.95 out of 5 average rating, 262 reviews

Euro House, Bright! Near Mayo-Single Family Home

Welcome to your home away from home! This private, single-family home was thoughtfully designed and is located in a quiet area just 5 minutes (0.9 miles) from the Mayo Clinic. Step into a master gardener’s dream—a beautifully landscaped yard filled with native plants and outdoor seating, perfect for relaxing after a long day. 2 Queen Bedrooms, 2 Full Bathrooms, modern finishes throughout, Super clean and pet-free. Off-street parking, Washer & dryer, Wi-Fi, Smart TVs & Fully stocked kitchen.

4.97 out of 5 average rating, 150 reviews

Charming 3BR family home - 8 min drive to Mayo

Your home away from home. Cozy 3 BR, 3 beds + futon, 1.5 bath home located centrally in Rochester. Approximately 2 miles from Mayo & St. Mary’s hospital, 700 ft to nearest small grocery store, 0.6 miles to nearest gas station, and 1.5 miles to nearest shopping area w/Target, Chipotle, Applebee’s & more. Close to the Bus lines, bike trails & parks. This home is in the center of the city and is easily accessible. Come home and relax in a quiet, quaint neighborhood. All bedrooms on top floor.

A single-story home is shown, featuring a red front door and a well-maintained exterior. Vibrant autumn trees with golden leaves line the walkway, and a grassy area is depicted in front of the house, inviting a sense of tranquility to the setting.

4.87 out of 5 average rating, 400 reviews

Mayo Downtown's Prairie Home Retreat

Nestled in a serene corner, this home offers a perfect blend of tranquility and accessibility; being near the Mayo campus and Rochester's key attractions. Enjoy comfortable beds, a well-appointed kitchen, and a fenced yard with patio gardens. It's an excellent spot for family bonding, featuring three smart TVs, rapid Wi-Fi, and a variety of indoor and outdoor entertainment options. We strive to accommodate flexible check-in/check-out arrangements whenever feasible. Rollator accessible.

A dining table with wooden chairs is positioned in the foreground, surrounded by light yellow walls. The open space leads to a cozy living area featuring a fireplace and comfortable seating. Natural light fills the room, enhanced by framed artwork on the walls.

4.93 out of 5 average rating, 113 reviews

Walk to St. Marys, 1/2 Block, Entire Private Home!

This beautiful home is half a block from St. Mary's hospital, you can almost see it out the back door! Natalie’s place is the ideal space for rest, relaxation, waiting, and healing. We are within walking distance to St Marys Hospital and the Mayo Campus Shuttle, as well as many things, including a natural grocery store, restaurants, and parks. Free parking in your own driveway, skip the drive to the hospital as well as parking fees at the ramps, and walk the half block out the door!

The exterior of the home features a welcoming entrance with a porch, adorned with an American flag. The driveway leads to an attached garage, and landscaped green areas surround the entrance, creating an inviting approach.

5 out of 5 average rating, 153 reviews

Convenient, comfortable rambler near Mayo Clinic

• 1 mile to Saint Marys hospital and Mayo Clinic (Gonda) • Main level living — one 1 step up to front door • King bed, queen bed and daybed • Attached garage — huge perk in Minnesnowta! • Smart TVs w sectionals on main floor & basement, smart TV mounted in primary bedroom and a Roku TV in the queen size bedroom. • Two work spaces • Walk-in shower with grab bar • Serene rear patio with gas grill • Quiet neighborhood near Soldiers Field park, Apache Mall and biking/walking trails

Home in Historic Southwest

The open-concept living area showcases vaulted ceilings and skylights, enhancing natural light. Two light grey sofas frame a wooden coffee table on a colorful area rug. A dining area with a large table and chairs is visible, with stairs leading to the upper level in the background.

4.97 out of 5 average rating, 192 reviews

Spacious Modern Home Near Mayo, St. Mary's Campus

- 5 min walk to Mayo Clinic, St. Mary’s campus - 3 bedrooms, 3 bathrooms, and a loft - unique design with vaulted ceiling and skylights in the style of Frank Lloyd Wright, one of its kind in the whole neighborhood - two-car garage + another dedicated parking space outside - walkable and safe family-friendly neighborhood close to downtown and all amenities - outside front and back patios - fusball play table - dedicated workspace - high speed wifi - Apple TVs - washer and dryer

The living area is highlighted by a modern gray sofa, accentuated with textured cushions. A sleek coffee table holds a glass vase with greenery, while art pieces adorn the wall. Natural light filters through sheer curtains, creating a bright and inviting space.

