House vacation rentals in Rochester

A cozy living area features a patterned sofa with a red accent pillow, complemented by warm wooden flooring. A brick wall provides texture, and natural light filters through the windows. In the background, a dining area with a wooden table and chairs can be seen, along with a staircase.

4.98 out of 5 average rating, 114 reviews

Cottage in Lowertown–Perfect for Mayo & Downtown

In Lowertown-this quaint cottage with modern updates is your home away from home! Fully furnished and a well stocked kitchen make it a wonderful place for overnight stays or longer term rentals. Beautiful patio provides an urban sanctuary at the end of a long day. Close proximity to Mayo Clinic-downtown restaurants, grocery stores and shopping are within walking distance. Two blocks in either direction puts you on the trail system. Public transit 1 ½ blocks away and a laundromat is ½ block away.

A spacious living area features warm wood beam ceilings and large windows, allowing natural light to fill the room. Modern furniture, including a comfortable white sofa and a glass dining table, is arranged to create an inviting space. Double doors lead to a backyard patio.

4.95 out of 5 average rating, 254 reviews

Euro House, Bright! Near Mayo-Single Family Home

Welcome to your home away from home! This private, single-family home was thoughtfully designed and is located in a quiet area just 5 minutes (0.9 miles) from the Mayo Clinic. Step into a master gardener’s dream—a beautifully landscaped yard filled with native plants and outdoor seating, perfect for relaxing after a long day. 2 Queen Bedrooms, 2 Full Bathrooms, modern finishes throughout, Super clean and pet-free. Off-street parking, Washer & dryer, Wi-Fi, Smart TVs & Fully stocked kitchen.

4.99 out of 5 average rating, 188 reviews

NEW: Renovated rambler with ramp - no stairs!

• Main floor living w exterior ramp for easy access on Mayo Clinic stays • Fully renovated house in winter 2022 • 3 bedrooms w king & 2 queen beds • Fully stocked kitchen w dishwasher, Keurig and k-cups • Main floor living room w sectional and smart TV • Huge basement w sectional, TV, kids toys • Free garage & driveway parking • High-speed wifi for work/streaming • Central AC & furnace w thermostat you control • Main floor bath tub & lower level walk in shower • Main floor office with desk

A single-story home is shown, featuring a red front door and a well-maintained exterior. Vibrant autumn trees with golden leaves line the walkway, and a grassy area is depicted in front of the house, inviting a sense of tranquility to the setting.

4.87 out of 5 average rating, 386 reviews

Mayo Downtown's Prairie Home Retreat

Nestled in a serene corner, this home offers a perfect blend of tranquility and accessibility; being near the Mayo campus and Rochester's key attractions. Enjoy comfortable beds, a well-appointed kitchen, and a fenced yard with patio gardens. It's an excellent spot for family bonding, featuring three smart TVs, rapid Wi-Fi, and a variety of indoor and outdoor entertainment options. We strive to accommodate flexible check-in/check-out arrangements whenever feasible. Rollator accessible.

A dining table with wooden chairs is positioned in the foreground, surrounded by light yellow walls. The open space leads to a cozy living area featuring a fireplace and comfortable seating. Natural light fills the room, enhanced by framed artwork on the walls.

4.94 out of 5 average rating, 108 reviews

Walk to St. Marys, 1/2 Block, Entire Private Home!

This beautiful home is half a block from St. Mary's hospital, you can almost see it out the back door! Natalie’s place is the ideal space for rest, relaxation, waiting, and healing. We are within walking distance to St Marys Hospital and the Mayo Campus Shuttle, as well as many things, including a natural grocery store, restaurants, and parks. Free parking in your own driveway, skip the drive to the hospital as well as parking fees at the ramps, and walk the half block out the door!

A welcoming book titled 'Welcome to Oasis' is displayed prominently, featuring a lotus flower design and neatly placed beside a decorative white vase. Greenery is visible in the background, adding a touch of nature to the inviting setting.

