
Vacation rentals in Panama Canal
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Panama Canal
Guests agree: these stays are highly rated for location, cleanliness, and more.

Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Best location - Unique and charming loft
Relax and enjoy the elegance of a bygone era when you stay in this charming Loft. Carefully built with wooden floors, calicanto walls, high beamed ceilings and antique details for a luxurious yet charming feel. Take an early morning walk and enjoy the ruins, churches, and museums of Casco Viejo. Stroll through the historic streets while the city sleeps, then return for morning coffee in this classic and elegant Loft with a dreamy terrace. This apartment is located in the heart of Casco Viejo!

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Aqeel cabin in the nature
Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Patty’s Casco 2BR Loft | Balcony & Personal Touch
“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Los Domos Panama, Domo Fuego, Glamping en Altura.
Immerse yourself in a natural oasis where the connection with nature becomes palpable. Surrounded by trees and coffee plantations, our space offers a unique experience for those looking to reconnect with nature. From the birdsong to the pure air you breathe, every moment here is an invitation to harmony. We have a private river of totally fresh spring water and immerse yourself in the night experience with our outdoor hot tub.

Armadillo Shelter & Garden Valle de Anton
It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Exceptional three-story building with sea view
This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Sky Lounge/ APT 1 BR-vista al Mar/Pool bar & GYM
Moderno apartamento de lujo en la Cinta Costera, ideal para ejecutivos, parejas o familias. Dormitorio amplio con vista al mar, baño privado, cocina y electrodomésticos. Diseño elegante con seguridad 24/7, gimnasio, piscinas, 4 restaurantes, bar y Sky Lounge. Ubicación privilegiada cerca de supermercados y excelente oferta gastronómica en Ciudad de Panamá. PANAMA

2B Loft Studio | Design By Paradox
PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.
Popular amenities for Panama Canal vacation rentals
Other great vacation rentals in Panama Canal

Mountain Retreat

Justinatinyhouse disconnects to connect

Most Beautiful Loft in the Heart of Casco Viejo

La Florecita - Country house in Valle de Antón

Luxury apartment in the heart of Panama

BirdHouse@ Gamboa Panama Canal

Blue Sky Lodge; the best view in Altos del María

Casco Antiguo Apartment with Balcony & Stone Wall
Destinations to explore
- Waterfront rentals Panama Canal
- Hotel rooms Panama Canal
- Rentals with pools Panama Canal
- Serviced apartment rentals Panama Canal
- Hostel rentals Panama Canal
- Rentals with a patio Panama Canal
- Rentals with breakfast Panama Canal
- Loft rentals Panama Canal
- Fitness-friendly rentals Panama Canal
- Townhouse rentals Panama Canal
- Rentals with a sauna Panama Canal
- Family-friendly rentals Panama Canal
- Rentals with an EV charger Panama Canal
- Private suite rentals Panama Canal
- Boutique hotels Panama Canal
- Smoking-friendly rentals Panama Canal
- Rentals with a washer and dryer Panama Canal
- Apartment rentals Panama Canal
- Bed and breakfasts Panama Canal
- Rentals with beach access Panama Canal
- Rentals with a fire pit Panama Canal
- Pet-friendly rentals Panama Canal
- Rentals with a kayak Panama Canal
- Rentals with lake access Panama Canal
- Rentals with a home theater Panama Canal
- Condo rentals Panama Canal
- Beachfront rentals Panama Canal
- House rentals Panama Canal
- Rentals with outdoor seating Panama Canal
- Rentals with a hot tub Panama Canal
- Rentals with an accessible height bed Panama Canal
- Guesthouse rentals Panama Canal
- Things to do Panama Canal
- Tours Panama Canal
- Sightseeing Panama Canal
- Art and culture Panama Canal
- Nature and outdoors Panama Canal
- Food and drink Panama Canal
- Things to do Panama
- Sports activities Panama
- Art and culture Panama
- Nature and outdoors Panama
- Entertainment Panama
- Food and drink Panama
- Sightseeing Panama
- Tours Panama




