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Vacation rentals in Panama Canal

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Top-rated vacation rentals in Panama Canal

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A historic building with a striking clock tower and decorative architecture is prominently featured in the image. Lush green trees surround the structure, and colorful rooftops of nearby buildings create a vibrant setting, emphasizing the area's cultural significance.
Apartment in Panamá
4.92 out of 5 average rating, 183 reviews

Best Location – Spacious Luxury Apartment for 8 wi

Welcome to our spacious and elegant apartment, designed to comfortably host up to 8 guests in the heart of Casco Viejo. Located directly in front of one of the most beautiful and lively plazas in the historic district, you’ll be surrounded by top restaurants, cafés, and vibrant city life. The building also features an elevator for your convenience and access to a rooftop pool, perfect for relaxing after a day exploring the city. Its prime location allows you to easily discover the best attract

Guest favorite
An indoor garden is showcased, featuring lush greenery and soft lighting. A glass roof allows natural light to illuminate the space, which is accented by warm-toned stone walls. Two stylish chairs are positioned nearby, creating a comfortable seating area.
Condo in Panamá
4.91 out of 5 average rating, 134 reviews

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES

Espectacular ático Duplex en Panamá Casco antiguo, de 265 M2 con balcones, terrazas privadas exterior, cuenta con una salón jardín interior, un comedor, 3 hab. (+ sofá cama en studio), recientemente reformado con concepto Loft, diseño exclusivo único y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina , lavavajilla, sala con lavadora. piscina compartida, asc, portero 24-7, no se permiten niños que no sepan nadar, gran variedad de ocio en la zona.

Guest favorite
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Apartment in Panamá
4.87 out of 5 average rating, 387 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favorite
A modern living area features a large wave mural that enhances the space's vibrant decor. Comfortable seating arrangements include a sleek white sofa and a pair of stylish armchairs. A glass coffee table is centered among the furnishings, with tastefully arranged decorative accents.
Apartment in Panamá
4.93 out of 5 average rating, 300 reviews

Modern apt ocean view in heart of Panamá yoo tower

Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Guest favorite
An open living space features a large gray sectional sofa paired with a round wooden coffee table. A patterned rug lies beneath, complementing the light wooden flooring. The kitchen area is visible in the background, showcasing modern appliances and a breakfast bar with stools.
Apartment in Panamá
4.94 out of 5 average rating, 179 reviews

Cozy 2 Bedroom w/ Splash Pool

Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Top guest favorite
A balcony is visible with colorful tiled tables and black wrought iron chairs. Lush potted greenery adds a natural touch, while surrounding buildings with terracotta roofs can be seen in the background. The scene is illuminated by daylight, enhancing the vibrant colors.
Loft in Panama
4.99 out of 5 average rating, 172 reviews

Patty’s Casco 2BR Loft | Balcony & Personal Touch

“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Top guest favorite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 176 reviews

The apartment of a legendary Panamanian footballer

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Top guest favorite
Apartment in Panama City
4.97 out of 5 average rating, 110 reviews

Amazing loft with an iconic view of Casco Viejo

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Las Colinas de Caceres de Arraijan
4.98 out of 5 average rating, 227 reviews

Tropical Haven with Pickleball/Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favorite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in Panamá
4.92 out of 5 average rating, 115 reviews

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Guest favorite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Panamá
4.85 out of 5 average rating, 111 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Guest favorite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.92 out of 5 average rating, 157 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Popular amenities for Panama Canal vacation rentals

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panama Canal