House vacation rentals in Rochester

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Top-rated house rentals in Rochester

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Top guest favorite

A cozy living area features a patterned sofa with a red accent pillow, complemented by warm wooden flooring. A brick wall provides texture, and natural light filters through the windows. In the background, a dining area with a wooden table and chairs can be seen, along with a staircase.

Home in Rochester

4.98 out of 5 average rating, 109 reviews

Cottage in Lowertown–Perfect for Mayo & Downtown

In Lowertown-this quaint cottage with modern updates is your home away from home! Fully furnished and a well stocked kitchen make it a wonderful place for overnight stays or longer term rentals. Beautiful patio provides an urban sanctuary at the end of a long day. Close proximity to Mayo Clinic-downtown restaurants, grocery stores and shopping are within walking distance. Two blocks in either direction puts you on the trail system. Public transit 1 ½ blocks away and a laundromat is ½ block away.

Top guest favorite

A bright living room features a large window with sheer curtains allowing natural light. A comfortable gray sofa is paired with a black recliner and a glass coffee table, complemented by a patterned area rug and decorative wall art.

Home in Rochester

4.99 out of 5 average rating, 170 reviews

NEW: Renovated rambler with ramp - no stairs!

• Enhanced cleaning protocols due to COVID • Main floor living w exterior ramp for easy access on Mayo Clinic stays • Fully renovated house in winter 2022 • 3 bedrooms w queen beds • Fully stocked kitchen w dishwasher, Keurig and k-cups • Main floor living room w sectional and smart TV • Huge basement w sectional, TV, kids toys • Free garage & driveway parking • High-speed wifi for work/streaming • Central AC & furnace w thermostat you control • Main floor bath tub & lower level walk in shower

Top guest favorite

A spacious living area features warm wood beam ceilings and large windows, allowing natural light to fill the room. Modern furniture, including a comfortable white sofa and a glass dining table, is arranged to create an inviting space. Double doors lead to a backyard patio.

Home in Rochester

4.95 out of 5 average rating, 246 reviews

Euro House, Bright! Near Mayo-Single Family Home

Welcome to your home away from home! This private, single-family home was thoughtfully designed and is located in a quiet area just 5 minutes (0.9 miles) from the Mayo Clinic. Step into a master gardener’s dream—a beautifully landscaped yard filled with native plants and outdoor seating, perfect for relaxing after a long day. 2 Queen Bedrooms, 2 Full Bathrooms, modern finishes throughout, Super clean and pet-free. Off-street parking, Washer & dryer, Wi-Fi, Smart TVs & Fully stocked kitchen.

Top guest favorite

A bright living area features a yellow chaise lounge, a dark upholstered chair, and a wooden table with books. A textured rug adds color underfoot. The wall is adorned with light-colored bricks and two windows with bamboo blinds. A TV is mounted for entertainment.

Home in Rochester

4.98 out of 5 average rating, 124 reviews

The Little House | 1 mi from downtown, Love Pets!

The Little House is the perfect place of you're looking for something Cozy, stylish, and close to everything that you need. This home was a fun renovation project for my husband and I. It's located in the family friendly Sunnyside Addition neighborhood and we've worked hard to make sure you have everything you need during your stay. This home has a beautiful fully fenced in yard with a neighborhood feel while still being less than a 5 minute drive from Downtown & Mayo Clinic Campuses!

Guest favorite

A charming home is presented with a steep roof and bay windows framed by landscaped bushes. A small porch is visible at the entrance, complemented by a paved walkway leading to the street. The front yard features well-maintained grass and a few scattered leaves.

Home in Kutzky

4.87 out of 5 average rating, 202 reviews

2 Blks St Marys Main Fl Beds Bath CoveredByFaith

Storybook home is only 2 blocks from St. Mary's hospital and 9 blocks from Mayo Clinic. 2 bedrooms and bathroom are on the main floor and 1 bedroom upstairs. 1 King bed. Two bedrooms queen size bed. Over 2,200 square feet for you to enjoy. Relax in a safe neighborhood. There are 3 steps to get into the home. Oak hardwood floors on the main level, fir hardwood floor upstairs. We are only 2 blocks from restaurants, a mall, and a grocery store. We also have many additional houses downtown.

Guest favorite

Home in Rochester

4.87 out of 5 average rating, 362 reviews

Mayo Downtown's Prairie Home Retreat

Nestled in a serene corner, this home offers a perfect blend of tranquility and accessibility; being near the Mayo campus and Rochester's key attractions. Enjoy comfortable beds, a well-appointed kitchen, and a fenced yard with patio gardens. It's an excellent spot for family bonding, featuring three smart TVs, rapid Wi-Fi, and a variety of indoor and outdoor entertainment options. We strive to accommodate flexible check-in/check-out arrangements whenever feasible. Rollator accessible.