4.96 out of 5 average rating, 137 reviews

Entire Boutique Home Kutzky Park ★ Walk to Mayo ★

Welcome to Asfar house! Expertly designed and centrally-located in a desirable Kutzky Park neighborhood, walking distance to Mayo Clinic, restaurants and shops. Whether you are relocating or visiting Rochester, this house will be sure to impress. Blasting fast WIFI, 3 relaxing bedrooms & a fully equipped kitchen. A perfect retreat to enjoy the coffee bar, read, watch a Netflix episode, play and relax. Enjoy the perfect shower, conveniently adjoined with free washer and dryer.

A bright bedroom features a spacious bed with white linens and a decorative pillow. A bedside lamp emits soft light beside a window with light curtains. A green dresser and a mirror complement the neutral walls, adding a fresh touch to the space.

4.98 out of 5 average rating, 376 reviews

The Guesthouse Cottage, walkable to Mayo Clinic

Our Guesthouse has a clean cottage feel. The king and queen bedrooms offer closets and quality linens. Cook meals in a fully stocked kitchen. Book an Uber, or walk 0.6 miles to Mayo's main Gonda building. We're close to grocers, coffee, parks and trails, and downtown's restaurants, shops, and a lovely public library. Free washer and dryer on site. Google TV and internet. 3-season porch. Small guest garage. No smoking on the property.

4.96 out of 5 average rating, 162 reviews

The Sierra! Close to Mayo Clinic

Gorgeous Home close to Mayo Clinic. The family room and living include Roku 4K UHD TVs, Foosball, and darts. Free WIFI. Office on Main with great light. Beautiful front porch or patio in the rear. TVs Enjoy luxurious finishes like crown molding, a fireplace in the family room, quartz countertops and a stunning vaulted Primary Ensuite with custom tile work and paneled doors. All of this is conveniently just minutes from downtown!

A welcoming entryway features a white bench adorned with patterned cushions and a decorative pillow. A small side table holds a flower vase and a sign that reads 'Hello.' On the wall, a rustic wooden hook rack displays a seasonal wreath. Natural light filters through nearby windows.

4.95 out of 5 average rating, 118 reviews

Apple Blossom Cottage | 2 Minutes from Mayo Clinic

The Apple Blossom Cottage is designed to be your home away from home. With a large yard and lovely little patio you will feel like you are far away while only being 2 miles away from the world renown Mayo Clinic. This two bedroom private home has an attached garage with the best of both worlds, privacy and quiet, while being less than 5 minutes away from grocery & restaurants and only 10 minute drive from Mayo Clinic Campuses.

A modern kitchen is displayed, featuring white cabinetry contrasted against a deep blue wall. A stainless steel oven and a retro-style microwave are present on the countertop, alongside a coffee maker and kitchen utensils. Natural light enters through the window above the sink.

4.83 out of 5 average rating, 564 reviews

Cozy home next to Mayo Clinic & historic parks!

Cozy single level 2 bedroom, 1 bath. Fully furnished kitchen with TV, WiFi, and smart lock. It’s a 1.6 miles to Mayo Clinic. Walking distance to Historic Quarry Hill Park and Silver Lake Park. City bus line to Mayo Clinic 1/2 block away. Newly remodeled bathroom with full linen and toiletries. Quiet neighborhood, with full driveway parking. We also have a baby gate for the stairs. Enjoy your next home away from home !

Popular amenities for Rochester house rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

House rentals with a pool

The exterior of a modern two-story home showcases a contrasting black and white color scheme. A spacious driveway leads to a large, white garage door. Clear blue skies serve as a backdrop, and well-maintained landscaping frames the property.

4.86 out of 5 average rating, 7 reviews

4bd/2.5bth Single-Family Home Close to Mayo

A modern two-story single-family home is depicted, featuring a clean white and black exterior. A large garage door complements the ample driveway. The well-maintained lawn offers a green backdrop, while the sunlit blue sky enhances the overall inviting appearance of the property.

5 out of 5 average rating, 7 reviews

4bd/2.5bth Single-Family Home Close to Mayo

Superhost

A modern single-family home is depicted, featuring a sleek black exterior with a prominent garage. The driveway leads to a well-maintained lawn, flanked by young trees and ornamental grasses, creating an inviting entrance. Clear blue skies complete the serene setting.

5 out of 5 average rating, 4 reviews

Unit 2377J | 3bd/2bth | Single-Family Home

A serene outdoor space is highlighted by a stunning sunset over lush greenery. Comfortable seating is arranged around a fire pit, surrounded by blooming flowers and various plants. A swimming pool is visible in the background, nestled into the landscape.

