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Apartment vacation rentals in Panama Canal

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama Canal

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Top guest favorite
Apartment in Panamá
4.94 out of 5 average rating, 108 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 232 reviews

En el corazón de Casco, remodelado y con parking

Escápate y descubre casco antiguo en este remodelado , cómodo y céntrico alojamiento en el corazón de Casco Viejo. Nuestra ubicación es lo mejor, te hará regresar. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. La propiedad data del siglo XVII (1756) historia y buen ambiente. Podrás explorar la zona a pie, cocina full equipada, cama king europea, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar -Cocina full equipada

Guest favorite
Apartment in Panamá
5 out of 5 average rating, 9 reviews

Amplio Apartamento en La Cuadra - Casco | By Alura

El Casco Antiguo de Panamá es uno de los barrios más encantadores y vibrantes de la ciudad. Declarado Patrimonio de la Humanidad por la UNESCO. El Apartamento El espacio combina líneas modernas con detalles originales del barrio. Cuenta con una distribución luminosa, cocina equipada, sala amplia y acabados pensados para brindar comodidad. Posee un dormitorio con cama king y un hermoso balcón. Es ideal para quienes buscan vivir una experiencia auténtica en el Casco Antiguo.

Guest favorite
Apartment in Panamá
4.92 out of 5 average rating, 38 reviews

VIP Suite/ Sea View + Pool & Sky Lounge + Gym

Elegant studio suite with stunning ocean views, located on Panama city iconic Cinta Costera. Ideal for business travelers, couples, or tourists seeking style, comfort, and convenience. Features a full kitchen, spacious bathroom, fast Wi-Fi, and washer/dryer. Enjoy top amenities: pool, gym, sky lounge, game room, restaurants, and 24/7 security. Hosted with care by César & Claudia to ensure a warm and memorable stay in Panama . Remember to check our Guide. With parking include !

Guest favorite
An open living space features a large gray sectional sofa paired with a round wooden coffee table. A patterned rug lies beneath, complementing the light wooden flooring. The kitchen area is visible in the background, showcasing modern appliances and a breakfast bar with stools.
Apartment in Panamá
4.94 out of 5 average rating, 170 reviews

Cozy 2 Bedroom w/ Splash Pool

Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Top guest favorite
A rooftop terrace features a wooden hot tub surrounded by potted plants and a stone pathway. In the background, historical ruins are visible, complementing the vibrant atmosphere of the area. Seating areas and greenery contribute to a relaxing outdoor space.
Apartment in Panamá
4.94 out of 5 average rating, 102 reviews

Beautiful apartment in Casco Viejo ST. George D

Bienvenido a nuestro espacioso y encantador apartamento en el Casco Viejo. Situado en un vibrante y histórico barrio. Te encantará la cálida atmósfera creada por las paredes de cal y canto, en perfecta armonía con nuestra moderna y elegante decoración. El espacio es grande y cómodo, ideal para relajarte después de un día explorando la ciudad. Como anfitrión, estoy disponible las 24/7 para responder a tus preguntas y asegurarme de que disfrutas al máximo de tu estancia.

Superhost
Apartment in Panamá
4.79 out of 5 average rating, 24 reviews

Casco Viejo / Penthouse w/ Terrace & Pool Access

Nuestro Penthouse, en el último piso de La Cuadra Residence, en Casco Antiguo, cuenta con terraza privada con vista al Océano Pacifico y su entrada al Canal de Panamá, Cerro Ancón, Casco Antiguo, Cinta Costera, Biomuseo, Puerto de Cruceros de Amador y el skyline de la hermosa Ciudad de Panamá. Contamos con acceso privado al área social y piscina, desde nuestra terraza. Nuestro Lobby cuenta con acceso privado al restaurante Ayala Vida, de autentica comida panameña.

Superhost
A modern living area is featured with a neutral-toned sofa adorned with accent pillows. Natural light floods the space through large windows, showcasing views of the city. A circular coffee table sits in front of the sofa, complemented by a decorative plant and wall art.
Apartment in Panamá
4.82 out of 5 average rating, 111 reviews

Modern Cozy Apartment · Pool, Gym & Coworking

Welcome to our charming apartment in the heart of Panama City! Perfect for digital nomads who take their office with them. At LIVING 73 you will enjoy a wide range of amenities, such as swimming pool, a coworking space and gym. Located in the San Francisco area, it's the perfect starting point for exploring the city. You will find within a 5 minute walk a wide range of restaurants, supermarkets and the Multiplaza Mall, the largest and most varied in the city.

Guest favorite
The spacious bedroom features a comfortable queen-sized bed with fresh linens. Light from bedside lamps creates a soft glow. Unique tiled flooring adds character, and the slanted ceiling enhances the room's spaciousness. A piece of artwork is displayed above the headboard, contributing to the overall ambiance.
Apartment in Panamá
4.91 out of 5 average rating, 152 reviews

Perfect Location - Beautiful Apt in Casco Viejo

Peaceful, beautiful and spacious apartment in perfect location. Located in a quiet area of Casco Antiguo, just steps away from lively Plaza Herrera. It cannot get any better, as just across from this unit you have Museo de La Mola, also restaurant Fonda Lo Que Hay and Felipe Motta Wine Store. Downstairs you have one of the best pizzas in the neighborhood. It’s walking distance from the best coffee shops, restaurants, supermarkets, shops, pharmacies and more.

Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 34 reviews

Gorgeous Flat in the best location in Casco Viejo

This cute and stylish studio is perfectly located in the heart of Casco Viejo, Panama City’s most charming historic district. Recently renovated, it combines modern comfort with classic charm inside a beautiful colonial building—just steps from top restaurants, bars, monuments, and attractions. The space includes a comfortable sofa bed, making it ideal for a couple or a small family looking to enjoy the vibrant atmosphere of Casco right outside their door.

Guest favorite
Apartment in Panamá
5 out of 5 average rating, 15 reviews

Private parking & rooftop | Studio Casco Center

This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 138 reviews

Apartamento completo en Panama

Este encantador apartamento está ubicado en uno de los mejores barrios de Panamá, San Francisco, un lugar céntrico donde encontrarás amplía gastronomía, lugares de diversión, cerca a estaciones de buses, y al centro comercial más importante de la ciudad, Multiplaza. Este apartamento céntrico y tranquilo es una oportunidad que no querrás dejar pasar. Ofrece la combinación perfecta de comodidad, belleza y ubicación conveniente.

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