Top guest favorite

A dining table with wooden chairs is positioned in the foreground, surrounded by light yellow walls. The open space leads to a cozy living area featuring a fireplace and comfortable seating. Natural light fills the room, enhanced by framed artwork on the walls.

Home in Kutzky

4.94 out of 5 average rating, 102 reviews

Walk to St. Marys, 1/2 Block, Entire Private Home!

This beautiful home is half a block from St. Mary's hospital, you can almost see it out the back door! Natalie’s place is the ideal space for rest, relaxation, waiting, and healing. We are within walking distance to St Marys Hospital and the Mayo Campus Shuttle, as well as many things, including a natural grocery store, restaurants, and parks. Free parking in your own driveway, skip the drive to the hospital as well as parking fees at the ramps, and walk the half block out the door!

Top guest favorite

The exterior of the home features a welcoming entrance with a porch, adorned with an American flag. The driveway leads to an attached garage, and landscaped green areas surround the entrance, creating an inviting approach.

Home in Rochester

5 out of 5 average rating, 137 reviews

Convenient, comfortable rambler near Mayo Clinic

• 1 mile to Saint Marys hospital and Mayo Clinic (Gonda) • Main level living — one 1 step up to front door • King bed, queen bed and daybed • Attached garage — huge perk in Minnesnowta! • Smart TVs w sectionals on main floor & basement, smart TV mounted in primary bedroom and a Roku TV in the queen size bedroom. • Two work spaces • Walk-in shower with grab bar • Serene rear patio with gas grill • Quiet neighborhood near Soldiers Field park, Apache Mall and biking/walking trails

Top guest favorite

The open-concept living area showcases vaulted ceilings and skylights, enhancing natural light. Two light grey sofas frame a wooden coffee table on a colorful area rug. A dining area with a large table and chairs is visible, with stairs leading to the upper level in the background.

Home in Historic Southwest

4.97 out of 5 average rating, 176 reviews

Spacious Modern Home Near Mayo, St. Mary's Campus

- 5 min walk to Mayo Clinic, St. Mary’s campus - 3 bedrooms, 3 bathrooms, and a loft - unique design with vaulted ceiling and skylights in the style of Frank Lloyd Wright, one of its kind in the whole neighborhood - two-car garage + another dedicated parking space outside - walkable and safe family-friendly neighborhood close to downtown and all amenities - outside front and back patios - fusball play table - dedicated workspace - high speed wifi - Apple TVs - washer and dryer

Top guest favorite

The living area is highlighted by a modern gray sofa, accentuated with textured cushions. A sleek coffee table holds a glass vase with greenery, while art pieces adorn the wall. Natural light filters through sheer curtains, creating a bright and inviting space.

Home in Kutzky

4.96 out of 5 average rating, 119 reviews

Entire Boutique Home Kutzky Park ★ Walk to Mayo ★

Welcome to Asfar house! Expertly designed and centrally-located in a desirable Kutzky Park neighborhood, walking distance to Mayo Clinic, restaurants and shops. Whether you are relocating or visiting Rochester, this house will be sure to impress. Blasting fast WIFI, 3 relaxing bedrooms & a fully equipped kitchen. A perfect retreat to enjoy the coffee bar, read, watch a Netflix episode, play and relax. Enjoy the perfect shower, conveniently adjoined with free washer and dryer.

Guest favorite

A welcoming bedroom is presented, featuring a bed adorned with floral-patterned bedding and several accent pillows. Soft light emits from a bedside lamp, and two curtains frame a window, adding warmth to the space. Hardwood flooring complements the room's tranquil atmosphere.

Home in Rochester

4.91 out of 5 average rating, 156 reviews

September Sale! House/Garage/Mayo Clinic

Location, location, location! Cozy up and save money while staying at our sweet, cozy 2 bedroom apartment 2-3 minutes from the Mayo Clinic, downtown, restaurants, grocery stores, coffee shops, parks, fitness centers, pharmacies, the mall, gas stations, and everything else in between! Home features 2 bedrooms, full bath, living room, kitchen, recliner, washer and dryer. All hardwood/tile floors. Fast Wifi/Washer Dryer included. Garage parking included.

Top guest favorite

A bright bedroom features a spacious bed with white linens and a decorative pillow. A bedside lamp emits soft light beside a window with light curtains. A green dresser and a mirror complement the neutral walls, adding a fresh touch to the space.

Home in Rochester

4.98 out of 5 average rating, 355 reviews

The Guesthouse Cottage, walkable to Mayo Clinic

Our Guesthouse has a clean cottage feel. The king and queen bedrooms offer closets and quality linens. Cook meals in a fully stocked kitchen. Book an Uber, or walk 0.6 miles to Mayo's main Gonda building. We're close to grocers, coffee, parks and trails, and downtown's restaurants, shops, and a lovely public library. Free washer and dryer on site. Google TV and internet. 3-season porch. Small guest garage. No smoking on the property.