5 out of 5 average rating, 47 reviews

RARE! Pool, hot tub, garden &chickens! 4m to Mayo

A modern single-family home showcases a dark exterior with a spacious two-car garage. The front yard is neatly landscaped, featuring green grass and a young tree. A covered porch provides shaded entry, with large windows allowing natural light to stream indoors.

5 out of 5 average rating, 12 reviews

Unit 2365J | 2bd/2bth | Single-Family Home

Weekly house rentals

A comfortable living area features a modern sectional sofa and a wooden coffee table. A ceiling fan provides a refreshing breeze, while an electric fireplace adds warmth. Natural light fills the space from nearby windows, and elegant wall art enhances the relaxed atmosphere.

4.91 out of 5 average rating, 70 reviews

Chic 3BR Cozy Nook I Mins to Mayo & Dwtwn I Pets

4.95 out of 5 average rating, 20 reviews

Warm and Luxurious 4 bedroom Executive Estate

Home in Historic Southwest

A charming house features a light-colored exterior with a red-trimmed archway and large windows. The front walkway is bordered by a small lawn, and neighboring houses are visible on either side, showcasing diverse architectural styles.

4.93 out of 5 average rating, 41 reviews

Newly remodeled home 1 block to Mayo & St. Mary's

A comfortable seating area features a light-colored couch adorned with dark pillows and a round coffee table stacked with blankets. A black recliner is positioned nearby. Natural light flows through two windows, complemented by soft curtains. A round mirror reflects the serene space.

4.98 out of 5 average rating, 41 reviews

Recline & Reset- Main Floor Bed/Bath Edge of Mayo

The spacious kitchen features warm wood cabinetry and a large island with granite countertops. A dining area is visible with wooden chairs and a table, illuminated by natural light from large windows. The open layout connects the kitchen to an outdoor deck space beyond.

5 out of 5 average rating, 21 reviews

10 min to Mayo | No Stairs | Wildlife | Fire place

The spacious living area features inviting leather sofas and a textured ottoman, complemented by a large art piece of a tree. Natural light streams in from the nearby windows, illuminating the open floor plan that connects to the dining and kitchen areas.

5 out of 5 average rating, 36 reviews

Luxury Stay/ Theater / No step entry/ Dogs Welcome

The enclosed front porch features comfortable seating, inviting natural light from multiple windows. Blinds provide adjustable privacy, while the door showcases a decorative glass panel, enhancing the entrance. The space encourages relaxation with a view of the neighborhood outside.

4.92 out of 5 average rating, 65 reviews

Blue Door 3 new luxury bedrooms

Home in Historic Southwest

A comfortable living area features a light-colored sofa and an armchair, both adorned with decorative cushions. A central wooden coffee table is positioned on a textured area rug. Natural light enters through windows, and a television is mounted above a brick fireplace, creating a cozy ambiance.

4.93 out of 5 average rating, 56 reviews

Beautiful Home Single Story Living Near Mayo

Private house rentals

4.9 out of 5 average rating, 10 reviews

Home in Rochester-Mayo Clinic

4.88 out of 5 average rating, 16 reviews

Private Home Close to Mayo Clinic ~The Olive Inn~

Superhost

A modern single-story home is showcased, featuring a mix of dark exterior siding and large windows that allow natural light to flood the interior. A small staircase leads up to the front door, framed by well-maintained greenery and potted plants.

5 out of 5 average rating, 6 reviews

Rest Easy in Rochester

The back patio features a newly added gazebo with a metal roof, surrounded by stone pathways and landscaped greenery. Two seating areas are visible underneath the gazebo, providing an inviting outdoor space for relaxation.

4.9 out of 5 average rating, 20 reviews

Dorys Cottage

The kitchen features modern appliances, including a stainless steel microwave and oven. White cabinetry contrasts with the speckled granite countertops, providing ample workspace. A coffee maker and sink are included, with natural light illuminating the room through a nearby window.

4.9 out of 5 average rating, 114 reviews

Remodeled 1 bedroom house - Close to Mayo Clinic

4.83 out of 5 average rating, 157 reviews

Lowertown Lake House - Close To Mayo Clinic

A modern kitchen space is showcased with sleek, dark cabinetry and stainless steel appliances. An island with seating for two is centered, complemented by a reclining chair nearby. Soft lighting enhances the overall space, creating a functional cooking and dining area.

5 out of 5 average rating, 54 reviews

Beautifully Designed Space. 1 Mile to Mayo Clinic

A cozy living area features a comfortable gray sofa paired with a stylish armchair. A wooden coffee table sits on a soft area rug, while natural light fills the room through an arched entryway. A dining area with a dark wooden table and black chairs is visible in the background.