4.94 out of 5 average rating, 122 reviews

Oasis - Comfort & Serenity (Full house near Mayo)

*Discount for extended stays* Seeking a peaceful respite near Mayo Clinic in Rochester, MN? Look no further than "Oasis"–your ultimate home away from home. We offer 5 beds, 2 baths, & can accommodate up to 8 guests. Recharge in the workout & yoga meditation room, stay connected in the office area, & explore Rochester's attractions. Your dedicated host Peggy, a Mayo employee, will ensure a seamless/enjoyable stay. Book now & experience the perfect blend of comfort & serenity at Oasis.

The exterior of the home features a welcoming entrance with a porch, adorned with an American flag. The driveway leads to an attached garage, and landscaped green areas surround the entrance, creating an inviting approach.

5 out of 5 average rating, 146 reviews

Convenient, comfortable rambler near Mayo Clinic

• 1 mile to Saint Marys hospital and Mayo Clinic (Gonda) • Main level living — one 1 step up to front door • King bed, queen bed and daybed • Attached garage — huge perk in Minnesnowta! • Smart TVs w sectionals on main floor & basement, smart TV mounted in primary bedroom and a Roku TV in the queen size bedroom. • Two work spaces • Walk-in shower with grab bar • Serene rear patio with gas grill • Quiet neighborhood near Soldiers Field park, Apache Mall and biking/walking trails

Home in Historic Southwest

The open-concept living area showcases vaulted ceilings and skylights, enhancing natural light. Two light grey sofas frame a wooden coffee table on a colorful area rug. A dining area with a large table and chairs is visible, with stairs leading to the upper level in the background.

4.97 out of 5 average rating, 187 reviews

Spacious Modern Home Near Mayo, St. Mary's Campus

- 5 min walk to Mayo Clinic, St. Mary’s campus - 3 bedrooms, 3 bathrooms, and a loft - unique design with vaulted ceiling and skylights in the style of Frank Lloyd Wright, one of its kind in the whole neighborhood - two-car garage + another dedicated parking space outside - walkable and safe family-friendly neighborhood close to downtown and all amenities - outside front and back patios - fusball play table - dedicated workspace - high speed wifi - Apple TVs - washer and dryer

The living area is highlighted by a modern gray sofa, accentuated with textured cushions. A sleek coffee table holds a glass vase with greenery, while art pieces adorn the wall. Natural light filters through sheer curtains, creating a bright and inviting space.

4.96 out of 5 average rating, 131 reviews

Entire Boutique Home Kutzky Park ★ Walk to Mayo ★

Welcome to Asfar house! Expertly designed and centrally-located in a desirable Kutzky Park neighborhood, walking distance to Mayo Clinic, restaurants and shops. Whether you are relocating or visiting Rochester, this house will be sure to impress. Blasting fast WIFI, 3 relaxing bedrooms & a fully equipped kitchen. A perfect retreat to enjoy the coffee bar, read, watch a Netflix episode, play and relax. Enjoy the perfect shower, conveniently adjoined with free washer and dryer.

The living room features a gray sofa adorned with soft pillows, paired with two chair seats. A wooden coffee table sits atop a decorative rug, while a television on a white stand displays a serene nature scene. Light filters through sheer curtains, enhancing a calm atmosphere.

4.84 out of 5 average rating, 281 reviews

Coastal Charm w/Jacuzzi Tub-8min to Mayo

Recently restyled/refurnished in March 2024. Coastal and a bit of boho, cozy single-family, styled to be your home away from home. 8 Min to Mayo & 7 Min to St. Mary's. Relax after a long day in a Jacuzzi tub. Equipped with various kitchen appliances and utensils (No Dishwasher). Short drive to parks, groceries, Walmart, Target, etc. Smart TV & veggie garden. We're a phone call away if you have any needs. Relax, sit on the deck, or enjoy a cozy campfire.

