Guesthouse vacation rentals in Panama Canal

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Top-rated guesthouse rentals in Panama Canal

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Panamá

4.76 out of 5 average rating, 241 reviews

Garden Cottage in city center

Cozy Private Cottage in Panama City Enjoy a comfortable stay in this charming garden cottage located in a central area of Panama City. With a private entrance, garden, and outdoor barbecue area, you'll have everything you need for a perfect getaway. The property features WiFi, smart TV, air conditioning, a double bed, and a sofa bed in the living room, as well as a fully equipped kitchen and bathroom. It also includes a washer and dryer for your convenience Perfect for an unforgettable escape

Top guest favorite

Guesthouse in Gamboa

4.95 out of 5 average rating, 75 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Guest favorite

Guesthouse in Panamá

4.92 out of 5 average rating, 36 reviews

Home Harmony 15 min. Aeropuerto.

"Experimenta una estancia cómoda y conveniente en nuestro acogedor apartamento, ubicado a solo 10 minutos del aeropuerto Tocumen. Equipado con todas las comodidades necesarias para tu descanso, desde conexión WiFi hasta una cocina equipada, este espacio te ofrece la oportunidad de relajarte y recargar energías. Disfruta del confort del aire acondicionado, agua caliente/fria en el baño, una cama y sofá cama para tu comodidad, televisión con cable , y toallas y sobrecama para tu conveniencia.

Superhost

Guesthouse in Panamá

Trendy Tiny Apartment in Ancon

Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

Superhost

Guesthouse in Panamá

4.75 out of 5 average rating, 4 reviews

The Black Studio near airport & city

This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Guest favorite

Guesthouse in Panamá

4.88 out of 5 average rating, 17 reviews

Charming Urban Retreat with Private Green Oasis

A peaceful, art-filled retreat in the heart of El Cangrejo. This ground-floor apartment features a private green yard — perfect for relaxing or spotting hummingbirds. There is an outdoor furniture dining set (available upon request). Steps from cafés, galleries, parks, and nightlife, yet quiet and tucked away. Only one neighbor on site. Thoughtfully decorated with pieces from local artisans. Watch the video: “El Cangrejo – Unique Oasis Apartment” on YouTube.

Superhost

Guesthouse in Panamá

4.47 out of 5 average rating, 15 reviews

Convenient, centrally located suite with parking

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Guest favorite

Guesthouse in Panamá

4.93 out of 5 average rating, 42 reviews

CASA PINO, a forest in the city

Excellent independent studio apartment with everything you need, private bathroom, kitchenette, fridge, and WiFi. Very safe. You can use machines in the park to exercise. We are located in a privileged area on the banks of the Canal, with lots of vegetation and forests, but very close to all the recreational amenities of the City of Knowledge. Very central, 10 minutes by metro-bus to Albrook Mall, 10 minutes from the Panama Canal.

Guest favorite

Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City

5 out of 5 average rating, 26 reviews

Apartment in a safe residential area

You will be Close to everything when you stay in this central home. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, on the way to Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether traveling for business, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We're available if you need any additional information.

Guest favorite

Guesthouse in Panamá

4.87 out of 5 average rating, 53 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet and central accommodation. Close to sights such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Guest favorite

Guesthouse in Panama City

4.89 out of 5 average rating, 214 reviews

#1 Personal Studio 9 km International Airport

Independent mini room, with A/C, with its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is Close to 2 Shopping Centers, Metromall and Los Pueblos. The residential area is safe when walking, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall. Space to prepare light food.

Guest favorite

Guesthouse in Panama City

4.88 out of 5 average rating, 74 reviews

A small apartment-style annex

The place is close to Tocumen airport (15 minutes), has WiFi, cable service, Netflix and has shops and supermarkets around it, very close to nature, it is a quiet and cozy place. You can also take a taxi or Uber to get to the Panama Metro (10 minutes). We have round-trip transportation service to Tocumen Airport, for an additional cost.