A bright bedroom features a spacious bed with white linens and a decorative pillow. A bedside lamp emits soft light beside a window with light curtains. A green dresser and a mirror complement the neutral walls, adding a fresh touch to the space.

4.98 out of 5 average rating, 369 reviews

The Guesthouse Cottage, walkable to Mayo Clinic

Our Guesthouse has a clean cottage feel. The king and queen bedrooms offer closets and quality linens. Cook meals in a fully stocked kitchen. Book an Uber, or walk 0.6 miles to Mayo's main Gonda building. We're close to grocers, coffee, parks and trails, and downtown's restaurants, shops, and a lovely public library. Free washer and dryer on site. Google TV and internet. 3-season porch. Small guest garage. No smoking on the property.

A welcoming entryway features a white bench adorned with patterned cushions and a decorative pillow. A small side table holds a flower vase and a sign that reads 'Hello.' On the wall, a rustic wooden hook rack displays a seasonal wreath. Natural light filters through nearby windows.

4.95 out of 5 average rating, 114 reviews

Apple Blossom Cottage | 2 Minutes from Mayo Clinic

The Apple Blossom Cottage is designed to be your home away from home. With a large yard and lovely little patio you will feel like you are far away while only being 2 miles away from the world renown Mayo Clinic. This two bedroom private home has an attached garage with the best of both worlds, privacy and quiet, while being less than 5 minutes away from grocery & restaurants and only 10 minute drive from Mayo Clinic Campuses.

Popular amenities for Rochester house rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

House rentals with a pool

The exterior of a modern two-story home showcases a contrasting black and white color scheme. A spacious driveway leads to a large, white garage door. Clear blue skies serve as a backdrop, and well-maintained landscaping frames the property.

4.83 out of 5 average rating, 6 reviews

4bd/2.5bth Single-Family Home Close to Mayo

A modern two-story single-family home is depicted, featuring a clean white and black exterior. A large garage door complements the ample driveway. The well-maintained lawn offers a green backdrop, while the sunlit blue sky enhances the overall inviting appearance of the property.

5 out of 5 average rating, 5 reviews

4bd/2.5bth Single-Family Home Close to Mayo

A modern single-family home is depicted, featuring a sleek black exterior with a prominent garage. The driveway leads to a well-maintained lawn, flanked by young trees and ornamental grasses, creating an inviting entrance. Clear blue skies complete the serene setting.

5 out of 5 average rating, 4 reviews

Unit 2377J | 3bd/2bth | Single-Family Home

A serene outdoor space is highlighted by a stunning sunset over lush greenery. Comfortable seating is arranged around a fire pit, surrounded by blooming flowers and various plants. A swimming pool is visible in the background, nestled into the landscape.

5 out of 5 average rating, 47 reviews

RARE! Pool, hot tub, garden &chickens! 4m to Mayo

A modern single-family home showcases a dark exterior with a spacious two-car garage. The front yard is neatly landscaped, featuring green grass and a young tree. A covered porch provides shaded entry, with large windows allowing natural light to stream indoors.

5 out of 5 average rating, 11 reviews

Unit 2365J | 2bd/2bth | Single-Family Home

Weekly house rentals

An inviting living room features a dark sofa, a patterned armchair, and a coffee table at its center. Artwork adorns the walls, while light streams in through a window covered with curtains. A cozy area rug adds warmth to the wooden floor.

4.95 out of 5 average rating, 64 reviews

Come From Away!

Home in Historic Southwest

A charming two-story home featuring a yellow exterior with white trim and a dark blue front door. The entrance is framed by decorative windows and is surrounded by lush greenery and autumn leaves. A concrete walkway leads up to the front steps.

4.93 out of 5 average rating, 15 reviews

Oasis by the Mayo Clinic

A light-filled living room features a soft beige sofa with blue accent pillows. Two teal chairs with decorative pillows are positioned nearby. A small coffee table is centered in the room, with a mirror and lamps providing ambient lighting. Large windows offer views of the outside.

5 out of 5 average rating, 5 reviews

Gorgeous Rochester Home

A modern kitchen features white cabinetry and stainless steel appliances, including a refrigerator and oven. An island with seating for two enhances the space, while natural light enters through a window above the sink. Sleek countertops provide a clean and functional workspace.

4.99 out of 5 average rating, 79 reviews

Apple Hill guest house close to Mayo Clinic

The living area features a comfortable gray sofa adorned with white and burgundy pillows. Natural light streams through a window covered by light curtains, illuminating the space. A decorative plant is positioned nearby, while a wooden coffee table and a smart TV are also present.

4.98 out of 5 average rating, 65 reviews

Mayo Discount! 2 main floor Bedrooms. Recliner

A spacious living area is furnished with two comfortable sofas, a coffee table, and a flat-screen television. Natural light enters through large windows adorned with light curtains, and a ceiling fan provides a cooling breeze. A welcoming entrance with a modern door is visible.

5 out of 5 average rating, 32 reviews

Quaint Home 2 miles from Mayo

Home in Historic Southwest

A comfortable living area features a light-colored sofa and an armchair, both adorned with decorative cushions. A central wooden coffee table is positioned on a textured area rug. Natural light enters through windows, and a television is mounted above a brick fireplace, creating a cozy ambiance.

4.93 out of 5 average rating, 55 reviews

Beautiful Home Single Story Living Near Mayo

The kitchen features modern appliances, including a stainless steel refrigerator and an oven. White cabinets and dark countertops create a clean and functional space. Natural light enters through the window, illuminating the tile backsplash and adding a bright atmosphere.

4.86 out of 5 average rating, 69 reviews

Spacious park-side home, close to Mayo Clinic

Private house rentals

The kitchen features modern appliances, including a stainless steel microwave and oven. White cabinetry contrasts with the speckled granite countertops, providing ample workspace. A coffee maker and sink are included, with natural light illuminating the room through a nearby window.

4.9 out of 5 average rating, 111 reviews

Remodeled 1 bedroom house - Close to Mayo Clinic

4.95 out of 5 average rating, 151 reviews

The Sierra! Close to Mayo Clinic

A modern kitchen is showcased with an island featuring a light wood countertop. Stainless steel appliances, including a refrigerator, are visually prominent. A cozy living area is visible with a dark sofa, illuminating natural light from a large front window. A dedicated laundry area is seen to the right.

4.88 out of 5 average rating, 17 reviews

Woodhaven West

A cozy living room features a soft sofa and two accent chairs positioned around a glass coffee table. A patterned area rug adds warmth to the space, while windows with blinds allow natural light to enter. Decorative plants are placed beside the seating areas.

4.53 out of 5 average rating, 17 reviews

Clean, quiet 3BR, 1.5 BA home, 4 miles from Mayo

A spacious living area features a stone fireplace as a focal point, with a mounted television above. Comfortable leather sofas are arranged around a large, rectangular coffee table. Natural light filters in through windows, contributing to an inviting ambiance.

4.95 out of 5 average rating, 78 reviews

Luxury Home - Newer Construction - 3 BR/2 Bath

A bright kitchen area is featured, showcasing wooden cabinetry with glass-front doors. A modern black faucet is positioned over a neutral countertop, and a welcoming sign decorates the wall above. Natural light filters through the window, illuminating the backsplash tiles.

4.94 out of 5 average rating, 63 reviews

The Cozy Hope House -- Minutes from Mayo Clinic

A cozy living area features a comfortable gray sofa paired with a stylish armchair. A wooden coffee table sits on a soft area rug, while natural light fills the room through an arched entryway. A dining area with a dark wooden table and black chairs is visible in the background.

4.58 out of 5 average rating, 12 reviews

Walk to Mayo: Two bedroom with free parking

A modern kitchen space is showcased with sleek, dark cabinetry and stainless steel appliances. An island with seating for two is centered, complemented by a reclining chair nearby. Soft lighting enhances the overall space, creating a functional cooking and dining area.